Denise Valenti - Academia.edu (original) (raw)

Papers by Denise Valenti

which permits unrestricted use, distribution, and reproduction in any medium, provided the origin... more which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This study was to investigate the feasibility of frequency doubling technology (FDT) visual field testing in Alzheimer’s disease (AD) in order to identify early biomarkers of AD in patients already diagnosed with AD and compare the findings to participants not having Alzheimer’s disease. This biomarker would be useful in a battery of tests for the early identification of those with AD. It was not the intent to correlate the visual system biomarker with severity of disease, but to determine if the biomarker was present in pass or fail screening criteria. The study showed with very strong significance that the FDT can identify biomarkers of those with AD compared to an age-matched population that does not have AD. FDT is a simple test to take and administer and has been used to screen for eye and retinal diseases such as glaucoma, retinal macular degeneration, an...

Investigative Ophthalmology & Visual Science, 2012

Ten million baby boomers in the United States will get Alzheimer's disease. Public health pro... more Ten million baby boomers in the United States will get Alzheimer's disease. Public health professionals can benefit from understanding the impact this neurodegenerative disease has on the visual system. This would result in more effective management of the condition and in more effective communication between providers within the neurodegenerative disease multidisciplinary team. Biomarkers through the visual system; nerve fiber deficits, lens opacities, retinal findings related to amyloid, as well as functional losses in eye movement, pupil response, contrast sensitivity and motion cognitive processing of visual information are important in disease diagnosis and management. Contributions from clinicians, rehabilitation specialists and public health providers with clinical expertise in vision can contribute to a higher quality of life for those with Alzheimer's disease and their families. Attendees will be able to identify biomarkers in the visual system that are part of the ...

Investigative Ophthalmology & Visual Science, 2018

Research publications - Association for Research in Nervous and Mental Disease, 1990

which permits unrestricted use, distribution, and reproduction in any medium, provided the origin... more which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Imaging through the visual system in Alzheimer’s disease, with the technology currently in widespread use for the diagnosis and management of eye disease such as glaucoma and macular degeneration, is proving to be promising. In vivo cross-section imaging during an annual comprehensive eye exam has been available for a decade for glaucoma and macular degeneration, and this same imaging, using Optical Coherence Tomography, has been demonstrated to show deficits specific to AD and mild cognitive impairment. These deficits are in the form of nerve fiber layer tissue drop out in the retina and optic nerve. The retrograde loss of nerve fiber layer tissue in the retina and optic nerve may be an early biomarker of AD, and these deficits in the nerve fiber layer of the retina and optic nerve may be the earliest sign of AD, even prior to damage to the hippocampal region ...

Interdisciplinary Topics in Gerontology, 2004

Falls are a major public health concern. In 2009 there were 2.2 million nonfatal falls in the eld... more Falls are a major public health concern. In 2009 there were 2.2 million nonfatal falls in the elderly population treated in emergency rooms with close to 581,000 of these visits requiring hospitalization. It is estimated that the direct medical costs of falls were over 19 billion dollars in the year 2000. In general up to thirty percent of elderly over the age of 65, still living in the community, experience a fall each year. Studies have shown that from 10 to 40% of those residing at home are permanently placed in nursing facilities six to twelve months after experiencing a hip fracture. The risk for falls increases with age and changes in the visual system with normal aging are considered to be contributing to increases risk for falls with age. Uncorrected refractive errors or not wearing appropriate glasses also creates postural instability. Reports indicate that the use of multifocal lenses contributes to a higher risk of falls, but such work does not differentiate between bifoc...

Dr. Valenti was the first OSU student member of her family not to play Beaver Football. She atten... more Dr. Valenti was the first OSU student member of her family not to play Beaver Football. She attended the Southern California College of Optometry and did a Low Vision Residency at the University of Houston College of Optometry. Dr. Valenti provided direct clinical care for over twenty-five years. Her research includes the study of neurodegenerative diseases in the visual system, Alzheimer's disease, Parkinson's disease, brain injury and glaucoma. She collaborates with Dr. Marc Pomplun, eye movement specialist, and athletic trainer Ed Perkins at the University of Massachusetts Boston on visual assessments in sports concussive injury. With three National Football League (NFL) teams within the state, California health care providers cannot help but be aware of the controversy over head injury, concussion and the increased vulnerability to Alzheimer's disease (AD) due to traumatic brain injury. This fall, the for concussions. The San Francisco 49ers pulled Eric Reid and Vern...

Alzheimer's disease (AD) is the most common form of dementia among the aged. It is irreversib... more Alzheimer's disease (AD) is the most common form of dementia among the aged. It is irreversible and progressive. There is indication that not memory, but visual integration processing such as contrast and motion are impacted even before memory. AD impacts vision early in the course of the disease and functional losses correlate with cognitive losses. That initial pathology of Alzheimer's disease originates in the visual association area is evidenced by studies of autopsied brains in the Framingham Heart Study. Visual losses in AD have many aspects in common with the functional losses in other neurodegenerative processes affecting the eye such as age related macular degeneration and glaucoma. Contrast sensitivity deficits in lower spatial frequencies are found in those with AD, motion perception is deficient in AD and there are visual field defects. Glaucoma impacts lower spatial frequencies in contrast sensitivity, produces visual field defects and reductions in motion perce...

Journal of the American Optometric Association

Infants exposed to cocaine during fetal growth are at risk for developmental difficulties, includ... more Infants exposed to cocaine during fetal growth are at risk for developmental difficulties, including vision problems. It is estimated that over 10 percent of the infants born in city hospitals have been exposed to cocaine. Additionally, older infants and children exposed to environmental cocaine are also at risk. All health care providers seeing children will need to be sensitive to the needs of these at-risk children.

Optometry and Vision Science

As people age they are more susceptible to various problems in the visual system. The optometrist... more As people age they are more susceptible to various problems in the visual system. The optometrist is in the position to take care of many of the functional losses that result from age-related problems and diseases. With increased awareness of basic low vision and rehabilitation services, the practitioner can continue to care for the visual needs of the older patient.

International journal of Alzheimer's disease, 2011

Imaging through the visual system in Alzheimer's disease, with the technology currently in wi... more Imaging through the visual system in Alzheimer's disease, with the technology currently in widespread use for the diagnosis and management of eye disease such as glaucoma and macular degeneration, is proving to be promising. In vivo cross-section imaging during an annual comprehensive eye exam has been available for a decade for glaucoma and macular degeneration, and this same imaging, using Optical Coherence Tomography, has been demonstrated to show deficits specific to AD and mild cognitive impairment. These deficits are in the form of nerve fiber layer tissue drop out in the retina and optic nerve. The retrograde loss of nerve fiber layer tissue in the retina and optic nerve may be an early biomarker of AD, and these deficits in the nerve fiber layer of the retina and optic nerve may be the earliest sign of AD, even prior to damage to the hippocampal region that impacts memory.

ISRN neurology, 2013

This study was to investigate the feasibility of frequency doubling technology (FDT) visual field... more This study was to investigate the feasibility of frequency doubling technology (FDT) visual field testing in Alzheimer's disease (AD) in order to identify early biomarkers of AD in patients already diagnosed with AD and compare the findings to participants not having Alzheimer's disease. This biomarker would be useful in a battery of tests for the early identification of those with AD. It was not the intent to correlate the visual system biomarker with severity of disease, but to determine if the biomarker was present in pass or fail screening criteria. The study showed with very strong significance that the FDT can identify biomarkers of those with AD compared to an age-matched population that does not have AD. FDT is a simple test to take and administer and has been used to screen for eye and retinal diseases such as glaucoma, retinal macular degeneration, and diabetic retinopathy. The results obtained in the FDT readout are analyzed and compared to the age normative datab...

Optometry - Journal of the American Optometric Association, 2010

Optometry - Journal of the American Optometric Association, 2005

Optometry and Vision Science, 2011

Purpose-To investigate abandonment rate of prescribed low vision devices for near tasks and facto... more Purpose-To investigate abandonment rate of prescribed low vision devices for near tasks and factors associated with abandonment in a U.S. outpatient population.

which permits unrestricted use, distribution, and reproduction in any medium, provided the origin... more which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This study was to investigate the feasibility of frequency doubling technology (FDT) visual field testing in Alzheimer’s disease (AD) in order to identify early biomarkers of AD in patients already diagnosed with AD and compare the findings to participants not having Alzheimer’s disease. This biomarker would be useful in a battery of tests for the early identification of those with AD. It was not the intent to correlate the visual system biomarker with severity of disease, but to determine if the biomarker was present in pass or fail screening criteria. The study showed with very strong significance that the FDT can identify biomarkers of those with AD compared to an age-matched population that does not have AD. FDT is a simple test to take and administer and has been used to screen for eye and retinal diseases such as glaucoma, retinal macular degeneration, an...

Investigative Ophthalmology & Visual Science, 2012

Ten million baby boomers in the United States will get Alzheimer's disease. Public health pro... more Ten million baby boomers in the United States will get Alzheimer's disease. Public health professionals can benefit from understanding the impact this neurodegenerative disease has on the visual system. This would result in more effective management of the condition and in more effective communication between providers within the neurodegenerative disease multidisciplinary team. Biomarkers through the visual system; nerve fiber deficits, lens opacities, retinal findings related to amyloid, as well as functional losses in eye movement, pupil response, contrast sensitivity and motion cognitive processing of visual information are important in disease diagnosis and management. Contributions from clinicians, rehabilitation specialists and public health providers with clinical expertise in vision can contribute to a higher quality of life for those with Alzheimer's disease and their families. Attendees will be able to identify biomarkers in the visual system that are part of the ...

Investigative Ophthalmology & Visual Science, 2018

Research publications - Association for Research in Nervous and Mental Disease, 1990

which permits unrestricted use, distribution, and reproduction in any medium, provided the origin... more which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Imaging through the visual system in Alzheimer’s disease, with the technology currently in widespread use for the diagnosis and management of eye disease such as glaucoma and macular degeneration, is proving to be promising. In vivo cross-section imaging during an annual comprehensive eye exam has been available for a decade for glaucoma and macular degeneration, and this same imaging, using Optical Coherence Tomography, has been demonstrated to show deficits specific to AD and mild cognitive impairment. These deficits are in the form of nerve fiber layer tissue drop out in the retina and optic nerve. The retrograde loss of nerve fiber layer tissue in the retina and optic nerve may be an early biomarker of AD, and these deficits in the nerve fiber layer of the retina and optic nerve may be the earliest sign of AD, even prior to damage to the hippocampal region ...

Interdisciplinary Topics in Gerontology, 2004

Falls are a major public health concern. In 2009 there were 2.2 million nonfatal falls in the eld... more Falls are a major public health concern. In 2009 there were 2.2 million nonfatal falls in the elderly population treated in emergency rooms with close to 581,000 of these visits requiring hospitalization. It is estimated that the direct medical costs of falls were over 19 billion dollars in the year 2000. In general up to thirty percent of elderly over the age of 65, still living in the community, experience a fall each year. Studies have shown that from 10 to 40% of those residing at home are permanently placed in nursing facilities six to twelve months after experiencing a hip fracture. The risk for falls increases with age and changes in the visual system with normal aging are considered to be contributing to increases risk for falls with age. Uncorrected refractive errors or not wearing appropriate glasses also creates postural instability. Reports indicate that the use of multifocal lenses contributes to a higher risk of falls, but such work does not differentiate between bifoc...

Dr. Valenti was the first OSU student member of her family not to play Beaver Football. She atten... more Dr. Valenti was the first OSU student member of her family not to play Beaver Football. She attended the Southern California College of Optometry and did a Low Vision Residency at the University of Houston College of Optometry. Dr. Valenti provided direct clinical care for over twenty-five years. Her research includes the study of neurodegenerative diseases in the visual system, Alzheimer's disease, Parkinson's disease, brain injury and glaucoma. She collaborates with Dr. Marc Pomplun, eye movement specialist, and athletic trainer Ed Perkins at the University of Massachusetts Boston on visual assessments in sports concussive injury. With three National Football League (NFL) teams within the state, California health care providers cannot help but be aware of the controversy over head injury, concussion and the increased vulnerability to Alzheimer's disease (AD) due to traumatic brain injury. This fall, the for concussions. The San Francisco 49ers pulled Eric Reid and Vern...

Alzheimer's disease (AD) is the most common form of dementia among the aged. It is irreversib... more Alzheimer's disease (AD) is the most common form of dementia among the aged. It is irreversible and progressive. There is indication that not memory, but visual integration processing such as contrast and motion are impacted even before memory. AD impacts vision early in the course of the disease and functional losses correlate with cognitive losses. That initial pathology of Alzheimer's disease originates in the visual association area is evidenced by studies of autopsied brains in the Framingham Heart Study. Visual losses in AD have many aspects in common with the functional losses in other neurodegenerative processes affecting the eye such as age related macular degeneration and glaucoma. Contrast sensitivity deficits in lower spatial frequencies are found in those with AD, motion perception is deficient in AD and there are visual field defects. Glaucoma impacts lower spatial frequencies in contrast sensitivity, produces visual field defects and reductions in motion perce...

Journal of the American Optometric Association

Infants exposed to cocaine during fetal growth are at risk for developmental difficulties, includ... more Infants exposed to cocaine during fetal growth are at risk for developmental difficulties, including vision problems. It is estimated that over 10 percent of the infants born in city hospitals have been exposed to cocaine. Additionally, older infants and children exposed to environmental cocaine are also at risk. All health care providers seeing children will need to be sensitive to the needs of these at-risk children.

Optometry and Vision Science

As people age they are more susceptible to various problems in the visual system. The optometrist... more As people age they are more susceptible to various problems in the visual system. The optometrist is in the position to take care of many of the functional losses that result from age-related problems and diseases. With increased awareness of basic low vision and rehabilitation services, the practitioner can continue to care for the visual needs of the older patient.

International journal of Alzheimer's disease, 2011

Imaging through the visual system in Alzheimer's disease, with the technology currently in wi... more Imaging through the visual system in Alzheimer's disease, with the technology currently in widespread use for the diagnosis and management of eye disease such as glaucoma and macular degeneration, is proving to be promising. In vivo cross-section imaging during an annual comprehensive eye exam has been available for a decade for glaucoma and macular degeneration, and this same imaging, using Optical Coherence Tomography, has been demonstrated to show deficits specific to AD and mild cognitive impairment. These deficits are in the form of nerve fiber layer tissue drop out in the retina and optic nerve. The retrograde loss of nerve fiber layer tissue in the retina and optic nerve may be an early biomarker of AD, and these deficits in the nerve fiber layer of the retina and optic nerve may be the earliest sign of AD, even prior to damage to the hippocampal region that impacts memory.

ISRN neurology, 2013

This study was to investigate the feasibility of frequency doubling technology (FDT) visual field... more This study was to investigate the feasibility of frequency doubling technology (FDT) visual field testing in Alzheimer's disease (AD) in order to identify early biomarkers of AD in patients already diagnosed with AD and compare the findings to participants not having Alzheimer's disease. This biomarker would be useful in a battery of tests for the early identification of those with AD. It was not the intent to correlate the visual system biomarker with severity of disease, but to determine if the biomarker was present in pass or fail screening criteria. The study showed with very strong significance that the FDT can identify biomarkers of those with AD compared to an age-matched population that does not have AD. FDT is a simple test to take and administer and has been used to screen for eye and retinal diseases such as glaucoma, retinal macular degeneration, and diabetic retinopathy. The results obtained in the FDT readout are analyzed and compared to the age normative datab...

Optometry - Journal of the American Optometric Association, 2010

Optometry - Journal of the American Optometric Association, 2005

Optometry and Vision Science, 2011

Purpose-To investigate abandonment rate of prescribed low vision devices for near tasks and facto... more Purpose-To investigate abandonment rate of prescribed low vision devices for near tasks and factors associated with abandonment in a U.S. outpatient population.