Tibor Ertl | University of Pécs (original) (raw)

Papers by Tibor Ertl

International Journal of Pancreatology, 1994

3. Participants giving talks were asked to consider as their first priority to analyze of what is... more 3. Participants giving talks were asked to consider as their first priority to analyze of what is known and needs to be known in the subject area, and correlation of what formation with the objectives of the workshop. Second priority would be presentation of the participant's ...

Antioxidants

Less invasive surfactant administration techniques, together with nasal continuous airway pressur... more Less invasive surfactant administration techniques, together with nasal continuous airway pressure (LISA-nCPAP) ventilation, an emerging noninvasive ventilation (NIV) technique in neonatology, are gaining more significance, even in extremely premature newborns (ELBW), under 27 weeks of gestational age. In this review, studies on LISA-nCPAP are compiled with an emphasis on short- and long-term morbidities associated with prematurity. Several perinatal preventative and therapeutic investigations are also discussed in order to start integrated therapies as numerous organ-saving techniques in addition to lung-protective ventilations. Two thirds of immature newborns can start their lives on NIV, and one third of them never need mechanical ventilation. With adjuvant intervention, these ratios are expected to be increased, resulting in better outcomes. Optimized cardiopulmonary transition, especially physiologic cord clamping, could have an additively beneficial effect on patient outcomes ...

PubMed, 1992

Prolactin (PRL) has been detected in the cerebrospinal fluid (CSF) in humans and the absolute lev... more Prolactin (PRL) has been detected in the cerebrospinal fluid (CSF) in humans and the absolute level appears to reflect the serum PRL concentration. Because PRL is thought to be involved in the regulation of brain water and electrolyte content attempt has been made to determine CSF and plasma PRL and dopamine (DA) concentrations, osmolality, and sodium level in 21 newborn infants undergoing lumbar punction because of apneic spells, fever, or perinatal asphyxia. The mean of gestational age was 36.5 weeks (range: 31-41) and birthweight was 2572 g (range: 1140-3550). The lumbar puncture was performed at the 8.3 postnatal day (range: 1-38). The plasma concentration of PRL was 106.52 +/- 14.43 ng/ml, significantly higher than the CSF PRL level (43.24 +/- 7.39 ng/ml, p < 0.01). This elevated level was observed in all individual cases. DA concentration in the plasma was much higher than the value detected in the CSF (64.75 +/- 13.83 vs 8.64 +/- 0.72 ng/ml, p < 0.01). No difference was observed between the sodium content of the CSF and plasma (138.94 +/- 1.28 vs 138.04 +/- 1.03 mmol/l), however, the osmolality of the plasma tended to be higher than the CSF osmolality (286.7 +/- 3.81 vs 276.76 +/- 2.19 mosm/kg, p < 0.05). In the CSF osmolality, PRL, DA, and sodium concentrations did not show any correlation. In conclusion: in the CSF PRL probably does not play a primary role in controlling the osmolality and sodium content. PRL in CSF seems to be independent from CSF DA concentration.

Gynecologic and Obstetric Investigation, 1992

Similar plasma fibrinoectin levels were found in nonpregnant volunteers and first or third trimes... more Similar plasma fibrinoectin levels were found in nonpregnant volunteers and first or third trimester normal pregnant women, while in preeclamptics it was two times higher. The close relationship observed between maternal plasma fibronectin content and corrected fetal birth weight suggests that the state of microcirculation has a profound influence on neonatal birth weight.

Hastings Center Report, 2005

PubMed, 1980

To assess the influences of intrauterine growth retardation on the electrolyte status and the act... more To assess the influences of intrauterine growth retardation on the electrolyte status and the activity of renin-angiotensin-aldosterone system of newborn infants, sodium and potassium balance, as well as plasma renin activity, plasma aldosterone concentration and urinary aldosterone excretion were determined simultaneously in a group of healthy growth retarded and healthy normally grown neonates. It was observed that intake, urinary excretion and retention rate of sodium and potassium as well as the plasma sodium and potassium levels were essentially the same in the two groups. Similarly, no significant difference was found in plasma renin activity, plasma aldosterone level and urinary aldosterone excretion between the neonates whose birth weight was small or appropriate for gestational age. It is concluded that intrauterine growth retardation has no significant influence on the electrolyte status and the activity of the renin--angiotensin--aldosterone system, suggesting that in the regulation of these functions gestational factors are mainly involved.

PubMed, 1982

The possible role of prolactin (PRL) and aldosterone (Aldo) in regulation of Na content of human ... more The possible role of prolactin (PRL) and aldosterone (Aldo) in regulation of Na content of human milk was investigated. Simultaneous determinations of Na and K in milk, PRL and Aldo in maternal plasma and milk were performed on postpartum days 2, 4 and 6, in samples from 15 mothers giving birth at term and from 8 mothers giving preterm birth. Na concentration and Na/K ratio in milk, Aldo concentration in milk and maternal plasma decreased significantly with advancing lactation. In preterm plasma and milk PRL concentration remained unchanged, whereas in term plasma PRL decreased, milk PRL increased significantly by the 6th day post partum. After preterm delivery milk Na and K levels were significantly higher, maternal plasma and milk Aldo slightly lower than after delivery at term. Daily Aldo and PRL excretion into the milk markedly increased during lactation irrespective of the length of gestation and showed a significant negative correlation with milk Na level and Na/K ratio. It is suggested that the increasing rate of Aldo and PRL excretion into the milk may be of importance in the regulation of Na concentration in human milk.

PubMed, 1991

The breast milk prolactin (PRL) has been claimed to play a role in the control of electrolyte com... more The breast milk prolactin (PRL) has been claimed to play a role in the control of electrolyte composition of the milk. Since metoclopramide has been shown to increase milk production in humans, we have made an attempt to investigate the production, the PRL and sodium concentrations in milk with (group I) and without (group II) maternal metoclopramide treatment (5 days, 30 mg/day). Both groups consisted of 11 mothers and their full-term newborn infants. The daily milk production was significantly higher in the treated group (276.4 +/- 36.6 vs 150.9 +/- 25.3 ml/day, p less than 0.01). The PRL measured by RIA was similar in the milk samples of the metoclopramide treated and control groups (80.5 +/- 17.7 vs 90.7 +/- 27.3 ng/ml). The sodium concentration in the milk of mothers taking metoclopramide was 22.1 +/- 1.6 mmol/l and 24.3 +/- 3.2 mmol/l in the control group (p = 0.59). On the 5th postnatal day the plasma PRL of the newborns of mothers treated with metoclopramide does not differ from the values of the control babies (29.8 +/- 2.6 vs 30.7 +/- 2.4 ng/ml) indicating that the amount of metoclopramide transferred into the milk has no apparent influence on the hypothalamo-hypophyseal axis of the neonate. In conclusion: the maternal metoclopramide treatment augments the milk production without having any effect on the PRL and sodium concentration of human "mature" milk.

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Neonatology, 1993

The study was carried out to assess the possible involvement of excess AVP and free water retenti... more The study was carried out to assess the possible involvement of excess AVP and free water retention in the development of late hyponatremia by comparing the postnatal course of plasma AVP and urinary excretion of AVP and sodium as well as creatinine, osmolar and free water clearances in premature infants with (group S) and without (group NS) NaCl supplementation. Plasma total protein and albumin concentrations were also determined. Group NS consisted of 8 infants with a birth weight of 1,150–1,730 g (mean: 1,440 g) and gestational age of 28–32 weeks (mean: 30.4 weeks). Group S included 8 infants with a mean birth weight of 1,390 g (range: 980–1,700 g) and a mean gestational age of 30.1 weeks (range: 27–32 weeks). Measurements were made on the 7th day and weekly thereafter until the 5th week of life. NaCl supplementation was given in a dose of 3–5 and 1.5–2.5 mmol/kg/day for 8–21 and 22–35 days, respectively. Infants receiving sodium supplements had significantly greater urinary sodium excretion (p < 0.01), retained more sodium (p < 0.01), maintained plasma sodium at normal levels and gained weight at slightly higher rates when compared with those on low sodium. Plasma AVP tended to be higher in group S but did not differ significantly from that in NS group. Urinary AVP excretion, however, either expressed in ng/day or ng/l00 ml GFR, was significantly higher in group S, although the age-related increase could not be seen when correction was made for GFR. The respective values of AVP excretion in weeks 1,2-3 and 4-5 were 1.02 ± 0.17,3.19 ± 0.47 and 2.44 ± 0.22 ng/day in group S and 0.60 ± 0.12, 0.96 ± 0.12 (p < 0.001) and 1.61 ± 0.26 ng/day (p < 0.01) in group NS. NaCl supplementation and the increased AVP excretion was associated with significant decreases in GFR (p < 0.05), free water excretion (p < 0.01), plasma total protein (p < 0.01) and plasma albumin (p < 0.01) concentrations. These data suggest that NaCl supplementation prevents late hyponatremia at the expense of AVP-mediated water retention and subsequent volume expansion.

Pediatric Research, 1990

47 cixrd Kra-r. m l i o Bassi. Demrtmat of Pediatrics. Uciwrsity o f '~r n e , *itze;lanh. Ventil... more 47 cixrd Kra-r. m l i o Bassi. Demrtmat of Pediatrics. Uciwrsity o f '~r n e , *itze;lanh. Ventilation for HMD csn lead t o BPD resu1tir.g ir! long lasting functiona.1 1w.g i r r p a i m t. W-etkr this alsc occurs when BPD does not develc~, i s nct kncwn. Therefore, k~ tested lung function i r. 18 children (d i m age 7 7/12 years) who h2d k e n ventilated for HMC withcut BPD, iri 20 nm.-ventilated sib-1ir.g~ (9 1C/12) a d ir. 20 ccntrols ~?at&.ed for gestaticmal age, birth wight, and. sex (6 2/12). Methcd: Lung function was masurd by whole-bcdy p1eth)smcgraphy. Airway reactivity was assessed by carbachol provxation. Abnolmal lung fw.ctim was defined when hyperir,flation (TGV>130 % predictec!) ar,d/or m a l l ailway ohstrue t i m (maxinal expiratory flcw a t 50 % WG30 %) was present. Results: 10/18 ventilated children, 1/20 siblkgs (m.021) and 3/23

International Journal of Cancer, Oct 9, 1995

We investigated the effects of bombesin/GRP antagonists RC‐3095 and RC‐3940‐II on the growth of S... more We investigated the effects of bombesin/GRP antagonists RC‐3095 and RC‐3940‐II on the growth of SW‐1990 human pancreatic adenocarcinoma cells xenografted into nude mice or cultured in vitro. Nude mice implanted with SW‐1990 tumors received s.c. injections of RC‐3095 and RC‐3940‐II or the vehicle (control) for 28 days. Chronic administration of RC‐3940‐II inhibited the growth of SW‐1990 tumors, as shown by a reduction in tumor volume during the treatment and a significant increase in tumor doubling time. RC‐3940‐II decreased final tumor volume by 57.7% and tumor growth rate by 65%. Final tumor weights in mice treated with RC‐3940‐II were 75% lower than in controls. Treatment with RC‐3095 induced smaller, and not significant, decreases in tumor volume and weight. In cell cultures, both RC‐3095 and RC‐3940‐II effectively inhibited the proliferation of SW‐1990 cells, inducing a dose‐ and time‐dependent decrease in the number of cells. RC‐3940‐II again suppressed in vitro growth of SW‐1990 cells more effectively than RC‐3095. After 72 hr of culture, RC‐3940‐II and RC‐3095 at I μM concentrations decreased cell numbers by 45.7% and 27.7%, respectively. The estimated EC50 value for RC‐3940‐II was I nM. When SW‐1990 cells were cultured in the presence of I nM and 10 nM RC‐3095 for 72 hr, cAMP levels in the incubation medium were decreased to 77.3% and 26.9% of the control value. Our results indicate that bombesin/GRP antagonist RC‐3940‐II can inhibit the proliferation of SW‐1990 human pancreatic adenocarcinoma cells in vivo and in vitro. Our findings also suggest that this effect may involve the intracellular cAMP pathway.

International Journal of Oncology, Jun 1, 1995

It has been demonstrated that bombesin/GRP antagonist D-Tpi 6 ,Leu 13 w(CH 2 NH) Leu 14-BN(6-14) ... more It has been demonstrated that bombesin/GRP antagonist D-Tpi 6 ,Leu 13 w(CH 2 NH) Leu 14-BN(6-14) (RC-3095) inhibits effectively the growth of pancreatic cancer and other tumors in experimental animals and in cell cultures. In an attempt to develop antagonists with still greater antitumor activity, several new pseudononapeptide bombesin/GRP antagonists containing C-terminal LeuW(CH 2 N)Tac-NH 2 have been synthesized in our laboratory. In this study, we investigated the ability of four Leu'MCH 2 N)Tac 14-BN(6-14) antagonists to inhibit the binding of bombesin to specific receptors for bombesin/GRP on CFPAC-1 human pancreatic cancer cells. Receptor binding assays were performed by incubating CFPAC-1 cells (5xl0 4 cells/well) with 0.5 nM ['^IJ-Ty^-bombesin in the absence or presence of (1 pM to 10 (4.M) unlabeled bombesin, GRP(14-27) and various antagonists for 2 h at 22°C. Displacement assays showed that antagonist D-Tpi 6 ,Leu 13 w(CH 2 N)Tac 14-BN(6-14) (RC-3910-II) with a similar structure to RC-3095, but a different Cterminal, had a binding affinity to CFPAC-1 cells 15 times higher than RC-3095. Three other antagonists, RC-3925-II, RC-3940-II and RC-3950-II contained the same C-terminal

Nutrients

Background: Infants have three options for feeding: their own mother’s breast milk, donor milk, o... more Background: Infants have three options for feeding: their own mother’s breast milk, donor milk, or infant formula. Insulin, testosterone, total protein, and albumin levels were measured in breast milk samples from the first 6 months of lactation, in donor milk samples, and in different infant formulas. Methods: Mothers who gave birth to term (n = 19) or preterm (n = 19) infants were recruited to collect breast milk samples during the first 6 months of lactation. The Breast Milk Collection Center (Unified Health Institution, Pécs, Hungary) provided 96 donor milk (DM) samples for analysis in our study. Insulin, testosterone, total protein, and albumin levels were measured in breast milk, donor milk, and infant formulas. Results: During the first 2 months of lactation, the concentration of insulin was lower (−27.4%) while the testosterone concentration was higher (+20.8%) compared to the period between the 3rd and 6th months only in the preterm breast milk samples. The infant formulas ...

Magyar nöorvosok lapja, 2005

The Journal of Pediatrics, 1982

In this study, we investigated the effect of bombesin/GRP antagonist RC-3095 on the growth of CFP... more In this study, we investigated the effect of bombesin/GRP antagonist RC-3095 on the growth of CFPAC-1 human pancreatic cancer cells transplanted to nude mice or cultured in vitro. Nude mice bearing xenografts of the CFPAC-1 cell line received s.c. injections of RC-3095 (10/tg twice a day) or the vehicle (control) for 25 days. Chronic administration of RC3095 inhibited the growth of CFPAC-1 tumors in nude mice as shown by a significant decrease in tumor volume throughout the period of treatment. Tumor volume doubling time was prolonged by RC-3095 treatment from 7.2 days to 10 days, and the tumor growth rate was decreased by 49%. In mice treated with RC-3095, the tumor growth delay time was 5.8 days. ~I~reatment with RC-3095 decreased the final tumor weight by 37% and reduced DNA and protein contents in tumor tissues by 44 and 39.9%, respectively, compared to the controls. In cultures of the CFPAC-I cell line, the addition of bombesin(1-14) (1 p~a-0.1 pM) to the medium induced a dose-...

Magyar nöorvosok lapja, 2001