Mustafa Cekmen | Istanbul Medeniyet University (original) (raw)

Papers by Mustafa Cekmen

Dermatology, 2000

Access to full text and tables of contents, including tentative ones for forthcoming issues:

The main cause of endemic goitre is iodine deficiency. The severity of iodine deficiency in any r... more The main cause of endemic goitre is iodine deficiency. The severity of iodine deficiency in any region can be evaluated from goitre prevalance, the iodine excretion in the urine, and the iodine content of drinking water. Thyroid function was evaluated in 41 patients with goitre, and compared with 15 healthy subjects (G0). The relationships between thyroid size, serum and urine iodine levels, and thyroid hormones were investigated. Patients were divided into three subgroups according to WHO's modified criteria. Serum iodine levels, 24-hour urinary iodine excretion (mg/24h), and iodine/creatinine (mgI/g) ratios of single urine samples correlated inversely with goitre size (Go; 6.37p2.35 mg/dl, G1b; 5.35p1.55 mg/dl, G2; 4.39p1.77 mg/dl, G3; 4.13p1.87 mg/dl, G0; 59.6p18.2 mg/24h, G1b; 48.5p22.7 mg/24h, G2; 30.8p12.3 mg/24h, G3; 39.4p21.4 mg/24h, G0; 83.54p38.6 mg/g, G1b; 60.82p8.91 mg/g, G2; 51.04p15.18 mg/g, G3; 44.82p21.47 mg/g' pl0.05, respectively). Serum thyroglobulin level...

OBJECTIVE Bacterial translocation (BT) is the passage of viable indigenous bacteria from one site... more OBJECTIVE Bacterial translocation (BT) is the passage of viable indigenous bacteria from one site to another, such as from gastrointestinal tract to the normally sterile regional mesenteric lymph nodes and than other internal organs. In this study we aimed to investigate the BT to kidney and the protective effect of nitric oxide (NO) inhibition. MATERIAL AND METHODS A total of 40 adult male Wistar albino rats weighing 320-350g were divided into four equal groups. Group 1 (n = 10): control group, group-2 (n = 10) sham control, group-3 (n = 10) simple obstruction, in which ileum was ligated 1-2 cm proximal to the ileocecal valve, group-4 (n = 10), simple obstruction and treated with L-NAME. Twenty four hour after the operation rats were sacrificed and kidneys were removed by sterile manner and trunk blood obtained for NO analysis. BT was defined as any positive culture from the blood and kidney. Results were compared with Mann- Whitney U test. RESULTS NO levels in control, sham group,...

Journal of the European Academy of Dermatology and Venereology, 2012

Background The pathogenesis of psoriasis has not been known exactly yet. Recently, it has been su... more Background The pathogenesis of psoriasis has not been known exactly yet. Recently, it has been suggested that increased reactive oxygen species (ROS) such as nitric oxide (NO) and malondialdehyde (MDA) may play a part in the pathogenesis of various skin diseases, including psoriasis. Objectives In this study, we aimed to investigate the role of ROS in the pathogenesis of psoriasis. Methods A convenience sample of 23 patients with psoriasis and 23 healthy subjects consented to participate in the study. Plasma NO and MDA levels were measured in all participants. Psoriasis area and severity index (PASI) and tissue levels of MDA on lesional and non-lesional skin regions of psoriasis patients were measured. In addition, the correlation between age, gender with plasma NO, plasma MDA and tissue MDA was assessed. Results Plasma levels of NO and MDA in psoriasis patients (135.8 lmol ⁄ L, 4.33 lmol ⁄ L, respectively) were statistically significantly higher than those in controls (33.6 lmol ⁄ L, 2.03 lmol ⁄ L, respectively). Tissue levels of MDA in lesional tissues (49.18 nmol ⁄ gr) were significantly higher than those in non-lesional tissues (28.41 nmol ⁄ gr). A significant correlation was not found between the PASI and levels of NO and MDA. In addition, a significant negative correlation was found between the plasma NO levels and age. Conclusion NO and MDA levels are elevated in psoriasis patients, which may indicate that oxidative stress plays an important role in the aetiopathogenesis of psoriasis.

Journal of …, 2007

RefDoc Bienvenue - Welcome. Refdoc est un service / is powered by. ...

Pakistan journal of medical sciences

Serum leptin levels of chronic kidney disease patients have been detected higher than normal popu... more Serum leptin levels of chronic kidney disease patients have been detected higher than normal population. The aim of this study was to investigate the effects of serum leptin levels on thrombocyte aggregation in peritoneal dialysis patients. Fourty three peritoneal dialysis patients were included in the study. Thrombocyte aggregation was calculated from the whole blood subsequently the effects of different concentrations of human recombinant leptin on thrombocyte aggregations were investigated. Four test cells were used for this process. While leptin was not added into the first test cell, increasing amounts of leptin was added into the second, third and fourth test cells to attain the concentrations of 25, 50 and 100 ng/ml respectively. Thrombocyte aggregation was inhibited by recombinant leptin in peritoneal dialysis patients. Thrombocyte aggregation mean values were found statistically significantly higher in first test cell when compared to leptin groups in peritoneal dialysis pa...

Journal of assisted reproduction and genetics, 2016

The aim of this study is to investigate the association of perifollicular blood flow (PFBF) with ... more The aim of this study is to investigate the association of perifollicular blood flow (PFBF) with follicular fluid EG-VEGF, inhibin-a, and insulin-like growth factor-1 (IGF-1) concentrations, endometrial vascularity, and IVF outcomes. Forty women with tubal factor infertility were included in a prospective cohort study. Each woman underwent IVF/ICSI procedure. Individual follicles of ≥16 mm (n = 156) were evaluated by power Doppler analysis and categorized as well-vascularized follicles (WVFs) or poorly vascularized follicles (PVFs). WVFs referred to those with perifollicular vascularity of 51-100 %. Each follicular fluid (FF) was individually aspirated and FF/serum EG-VEGF, inhibin-a, and FF IGF-1 levels were evaluated. Zones III-IV endometrial vascularity was classified as a well-vascularized endometrium (WVE). The presence of a WVE and mature oocytes, in addition to the embryo quality and clinical pregnancy rate (CPR), were recorded for each follicle. The main outcome measures wer...

Gaziantep Medical Journal, 2014

International braz j urol, 2016

SUI, involuntary loss of urine, occurs when intra abdominal pressure exceeds urethral pressure in... more SUI, involuntary loss of urine, occurs when intra abdominal pressure exceeds urethral pressure in women. Recent animal study has shown that there are therapeutic effects of Insulin-like growth factors (IGF-1) on stress urinary incontinence in rats with simulated childbirth trauma. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues and stimulates fibroblast proliferation and enhances collagen synthesis. The purpose of the current study was to determine the association between IGF-1 levels and SUI. All patients were evaluated for SUI and divided into two groups: 116 women with SUI and 76 women without SUI. Diagnosis of SUI was based on the International Consultation on Incontinence Questionnaire-Short Form (ICIQSF). Levels of IGF-1 were measured in serum by enzyme-linked immunosorbent assay. The relationship between IGF-1 levels and SUI in patients was evaluated statisticaly. The mean age of patients wiyh SUI was 49.9±8.6 and 48.7±7.8 in control group. Plasma IGF-1 levels were significantly lower in SUI than in control group (106.5±26.4 and 133.3±37.1ng/mL, respectively, P <0.001). Body mass indexes were higher in women with SUI than women without SUI. In this study lower serum IGF-1 levels were found to be associated with SUI. Serum IGF-1 level appears to be a specific predictor of SUI, and it may be used in early prediction of SUI in female population.

Turkiye Klinikleri Journal of Pediatrics, 2001

Nitrik oksit (NO) son yýllarda tanýnan, birçok biyolojik olayda önemli rolü olan, çok kýsa yarý ö... more Nitrik oksit (NO) son yýllarda tanýnan, birçok biyolojik olayda önemli rolü olan, çok kýsa yarý ömürlü bir serbest radikaldir. Önceleri vasküler sistemde, endotel kaynaklý gevþeme faktörü (EDRF) olarak tanýmlandý. NO ve diðer bir son ürün olan sitrüllin, argininden NO sentaz (NOS) enzimi aracýlýðýyla sentezlenir. NOS'in genetik olarak farklý üç izoformu tespit edilmiþtir. Bunlar; düþük miktarda üretilerek vasküler tonüsü ayarlayan bir konstitutif endoteliyal izoform (eNOS), yine düþük miktar üretilen sinaptik þekillenme ve nörotransmisyonu düzenleyen bir konstitutif nöronal izoform (nNOS) ve yüksek miktarda üretilerek, immün/inflamatuar olaylarda rol alan ve hücre aracýlý immün cevapta etkili bir komponent olan uyarýlabilir form (iNOS)'dur. nNOS ve eNOS izoenzimleri NO üretimi için Ca ++ kalmodulin kompleksine baðýmlýdýr, buna karþýn iNOS bundan baðýmsýzdýr.

Urologia Internationalis, 2016

In this study, we evaluated the effect of 5 mg tadalafil once daily in men with premature ejacula... more In this study, we evaluated the effect of 5 mg tadalafil once daily in men with premature ejaculation (PE). Thirty married men with lifelong PE and 30 healthy men as control group were included in this study. All the patients received 5 mg tadalafil once a day for a month. The international index of erectile function questionnaire and intravaginal ejaculatory latency times (IELTs) and PE profile were recorded before and after treatment. Plasma samples were collected before and after treatment. The mean baseline IELTs was 40.8 ± 8.1 s in the PE group and 196.5 ± 26.2 s in the control group. After treatment in the PE group, the mean IELTs values showed a statistically significant improvement from the baseline values. At the end of 4 weeks, in the PE group, the mean IELT values showed a statistically significant improvement from the baseline values. Baseline serum nitric oxide (NO) levels were 27.3 ± 1.7 in the PE group and in the 31.1 ± 1.4 healthy control groups. After treatment, NO levels were increased from baseline. We consider that 5 mg tadalafil once daily is safety and effective for the treatment of PE.

The Journal of Urology, 2016

Basic and clinical andrology, 2016

Endothelial dysfunction and microvascular damage play a crurical role in the pathogenesis of erec... more Endothelial dysfunction and microvascular damage play a crurical role in the pathogenesis of erectile dysfunction (ED). Insulin-like growth factor-1 (IGF-1) is one of the growth factors that have a wide range of biologic effects. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues. The purpose of the current study was to determine the association between IGF-1 levels and ED. All men were evaluated for ED and divided into two groups: 80 patients suffering from ED for > 1 year and 80 subjects without ED were enrolled as a control group in this study. Diagnosis of ED was based on the International Index of Erectile Function Score-5. IGF-1 levels were measured in serum by an automated chemiluminescence immunoassay. The relationship between IGF-1 levels and ED scores in patients was statistically evaluated. The mean age of patients in ED group was 60.4 ± 11.3 years and 55.4 ± 9.6 in control group. The plasma IGF-1 levels were significan...

International braz j urol : official journal of the Brazilian Society of Urology

Ureteral obstruction is a common pathology and causes kidney fibrosis and dysfunction at late per... more Ureteral obstruction is a common pathology and causes kidney fibrosis and dysfunction at late period. In this present study, we investigated the antifibrotic and antiinflammatory effects of hydrogen sulfide on kidney damage after unilateral ureteral obstruction (UUO) in rats. 24 rats were divided into four groups. Group 1 was control, group 2 was sham, group 3 included rats with UUO and group 4 rats with UUO which were given sodium hydrogen sulfide (NaHS)-exogenous donor of hydrogen sulfide (intraperitoneally 56µmoL/kg/day). After 14 days, rats were killed and their kidneys were taken and blood analysis was performed. Tubular necrosis, mononuclear cell infiltration and interstitial fibrosis were determined histopathologically in a part of the kidneys; nitric oxide (NO), malondialdehyde (MDA) and reduced glutathione (GSH) levels were determined in the other part of the kidneys. Urea-creatinine levels were investigated by blood analysis. Statistical analyses were made by the Chi-squar...

Turgut Ozal Tıp Merkezi Dergisi, 1997

European journal of ophthalmology

Pro-inflammatory cytokines are produced by tissues and play a vital role in the host inflammatory... more Pro-inflammatory cytokines are produced by tissues and play a vital role in the host inflammatory response and uveitis. Nitric oxide (NO) can be produced in large amounts as a response to experimentally-induced uveitis or cytokines. In this study, we measured the levels of pro-inflammatory cytokines such as interleukin (IL)-1beta, IL-6, IL-8, tumor necrosis factor (TNF)-alpha and free-radical in aqueous humor after Nd:YAG laser iridotomy in rabbits, and investigated whether timolol maleate an anti-glaucoma drug, or a NO synthase inhibitor, NG-nitro-L-arginine methyl esther (L-NAME) had an inhibitory effect on these molecules, since L-NAME is a known anti-inflammatory agent in rabbits. Bilateral experimental Nd:YAG laser iridotomy (power 7.5 mJ, mode single burst, aiming beam 4) was performed on 18 rabbits under general plus topical anesthesia. Aqueous humor samples were taken by clear corneal paracentesis preoperatively, and 1 and 24 h postoperatively. Six rabbits (12 eyes) were given bilateral topical timolol maleate 0.5% (Timoptic) drop b.i.d. (group 1), six rabbits (12 eyes) received bilateral 0.1 ml subconjuntival injections of L-NAME (150 mg/kg) (group 2), and six rabbits (12 eyes) were treated with topical balanced salt solution (BSS) b.i.d. (control). RESULTS. Preoperative cytokine and NO levels were comparable in the three groups, with no significant differences. In addition, there was no significant difference in baseline cytokine levels between the right and left eyes. In all groups, pre- and postoperative mean IL-1beta levels were below the detection limit of the assay (<5.0 pg/ml). In the control group, postoperative mean IL-6, IL-8 and NO levels were significantly higher after Nd:YAG laser iridotomy than before (for each, p < 0.01). Timolol and L-NAME both inhibited the rise in IL-8 and TNF-alpha levels. Timolol also inhibited the rise in IL-6 but not NO. L-NAME had an inhibitory effect against NO, but not IL-6. L-NAME has an inhibitory effect on IL-8, TNF-alpha and NO, but not on IL-6. Timolol had inhibitory effects on IL-6, IL-8 and TNF-alpha, but not on NO. These preliminary experimental results might help in assssing the effect of Nd:YAG laser iridotomy in aqueous humor, and to understand the inhibitory effects of timolol and L-NAME against these molecules.

European journal of gynaecological oncology

There is no adequate data in the medical literature defining serum CA-125 levels after laparoscop... more There is no adequate data in the medical literature defining serum CA-125 levels after laparoscopy. Therefore we designed this prospective study to evaluate the effects of laparoscopy on serum CA-125 levels. Eighty-two women (mean age 34.2 +/- 12.30 years) were included in the study between January, 2001 and April, 2003. Laparoscopies were performed in patients with chronic pelvic pain, dysmenorrhea, infertility, ovarian cysts and for tubal ligation. Mean serum CA-125 levels of the patients before and after the laparoscopic procedures were 13.96 +/- 4.86 U/ml and 14.02 +/- 4.96 U/ml, respectively. The change in serum CA-125 levels prior to laparoscopy was statistically insignificant when compared with the levels obtained at 24 hours after laparoscopic procedure (p > 0.05). We found that diagnostic laparoscopy or laparoscopic surgical procedures did not change the levels of CA-125 at the 24th hour after laparoscopy indicating either serum CA-125 levels are not correlated, at least within 24 hours, with peritoneal irritation or peritoneal irritation is minimal or absent in our operations.

European journal of gynaecological oncology

There is no adequate data in the medical literature defining serum CA-125 levels after laparotomy... more There is no adequate data in the medical literature defining serum CA-125 levels after laparotomy. Therefore we designed this prospective study to evaluate the effects of laparotomy for hysterectomy on serum CA-125 levels. Ninety-four women (mean age 44.6 +/- 6.9 years) were included in the study between January, 2001 and April, 2003. Hysterectomies were performed in patients with chronic pelvic pain, dysfunctional uterine bleeding and myoma uteri. Mean serum CA-125 levels of the patients before and after laparotomy were 16.29 +/- 8.11 U/ml and 16.37 +/- 8.05 U/ml, respectively. The change in serum CA-125 levels prior to the operation was statistically insignificant when compared with the levels obtained at 24 hours after laparotomy (p > 0.05). We found that laparotomy for hysterectomy did not change the levels of CA-125 at the 24th hour after the operation, indicating either serum CA-125 levels are not correlated, at least within 24 hours, with peritoneal irritation or peritoneal irritation was minimal or absent in our operations.

Ophthalmic surgery and lasers

ABSTRACT

Transplantation Proceedings

BK virus nephropathy (BKVN) is among the most important problems in renal transplant recipients. ... more BK virus nephropathy (BKVN) is among the most important problems in renal transplant recipients. This report presented an assessment of treatment with a fluoroquinolone antibiotic, ciprofloxacin, for 6 months in a 21-year-old male patient who developed BKVN after transplantation. Ciprofloxacin treatment reduced the viral load and improved the clinical findings.

Dermatology, 2000

Access to full text and tables of contents, including tentative ones for forthcoming issues:

The main cause of endemic goitre is iodine deficiency. The severity of iodine deficiency in any r... more The main cause of endemic goitre is iodine deficiency. The severity of iodine deficiency in any region can be evaluated from goitre prevalance, the iodine excretion in the urine, and the iodine content of drinking water. Thyroid function was evaluated in 41 patients with goitre, and compared with 15 healthy subjects (G0). The relationships between thyroid size, serum and urine iodine levels, and thyroid hormones were investigated. Patients were divided into three subgroups according to WHO's modified criteria. Serum iodine levels, 24-hour urinary iodine excretion (mg/24h), and iodine/creatinine (mgI/g) ratios of single urine samples correlated inversely with goitre size (Go; 6.37p2.35 mg/dl, G1b; 5.35p1.55 mg/dl, G2; 4.39p1.77 mg/dl, G3; 4.13p1.87 mg/dl, G0; 59.6p18.2 mg/24h, G1b; 48.5p22.7 mg/24h, G2; 30.8p12.3 mg/24h, G3; 39.4p21.4 mg/24h, G0; 83.54p38.6 mg/g, G1b; 60.82p8.91 mg/g, G2; 51.04p15.18 mg/g, G3; 44.82p21.47 mg/g' pl0.05, respectively). Serum thyroglobulin level...

OBJECTIVE Bacterial translocation (BT) is the passage of viable indigenous bacteria from one site... more OBJECTIVE Bacterial translocation (BT) is the passage of viable indigenous bacteria from one site to another, such as from gastrointestinal tract to the normally sterile regional mesenteric lymph nodes and than other internal organs. In this study we aimed to investigate the BT to kidney and the protective effect of nitric oxide (NO) inhibition. MATERIAL AND METHODS A total of 40 adult male Wistar albino rats weighing 320-350g were divided into four equal groups. Group 1 (n = 10): control group, group-2 (n = 10) sham control, group-3 (n = 10) simple obstruction, in which ileum was ligated 1-2 cm proximal to the ileocecal valve, group-4 (n = 10), simple obstruction and treated with L-NAME. Twenty four hour after the operation rats were sacrificed and kidneys were removed by sterile manner and trunk blood obtained for NO analysis. BT was defined as any positive culture from the blood and kidney. Results were compared with Mann- Whitney U test. RESULTS NO levels in control, sham group,...

Journal of the European Academy of Dermatology and Venereology, 2012

Background The pathogenesis of psoriasis has not been known exactly yet. Recently, it has been su... more Background The pathogenesis of psoriasis has not been known exactly yet. Recently, it has been suggested that increased reactive oxygen species (ROS) such as nitric oxide (NO) and malondialdehyde (MDA) may play a part in the pathogenesis of various skin diseases, including psoriasis. Objectives In this study, we aimed to investigate the role of ROS in the pathogenesis of psoriasis. Methods A convenience sample of 23 patients with psoriasis and 23 healthy subjects consented to participate in the study. Plasma NO and MDA levels were measured in all participants. Psoriasis area and severity index (PASI) and tissue levels of MDA on lesional and non-lesional skin regions of psoriasis patients were measured. In addition, the correlation between age, gender with plasma NO, plasma MDA and tissue MDA was assessed. Results Plasma levels of NO and MDA in psoriasis patients (135.8 lmol ⁄ L, 4.33 lmol ⁄ L, respectively) were statistically significantly higher than those in controls (33.6 lmol ⁄ L, 2.03 lmol ⁄ L, respectively). Tissue levels of MDA in lesional tissues (49.18 nmol ⁄ gr) were significantly higher than those in non-lesional tissues (28.41 nmol ⁄ gr). A significant correlation was not found between the PASI and levels of NO and MDA. In addition, a significant negative correlation was found between the plasma NO levels and age. Conclusion NO and MDA levels are elevated in psoriasis patients, which may indicate that oxidative stress plays an important role in the aetiopathogenesis of psoriasis.

Journal of …, 2007

RefDoc Bienvenue - Welcome. Refdoc est un service / is powered by. ...

Pakistan journal of medical sciences

Serum leptin levels of chronic kidney disease patients have been detected higher than normal popu... more Serum leptin levels of chronic kidney disease patients have been detected higher than normal population. The aim of this study was to investigate the effects of serum leptin levels on thrombocyte aggregation in peritoneal dialysis patients. Fourty three peritoneal dialysis patients were included in the study. Thrombocyte aggregation was calculated from the whole blood subsequently the effects of different concentrations of human recombinant leptin on thrombocyte aggregations were investigated. Four test cells were used for this process. While leptin was not added into the first test cell, increasing amounts of leptin was added into the second, third and fourth test cells to attain the concentrations of 25, 50 and 100 ng/ml respectively. Thrombocyte aggregation was inhibited by recombinant leptin in peritoneal dialysis patients. Thrombocyte aggregation mean values were found statistically significantly higher in first test cell when compared to leptin groups in peritoneal dialysis pa...

Journal of assisted reproduction and genetics, 2016

The aim of this study is to investigate the association of perifollicular blood flow (PFBF) with ... more The aim of this study is to investigate the association of perifollicular blood flow (PFBF) with follicular fluid EG-VEGF, inhibin-a, and insulin-like growth factor-1 (IGF-1) concentrations, endometrial vascularity, and IVF outcomes. Forty women with tubal factor infertility were included in a prospective cohort study. Each woman underwent IVF/ICSI procedure. Individual follicles of ≥16 mm (n = 156) were evaluated by power Doppler analysis and categorized as well-vascularized follicles (WVFs) or poorly vascularized follicles (PVFs). WVFs referred to those with perifollicular vascularity of 51-100 %. Each follicular fluid (FF) was individually aspirated and FF/serum EG-VEGF, inhibin-a, and FF IGF-1 levels were evaluated. Zones III-IV endometrial vascularity was classified as a well-vascularized endometrium (WVE). The presence of a WVE and mature oocytes, in addition to the embryo quality and clinical pregnancy rate (CPR), were recorded for each follicle. The main outcome measures wer...

Gaziantep Medical Journal, 2014

International braz j urol, 2016

SUI, involuntary loss of urine, occurs when intra abdominal pressure exceeds urethral pressure in... more SUI, involuntary loss of urine, occurs when intra abdominal pressure exceeds urethral pressure in women. Recent animal study has shown that there are therapeutic effects of Insulin-like growth factors (IGF-1) on stress urinary incontinence in rats with simulated childbirth trauma. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues and stimulates fibroblast proliferation and enhances collagen synthesis. The purpose of the current study was to determine the association between IGF-1 levels and SUI. All patients were evaluated for SUI and divided into two groups: 116 women with SUI and 76 women without SUI. Diagnosis of SUI was based on the International Consultation on Incontinence Questionnaire-Short Form (ICIQSF). Levels of IGF-1 were measured in serum by enzyme-linked immunosorbent assay. The relationship between IGF-1 levels and SUI in patients was evaluated statisticaly. The mean age of patients wiyh SUI was 49.9±8.6 and 48.7±7.8 in control group. Plasma IGF-1 levels were significantly lower in SUI than in control group (106.5±26.4 and 133.3±37.1ng/mL, respectively, P <0.001). Body mass indexes were higher in women with SUI than women without SUI. In this study lower serum IGF-1 levels were found to be associated with SUI. Serum IGF-1 level appears to be a specific predictor of SUI, and it may be used in early prediction of SUI in female population.

Turkiye Klinikleri Journal of Pediatrics, 2001

Nitrik oksit (NO) son yýllarda tanýnan, birçok biyolojik olayda önemli rolü olan, çok kýsa yarý ö... more Nitrik oksit (NO) son yýllarda tanýnan, birçok biyolojik olayda önemli rolü olan, çok kýsa yarý ömürlü bir serbest radikaldir. Önceleri vasküler sistemde, endotel kaynaklý gevþeme faktörü (EDRF) olarak tanýmlandý. NO ve diðer bir son ürün olan sitrüllin, argininden NO sentaz (NOS) enzimi aracýlýðýyla sentezlenir. NOS'in genetik olarak farklý üç izoformu tespit edilmiþtir. Bunlar; düþük miktarda üretilerek vasküler tonüsü ayarlayan bir konstitutif endoteliyal izoform (eNOS), yine düþük miktar üretilen sinaptik þekillenme ve nörotransmisyonu düzenleyen bir konstitutif nöronal izoform (nNOS) ve yüksek miktarda üretilerek, immün/inflamatuar olaylarda rol alan ve hücre aracýlý immün cevapta etkili bir komponent olan uyarýlabilir form (iNOS)'dur. nNOS ve eNOS izoenzimleri NO üretimi için Ca ++ kalmodulin kompleksine baðýmlýdýr, buna karþýn iNOS bundan baðýmsýzdýr.

Urologia Internationalis, 2016

In this study, we evaluated the effect of 5 mg tadalafil once daily in men with premature ejacula... more In this study, we evaluated the effect of 5 mg tadalafil once daily in men with premature ejaculation (PE). Thirty married men with lifelong PE and 30 healthy men as control group were included in this study. All the patients received 5 mg tadalafil once a day for a month. The international index of erectile function questionnaire and intravaginal ejaculatory latency times (IELTs) and PE profile were recorded before and after treatment. Plasma samples were collected before and after treatment. The mean baseline IELTs was 40.8 ± 8.1 s in the PE group and 196.5 ± 26.2 s in the control group. After treatment in the PE group, the mean IELTs values showed a statistically significant improvement from the baseline values. At the end of 4 weeks, in the PE group, the mean IELT values showed a statistically significant improvement from the baseline values. Baseline serum nitric oxide (NO) levels were 27.3 ± 1.7 in the PE group and in the 31.1 ± 1.4 healthy control groups. After treatment, NO levels were increased from baseline. We consider that 5 mg tadalafil once daily is safety and effective for the treatment of PE.

The Journal of Urology, 2016

Basic and clinical andrology, 2016

Endothelial dysfunction and microvascular damage play a crurical role in the pathogenesis of erec... more Endothelial dysfunction and microvascular damage play a crurical role in the pathogenesis of erectile dysfunction (ED). Insulin-like growth factor-1 (IGF-1) is one of the growth factors that have a wide range of biologic effects. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues. The purpose of the current study was to determine the association between IGF-1 levels and ED. All men were evaluated for ED and divided into two groups: 80 patients suffering from ED for > 1 year and 80 subjects without ED were enrolled as a control group in this study. Diagnosis of ED was based on the International Index of Erectile Function Score-5. IGF-1 levels were measured in serum by an automated chemiluminescence immunoassay. The relationship between IGF-1 levels and ED scores in patients was statistically evaluated. The mean age of patients in ED group was 60.4 ± 11.3 years and 55.4 ± 9.6 in control group. The plasma IGF-1 levels were significan...

International braz j urol : official journal of the Brazilian Society of Urology

Ureteral obstruction is a common pathology and causes kidney fibrosis and dysfunction at late per... more Ureteral obstruction is a common pathology and causes kidney fibrosis and dysfunction at late period. In this present study, we investigated the antifibrotic and antiinflammatory effects of hydrogen sulfide on kidney damage after unilateral ureteral obstruction (UUO) in rats. 24 rats were divided into four groups. Group 1 was control, group 2 was sham, group 3 included rats with UUO and group 4 rats with UUO which were given sodium hydrogen sulfide (NaHS)-exogenous donor of hydrogen sulfide (intraperitoneally 56µmoL/kg/day). After 14 days, rats were killed and their kidneys were taken and blood analysis was performed. Tubular necrosis, mononuclear cell infiltration and interstitial fibrosis were determined histopathologically in a part of the kidneys; nitric oxide (NO), malondialdehyde (MDA) and reduced glutathione (GSH) levels were determined in the other part of the kidneys. Urea-creatinine levels were investigated by blood analysis. Statistical analyses were made by the Chi-squar...

Turgut Ozal Tıp Merkezi Dergisi, 1997

European journal of ophthalmology

Pro-inflammatory cytokines are produced by tissues and play a vital role in the host inflammatory... more Pro-inflammatory cytokines are produced by tissues and play a vital role in the host inflammatory response and uveitis. Nitric oxide (NO) can be produced in large amounts as a response to experimentally-induced uveitis or cytokines. In this study, we measured the levels of pro-inflammatory cytokines such as interleukin (IL)-1beta, IL-6, IL-8, tumor necrosis factor (TNF)-alpha and free-radical in aqueous humor after Nd:YAG laser iridotomy in rabbits, and investigated whether timolol maleate an anti-glaucoma drug, or a NO synthase inhibitor, NG-nitro-L-arginine methyl esther (L-NAME) had an inhibitory effect on these molecules, since L-NAME is a known anti-inflammatory agent in rabbits. Bilateral experimental Nd:YAG laser iridotomy (power 7.5 mJ, mode single burst, aiming beam 4) was performed on 18 rabbits under general plus topical anesthesia. Aqueous humor samples were taken by clear corneal paracentesis preoperatively, and 1 and 24 h postoperatively. Six rabbits (12 eyes) were given bilateral topical timolol maleate 0.5% (Timoptic) drop b.i.d. (group 1), six rabbits (12 eyes) received bilateral 0.1 ml subconjuntival injections of L-NAME (150 mg/kg) (group 2), and six rabbits (12 eyes) were treated with topical balanced salt solution (BSS) b.i.d. (control). RESULTS. Preoperative cytokine and NO levels were comparable in the three groups, with no significant differences. In addition, there was no significant difference in baseline cytokine levels between the right and left eyes. In all groups, pre- and postoperative mean IL-1beta levels were below the detection limit of the assay (<5.0 pg/ml). In the control group, postoperative mean IL-6, IL-8 and NO levels were significantly higher after Nd:YAG laser iridotomy than before (for each, p < 0.01). Timolol and L-NAME both inhibited the rise in IL-8 and TNF-alpha levels. Timolol also inhibited the rise in IL-6 but not NO. L-NAME had an inhibitory effect against NO, but not IL-6. L-NAME has an inhibitory effect on IL-8, TNF-alpha and NO, but not on IL-6. Timolol had inhibitory effects on IL-6, IL-8 and TNF-alpha, but not on NO. These preliminary experimental results might help in assssing the effect of Nd:YAG laser iridotomy in aqueous humor, and to understand the inhibitory effects of timolol and L-NAME against these molecules.

European journal of gynaecological oncology

There is no adequate data in the medical literature defining serum CA-125 levels after laparoscop... more There is no adequate data in the medical literature defining serum CA-125 levels after laparoscopy. Therefore we designed this prospective study to evaluate the effects of laparoscopy on serum CA-125 levels. Eighty-two women (mean age 34.2 +/- 12.30 years) were included in the study between January, 2001 and April, 2003. Laparoscopies were performed in patients with chronic pelvic pain, dysmenorrhea, infertility, ovarian cysts and for tubal ligation. Mean serum CA-125 levels of the patients before and after the laparoscopic procedures were 13.96 +/- 4.86 U/ml and 14.02 +/- 4.96 U/ml, respectively. The change in serum CA-125 levels prior to laparoscopy was statistically insignificant when compared with the levels obtained at 24 hours after laparoscopic procedure (p > 0.05). We found that diagnostic laparoscopy or laparoscopic surgical procedures did not change the levels of CA-125 at the 24th hour after laparoscopy indicating either serum CA-125 levels are not correlated, at least within 24 hours, with peritoneal irritation or peritoneal irritation is minimal or absent in our operations.

European journal of gynaecological oncology

There is no adequate data in the medical literature defining serum CA-125 levels after laparotomy... more There is no adequate data in the medical literature defining serum CA-125 levels after laparotomy. Therefore we designed this prospective study to evaluate the effects of laparotomy for hysterectomy on serum CA-125 levels. Ninety-four women (mean age 44.6 +/- 6.9 years) were included in the study between January, 2001 and April, 2003. Hysterectomies were performed in patients with chronic pelvic pain, dysfunctional uterine bleeding and myoma uteri. Mean serum CA-125 levels of the patients before and after laparotomy were 16.29 +/- 8.11 U/ml and 16.37 +/- 8.05 U/ml, respectively. The change in serum CA-125 levels prior to the operation was statistically insignificant when compared with the levels obtained at 24 hours after laparotomy (p > 0.05). We found that laparotomy for hysterectomy did not change the levels of CA-125 at the 24th hour after the operation, indicating either serum CA-125 levels are not correlated, at least within 24 hours, with peritoneal irritation or peritoneal irritation was minimal or absent in our operations.

Ophthalmic surgery and lasers

ABSTRACT

Transplantation Proceedings

BK virus nephropathy (BKVN) is among the most important problems in renal transplant recipients. ... more BK virus nephropathy (BKVN) is among the most important problems in renal transplant recipients. This report presented an assessment of treatment with a fluoroquinolone antibiotic, ciprofloxacin, for 6 months in a 21-year-old male patient who developed BKVN after transplantation. Ciprofloxacin treatment reduced the viral load and improved the clinical findings.