Blaženka Grahovac | University of Rijeka, Faculty of Medicine (original) (raw)
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Papers by Blaženka Grahovac
Acta medica Croatica, 2001
Retreatment of chronic hepatitis C patients resistant to previous interferon/ribavirin combinatio... more Retreatment of chronic hepatitis C patients resistant to previous interferon/ribavirin combination therapy with interferon alpha, ribavirin and amantadin: a triple therapy pilot study
Medicina Fluminensis, Mar 1, 2022
Clinical Chemistry, 1988
We report an effective follow-up of the establishment of bone-marrow function after an allogeneic... more We report an effective follow-up of the establishment of bone-marrow function after an allogeneic bone-marrow transplantation in a patient with acute lymphoblastic leukemia, by means of a suitable genetic marker, phosphoglucomutase-1 (EC 5.4.2.2) isoenzyme. A patient with acute lymphoblastic leukemia received allogeneic bone-marrow graft from a sibling who was of the same sex and blood group, HLA-identical, and mixed-lymphocyte-culture nonreactive. To monitor the bone-marrow engraftment and the type and degree of chimerism established, we used a genetic marker, the phosphoglucomutase-1 isoenzyme system, to reveal the difference between the bone-marrow host and donor. We did phosphoglucomutase-1 isoenzyme subtyping of the host's and donor's erythrocytes before transplantation, and isoenzyme phenotyping of the host's erythrocytes during a year after transplantation. Establishment of bone-marrow graft function, a period of temporary mixed chimerism with a population of both...
Bone marrow transplantation, 1989
Molecular Evolution of the Major Histocompatibility Complex, 1991
At least two DRB loci are transcribed in the B lymphocytes of the cotton-top tamarin, Saguinus oe... more At least two DRB loci are transcribed in the B lymphocytes of the cotton-top tamarin, Saguinus oedipus, a representative of the Platyrrhini (New World monkeys). One of the loci, Saoe-DRB1, is functional, the other (Saoe-DRB2) seems to be occupied by pseudogenes. The polymorphism of the genes at the functional DRB1 locus may be low. Neither of the two loci is directly orthologous to any of the known DRB genes thus far found in the Catarrhini. We suggest that the Platyrrhini were founded by a small number of animals and that the switch from one set of functional genes to another occurred as a result of genetic drift in the founding population.
Wiener klinische Wochenschrift, 2007
PubMed, 2004
There is considerable epidemiologic evidence that genetic component plays a key role in the patho... more There is considerable epidemiologic evidence that genetic component plays a key role in the pathogenesis of psoriasis. The disease is multifactorial in origin and shows polygeneic inheritance. In the last decade, there have been significant advances in our understanding of the genetic basis of this common disease. Susceptibility gene characterization and knowledge of the immune basis of psoriasis have better defined the disease pathways involved in the pathogenesis of psoriasis. A number of genetic loci have been identified by genome wide-linkage scans. In particular, the importance of PSORS 1 linkage characterization is emphasized, as this information will help develop more specific diagnostic and prognostic tools.
At least two DRB loci are transcribed in the B lymphocytes of the cotton-top tamarin, Saguinus oe... more At least two DRB loci are transcribed in the B lymphocytes of the cotton-top tamarin, Saguinus oedipus, a representative of the Platyrrhini (New World monkeys). One of the loci, Saoe-DRB1, is functional, the other (Saoe-DRB2) seems to be occupied by pseudogenes. The polymorphism of the genes at the functional DRB1 locus may be low. Neither of the two loci is directly orthologous to any of the known DRB genes thus far found in the Catarrhini. We suggest that the Platyrrhini were founded by a small number of animals and that the switch from one set of functional genes to another occurred as a result of genetic drift in the founding population.
Clinical Chemistry, Dec 1, 1988
We report an effective follow-up of the establishment of bone-marrow function after an allogeneic... more We report an effective follow-up of the establishment of bone-marrow function after an allogeneic bone-marrow transplantation in a patient with acute lymphoblastic leukemia, by means of a suitable genetic marker, phosphoglucomutase-1 (EC 5.4.2.2) isoenzyme. A patient with acute lymphoblastic leukemia received allogeneic bone-marrow graft from a sibling who was of the same sex and blood group, HLA-identical, and mixed-lymphocyte-culture nonreactive. To monitor the bone-marrow engraftment and the type and degree of chimerism established, we used a genetic marker, the phosphoglucomutase-1 isoenzyme system, to reveal the difference between the bone-marrow host and donor. We did phosphoglucomutase-1 isoenzyme subtyping of the host's and donor's erythrocytes before transplantation, and isoenzyme phenotyping of the host's erythrocytes during a year after transplantation. Establishment of bone-marrow graft function, a period of temporary mixed chimerism with a population of both host's and donor's erythrocytes, a period of the exclusive presence of donor's erythrocytes, and the resumed appearance of host's erythrocytes after eight months, with no signs of relapse of leukemia, were all observed by analysis of phenotypes. These isoenzymes served as a significant and practical genetic marker, which could be successfully used in studies on bone-marrow transplantation.
Wiener Klinische Wochenschrift, Jul 1, 2007
Reaktivierung von latentem Cytomegalovirus nach niedrigdosierter Kortikosteroidtherapie einer häm... more Reaktivierung von latentem Cytomegalovirus nach niedrigdosierter Kortikosteroidtherapie einer hämolytischen Anämie bei einem Patienten mit primärer Epstein-Barr-Virus-Infektion Zusammenfassung. Bei Cytomegalie-seropositiven Patienten kann eine intensive therapeutische Suprimierung der Immunabwehr zur Reaktivierung einer latenten Cytomegalovirus-Infektion führen. Viele dieser immunsuppressiven Therapie-Protokolle enthalten auch hochdosierte Kortikosteroide. Nicht bekannt ist hingegen, ob eine Behandlung mit niedrigen Dosen von Kortikosteroiden bei sonst gesunden Personen eindeutig mit einer Reaktivierung von Cytomegalovirus verbunden ist. Wir beschreiben die Reaktivierung einer Cytomegalovirus-Infektion mit bei einem 21-jährigen immunkompetenten Mann, der einen Monat lang mit niedrigen Dosen von Kortikosteroiden behandelt wurde. Die Indikation zur Steroidtherapie war eine ausgeprägte hämolytische Anämie, ausgelöst durch eine primäre Mononukleose (Epstein-Barr). Summary. Cytomegalovirus reactivation is a well described event occurring after intensive therapeutic suppression of the immune function in patients with latent infection. Treatment protocols for suppression of the immune response often include high-dose steroids. However, it is not known whether even a low-dose steroid treatment can reactivate latent cytomegalovirus in otherwise healthy persons. We documented cytomegalovirus reactivation after low-dose steroid treatment for autoimmune hemolytic anemia as a complication of Epstein-Barr virus mononucleosis in an immunocompetent 21-year-old man.
Cytopathology, Mar 18, 2016
Medicina Fluminensis : Medicina Fluminensis, Jun 7, 2010
Multipli mijelom (MM) je B-stanicna neoplazma obilježena infiltracijom kostane srži s malignim pl... more Multipli mijelom (MM) je B-stanicna neoplazma obilježena infiltracijom kostane srži s malignim plazma stanicama.Molekularna je osnova bolesti nejasna.Angiogeneza kao bioloski fenomen stvaranja novih krvnih žila, prisutna je u kostanoj srži kod raznih plazmastanicnih poremecaja i posebno je znacajna karakteristika aktivnog MM....
Lijec̆nic̆ki vjesnik, Mar 1, 2001
Medicina Fluminensis : Medicina Fluminensis, Jun 25, 2007
Molecular Biology and Evolution, May 1, 1992
Collegium Antropologicum, Apr 1, 2007
Acta medica Croatica, 2001
Retreatment of chronic hepatitis C patients resistant to previous interferon/ribavirin combinatio... more Retreatment of chronic hepatitis C patients resistant to previous interferon/ribavirin combination therapy with interferon alpha, ribavirin and amantadin: a triple therapy pilot study
Medicina Fluminensis, Mar 1, 2022
Clinical Chemistry, 1988
We report an effective follow-up of the establishment of bone-marrow function after an allogeneic... more We report an effective follow-up of the establishment of bone-marrow function after an allogeneic bone-marrow transplantation in a patient with acute lymphoblastic leukemia, by means of a suitable genetic marker, phosphoglucomutase-1 (EC 5.4.2.2) isoenzyme. A patient with acute lymphoblastic leukemia received allogeneic bone-marrow graft from a sibling who was of the same sex and blood group, HLA-identical, and mixed-lymphocyte-culture nonreactive. To monitor the bone-marrow engraftment and the type and degree of chimerism established, we used a genetic marker, the phosphoglucomutase-1 isoenzyme system, to reveal the difference between the bone-marrow host and donor. We did phosphoglucomutase-1 isoenzyme subtyping of the host's and donor's erythrocytes before transplantation, and isoenzyme phenotyping of the host's erythrocytes during a year after transplantation. Establishment of bone-marrow graft function, a period of temporary mixed chimerism with a population of both...
Bone marrow transplantation, 1989
Molecular Evolution of the Major Histocompatibility Complex, 1991
At least two DRB loci are transcribed in the B lymphocytes of the cotton-top tamarin, Saguinus oe... more At least two DRB loci are transcribed in the B lymphocytes of the cotton-top tamarin, Saguinus oedipus, a representative of the Platyrrhini (New World monkeys). One of the loci, Saoe-DRB1, is functional, the other (Saoe-DRB2) seems to be occupied by pseudogenes. The polymorphism of the genes at the functional DRB1 locus may be low. Neither of the two loci is directly orthologous to any of the known DRB genes thus far found in the Catarrhini. We suggest that the Platyrrhini were founded by a small number of animals and that the switch from one set of functional genes to another occurred as a result of genetic drift in the founding population.
Wiener klinische Wochenschrift, 2007
PubMed, 2004
There is considerable epidemiologic evidence that genetic component plays a key role in the patho... more There is considerable epidemiologic evidence that genetic component plays a key role in the pathogenesis of psoriasis. The disease is multifactorial in origin and shows polygeneic inheritance. In the last decade, there have been significant advances in our understanding of the genetic basis of this common disease. Susceptibility gene characterization and knowledge of the immune basis of psoriasis have better defined the disease pathways involved in the pathogenesis of psoriasis. A number of genetic loci have been identified by genome wide-linkage scans. In particular, the importance of PSORS 1 linkage characterization is emphasized, as this information will help develop more specific diagnostic and prognostic tools.
At least two DRB loci are transcribed in the B lymphocytes of the cotton-top tamarin, Saguinus oe... more At least two DRB loci are transcribed in the B lymphocytes of the cotton-top tamarin, Saguinus oedipus, a representative of the Platyrrhini (New World monkeys). One of the loci, Saoe-DRB1, is functional, the other (Saoe-DRB2) seems to be occupied by pseudogenes. The polymorphism of the genes at the functional DRB1 locus may be low. Neither of the two loci is directly orthologous to any of the known DRB genes thus far found in the Catarrhini. We suggest that the Platyrrhini were founded by a small number of animals and that the switch from one set of functional genes to another occurred as a result of genetic drift in the founding population.
Clinical Chemistry, Dec 1, 1988
We report an effective follow-up of the establishment of bone-marrow function after an allogeneic... more We report an effective follow-up of the establishment of bone-marrow function after an allogeneic bone-marrow transplantation in a patient with acute lymphoblastic leukemia, by means of a suitable genetic marker, phosphoglucomutase-1 (EC 5.4.2.2) isoenzyme. A patient with acute lymphoblastic leukemia received allogeneic bone-marrow graft from a sibling who was of the same sex and blood group, HLA-identical, and mixed-lymphocyte-culture nonreactive. To monitor the bone-marrow engraftment and the type and degree of chimerism established, we used a genetic marker, the phosphoglucomutase-1 isoenzyme system, to reveal the difference between the bone-marrow host and donor. We did phosphoglucomutase-1 isoenzyme subtyping of the host's and donor's erythrocytes before transplantation, and isoenzyme phenotyping of the host's erythrocytes during a year after transplantation. Establishment of bone-marrow graft function, a period of temporary mixed chimerism with a population of both host's and donor's erythrocytes, a period of the exclusive presence of donor's erythrocytes, and the resumed appearance of host's erythrocytes after eight months, with no signs of relapse of leukemia, were all observed by analysis of phenotypes. These isoenzymes served as a significant and practical genetic marker, which could be successfully used in studies on bone-marrow transplantation.
Wiener Klinische Wochenschrift, Jul 1, 2007
Reaktivierung von latentem Cytomegalovirus nach niedrigdosierter Kortikosteroidtherapie einer häm... more Reaktivierung von latentem Cytomegalovirus nach niedrigdosierter Kortikosteroidtherapie einer hämolytischen Anämie bei einem Patienten mit primärer Epstein-Barr-Virus-Infektion Zusammenfassung. Bei Cytomegalie-seropositiven Patienten kann eine intensive therapeutische Suprimierung der Immunabwehr zur Reaktivierung einer latenten Cytomegalovirus-Infektion führen. Viele dieser immunsuppressiven Therapie-Protokolle enthalten auch hochdosierte Kortikosteroide. Nicht bekannt ist hingegen, ob eine Behandlung mit niedrigen Dosen von Kortikosteroiden bei sonst gesunden Personen eindeutig mit einer Reaktivierung von Cytomegalovirus verbunden ist. Wir beschreiben die Reaktivierung einer Cytomegalovirus-Infektion mit bei einem 21-jährigen immunkompetenten Mann, der einen Monat lang mit niedrigen Dosen von Kortikosteroiden behandelt wurde. Die Indikation zur Steroidtherapie war eine ausgeprägte hämolytische Anämie, ausgelöst durch eine primäre Mononukleose (Epstein-Barr). Summary. Cytomegalovirus reactivation is a well described event occurring after intensive therapeutic suppression of the immune function in patients with latent infection. Treatment protocols for suppression of the immune response often include high-dose steroids. However, it is not known whether even a low-dose steroid treatment can reactivate latent cytomegalovirus in otherwise healthy persons. We documented cytomegalovirus reactivation after low-dose steroid treatment for autoimmune hemolytic anemia as a complication of Epstein-Barr virus mononucleosis in an immunocompetent 21-year-old man.
Cytopathology, Mar 18, 2016
Medicina Fluminensis : Medicina Fluminensis, Jun 7, 2010
Multipli mijelom (MM) je B-stanicna neoplazma obilježena infiltracijom kostane srži s malignim pl... more Multipli mijelom (MM) je B-stanicna neoplazma obilježena infiltracijom kostane srži s malignim plazma stanicama.Molekularna je osnova bolesti nejasna.Angiogeneza kao bioloski fenomen stvaranja novih krvnih žila, prisutna je u kostanoj srži kod raznih plazmastanicnih poremecaja i posebno je znacajna karakteristika aktivnog MM....
Lijec̆nic̆ki vjesnik, Mar 1, 2001
Medicina Fluminensis : Medicina Fluminensis, Jun 25, 2007
Molecular Biology and Evolution, May 1, 1992
Collegium Antropologicum, Apr 1, 2007