Juan J Aurrekoetxea | Universidad del País Vasco UPV/EHU (original) (raw)
Papers by Juan J Aurrekoetxea
Cancer Causes & Control, 2004
Objective: The present study aimed to determine whether the combined effects of environmental est... more Objective: The present study aimed to determine whether the combined effects of environmental estrogens measured as the total effective xenoestrogen burden (TEXB-alpha) are a risk factor for breast cancer over and above the risk potentially linked to specific pesticides. Methods: We measured the levels of 16 organochlorine pesticides as well as TEXB in adipose tissue of 198 women at the time of breast cancer diagnosis. These were compared with findings in 260 age and hospital matched control women without breast cancer. Results: The median levels of p,p¢-DDE (1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene), aldrin, endosulfan ether and lindane (the pesticides detected in >40% of the study population) were higher in cases than controls, although the differences did not reach statistical significance. After adjusting for potential confounders, the odds ratio (OR) for breast cancer in women with detectable levels of aldrin was 1.55 (95% confidence interval (CI) 1.00-2.40). Among the postmenopausal women, the OR for aldrin and lindane was 1.84 (95% CI 1.06-3.18) and 1.76 (95% CI 1.04-2.98), respectively. Among cases with body mass index (BMI) below the median (28.6 kg/m 2 ), the OR was 3.42 (95% CI 1.22-9.58) for women in the highest quartile of TEXB-alpha versus those in the lowest. The subgroup of leaner postmenopausal women showed an increased risk (OR: 5.67; 95% CI 1.59-20.21) for those in the highest tertile versus those in the lowest. Conclusions: We found an increased risk for breast cancer in the leaner women, especially in the leaner postmenopausal subgroup, related to the TEXB-alpha. The pesticides aldrin and lindane are also individually associated with risk.
Environmental Research, 2016
Second-hand smoke exposure (SHS) in children remains as a major pollution problem, with important... more Second-hand smoke exposure (SHS) in children remains as a major pollution problem, with important consequences for children's health. This study aimed to identify the sources of exposure to SHS among 4-year-old children, comparing self-reports to a urinary biomarker of exposure, and characterize the most important variables related to SHS exposure in this population. 4-year-old children's exposure to SHS was assessed by a parental-reported questionnaire and by urinary cotinine (UC) measurements in 1757 participants from 4 different areas of the Spanish INMA (INfancia y Medio Ambiente - Environment and Childhood) Project. The questionnaire about SHS included information about smoking habits at home by household members, and about exposure to SHS in other places including other homes, bars, restaurants or transportation. The association between quantified UC levels (>4ng/ml) and sociodemographic variables and the different sources of SHS exposure was examined using logistic regression. Based on parental reports, 21.6% of the children were exposed to SHS at home and 47.1% elsewhere; making a total 55.9% of the children exposed to SHS. In addition, 28.2% of the children whose parents reported being not regularly exposed to SHS had quantified UC values. Children from younger mothers (<34 vs. ≥39.4 y) had a higher odds of exposure to SHS [OR (95% CI): 2.28 (1.70-3.05) per year], as well as from families with a lower educational level [OR secondary: 2.12 (1.69-2.65); primary or less: 2.91 (2.19-3.88)]. The odds of quantifiable UC in children dropped after the smoking ban in public places [OR=0.59 (0.42-0.83)]. Regarding the sources of SHS exposure we observed that quantifiable UC odds was increased in children whose parents smoked at home in their presence [OR mother occasionally: 13.39 (7.03-25.50); mother often: 18.48 (8.40-40.66); father occasionally: 10.98 (6.52-18.49); father often: 11.50 (5.96-22.20)] or in children attending other confined places, mainly other houses where people smoked [OR: 2.23 (1.78-2.80)].…
Rev. salud ambient. 2014;14(2):98-106 EPIDEMIOLOGÍA AMBIENTAL. ORIGINALES 98 Antenas de telefonía... more Rev. salud ambient. 2014;14(2):98-106 EPIDEMIOLOGÍA AMBIENTAL. ORIGINALES 98 Antenas de telefonía móvil: emplazamiento y proximidad a espacios sensibles en la zona de estudio Inma-Gipuzkoa
Medicina Clínica
This study was conducted with the aim of evaluating the impact on health produced by the use of o... more This study was conducted with the aim of evaluating the impact on health produced by the use of organophosphorus pesticides in greenhouses. A representative sample of workers with high exposure to organophosphorus pesticides was taken in Vizcaya and Guipúzcoa, provinces where cultures under plastic are very extended. Forty four workers were interviewed to collect information about symptoms and signs related to past exposures. Blood samples were taken from 36 of these workers to measure the level of cholinesterase activity, before and after exposure to these pesticides. Fifty two per cent referred some signs and symptoms after use of pesticides. Nevertheless, no significant decrease in cholinesterase activity was observed, nor could any significant relationship between cholinesterase activity and the way to apply the pesticides. The exposure to organophosphorus pesticides, at the range studied in this group of workers, does not constitute today an important health risk.
Sumario: En este trabajo se recogen las posibles alteraciones de la salud mental originadas en el... more Sumario: En este trabajo se recogen las posibles alteraciones de la salud mental originadas en el medio laboral, sus manifestaciones y consecuencias, así como una serie de recomendaciones con el fin de elaborar estrategias de intervención en orden a la prevención de dichas alteraciones
Sumario: Entre la patología que puede asociarse a la exposición al polvo de madera se encuentra l... more Sumario: Entre la patología que puede asociarse a la exposición al polvo de madera se encuentra la bronquitis crónica, se estudia la forced vital capacity (FVC) y la forced expiratory volume in 1 second (FEV1) en 49 trabajadores expuestos y comparado a otro grupo control y se exponen los resultados y las conclusiones
Revista Española de Salud Pública
A plant of lindane in Barakaldo produced discharges of hexachlorocyclohexane (HCH). Closed in 198... more A plant of lindane in Barakaldo produced discharges of hexachlorocyclohexane (HCH). Closed in 1987 leaving inside 4500Tm; the problem was not solved until 2002. A judicial process required an epidemiological assessment of the possible contamination The aim of this study is to measure the degree of impregnation of the POPs in the nearby population. Cross-sectional study conducted in 2008, 154 volunteers from three health centres in Barakaldo and 270 controls from Bilbao, Alonsotegi and Balmaseda. We measured serum levels of eight organochlorine pesticides, and seven polychlorinated biphenyls (PCBs). We used the χ² test to study the association between categorical variables and t test of Student to compare geometric means. Confounding factors were adjusted using a linear regression model. There was a detectable compound average of 6.3 per person. PCBs 52 and 101, α -HCH, β-endosulfan and heptachlor epoxide could not be quantified; PCB 28, γ-HCH and p, p'-DDT were detected in 6.6, ...
Atención Primaria
To find out the recurrence of absence due to sick leave from the perspective of diagnosing the di... more To find out the recurrence of absence due to sick leave from the perspective of diagnosing the disease-causing absenteeism. Case-control study. Controls: workers who only had only been on sick leave once. Cases: workers with repeated sick leave. Cases with 2, 3, 4 or more absences due to sick leave were analysed separately. Guipuzcoa, from 2001 to 2005. There were 7,313 sick leave procedures collected from a Mutual Company with the medical reason, age and gender were duly registered and coded. Of the 6,030 workers who took some time off work, 5,016 had a single sick leave procedure, and were considered as controls and there were 1,014 cases that had two or more sick leave procedures. We calculated the odds ratio (OR) and 95% confidence intervals, adjusting for age and stratified by gender, using a logistic regression model. The slope of sick leave repeats was evaluated. An increase in the risk of recurrent sick leave was observed for both genders over the age of 45, with a significa...
Revista española de salud pública
The possible emissions from a municipal urban solid waste treatment plant (MUSWTP) include heavy ... more The possible emissions from a municipal urban solid waste treatment plant (MUSWTP) include heavy metals. The purpose of this study is to ascertain the levels of heavy metals in the blood and urine of the general population of Biscay. The level of Pb was measured in 95 blood samples (BPb) and Cd, Cr and Hg in 93 urine samples (UCd, UCr, UHg) taken from adults in the general population of Biscay, Basque Country, in 2006. The samples were obtained in two areas with high traffic density in the metropolitan area of Bilbao close to an MUSWTP which had just commenced operation, a third area in downtown Bilbao with heavy traffic and at a distance from the area of influence of possible emissions from the MUSWTP, and a fourth area at a distance from the plant and with low traffic density. The objective was to select a minimum of 20 participants from each area, with an equal number of male and female subjects, and with half the subjects aged between 20 and 44 years and the other half between 4...
Gaceta sanitaria / S.E.S.P.A.S
Most of mortality studies among steelworkers pointed out an increased frequency on cancer mortali... more Most of mortality studies among steelworkers pointed out an increased frequency on cancer mortality, above all by lung cancer, and, in a lower proportion, by cancers of digestive and genitourinary systems. In Spain mortality rates are not published by occupation and economic activity to contrast these observations. It was carried out a proportionate mortality study among active or retired workers from an steel mill, Altos Hornos de Vizcaya, died from 1986 to 1993, to make a preliminary death risk assessment associated with job in the steel industry. A sample of 1553 men was drawn from the mortality register of a private Insurance Company. Death causes within the sample and in general population of the Autonomous Community of the Basque Country were compared using a proportionate analysis. Mortality odds ratios (OR) were also computed. The results show an excess of cancer mortality (OR = 1.26, IC: 1.11-1.42), stomach cancer (OR = 1.50, IC: 1.14-1.98) and renal cancer (OR = 1.89; IC: ...
Rehabilitación, 2014
ABSTRACT Introduction This study aimed to determine the reference values for range of motion (ROM... more ABSTRACT Introduction This study aimed to determine the reference values for range of motion (ROM) and cervical isometric strength in a healthy population control group and to assess the influence on it variables such as gender, age, anthropometrical measures and physical activity. Methods and background Data: Sample: 80 healthy persons. Protocol: The Multi-Cervical Unit (MCU) records ROM and cervical isometric strength specific angle and coefficient of variation. These data were then compared with the American Medical Association values and values obtained by the Multi Cervical Unit (MCU) database. Body mass index, cervical circumference and physical activity were also recorded. Results The ROM values obtained are close to the American Medical Association values. The force values found in our series are below those of the MCU. No significant difference were found regarding the influence of gender on ROM. A strong statistical association was observed in regards to strength. Influence of age on ROM is only significant in men. Conclusions Significant differences in the ROM values were not found between both genders. Therefore, it is not necessary to use specific gender differentiation. The association between gender and isometric cervical spine strength is highly significant. The relationship between physical activity and an increase of the cervical strength has been verified.
Revista Española de Salud Pública, 2011
European Respiratory Journal, 2012
Tobacco consumption and exposure to second-hand smoke (SHS) are associated with reduced birth wei... more Tobacco consumption and exposure to second-hand smoke (SHS) are associated with reduced birth weight. One issue that has not been clarified previously is that of the potential higher risk of this outcome in mothers with asthma. We assessed the role of prenatal maternal tobacco use and SHS on reproductive outcomes and assessed the interaction with maternal history of asthma.
Atención Primaria, 2009
Recibido el 18 de abril de 2008; aceptado el 17 de noviembre de 2008 Disponible en Internet el 28... more Recibido el 18 de abril de 2008; aceptado el 17 de noviembre de 2008 Disponible en Internet el 28 de junio de 2009 PALABRAS CLAVE Absentismo; Diagnóstico; Discapacidad
Archives des Maladies Professionnelles et de l'Environnement, 2005
Anales de Pediatría, 2013
The prevalence of excess weight (obesity and overweight) is increasing in developed countries, wi... more The prevalence of excess weight (obesity and overweight) is increasing in developed countries, with preventive measures not shown to be sufficiently effective. The aim of this study was to investigate the effectiveness of the sustained prevention and treatment by Primary Care Paediatrics of overweight from early childhood. The BMI of 1669 patients from two Paediatric Teams, were compared using four different age intervals between 4 and 14 years during 2007-2009. One of the teams had spent 15 years carrying out a systematic strategy aimed at the prevention and monitoring of overweight. The BMI means in this study were higher than those shown in the 1988 Orbegozo tables, particularly in older ages and in males. The prevalence of overweight was lower in the population with the systematic intervention team, and this was significant at the end of the paediatric age, 14 years (P=.043). The overweight problem is so great that the measures aimed at their prevention are clearly beyond the scope of health professionals. However, interventions by health professionals can be effective in maintaining a healthy weight, if they are carried out on an ongoing basis.
Sumario: El presente articulo aborda la relación que existe entre el trabajo y la salud mental y,... more Sumario: El presente articulo aborda la relación que existe entre el trabajo y la salud mental y, posteriormente entre el no trabajo y la salud mental, proponiendo algunos elementos conceptuales y de reflexión
American Journal of Epidemiology, 2013
In utero tobacco exposure has been associated with fetal growth restriction, but uncertainty rema... more In utero tobacco exposure has been associated with fetal growth restriction, but uncertainty remains about critical windows of exposure and specific effects on body segments. In the present study, we aimed to examine the association of maternal smoking with fetal biometry in different stages of pregnancy. The study population comprised 2,478 fetuses from a Spanish birth cohort study that was established between 2003 and 2008. Biparietal diameter, femur length, abdominal circumference, and estimated fetal weight were evaluated at 12, 20, and 34 weeks of gestation. Fetal size and growth were assessed by standard deviation scores adjusted by maternal and fetal characteristics. Maternal smoking was assessed using questionnaire and a sample of urinary cotinine at week 32 of gestation. Associations were estimated using multiple regression analysis. Smokers at week 12 of gestation showed decreased fetal growth as reflected by all growth parameters at 20-34 weeks, leading to a reduced fetal size at week 34. The reduction was greatest in femur length, at −9.4% (95% confidence interval −13.4, −5.4) and least in abdominal circumference, at −4.4% (95% CI: −8.7, −0.1). Fetuses of smokers who quit smoking before week 12 showed reduced growth only in femur length (−5.5; 95% CI: −10.1, −0.9). Dose-response curves for smoking versus fetal growth parameters (abscissa: log 2 cotinine) were linear for biparietal diameter and femur length. cohort studies; fetal development; pregnancy; prenatal exposure; tobacco smoke Abbreviations: AC, abdominal circumference; BPD, biparietal diameter; CI, confidence interval; EFW, estimated fetal weight; FL, femur length; INMA, Infancia y Medio Ambiente.
Objective: To evaluate the association between mercury exposure and thyroid-stimulating hormone (... more Objective: To evaluate the association between mercury exposure and thyroid-stimulating hormone (TSH), total triiodothyronine (TT3) and free thyroxine (FT4) levels during pregnancy as well as to explore if there is any synergic action between mercury and intake of iodine from different sources. Methods: The study population was 1407 pregnant women participating in the Spanish INMA birth cohort study. Total mercury concentrations were analyzed in cord blood. Thyroid hormones (THs) were measured in serum samples collected at 13.2 71.5 weeks of gestation. The association between mercury and TH levels was evaluated with multivariate linear regression models. Effect modification caused by iodine intake from supplements and diet was also evaluated. Results: The geometric means of TSH, TT3, FT4 and mercury were 1.1 μU/L, 2.4 nmol/L, 10.5 pmol/L and 7.7 μg/L, respectively. Mercury levels were marginally significantly associated with TT3 (β: À 0.05; 95%CI: À 0.10, 0.01), but were neither associated with TSH nor FT4. The inverse association between mercury and TT3 levels was stronger among the iodine supplement consumers (À 0.08; 95%CI: À 0.15, À 0.02, interaction p-value¼ 0.07). The association with FT4 followed the same pattern, albeit not significant. Conclusion: Prenatal mercury exposure was inversely associated with TT3 levels among women who took iodine supplements during pregnancy. These results could be of public health concern, although further research is needed.
Cancer Causes & Control, 2004
Objective: The present study aimed to determine whether the combined effects of environmental est... more Objective: The present study aimed to determine whether the combined effects of environmental estrogens measured as the total effective xenoestrogen burden (TEXB-alpha) are a risk factor for breast cancer over and above the risk potentially linked to specific pesticides. Methods: We measured the levels of 16 organochlorine pesticides as well as TEXB in adipose tissue of 198 women at the time of breast cancer diagnosis. These were compared with findings in 260 age and hospital matched control women without breast cancer. Results: The median levels of p,p¢-DDE (1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene), aldrin, endosulfan ether and lindane (the pesticides detected in >40% of the study population) were higher in cases than controls, although the differences did not reach statistical significance. After adjusting for potential confounders, the odds ratio (OR) for breast cancer in women with detectable levels of aldrin was 1.55 (95% confidence interval (CI) 1.00-2.40). Among the postmenopausal women, the OR for aldrin and lindane was 1.84 (95% CI 1.06-3.18) and 1.76 (95% CI 1.04-2.98), respectively. Among cases with body mass index (BMI) below the median (28.6 kg/m 2 ), the OR was 3.42 (95% CI 1.22-9.58) for women in the highest quartile of TEXB-alpha versus those in the lowest. The subgroup of leaner postmenopausal women showed an increased risk (OR: 5.67; 95% CI 1.59-20.21) for those in the highest tertile versus those in the lowest. Conclusions: We found an increased risk for breast cancer in the leaner women, especially in the leaner postmenopausal subgroup, related to the TEXB-alpha. The pesticides aldrin and lindane are also individually associated with risk.
Environmental Research, 2016
Second-hand smoke exposure (SHS) in children remains as a major pollution problem, with important... more Second-hand smoke exposure (SHS) in children remains as a major pollution problem, with important consequences for children's health. This study aimed to identify the sources of exposure to SHS among 4-year-old children, comparing self-reports to a urinary biomarker of exposure, and characterize the most important variables related to SHS exposure in this population. 4-year-old children's exposure to SHS was assessed by a parental-reported questionnaire and by urinary cotinine (UC) measurements in 1757 participants from 4 different areas of the Spanish INMA (INfancia y Medio Ambiente - Environment and Childhood) Project. The questionnaire about SHS included information about smoking habits at home by household members, and about exposure to SHS in other places including other homes, bars, restaurants or transportation. The association between quantified UC levels (>4ng/ml) and sociodemographic variables and the different sources of SHS exposure was examined using logistic regression. Based on parental reports, 21.6% of the children were exposed to SHS at home and 47.1% elsewhere; making a total 55.9% of the children exposed to SHS. In addition, 28.2% of the children whose parents reported being not regularly exposed to SHS had quantified UC values. Children from younger mothers (<34 vs. ≥39.4 y) had a higher odds of exposure to SHS [OR (95% CI): 2.28 (1.70-3.05) per year], as well as from families with a lower educational level [OR secondary: 2.12 (1.69-2.65); primary or less: 2.91 (2.19-3.88)]. The odds of quantifiable UC in children dropped after the smoking ban in public places [OR=0.59 (0.42-0.83)]. Regarding the sources of SHS exposure we observed that quantifiable UC odds was increased in children whose parents smoked at home in their presence [OR mother occasionally: 13.39 (7.03-25.50); mother often: 18.48 (8.40-40.66); father occasionally: 10.98 (6.52-18.49); father often: 11.50 (5.96-22.20)] or in children attending other confined places, mainly other houses where people smoked [OR: 2.23 (1.78-2.80)].…
Rev. salud ambient. 2014;14(2):98-106 EPIDEMIOLOGÍA AMBIENTAL. ORIGINALES 98 Antenas de telefonía... more Rev. salud ambient. 2014;14(2):98-106 EPIDEMIOLOGÍA AMBIENTAL. ORIGINALES 98 Antenas de telefonía móvil: emplazamiento y proximidad a espacios sensibles en la zona de estudio Inma-Gipuzkoa
Medicina Clínica
This study was conducted with the aim of evaluating the impact on health produced by the use of o... more This study was conducted with the aim of evaluating the impact on health produced by the use of organophosphorus pesticides in greenhouses. A representative sample of workers with high exposure to organophosphorus pesticides was taken in Vizcaya and Guipúzcoa, provinces where cultures under plastic are very extended. Forty four workers were interviewed to collect information about symptoms and signs related to past exposures. Blood samples were taken from 36 of these workers to measure the level of cholinesterase activity, before and after exposure to these pesticides. Fifty two per cent referred some signs and symptoms after use of pesticides. Nevertheless, no significant decrease in cholinesterase activity was observed, nor could any significant relationship between cholinesterase activity and the way to apply the pesticides. The exposure to organophosphorus pesticides, at the range studied in this group of workers, does not constitute today an important health risk.
Sumario: En este trabajo se recogen las posibles alteraciones de la salud mental originadas en el... more Sumario: En este trabajo se recogen las posibles alteraciones de la salud mental originadas en el medio laboral, sus manifestaciones y consecuencias, así como una serie de recomendaciones con el fin de elaborar estrategias de intervención en orden a la prevención de dichas alteraciones
Sumario: Entre la patología que puede asociarse a la exposición al polvo de madera se encuentra l... more Sumario: Entre la patología que puede asociarse a la exposición al polvo de madera se encuentra la bronquitis crónica, se estudia la forced vital capacity (FVC) y la forced expiratory volume in 1 second (FEV1) en 49 trabajadores expuestos y comparado a otro grupo control y se exponen los resultados y las conclusiones
Revista Española de Salud Pública
A plant of lindane in Barakaldo produced discharges of hexachlorocyclohexane (HCH). Closed in 198... more A plant of lindane in Barakaldo produced discharges of hexachlorocyclohexane (HCH). Closed in 1987 leaving inside 4500Tm; the problem was not solved until 2002. A judicial process required an epidemiological assessment of the possible contamination The aim of this study is to measure the degree of impregnation of the POPs in the nearby population. Cross-sectional study conducted in 2008, 154 volunteers from three health centres in Barakaldo and 270 controls from Bilbao, Alonsotegi and Balmaseda. We measured serum levels of eight organochlorine pesticides, and seven polychlorinated biphenyls (PCBs). We used the χ² test to study the association between categorical variables and t test of Student to compare geometric means. Confounding factors were adjusted using a linear regression model. There was a detectable compound average of 6.3 per person. PCBs 52 and 101, α -HCH, β-endosulfan and heptachlor epoxide could not be quantified; PCB 28, γ-HCH and p, p'-DDT were detected in 6.6, ...
Atención Primaria
To find out the recurrence of absence due to sick leave from the perspective of diagnosing the di... more To find out the recurrence of absence due to sick leave from the perspective of diagnosing the disease-causing absenteeism. Case-control study. Controls: workers who only had only been on sick leave once. Cases: workers with repeated sick leave. Cases with 2, 3, 4 or more absences due to sick leave were analysed separately. Guipuzcoa, from 2001 to 2005. There were 7,313 sick leave procedures collected from a Mutual Company with the medical reason, age and gender were duly registered and coded. Of the 6,030 workers who took some time off work, 5,016 had a single sick leave procedure, and were considered as controls and there were 1,014 cases that had two or more sick leave procedures. We calculated the odds ratio (OR) and 95% confidence intervals, adjusting for age and stratified by gender, using a logistic regression model. The slope of sick leave repeats was evaluated. An increase in the risk of recurrent sick leave was observed for both genders over the age of 45, with a significa...
Revista española de salud pública
The possible emissions from a municipal urban solid waste treatment plant (MUSWTP) include heavy ... more The possible emissions from a municipal urban solid waste treatment plant (MUSWTP) include heavy metals. The purpose of this study is to ascertain the levels of heavy metals in the blood and urine of the general population of Biscay. The level of Pb was measured in 95 blood samples (BPb) and Cd, Cr and Hg in 93 urine samples (UCd, UCr, UHg) taken from adults in the general population of Biscay, Basque Country, in 2006. The samples were obtained in two areas with high traffic density in the metropolitan area of Bilbao close to an MUSWTP which had just commenced operation, a third area in downtown Bilbao with heavy traffic and at a distance from the area of influence of possible emissions from the MUSWTP, and a fourth area at a distance from the plant and with low traffic density. The objective was to select a minimum of 20 participants from each area, with an equal number of male and female subjects, and with half the subjects aged between 20 and 44 years and the other half between 4...
Gaceta sanitaria / S.E.S.P.A.S
Most of mortality studies among steelworkers pointed out an increased frequency on cancer mortali... more Most of mortality studies among steelworkers pointed out an increased frequency on cancer mortality, above all by lung cancer, and, in a lower proportion, by cancers of digestive and genitourinary systems. In Spain mortality rates are not published by occupation and economic activity to contrast these observations. It was carried out a proportionate mortality study among active or retired workers from an steel mill, Altos Hornos de Vizcaya, died from 1986 to 1993, to make a preliminary death risk assessment associated with job in the steel industry. A sample of 1553 men was drawn from the mortality register of a private Insurance Company. Death causes within the sample and in general population of the Autonomous Community of the Basque Country were compared using a proportionate analysis. Mortality odds ratios (OR) were also computed. The results show an excess of cancer mortality (OR = 1.26, IC: 1.11-1.42), stomach cancer (OR = 1.50, IC: 1.14-1.98) and renal cancer (OR = 1.89; IC: ...
Rehabilitación, 2014
ABSTRACT Introduction This study aimed to determine the reference values for range of motion (ROM... more ABSTRACT Introduction This study aimed to determine the reference values for range of motion (ROM) and cervical isometric strength in a healthy population control group and to assess the influence on it variables such as gender, age, anthropometrical measures and physical activity. Methods and background Data: Sample: 80 healthy persons. Protocol: The Multi-Cervical Unit (MCU) records ROM and cervical isometric strength specific angle and coefficient of variation. These data were then compared with the American Medical Association values and values obtained by the Multi Cervical Unit (MCU) database. Body mass index, cervical circumference and physical activity were also recorded. Results The ROM values obtained are close to the American Medical Association values. The force values found in our series are below those of the MCU. No significant difference were found regarding the influence of gender on ROM. A strong statistical association was observed in regards to strength. Influence of age on ROM is only significant in men. Conclusions Significant differences in the ROM values were not found between both genders. Therefore, it is not necessary to use specific gender differentiation. The association between gender and isometric cervical spine strength is highly significant. The relationship between physical activity and an increase of the cervical strength has been verified.
Revista Española de Salud Pública, 2011
European Respiratory Journal, 2012
Tobacco consumption and exposure to second-hand smoke (SHS) are associated with reduced birth wei... more Tobacco consumption and exposure to second-hand smoke (SHS) are associated with reduced birth weight. One issue that has not been clarified previously is that of the potential higher risk of this outcome in mothers with asthma. We assessed the role of prenatal maternal tobacco use and SHS on reproductive outcomes and assessed the interaction with maternal history of asthma.
Atención Primaria, 2009
Recibido el 18 de abril de 2008; aceptado el 17 de noviembre de 2008 Disponible en Internet el 28... more Recibido el 18 de abril de 2008; aceptado el 17 de noviembre de 2008 Disponible en Internet el 28 de junio de 2009 PALABRAS CLAVE Absentismo; Diagnóstico; Discapacidad
Archives des Maladies Professionnelles et de l'Environnement, 2005
Anales de Pediatría, 2013
The prevalence of excess weight (obesity and overweight) is increasing in developed countries, wi... more The prevalence of excess weight (obesity and overweight) is increasing in developed countries, with preventive measures not shown to be sufficiently effective. The aim of this study was to investigate the effectiveness of the sustained prevention and treatment by Primary Care Paediatrics of overweight from early childhood. The BMI of 1669 patients from two Paediatric Teams, were compared using four different age intervals between 4 and 14 years during 2007-2009. One of the teams had spent 15 years carrying out a systematic strategy aimed at the prevention and monitoring of overweight. The BMI means in this study were higher than those shown in the 1988 Orbegozo tables, particularly in older ages and in males. The prevalence of overweight was lower in the population with the systematic intervention team, and this was significant at the end of the paediatric age, 14 years (P=.043). The overweight problem is so great that the measures aimed at their prevention are clearly beyond the scope of health professionals. However, interventions by health professionals can be effective in maintaining a healthy weight, if they are carried out on an ongoing basis.
Sumario: El presente articulo aborda la relación que existe entre el trabajo y la salud mental y,... more Sumario: El presente articulo aborda la relación que existe entre el trabajo y la salud mental y, posteriormente entre el no trabajo y la salud mental, proponiendo algunos elementos conceptuales y de reflexión
American Journal of Epidemiology, 2013
In utero tobacco exposure has been associated with fetal growth restriction, but uncertainty rema... more In utero tobacco exposure has been associated with fetal growth restriction, but uncertainty remains about critical windows of exposure and specific effects on body segments. In the present study, we aimed to examine the association of maternal smoking with fetal biometry in different stages of pregnancy. The study population comprised 2,478 fetuses from a Spanish birth cohort study that was established between 2003 and 2008. Biparietal diameter, femur length, abdominal circumference, and estimated fetal weight were evaluated at 12, 20, and 34 weeks of gestation. Fetal size and growth were assessed by standard deviation scores adjusted by maternal and fetal characteristics. Maternal smoking was assessed using questionnaire and a sample of urinary cotinine at week 32 of gestation. Associations were estimated using multiple regression analysis. Smokers at week 12 of gestation showed decreased fetal growth as reflected by all growth parameters at 20-34 weeks, leading to a reduced fetal size at week 34. The reduction was greatest in femur length, at −9.4% (95% confidence interval −13.4, −5.4) and least in abdominal circumference, at −4.4% (95% CI: −8.7, −0.1). Fetuses of smokers who quit smoking before week 12 showed reduced growth only in femur length (−5.5; 95% CI: −10.1, −0.9). Dose-response curves for smoking versus fetal growth parameters (abscissa: log 2 cotinine) were linear for biparietal diameter and femur length. cohort studies; fetal development; pregnancy; prenatal exposure; tobacco smoke Abbreviations: AC, abdominal circumference; BPD, biparietal diameter; CI, confidence interval; EFW, estimated fetal weight; FL, femur length; INMA, Infancia y Medio Ambiente.
Objective: To evaluate the association between mercury exposure and thyroid-stimulating hormone (... more Objective: To evaluate the association between mercury exposure and thyroid-stimulating hormone (TSH), total triiodothyronine (TT3) and free thyroxine (FT4) levels during pregnancy as well as to explore if there is any synergic action between mercury and intake of iodine from different sources. Methods: The study population was 1407 pregnant women participating in the Spanish INMA birth cohort study. Total mercury concentrations were analyzed in cord blood. Thyroid hormones (THs) were measured in serum samples collected at 13.2 71.5 weeks of gestation. The association between mercury and TH levels was evaluated with multivariate linear regression models. Effect modification caused by iodine intake from supplements and diet was also evaluated. Results: The geometric means of TSH, TT3, FT4 and mercury were 1.1 μU/L, 2.4 nmol/L, 10.5 pmol/L and 7.7 μg/L, respectively. Mercury levels were marginally significantly associated with TT3 (β: À 0.05; 95%CI: À 0.10, 0.01), but were neither associated with TSH nor FT4. The inverse association between mercury and TT3 levels was stronger among the iodine supplement consumers (À 0.08; 95%CI: À 0.15, À 0.02, interaction p-value¼ 0.07). The association with FT4 followed the same pattern, albeit not significant. Conclusion: Prenatal mercury exposure was inversely associated with TT3 levels among women who took iodine supplements during pregnancy. These results could be of public health concern, although further research is needed.