MILAN K U M A R MANDAL | Vidyasagar University, WB, India (original) (raw)
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Phone: 8906055009
Address: Nandigram, East Medinipur, West Bengal, India, 721631
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Papers by MILAN K U M A R MANDAL
![Research paper thumbnail of Synthesis, characterization and antimicrobial evaluation of some novel 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine bearing substituted phenylquinolin-2-one moiety](https://attachments.academia-assets.com/76729876/thumbnails/1.jpg)
](Pathogenic microbes have mutated and developed resistance to the latest range of antibiotics, whi... more Pathogenic microbes have mutated and developed resistance to the latest range of antibiotics, which has kept synthetic chemist hunting for better and least toxic antimicrobial agents. Cyclocondensation of substituted anilines with 3-phenyl-2-propenoic acid yielded Phenyl-(substituted)-quinolin-2-one derivatives (1a–1t). In the next step phenylquinolin-2-one acetic acid derivatives (2a–2t) were prepared by the treatment of (1a–1t) with chloroacetic acid. Further (2a–2t) derivatives were reacted with thiocarbohydrazide to obtain a series of 4-amino-5-sulfanyl-4,5-dihydro-1,2,4-triazolo-4-pheny-(substituted)-quinolin-2-one derivatives (3a–3t). Then condensation of (3a–3t) with phenacyl bromide provided series of fused heterocyclic derivatives of 4-phenyl-1-({6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl}methyl)-(substituted)-1,2-dihydro quinolin-2-one (4a–4t). Structures of these newly synthesized derivatives were established by elemental analysis, FT-IR, 1H NMR and Mass spe...
Facta universitatis - series Physics Chemistry and Technology, 2009
Cobalt complex with histidine ligand was synthesized and physico-chemically characterized by solu... more Cobalt complex with histidine ligand was synthesized and physico-chemically characterized by solubility testing, melting point, UV-spectra and FTIR. The synthesized metal complex was evaluated for in-vitro antibacterial and antifungal activity against the multidrug resistant pathogens, such as Pseudomonas aeruginosa, Vibrio cholerae, Salmonella typhi, E. coli, Klebsiella pneumonia, Staphylococcus aureus, Aspergillus niger, Aspergillus flavus and Candida albicans. The metal complex showed the significant antibacterial and antifungal activity comparison with commercial antibiotics. Further work can be extended through In-silico docking of this metal complex and bacterial, fungal genome which can be given a better idea about genome metal interaction in molecular level.
Pathogenic microbes have mutated and developed resistance to the latest range of antibiotics, whi... more Pathogenic microbes have mutated and developed resistance to the latest range of antibiotics, which has kept synthetic chemist hunting for better and least toxic antimicrobial agents. Cyclocondensation of substituted anilines with 3-phenyl-2-propenoic acid yielded Phenyl-(substituted)-quinolin-2-one derivatives (1a–1t). In the next step phenylquinolin-2-one acetic acid derivatives (2a–2t) were prepared by the treatment of (1a–1t) with chloroacetic acid. Further (2a–2t) derivatives were reacted with thiocarbohydrazide to obtain a series of 4-amino-5-sulfanyl-4,5-dihydro-1,2,4-triazolo-4-pheny-(substituted)-quinolin-2-one derivatives (3a–3t). Then condensation of (3a–3t) with phenacyl bromide provided series of fused heterocyclic derivatives of 4-phenyl-1-({6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl}methyl)-(substituted)-1,2-dihydro quinolin-2-one (4a–4t). Structures of these newly synthesized derivatives were established by elemental analysis, FT-IR, 1H NMR and Mass spe...
Facta universitatis - series Physics Chemistry and Technology, 2009
Cobalt complex with histidine ligand was synthesized and physico-chemically characterized by solu... more Cobalt complex with histidine ligand was synthesized and physico-chemically characterized by solubility testing, melting point, UV-spectra and FTIR. The synthesized metal complex was evaluated for in-vitro antibacterial and antifungal activity against the multidrug resistant pathogens, such as Pseudomonas aeruginosa, Vibrio cholerae, Salmonella typhi, E. coli, Klebsiella pneumonia, Staphylococcus aureus, Aspergillus niger, Aspergillus flavus and Candida albicans. The metal complex showed the significant antibacterial and antifungal activity comparison with commercial antibiotics. Further work can be extended through In-silico docking of this metal complex and bacterial, fungal genome which can be given a better idea about genome metal interaction in molecular level.