R. Cantu | University of Miami (original) (raw)

Papers by R. Cantu

Research paper thumbnail of Summary and agreement statement of the 2nd International Conference on Concussion in Sport, Prague 2004

British Journal of Sports Medicine, 2005

Research paper thumbnail of Prague 2004 International Conference on Concussion in Sport, Summary and agreement statement of the 2nd

Research paper thumbnail of Prague 2004 International Conference on Concussion in Sport, Summary and agreement statement of the 2nd

Research paper thumbnail of Presbyopic advanced surface ablation (PASA) using the Nidek EC-5000

Research paper thumbnail of Objective quality of vision in presbyopic and non-presbyopic patients after pseudoaccommodative advanced surface ablation

Journal of refractive surgery (Thorofare, N.J. : 1995)

To analyze the objective quality of vision at 6 months postoperatively after pseudoaccommodative ... more To analyze the objective quality of vision at 6 months postoperatively after pseudoaccommodative (presbyopic) advanced surface ablation (PASA). The study comprised 62 eyes of 35 patients with 6-month follow-up that underwent primary or secondary treatments using PASA. Pre- and postoperative results of distance and near uncorrected visual acuity (UCVA), spherical aberration (coefficient of the Z12 Zernike polynomial), and the asphericity (Q) index were reviewed. The corresponding wavefront maps (total, low, and high order aberrations) and the corresponding point spread function and modulation transfer function (MTF) were also calculated. Our results show that PASA improves distance and near mean UCVA, increases negative spherical aberration and negative asphericity index, and improves the corresponding MTF. Pseudoaccommodative advanced surface ablation is a promising approach for the surgical correction of presbyopia with distance refractive error (myopia and hyperopia with or withou...

Research paper thumbnail of SYMPOSIUM ABSTRACTS-Comparison of the WF, PSF, Strehl Ratio, and MTF Between 20/20 Untreated, Post Advanced Surface Ablation (ASA), and Post Pseudoaccommodative (Presbyopic) Advanced Surface

Research paper thumbnail of <title>Average PFS and MTF analysis of undilated normal virgin whole eyes</title>

Medical Imaging, 2005

We started our study with a group of Mexican Males with an Uncorrected Visual Acuity (UCVA) of 20... more We started our study with a group of Mexican Males with an Uncorrected Visual Acuity (UCVA) of 20/20, 20/30, and 20/40. The data was obtained using a Nidek OPD Scan ARK 10000 with the Version 1.11b of the working software. With the resulting Zernike coefficients, we calculated the average of the total Wavefront map, the Point Spread Function (PSF), the

Research paper thumbnail of <title>Average PFS and MTF analysis of undilated normal virgin whole eyes</title>

Medical Imaging, 2005

We started our study with a group of Mexican Males with an Uncorrected Visual Acuity (UCVA) of 20... more We started our study with a group of Mexican Males with an Uncorrected Visual Acuity (UCVA) of 20/20, 20/30, and 20/40. The data was obtained using a Nidek OPD Scan ARK 10000 with the Version 1.11b of the working software. With the resulting Zernike coefficients, we calculated the average of the total Wavefront map, the Point Spread Function (PSF), the

Research paper thumbnail of Demonstration of a ventriculo-mastoid fistula (Paradoxical cerebrospinal fluid rhinorrhea) by pantopaque ventriculography

min - Minimally Invasive Neurosurgery, 1967

Research paper thumbnail of <title>PSF and MTF analysis of the visual performance in undilated Mexican normal virgin whole eyes (UCVA greater than or equal to 20/20, 20/30, and 20/40)</title>

Ophthalmic Technologies XV, 2005

In the area of ophthalmic refractive surgery research, the Zernike expansion of the Wavefront abe... more In the area of ophthalmic refractive surgery research, the Zernike expansion of the Wavefront aberrations has been the key factor in the measurement, representation and evaluation of the human eye aberrations in many different clinical situations. The Wavefront Aberrations described by the Zernike expansion can be translated as the polynomial expansion of the exit pupil of an optical system that

Research paper thumbnail of Catastrophic Head Injuries in High School and College Football Players

The American Journal of Sports Medicine, 2007

Catastrophic head injuries in football are rare but tragic events. To update the profile of catas... more Catastrophic head injuries in football are rare but tragic events. To update the profile of catastrophic head injuries in high school and college football players and to describe relevant risk factors. Case series; Level of evidence, 4. We reviewed 94 incidents of severe football head injuries reported to the National Center for Catastrophic Sports Injury Research during 13 academic years (September 1989 through June 2002). In the study period there were an average of 7.23 (standard deviation = 2.05) direct high school and college catastrophic head injuries in scholastic football participants per year. There were 0.67 injuries per 100 000 (95% confidence interval: 0.54, 0.81 per 100 000) high school and 0.21 injuries per 100 000 (95% confidence interval: 0.0, 0.49 per 100 000) college participants for a risk ratio of 3.28 (95% confidence interval: 0.81, 13.3). The injuries resulted in subdural hematoma in 75 athletes, subdural hematoma with diffuse brain edema in 10 athletes, diffuse brain edema in 5 athletes, and arteriovenous malformation or aneurysm in 4 athletes. Fifty-nine percent of the contacts reported that the athlete had a history of a previous head injury, of which 71% occurred within the same season as the catastrophic event. Thirty-nine percent of the athletes (21 of 54) were playing with residual neurologic symptoms from the prior head injury. There were 8 (9%) deaths as a result of the injury, 46 (51%) permanent neurologic injuries, and 36 (40%) serious injuries with full recovery. Most players sustained a major impact to the head either from tackling or being tackled. The incidence of catastrophic head injuries in football has remained low since the advent of the modern day football helmet in the early 1970s. The incidence of catastrophic head injuries in football is dramatically higher at the high school level than at the college level. Although the reason for this discrepancy is unclear, an unacceptably high percentage of high school players were playing with residual symptoms from a prior head injury. Coaches, athletes, athletic trainers, and medical personnel need to adhere to the guideline that an athlete with any neurologic symptoms from a head injury should be strongly discouraged from returning to play.

Research paper thumbnail of The spectrum of disease in chronic traumatic encephalopathy

Chronic traumatic encephalopathy is a progressive tauopathy that occurs as a consequence of repet... more Chronic traumatic encephalopathy is a progressive tauopathy that occurs as a consequence of repetitive mild traumatic brain injury. We analysed post-mortem brains obtained from a cohort of 85 subjects with histories of repetitive mild traumatic brain injury and found evidence of chronic traumatic encephalopathy in 68 subjects: all males, ranging in age from 17 to 98 years (mean 59.5 years), including 64 athletes, 21 military veterans (86% of whom were also athletes) and one individual who engaged in self-injurious head banging behaviour. Eighteen age- and gender-matched individuals without a history of repetitive mild traumatic brain injury served as control subjects. In chronic traumatic encephalopathy, the spectrum of hyperphosphorylated tau pathology ranged in severity from focal perivascular epicentres of neurofibrillary tangles in the frontal neocortex to severe tauopathy affecting widespread brain regions, including the medial temporal lobe, thereby allowing a progressive staging of pathology from stages I-IV. Multifocal axonal varicosities and axonal loss were found in deep cortex and subcortical white matter at all stages of chronic traumatic encephalopathy. TAR DNA-binding protein 43 immunoreactive inclusions and neurites were also found in 85% of cases, ranging from focal pathology in stages I-III to widespread inclusions and neurites in stage IV. Symptoms in stage I chronic traumatic encephalopathy included headache and loss of attention and concentration. Additional symptoms in stage II included depression, explosivity and short-term memory loss. In stage III, executive dysfunction and cognitive impairment were found, and in stage IV, dementia, word-finding difficulty and aggression were characteristic. Data on athletic exposure were available for 34 American football players; the stage of chronic traumatic encephalopathy correlated with increased duration of football play, survival after football and age at death. Chronic traumatic encephalopathy was the sole diagnosis in 43 cases (63%); eight were also diagnosed with motor neuron disease (12%), seven with Alzheimer&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease (11%), 11 with Lewy body disease (16%) and four with frontotemporal lobar degeneration (6%). There is an ordered and predictable progression of hyperphosphorylated tau abnormalities through the nervous system in chronic traumatic encephalopathy that occurs in conjunction with widespread axonal disruption and loss. The frequent association of chronic traumatic encephalopathy with other neurodegenerative disorders suggests that repetitive brain trauma and hyperphosphorylated tau protein deposition promote the accumulation of other abnormally aggregated proteins including TAR DNA-binding protein 43, amyloid beta protein and alpha-synuclein.

Research paper thumbnail of Chronic Traumatic Encephalopathy in the National Football League

Neurosurgery, 2007

... Cantu, Robert CMD. ... However, as the list of NFL players retired as a result of postconcuss... more ... Cantu, Robert CMD. ... However, as the list of NFL players retired as a result of postconcussion symptoms (eg, Harry Carson, Al Toon, Merrill Hodge, Troy Aikman, Steve Young, Ted Johnson, Wayne Chrebet) grows and as the number of documented CTE cases increases, I ...

Research paper thumbnail of Memory Dysfunction Eight Days Post-Concussion in High School Athletes

Medicine & Science in Sports & Exercise, 2002

Research paper thumbnail of Inaccuracy of Symptom Reporting Following Concussion in Athletes

Medicine & Science in Sports & Exercise, 2002

Research paper thumbnail of Sports neurology

The Lancet Neurology, 2004

Research paper thumbnail of APOE Gene and APOE Promoter Polymorphism G-219T Are Not Related to Neuropsychological Test Score in College Football and Soccer Players

Clinical Journal of Sport Medicine, 2005

Research paper thumbnail of Sports-related concussion: ongoing debate

British Journal of Sports Medicine, 2014

Research paper thumbnail of Consensus Statement on Concussion in Sport: the 3rd International Conference on Concussion in Sport held in Zurich, November 2008

British Journal of Sports Medicine, 2009

Research paper thumbnail of Summary and agreement statement of the first International Conference on Concussion in Sport, Vienna 2001

British Journal of Sports Medicine, 2002

Research paper thumbnail of Summary and agreement statement of the 2nd International Conference on Concussion in Sport, Prague 2004

British Journal of Sports Medicine, 2005

Research paper thumbnail of Prague 2004 International Conference on Concussion in Sport, Summary and agreement statement of the 2nd

Research paper thumbnail of Prague 2004 International Conference on Concussion in Sport, Summary and agreement statement of the 2nd

Research paper thumbnail of Presbyopic advanced surface ablation (PASA) using the Nidek EC-5000

Research paper thumbnail of Objective quality of vision in presbyopic and non-presbyopic patients after pseudoaccommodative advanced surface ablation

Journal of refractive surgery (Thorofare, N.J. : 1995)

To analyze the objective quality of vision at 6 months postoperatively after pseudoaccommodative ... more To analyze the objective quality of vision at 6 months postoperatively after pseudoaccommodative (presbyopic) advanced surface ablation (PASA). The study comprised 62 eyes of 35 patients with 6-month follow-up that underwent primary or secondary treatments using PASA. Pre- and postoperative results of distance and near uncorrected visual acuity (UCVA), spherical aberration (coefficient of the Z12 Zernike polynomial), and the asphericity (Q) index were reviewed. The corresponding wavefront maps (total, low, and high order aberrations) and the corresponding point spread function and modulation transfer function (MTF) were also calculated. Our results show that PASA improves distance and near mean UCVA, increases negative spherical aberration and negative asphericity index, and improves the corresponding MTF. Pseudoaccommodative advanced surface ablation is a promising approach for the surgical correction of presbyopia with distance refractive error (myopia and hyperopia with or withou...

Research paper thumbnail of SYMPOSIUM ABSTRACTS-Comparison of the WF, PSF, Strehl Ratio, and MTF Between 20/20 Untreated, Post Advanced Surface Ablation (ASA), and Post Pseudoaccommodative (Presbyopic) Advanced Surface

Research paper thumbnail of <title>Average PFS and MTF analysis of undilated normal virgin whole eyes</title>

Medical Imaging, 2005

We started our study with a group of Mexican Males with an Uncorrected Visual Acuity (UCVA) of 20... more We started our study with a group of Mexican Males with an Uncorrected Visual Acuity (UCVA) of 20/20, 20/30, and 20/40. The data was obtained using a Nidek OPD Scan ARK 10000 with the Version 1.11b of the working software. With the resulting Zernike coefficients, we calculated the average of the total Wavefront map, the Point Spread Function (PSF), the

Research paper thumbnail of <title>Average PFS and MTF analysis of undilated normal virgin whole eyes</title>

Medical Imaging, 2005

We started our study with a group of Mexican Males with an Uncorrected Visual Acuity (UCVA) of 20... more We started our study with a group of Mexican Males with an Uncorrected Visual Acuity (UCVA) of 20/20, 20/30, and 20/40. The data was obtained using a Nidek OPD Scan ARK 10000 with the Version 1.11b of the working software. With the resulting Zernike coefficients, we calculated the average of the total Wavefront map, the Point Spread Function (PSF), the

Research paper thumbnail of Demonstration of a ventriculo-mastoid fistula (Paradoxical cerebrospinal fluid rhinorrhea) by pantopaque ventriculography

min - Minimally Invasive Neurosurgery, 1967

Research paper thumbnail of <title>PSF and MTF analysis of the visual performance in undilated Mexican normal virgin whole eyes (UCVA greater than or equal to 20/20, 20/30, and 20/40)</title>

Ophthalmic Technologies XV, 2005

In the area of ophthalmic refractive surgery research, the Zernike expansion of the Wavefront abe... more In the area of ophthalmic refractive surgery research, the Zernike expansion of the Wavefront aberrations has been the key factor in the measurement, representation and evaluation of the human eye aberrations in many different clinical situations. The Wavefront Aberrations described by the Zernike expansion can be translated as the polynomial expansion of the exit pupil of an optical system that

Research paper thumbnail of Catastrophic Head Injuries in High School and College Football Players

The American Journal of Sports Medicine, 2007

Catastrophic head injuries in football are rare but tragic events. To update the profile of catas... more Catastrophic head injuries in football are rare but tragic events. To update the profile of catastrophic head injuries in high school and college football players and to describe relevant risk factors. Case series; Level of evidence, 4. We reviewed 94 incidents of severe football head injuries reported to the National Center for Catastrophic Sports Injury Research during 13 academic years (September 1989 through June 2002). In the study period there were an average of 7.23 (standard deviation = 2.05) direct high school and college catastrophic head injuries in scholastic football participants per year. There were 0.67 injuries per 100 000 (95% confidence interval: 0.54, 0.81 per 100 000) high school and 0.21 injuries per 100 000 (95% confidence interval: 0.0, 0.49 per 100 000) college participants for a risk ratio of 3.28 (95% confidence interval: 0.81, 13.3). The injuries resulted in subdural hematoma in 75 athletes, subdural hematoma with diffuse brain edema in 10 athletes, diffuse brain edema in 5 athletes, and arteriovenous malformation or aneurysm in 4 athletes. Fifty-nine percent of the contacts reported that the athlete had a history of a previous head injury, of which 71% occurred within the same season as the catastrophic event. Thirty-nine percent of the athletes (21 of 54) were playing with residual neurologic symptoms from the prior head injury. There were 8 (9%) deaths as a result of the injury, 46 (51%) permanent neurologic injuries, and 36 (40%) serious injuries with full recovery. Most players sustained a major impact to the head either from tackling or being tackled. The incidence of catastrophic head injuries in football has remained low since the advent of the modern day football helmet in the early 1970s. The incidence of catastrophic head injuries in football is dramatically higher at the high school level than at the college level. Although the reason for this discrepancy is unclear, an unacceptably high percentage of high school players were playing with residual symptoms from a prior head injury. Coaches, athletes, athletic trainers, and medical personnel need to adhere to the guideline that an athlete with any neurologic symptoms from a head injury should be strongly discouraged from returning to play.

Research paper thumbnail of The spectrum of disease in chronic traumatic encephalopathy

Chronic traumatic encephalopathy is a progressive tauopathy that occurs as a consequence of repet... more Chronic traumatic encephalopathy is a progressive tauopathy that occurs as a consequence of repetitive mild traumatic brain injury. We analysed post-mortem brains obtained from a cohort of 85 subjects with histories of repetitive mild traumatic brain injury and found evidence of chronic traumatic encephalopathy in 68 subjects: all males, ranging in age from 17 to 98 years (mean 59.5 years), including 64 athletes, 21 military veterans (86% of whom were also athletes) and one individual who engaged in self-injurious head banging behaviour. Eighteen age- and gender-matched individuals without a history of repetitive mild traumatic brain injury served as control subjects. In chronic traumatic encephalopathy, the spectrum of hyperphosphorylated tau pathology ranged in severity from focal perivascular epicentres of neurofibrillary tangles in the frontal neocortex to severe tauopathy affecting widespread brain regions, including the medial temporal lobe, thereby allowing a progressive staging of pathology from stages I-IV. Multifocal axonal varicosities and axonal loss were found in deep cortex and subcortical white matter at all stages of chronic traumatic encephalopathy. TAR DNA-binding protein 43 immunoreactive inclusions and neurites were also found in 85% of cases, ranging from focal pathology in stages I-III to widespread inclusions and neurites in stage IV. Symptoms in stage I chronic traumatic encephalopathy included headache and loss of attention and concentration. Additional symptoms in stage II included depression, explosivity and short-term memory loss. In stage III, executive dysfunction and cognitive impairment were found, and in stage IV, dementia, word-finding difficulty and aggression were characteristic. Data on athletic exposure were available for 34 American football players; the stage of chronic traumatic encephalopathy correlated with increased duration of football play, survival after football and age at death. Chronic traumatic encephalopathy was the sole diagnosis in 43 cases (63%); eight were also diagnosed with motor neuron disease (12%), seven with Alzheimer&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease (11%), 11 with Lewy body disease (16%) and four with frontotemporal lobar degeneration (6%). There is an ordered and predictable progression of hyperphosphorylated tau abnormalities through the nervous system in chronic traumatic encephalopathy that occurs in conjunction with widespread axonal disruption and loss. The frequent association of chronic traumatic encephalopathy with other neurodegenerative disorders suggests that repetitive brain trauma and hyperphosphorylated tau protein deposition promote the accumulation of other abnormally aggregated proteins including TAR DNA-binding protein 43, amyloid beta protein and alpha-synuclein.

Research paper thumbnail of Chronic Traumatic Encephalopathy in the National Football League

Neurosurgery, 2007

... Cantu, Robert CMD. ... However, as the list of NFL players retired as a result of postconcuss... more ... Cantu, Robert CMD. ... However, as the list of NFL players retired as a result of postconcussion symptoms (eg, Harry Carson, Al Toon, Merrill Hodge, Troy Aikman, Steve Young, Ted Johnson, Wayne Chrebet) grows and as the number of documented CTE cases increases, I ...

Research paper thumbnail of Memory Dysfunction Eight Days Post-Concussion in High School Athletes

Medicine & Science in Sports & Exercise, 2002

Research paper thumbnail of Inaccuracy of Symptom Reporting Following Concussion in Athletes

Medicine & Science in Sports & Exercise, 2002

Research paper thumbnail of Sports neurology

The Lancet Neurology, 2004

Research paper thumbnail of APOE Gene and APOE Promoter Polymorphism G-219T Are Not Related to Neuropsychological Test Score in College Football and Soccer Players

Clinical Journal of Sport Medicine, 2005

Research paper thumbnail of Sports-related concussion: ongoing debate

British Journal of Sports Medicine, 2014

Research paper thumbnail of Consensus Statement on Concussion in Sport: the 3rd International Conference on Concussion in Sport held in Zurich, November 2008

British Journal of Sports Medicine, 2009

Research paper thumbnail of Summary and agreement statement of the first International Conference on Concussion in Sport, Vienna 2001

British Journal of Sports Medicine, 2002