Khaled Baraka | Minia University (original) (raw)

Papers by Khaled Baraka

Assiut Scientific Nursing Journal, Aug 1, 2018

Background: Hyperglycemia doubles the risk of recurrent myocardial infarction, heart failure, car... more Background: Hyperglycemia doubles the risk of recurrent myocardial infarction, heart failure, cardiogenic shock, and death. Control of hyperglycemia is important to prevent complications. Aim: Evaluate the effect of implementing nursing guidelines on controlling hyperglycemia in patients with acute myocardial infarction. Design: Aquasi experimental research design. Setting: Coronary care unit at El-Minia University Hospital. Subjects and method: Sixty basically sick grown-up patients who satisfied the consideration criteria and gave intense myocardial infarction with hyperglycemia. Patients were partitioned into two equivalent groups 30 patients for each, (study and control groups). Study Tools: Three tools were utilized to collect data in the present study (Patient assessment tool, Cardiac assessment tool, and Hyperglycemia assessment sheet).Results: We discovered significantly less inconveniences was identified with Myocardial infarction and diabetes in the study group than in the control group, and additionally measurably critical change in the examination assemble regarding to all items of knowledge (P= 0.0001*). Conclusion: Implementation of nursing guidelines results an improvement on outcomes of hyperglycemic patients in the setting of intense myocardial infarction. Recommendation: Glucose levels should be monitored closely in patients admitted to a coronary care unit with acute myocardial infarction as long as hypoglycemia is avoided.

Journal of the Saudi Heart Association, 2017

Background: Microalbuminuria (MA) is a marker of vascular damage. However, many studies have obse... more Background: Microalbuminuria (MA) is a marker of vascular damage. However, many studies have observed an increased risk at lower levels of albuminuria than are currently used to define MA. Aim: To verify early cardiovascular changes occurring before MA in hypertensive patients. Materials and methods: One hundred and fifty hypertensive patients and 60 normotensive individuals were divided into normotensive individuals with normal left ventricular (LV) geometry (Group I), hypertensive patients with normal LV geometry (Group II), and hypertensive patients with abnormal LV geometry (Group III). The LV mass index, ambulatory arterial stiffness index, flow-mediated dilatation of the brachial artery, and intima-media thickness (IMT) of the common carotid were assessed. Urinary albumin/creatinine ratio was determined using a morning spot-urine sample. Results: Compared with Group I, ambulatory arterial stiffness index and IMT were significantly increased and flow-mediated dilatation was significantly decreased in Group II; however, MA did not differ between both groups. These changes were augmented when Group III was compared with Group II. MA significantly increased in Group III compared with Group II. Receiver operating characteristic analysis revealed that MA, with a cutoff value of 19.25 mg/g, predicted increased IMT, and abnormal LV geometry in a statistically significant manner. Conclusion: Many vascular changes, in the form of increased IMT, reduced vasodilator capacity, and increased arterial stiffness, preceded MA and any change in LV geometry. The results presented here strengthen the usefulness of adopting a lower cutoff to define MA.

Journal of medical and pharmaceutical sciences, Dec 30, 2019

Khaled Baraka 4 (1) MD of cardiovascular medicine,,researcher in medical biaotechnology MUST univ... more Khaled Baraka 4 (1) MD of cardiovascular medicine,,researcher in medical biaotechnology MUST university (2) Professor of molecular medicine,,college of biotechnology, MUST university (3) Assistant professor of genetics,college of biaotechnology, MUST university (4) Professor of cardiovascular diseases, faculty of medicine, menia university Abstract: Clopidogrel an oral thienopyridine derivative capable of inhibiting platelet activation. Clopidogrel is prodrug that is converted into an active drug by hepatic cytochrome CYP2C19, CYP2C19*2 and CYP2C19*3 polymorphic alleles are considered to be important loss-of-function alleles resulting in diminished response to clopidogrel. our study aimed to detect frequency of CYP2C19 gene polymorohisms and its impact on clinical outcome in ischemic heart disease patients taking clopidogrel. Matrial and methods: blood samples were collected from 102 ischemic heart disease patients and the frequency alleles was determined by PCR and all patients were followed by clinical assessment and invasive and non-invasive cardiac investigations .Results:. frequency of CYP2C19*1 was 49%, CYP2C19*2 was 15% and CYP2C19*3 was 1%, CYP2C19*17 was 34%, patients with recurrent ischemic attacks 37patients (35.8%), from those patients, 10 patients were normal metabolizer (27%), and 27 patients were abnormal metabolizers(73%) with p-value 0.047 to myocardial infarction and 0.020 to unstable angina. Conclusion:. Asignificance relation was found between CYP2C19polymorphism and recurrent ischemic attacks in this study and multicenter studies are required to confirm this results.

The Egyptian Heart Journal, 2018

Background: Patent ductus arteriosus is generally associated with hyperdynamic status. Given the ... more Background: Patent ductus arteriosus is generally associated with hyperdynamic status. Given the vascular shunt between the aorta and pulmonary artery, intrinsic aortic changes occur (aortic stiffness). In the present study, we attempted to assess the impact of PDA on aortic stiffness and its connection with cardiovascular function before and after transcatheter closure of PDA. Patient and methods: Our study consisted of 60 children who were preparing for transcatheter closure of PDA and 60 healthy controls. All patients had clinical and echocardiographic proof of hemodynamically significant PDA. Results: Patients with PDA exhibited significantly higher ASI than controls before closure (p-value < 0.05). After closure, ASI was significantly reduced (p-value < 0.05), but still higher than that of controls (pvalue < 0.05) at the six-month follow-up assessment. Patients with PDA had significantly lower LVEF than controls before closure (p-value < 0.05). After closure, LVEF was significantly enhanced (p-value < 0.05), and no significant difference was noted amongst patients and controls (p-value < 0.05) at the sixmonth follow-up assessment. Conclusion: Aortic stiffness is significantly increased in patients with PDA regardless of PDA size. Aortic stiffness is related to reduced heart function. ASI may be valuable for observing the course of patients with PDA before and after intervention.

ejnpn.org

Fifty two first-stroke (infarction or hemorrhage) patients with a mean age ±SD of 58.6±6.4 years,... more Fifty two first-stroke (infarction or hemorrhage) patients with a mean age ±SD of 58.6±6.4 years, as well as 20 control subjects with a mean age±SD of 56.1±4.4 were included in this study. All patients were subjected to full clinical evaluation, neurological assessment ...

Systematic Reviews in Pharmacy, 2021

Ischemic heart disease is a leading cause of morbidity and mortality worldwide. Infarct size is t... more Ischemic heart disease is a leading cause of morbidity and mortality worldwide. Infarct size is the single most important predictor of adverse ventricular remodeling, and it is linearly dependent upon the amount of myocardial salvage by reperfusion. Lack of timely reperfusion, due to ineffective treatment or delayed presentation, leads to an unfavorable prognosis. Micro Ribo Nucleic Acids (miRNAs) are small non-coding RNAs ~22 nucleotides in length that function as guide molecules in RNA silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all developmental and pathological processes in animals. The biogenesis of miRNAs is under tight control, and their dysregulation is associated with many human diseases. In cardiac diseases, including myocardial infarction (MI), expression of cardiac miRNAs is markedly altered which leads to deleterious effects associated with heart injury, arrhythmia, increased apoptosis, fibrosis, hypertrophy, and tissue remodeling...

Assiut Scientific Nursing Journal, Aug 1, 2018

Background: Hyperglycemia doubles the risk of recurrent myocardial infarction, heart failure, car... more Background: Hyperglycemia doubles the risk of recurrent myocardial infarction, heart failure, cardiogenic shock, and death. Control of hyperglycemia is important to prevent complications. Aim: Evaluate the effect of implementing nursing guidelines on controlling hyperglycemia in patients with acute myocardial infarction. Design: Aquasi experimental research design. Setting: Coronary care unit at El-Minia University Hospital. Subjects and method: Sixty basically sick grown-up patients who satisfied the consideration criteria and gave intense myocardial infarction with hyperglycemia. Patients were partitioned into two equivalent groups 30 patients for each, (study and control groups). Study Tools: Three tools were utilized to collect data in the present study (Patient assessment tool, Cardiac assessment tool, and Hyperglycemia assessment sheet).Results: We discovered significantly less inconveniences was identified with Myocardial infarction and diabetes in the study group than in the control group, and additionally measurably critical change in the examination assemble regarding to all items of knowledge (P= 0.0001*). Conclusion: Implementation of nursing guidelines results an improvement on outcomes of hyperglycemic patients in the setting of intense myocardial infarction. Recommendation: Glucose levels should be monitored closely in patients admitted to a coronary care unit with acute myocardial infarction as long as hypoglycemia is avoided.

Journal of the Saudi Heart Association, 2017

Background: Microalbuminuria (MA) is a marker of vascular damage. However, many studies have obse... more Background: Microalbuminuria (MA) is a marker of vascular damage. However, many studies have observed an increased risk at lower levels of albuminuria than are currently used to define MA. Aim: To verify early cardiovascular changes occurring before MA in hypertensive patients. Materials and methods: One hundred and fifty hypertensive patients and 60 normotensive individuals were divided into normotensive individuals with normal left ventricular (LV) geometry (Group I), hypertensive patients with normal LV geometry (Group II), and hypertensive patients with abnormal LV geometry (Group III). The LV mass index, ambulatory arterial stiffness index, flow-mediated dilatation of the brachial artery, and intima-media thickness (IMT) of the common carotid were assessed. Urinary albumin/creatinine ratio was determined using a morning spot-urine sample. Results: Compared with Group I, ambulatory arterial stiffness index and IMT were significantly increased and flow-mediated dilatation was significantly decreased in Group II; however, MA did not differ between both groups. These changes were augmented when Group III was compared with Group II. MA significantly increased in Group III compared with Group II. Receiver operating characteristic analysis revealed that MA, with a cutoff value of 19.25 mg/g, predicted increased IMT, and abnormal LV geometry in a statistically significant manner. Conclusion: Many vascular changes, in the form of increased IMT, reduced vasodilator capacity, and increased arterial stiffness, preceded MA and any change in LV geometry. The results presented here strengthen the usefulness of adopting a lower cutoff to define MA.

Journal of medical and pharmaceutical sciences, Dec 30, 2019

Khaled Baraka 4 (1) MD of cardiovascular medicine,,researcher in medical biaotechnology MUST univ... more Khaled Baraka 4 (1) MD of cardiovascular medicine,,researcher in medical biaotechnology MUST university (2) Professor of molecular medicine,,college of biotechnology, MUST university (3) Assistant professor of genetics,college of biaotechnology, MUST university (4) Professor of cardiovascular diseases, faculty of medicine, menia university Abstract: Clopidogrel an oral thienopyridine derivative capable of inhibiting platelet activation. Clopidogrel is prodrug that is converted into an active drug by hepatic cytochrome CYP2C19, CYP2C19*2 and CYP2C19*3 polymorphic alleles are considered to be important loss-of-function alleles resulting in diminished response to clopidogrel. our study aimed to detect frequency of CYP2C19 gene polymorohisms and its impact on clinical outcome in ischemic heart disease patients taking clopidogrel. Matrial and methods: blood samples were collected from 102 ischemic heart disease patients and the frequency alleles was determined by PCR and all patients were followed by clinical assessment and invasive and non-invasive cardiac investigations .Results:. frequency of CYP2C19*1 was 49%, CYP2C19*2 was 15% and CYP2C19*3 was 1%, CYP2C19*17 was 34%, patients with recurrent ischemic attacks 37patients (35.8%), from those patients, 10 patients were normal metabolizer (27%), and 27 patients were abnormal metabolizers(73%) with p-value 0.047 to myocardial infarction and 0.020 to unstable angina. Conclusion:. Asignificance relation was found between CYP2C19polymorphism and recurrent ischemic attacks in this study and multicenter studies are required to confirm this results.

The Egyptian Heart Journal, 2018

Background: Patent ductus arteriosus is generally associated with hyperdynamic status. Given the ... more Background: Patent ductus arteriosus is generally associated with hyperdynamic status. Given the vascular shunt between the aorta and pulmonary artery, intrinsic aortic changes occur (aortic stiffness). In the present study, we attempted to assess the impact of PDA on aortic stiffness and its connection with cardiovascular function before and after transcatheter closure of PDA. Patient and methods: Our study consisted of 60 children who were preparing for transcatheter closure of PDA and 60 healthy controls. All patients had clinical and echocardiographic proof of hemodynamically significant PDA. Results: Patients with PDA exhibited significantly higher ASI than controls before closure (p-value < 0.05). After closure, ASI was significantly reduced (p-value < 0.05), but still higher than that of controls (pvalue < 0.05) at the six-month follow-up assessment. Patients with PDA had significantly lower LVEF than controls before closure (p-value < 0.05). After closure, LVEF was significantly enhanced (p-value < 0.05), and no significant difference was noted amongst patients and controls (p-value < 0.05) at the sixmonth follow-up assessment. Conclusion: Aortic stiffness is significantly increased in patients with PDA regardless of PDA size. Aortic stiffness is related to reduced heart function. ASI may be valuable for observing the course of patients with PDA before and after intervention.

ejnpn.org

Fifty two first-stroke (infarction or hemorrhage) patients with a mean age ±SD of 58.6±6.4 years,... more Fifty two first-stroke (infarction or hemorrhage) patients with a mean age ±SD of 58.6±6.4 years, as well as 20 control subjects with a mean age±SD of 56.1±4.4 were included in this study. All patients were subjected to full clinical evaluation, neurological assessment ...

Systematic Reviews in Pharmacy, 2021

Ischemic heart disease is a leading cause of morbidity and mortality worldwide. Infarct size is t... more Ischemic heart disease is a leading cause of morbidity and mortality worldwide. Infarct size is the single most important predictor of adverse ventricular remodeling, and it is linearly dependent upon the amount of myocardial salvage by reperfusion. Lack of timely reperfusion, due to ineffective treatment or delayed presentation, leads to an unfavorable prognosis. Micro Ribo Nucleic Acids (miRNAs) are small non-coding RNAs ~22 nucleotides in length that function as guide molecules in RNA silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all developmental and pathological processes in animals. The biogenesis of miRNAs is under tight control, and their dysregulation is associated with many human diseases. In cardiac diseases, including myocardial infarction (MI), expression of cardiac miRNAs is markedly altered which leads to deleterious effects associated with heart injury, arrhythmia, increased apoptosis, fibrosis, hypertrophy, and tissue remodeling...