Gihan Omar | El-minya - Academia.edu (original) (raw)

Papers by Gihan Omar

Research paper thumbnail of Relation of osteopontine levels in plasma and synovial fluid of patients with knee osteoarthritis to magnetic resonance imaging findings of the knee joint

International Journal of Clinical Rheumatology, 2019

International Journal of Clinical Rheumatology Research Article Relation of osteopontine levels i... more International Journal of Clinical Rheumatology Research Article Relation of osteopontine levels in plasma and synovial fluid of patients with knee osteoarthritis to magnetic resonance imaging findings of the knee joint mediate cellular growth, survival, adhesion and migration in osteoarthritis [2,3]. The current reference standard for grading the severity of osteoarthritis (OA) in the knee is the radiography based Kellgren and Lawrence score [4]. This technique only indirectly visualizes the cartilage and is not able to (semi) quantitatively measure cartilage quality [5]. Therefore, quality of cartilage in terms of the sulphated glycosaminoglycan (sGAG), collagen or sodium content of articular cartilage can be measured using magnetic resonance imaging (MRI) techniques [6]. In last decades, MRI had become the most important modality for assessment of pathologic changes in knee cartilage as it allows the manipulation of contrast to highlight different tissue types [7]. The etiopathogenesis of disease

Research paper thumbnail of Pulmonary involvement: A potential independent factor for quality of life in systemic lupus erythematosus

Lupus

Background Systemic lupus erythematosus (SLE) is a chronic multi-systemic autoimmune disease. SLE... more Background Systemic lupus erythematosus (SLE) is a chronic multi-systemic autoimmune disease. SLE patients may experience a wide range of physical, psychological, and social perception of well-being influenced by the patient illness that are not always fully captured by descriptions of the disease’s physiological consequences alone. Nowadays, patients with SLE have a better survival than decades ago, nevertheless still experience a low health related quality of life (HRQoL). Assessing disease activity in SLE is crucial to the physician as it forms the basis for treatment decisions, moreover careful evaluation for respiratory involvement should be routinely considered. More chronic lung disease related to SLE can have a significant negative effect on patient well-being and physical performance status and are detrimental to quality of life. Objective The aim of this study was to evaluate quality of life changes in SLE patients using Lupus QoL scale, assessing their correlation with di...

Research paper thumbnail of Depression and COVID 19

Minia Journal of Medical Research

Background: Following recovery from COVID-19, it was found that an increasing number of individua... more Background: Following recovery from COVID-19, it was found that an increasing number of individuals have reported the persistence and/or presence of new onset symptoms which collectively have been identified as post-COVID-19 syndrome by the National Institute for Health 2020. Depressive symptoms in the acute phase of COVID-19 have been well described, the frequency of depression following recovery of the acute phase remains unknown. We thought to screen for depression as an important post COVID19 presentation among nurses, who serve as front line care givers. Method: 88 nurses with history of COVID 19 infection were enrolled in this study by using MINIDEP screening tool for depression. Results: 13.6% of the patients had post COVID19 depression according to MINIDEP score. It was found that female sex, duration of COVID illness, post COVID19 sleep disturbance (P=0.03, P=0.004, P=0.001, respectively) were significantly correlated with depression in post COVID patients. Conclusion: COVID 19 infection can trigger depression.

Research paper thumbnail of CCL21 and IP10 as serum biomarkers for pulmonary involvement in systemic lupus erythematosus

Lupus

Background Although the significance of inflammatory cytokines and chemokines in the pathogenesis... more Background Although the significance of inflammatory cytokines and chemokines in the pathogenesis of SLE is well established, the findings showed diversity and implied that combining different biomarkers could be useful in monitoring disease activity or organ involvement. Despite the potentially high prevalence of lung involvement in SLE, only a few studies have investigated for lung biomarkers. Objective The aim of this study was to assess the value of Chemokine Ligand 21 (CCL 21) and Interferon gamma–induced protein 10 (IP10) as serum biomarkers for pulmonary involvement in SLE and their correlation with disease activity, organ involvement, pulmonary function tests (PFTs), and chest CT findings. Materials and methods Sixty SLE patients and 30 age- and sex-matched controls were enrolled into this study. All patients underwent serological tests, PFTs, and chest CT examination. The serum levels of CCL21 and IP10 were analyzed, and their correlations with PFTs and CT were explored. Re...

Research paper thumbnail of Relation of osteopontine levels in plasma and synovial fluid of patients with knee osteoarthritis to magnetic resonance imaging findings of the knee joint

International Journal of Clinical Rheumatology, 2019

International Journal of Clinical Rheumatology Research Article Relation of osteopontine levels i... more International Journal of Clinical Rheumatology Research Article Relation of osteopontine levels in plasma and synovial fluid of patients with knee osteoarthritis to magnetic resonance imaging findings of the knee joint mediate cellular growth, survival, adhesion and migration in osteoarthritis [2,3]. The current reference standard for grading the severity of osteoarthritis (OA) in the knee is the radiography based Kellgren and Lawrence score [4]. This technique only indirectly visualizes the cartilage and is not able to (semi) quantitatively measure cartilage quality [5]. Therefore, quality of cartilage in terms of the sulphated glycosaminoglycan (sGAG), collagen or sodium content of articular cartilage can be measured using magnetic resonance imaging (MRI) techniques [6]. In last decades, MRI had become the most important modality for assessment of pathologic changes in knee cartilage as it allows the manipulation of contrast to highlight different tissue types [7]. The etiopathogenesis of disease

Research paper thumbnail of Symptoms of Depression and Disability among Rheumatoid Arthritis Patients

Background Rheumatoid arthritis (RA) is a significant and serious public illness affecting people... more Background Rheumatoid arthritis (RA) is a significant and serious public illness affecting peoples especially adults all over the world and emotional problems such as depressive symptoms are more common in patients with RA than in general population. Synovial inflammation, joint damage, degeneration of cartilage, bony destruction and limitation of physical functioning are the distinctive feature of RA that consequently leads to functional disability. This study aimed at assesses prevalence of symptoms of depression and disability among RA patients. Research Design: A descriptive correlational research design was utilized in this study. Study subjects: Established diagnosed 80 RA patients were included in the study. Two tools were used; Beck Depression Inventory (BDI) version I to assess symptoms of depression, and Health assessment questionnaire-disability index (HAQ-DI) to assess disease-related disability. Result: Majority of the participants were females with the age of (20-65) y...

Research paper thumbnail of Growth Assessment and Vitamin D Level in Egyptian Juvenile Idiopathic Arthritis Patients

International Journal of Pediatrics, 2019

Background Juvenile idiopathic arthritis (JIA) is one of the most common rheumatic diseases in ch... more Background Juvenile idiopathic arthritis (JIA) is one of the most common rheumatic diseases in childhood and is frequently associated with growth retardation. Vitamin D is critical to bone mineral metabolism and to the growth and development of the skeleton. We aimed to evaluate growth pattern and Vitamin D level in patients with JIA and its different subtypes. Materials and Methods 80 JIA patients and 80 healthy controls were included. For all patients and controls we assessed body weight, standing height, body mass index (BMI), Serum 25(OH) D3. Thyroid function tests were assessed to exclude patients with hypothyroidism or autoimmune thyroiditis, liver and renal function tests, calcium, phosphorus, alkaline phosphatase, fasting blood sugar were done to evaluate other causes of short stature. Results JIA patients' mean height, weight, and BMI were significantly lower compared to controls (135.4±22.1 vs. 145.7±21.8, p=0.042 for height), (34.6±13.6 vs. 39.8±11.4, p=0.039 for weig...

Research paper thumbnail of Femoral cartilage thickness in patients with systemic sclerosis: It’s relation to vitamin D

Annals of Musculoskeletal Medicine

developed a classifi cation criteria assumed to improve sensitivity, which would lead to earlier ... more developed a classifi cation criteria assumed to improve sensitivity, which would lead to earlier diagnosis, and it also incorporates the autoantibodies that are commonly used for diagnostic purposes [11]. Vitamin D have been the focus of a growing number of studies in past years, demonstrating their function not only in calcium metabolism and bone formation, but also their interaction with the immune system since vitamin D receptors are expressed in different tissues. Numerous studies have been conducted to study whether vitamin D is

Research paper thumbnail of Dry eye in rheumatoid arthritis: relation to disease activity

Immunological Medicine

The aim of this study was to find the correlation between severity of dry eye and rheumatoid arth... more The aim of this study was to find the correlation between severity of dry eye and rheumatoid arthritis (RA) disease activity. Forty-two RA patients with dry eye were recruited from Rheumatology Outpatient Clinic in Minia University Hospital. Assessment of RA disease activity was performed using disease activity score (DAS-28). Ocular tests include Schirmer test I, tear film break up time (TBUT) and ocular staining score (OSS) was performed by ophthalmologist to find evidence of ocular dryness. Erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), anti SSA/Ro and anti SSB/La was also tested. Patients with severe dry (OSS ! 3) underwent minor salivary gland biopsy (MSGB) as suspected to have secondary Sj€ ogren's syndrome (SS). Of 42 RA patients, 30 had definite dry eye. DAS-28 did not show significant correlation with any of ocular tests for dryness while the duration of RA was significantly positively correlated with Schirmer test and OSS. The biopsy results of RA patients with severe dry eye show no evidence of SS. The severity of dry eye is not correlated with activity of RA but with its duration.

Research paper thumbnail of SAT0283 CLINICAL and Serological Features of Systemic Sclerosis in Italian and Egyptian Patients

Saturday, 15 June 2019

Ab+ cases, 2 groups were found; one included TNF-a, MCP-1and IP-10, and the other had IFN-b as a ... more Ab+ cases, 2 groups were found; one included TNF-a, MCP-1and IP-10, and the other had IFN-b as a sole component. Conclusion: Cytokine profiles differ among subgroups in myositis. In anti-DDA5+ myositis, IL-15 and IFN-a with strong correlation and IL-6 were characteristic cytokines, while IFN-b was a unique one in anti-ARS+ myositis Disclosure of Interests: None declared

Research paper thumbnail of The distribution and outcome of vasculitic syndromes among Egyptians: A multi-centre study including 630 patients

The Egyptian Rheumatologist

Research paper thumbnail of Ultrasound-guided injection of carpal tunnel syndrome: A comparative study to blind injection

The Egyptian Rheumatologist

Research paper thumbnail of Diagnostic value of anti-annexin A5 antibodies in seropositive versus seronegative antiphospholipid syndrome patients

The Egyptian Rheumatologist

Research paper thumbnail of Asymptomatic Pulmonary Hypertension in Systemic

Research paper thumbnail of Early detection of spondyloarthropathy in patients with psoriasis by using the ultrasonography and magnetic resonance image

European Journal of Rheumatology, 2015

To assess the validity of ultrasound (US) in the early detection of arthritis and enthesitis, wit... more To assess the validity of ultrasound (US) in the early detection of arthritis and enthesitis, with assessment of the validity of magnetic resonance imaging (MRI) in the early detection of sacroiliitis and spondylitis in patients with psoriasis and to compare the findings of clinical examination and conventional radiography. The study included 50 patients with psoriasis and 20 healthy controls. All patients and controls underwent US and power Doppler analyses for the joints of both hands and feet and the entheseal sites. MRI of the lumbosacral spine and sacroiliac joints was performed. Abnormal US findings of arthritis were present in 18% patients, whereas only 6% patients had X-ray abnormalities, the enthesopathy represent 74%, at a higher percentage than clinical and radiological assessment (46, 26% respectively). MRI and radiological study demonstrated evidence of inflammation in the spine in 44% and 16% patients, respectively, and evidence of sacroiliitis in 10% and 6% patients, respectively. Use of newer imaging modalities allows early diagnosis and early initiation of therapy.

Research paper thumbnail of Asymptomatic Pulmonary Hypertension in Systemic Lupus Erythematosus

Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders, 2011

Introduction: Pulmonary arterial hypertension (PAH) is a serious and often fatal complication of ... more Introduction: Pulmonary arterial hypertension (PAH) is a serious and often fatal complication of systemic lupus erythematosus (SLE). Because the diagnosis of PAH often is made years after symptom onset, early diagnostic strategies are essential. Doppler echocardiography currently is considered the noninvasive screening test of choice for evaluating pulmonary hypertension. Aim: Screening for asymptomatic pulmonary hypertension in systemic lupus erythematosus patients using Doppler echocardiography, and correlating it with inflammatory parameters of the disease. Patients and methods: Doppler echocardiography was performed in 74 patients with systemic lupus erythematosus over one year (66 adult and 8 juvenile), adult SLE included 57 patients with adult-onset and 9 patients with childhood-onset. Pulmonary hypertension was diagnosed if the peak systolic pressure gradient at the tricuspid valve was more than 30 mmHg. All patients were subjected to full history taking, rheumatological examination, laboratory studies and chest x-ray. Results: In seventy four SLE patients, the pulmonary hypertension was detected in 8 patients (10.8%), 7 adult-onset SLE patients (aged from 19 to 30 years) and 1 juvenile SLE (aged 12 years). The range of pulmonary artery systolic pressure was 34-61.2 mmHg (43.19 ± 9.28). No significant differences between patients with and those without pulmonary hypertension as regard clinical features. Significantly higher frequencies of rheumatoid factor and anti-cardiolipin antibodies were found in patients with pulmonary hypertension versus those without (P = 0.02, P = 0.008 respectively). Positive rheumatoid factor and ACL were significantly associated with occurrence of PAH in SLE (P = 0.007, P = 0.006 respectively). No significant correlations were found between pulmonary artery pressure, disease duration, SLE Disease Activity Index (SLEDAI), ESR, and anti-ds DNA. Conclusion: Patients with SLE have an increased risk of pulmonary arterial hypertension. Echocardiography should be used as a screening tool in patients at high risk for development of pulmonary hypertension. Positive anti-cardiolipin antibodies and rheumatoid factor were significant predictors of pulmonary hypertension in our study.

Research paper thumbnail of Use of the SS Scale, FIQR, and FIQ VASs for assessment of symptom severity in Egyptian fibromyalgia patients

Egyptian Rheumatology and Rehabilitation, 2014

Research paper thumbnail of Diagnostic Value of Salivary Gland Ultrasonographic Scoring System in Primary Sjogren's Syndrome: A Comparison with Scintigraphy and Biopsy

The Journal of Rheumatology, 2009

Objective.To compare an ultrasonographic (US) scoring system of salivary glands with scintigraphy... more Objective.To compare an ultrasonographic (US) scoring system of salivary glands with scintigraphy and salivary gland biopsy, in order to evaluate its diagnostic value in primary Sjögren’s syndrome (SS).Methods.In 135 patients with suspected SS, the grades of 5 US measures of both parotid and submandibular salivary glands were scored (0–48 scale). Diagnosis of primary SS was established following the American-European Consensus Group criteria of 2002. The patients’ total scintigraphic score (0–12 scale) was determined and the histopathological changes of minor salivary glands graded. Area under the receiver-operating characteristic (ROC) curve was employed to evaluate the diagnostic value of the US scoring system.Results.Primary SS was diagnosed in 107 (79.2%) patients and the remaining 28 subjects (20.8%) constituted the control group. US changes of salivary glands were established in 98/107 patients with SS and in 14/28 controls. Mean US score was 26 in SS patients and 6 in control...

Research paper thumbnail of not me

Cornea, 2009

Cornea. Author manuscript; available in PMC 2010 June 1. ... 1 The Ocular Surface Diseases and Dr... more Cornea. Author manuscript; available in PMC 2010 June 1. ... 1 The Ocular Surface Diseases and Dry Eye Clinic, Division of Cornea and External Disease, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD.

Research paper thumbnail of Relation of osteopontine levels in plasma and synovial fluid of patients with knee osteoarthritis to magnetic resonance imaging findings of the knee joint

International Journal of Clinical Rheumatology, 2019

International Journal of Clinical Rheumatology Research Article Relation of osteopontine levels i... more International Journal of Clinical Rheumatology Research Article Relation of osteopontine levels in plasma and synovial fluid of patients with knee osteoarthritis to magnetic resonance imaging findings of the knee joint mediate cellular growth, survival, adhesion and migration in osteoarthritis [2,3]. The current reference standard for grading the severity of osteoarthritis (OA) in the knee is the radiography based Kellgren and Lawrence score [4]. This technique only indirectly visualizes the cartilage and is not able to (semi) quantitatively measure cartilage quality [5]. Therefore, quality of cartilage in terms of the sulphated glycosaminoglycan (sGAG), collagen or sodium content of articular cartilage can be measured using magnetic resonance imaging (MRI) techniques [6]. In last decades, MRI had become the most important modality for assessment of pathologic changes in knee cartilage as it allows the manipulation of contrast to highlight different tissue types [7]. The etiopathogenesis of disease

Research paper thumbnail of Pulmonary involvement: A potential independent factor for quality of life in systemic lupus erythematosus

Lupus

Background Systemic lupus erythematosus (SLE) is a chronic multi-systemic autoimmune disease. SLE... more Background Systemic lupus erythematosus (SLE) is a chronic multi-systemic autoimmune disease. SLE patients may experience a wide range of physical, psychological, and social perception of well-being influenced by the patient illness that are not always fully captured by descriptions of the disease’s physiological consequences alone. Nowadays, patients with SLE have a better survival than decades ago, nevertheless still experience a low health related quality of life (HRQoL). Assessing disease activity in SLE is crucial to the physician as it forms the basis for treatment decisions, moreover careful evaluation for respiratory involvement should be routinely considered. More chronic lung disease related to SLE can have a significant negative effect on patient well-being and physical performance status and are detrimental to quality of life. Objective The aim of this study was to evaluate quality of life changes in SLE patients using Lupus QoL scale, assessing their correlation with di...

Research paper thumbnail of Depression and COVID 19

Minia Journal of Medical Research

Background: Following recovery from COVID-19, it was found that an increasing number of individua... more Background: Following recovery from COVID-19, it was found that an increasing number of individuals have reported the persistence and/or presence of new onset symptoms which collectively have been identified as post-COVID-19 syndrome by the National Institute for Health 2020. Depressive symptoms in the acute phase of COVID-19 have been well described, the frequency of depression following recovery of the acute phase remains unknown. We thought to screen for depression as an important post COVID19 presentation among nurses, who serve as front line care givers. Method: 88 nurses with history of COVID 19 infection were enrolled in this study by using MINIDEP screening tool for depression. Results: 13.6% of the patients had post COVID19 depression according to MINIDEP score. It was found that female sex, duration of COVID illness, post COVID19 sleep disturbance (P=0.03, P=0.004, P=0.001, respectively) were significantly correlated with depression in post COVID patients. Conclusion: COVID 19 infection can trigger depression.

Research paper thumbnail of CCL21 and IP10 as serum biomarkers for pulmonary involvement in systemic lupus erythematosus

Lupus

Background Although the significance of inflammatory cytokines and chemokines in the pathogenesis... more Background Although the significance of inflammatory cytokines and chemokines in the pathogenesis of SLE is well established, the findings showed diversity and implied that combining different biomarkers could be useful in monitoring disease activity or organ involvement. Despite the potentially high prevalence of lung involvement in SLE, only a few studies have investigated for lung biomarkers. Objective The aim of this study was to assess the value of Chemokine Ligand 21 (CCL 21) and Interferon gamma–induced protein 10 (IP10) as serum biomarkers for pulmonary involvement in SLE and their correlation with disease activity, organ involvement, pulmonary function tests (PFTs), and chest CT findings. Materials and methods Sixty SLE patients and 30 age- and sex-matched controls were enrolled into this study. All patients underwent serological tests, PFTs, and chest CT examination. The serum levels of CCL21 and IP10 were analyzed, and their correlations with PFTs and CT were explored. Re...

Research paper thumbnail of Relation of osteopontine levels in plasma and synovial fluid of patients with knee osteoarthritis to magnetic resonance imaging findings of the knee joint

International Journal of Clinical Rheumatology, 2019

International Journal of Clinical Rheumatology Research Article Relation of osteopontine levels i... more International Journal of Clinical Rheumatology Research Article Relation of osteopontine levels in plasma and synovial fluid of patients with knee osteoarthritis to magnetic resonance imaging findings of the knee joint mediate cellular growth, survival, adhesion and migration in osteoarthritis [2,3]. The current reference standard for grading the severity of osteoarthritis (OA) in the knee is the radiography based Kellgren and Lawrence score [4]. This technique only indirectly visualizes the cartilage and is not able to (semi) quantitatively measure cartilage quality [5]. Therefore, quality of cartilage in terms of the sulphated glycosaminoglycan (sGAG), collagen or sodium content of articular cartilage can be measured using magnetic resonance imaging (MRI) techniques [6]. In last decades, MRI had become the most important modality for assessment of pathologic changes in knee cartilage as it allows the manipulation of contrast to highlight different tissue types [7]. The etiopathogenesis of disease

Research paper thumbnail of Symptoms of Depression and Disability among Rheumatoid Arthritis Patients

Background Rheumatoid arthritis (RA) is a significant and serious public illness affecting people... more Background Rheumatoid arthritis (RA) is a significant and serious public illness affecting peoples especially adults all over the world and emotional problems such as depressive symptoms are more common in patients with RA than in general population. Synovial inflammation, joint damage, degeneration of cartilage, bony destruction and limitation of physical functioning are the distinctive feature of RA that consequently leads to functional disability. This study aimed at assesses prevalence of symptoms of depression and disability among RA patients. Research Design: A descriptive correlational research design was utilized in this study. Study subjects: Established diagnosed 80 RA patients were included in the study. Two tools were used; Beck Depression Inventory (BDI) version I to assess symptoms of depression, and Health assessment questionnaire-disability index (HAQ-DI) to assess disease-related disability. Result: Majority of the participants were females with the age of (20-65) y...

Research paper thumbnail of Growth Assessment and Vitamin D Level in Egyptian Juvenile Idiopathic Arthritis Patients

International Journal of Pediatrics, 2019

Background Juvenile idiopathic arthritis (JIA) is one of the most common rheumatic diseases in ch... more Background Juvenile idiopathic arthritis (JIA) is one of the most common rheumatic diseases in childhood and is frequently associated with growth retardation. Vitamin D is critical to bone mineral metabolism and to the growth and development of the skeleton. We aimed to evaluate growth pattern and Vitamin D level in patients with JIA and its different subtypes. Materials and Methods 80 JIA patients and 80 healthy controls were included. For all patients and controls we assessed body weight, standing height, body mass index (BMI), Serum 25(OH) D3. Thyroid function tests were assessed to exclude patients with hypothyroidism or autoimmune thyroiditis, liver and renal function tests, calcium, phosphorus, alkaline phosphatase, fasting blood sugar were done to evaluate other causes of short stature. Results JIA patients' mean height, weight, and BMI were significantly lower compared to controls (135.4±22.1 vs. 145.7±21.8, p=0.042 for height), (34.6±13.6 vs. 39.8±11.4, p=0.039 for weig...

Research paper thumbnail of Femoral cartilage thickness in patients with systemic sclerosis: It’s relation to vitamin D

Annals of Musculoskeletal Medicine

developed a classifi cation criteria assumed to improve sensitivity, which would lead to earlier ... more developed a classifi cation criteria assumed to improve sensitivity, which would lead to earlier diagnosis, and it also incorporates the autoantibodies that are commonly used for diagnostic purposes [11]. Vitamin D have been the focus of a growing number of studies in past years, demonstrating their function not only in calcium metabolism and bone formation, but also their interaction with the immune system since vitamin D receptors are expressed in different tissues. Numerous studies have been conducted to study whether vitamin D is

Research paper thumbnail of Dry eye in rheumatoid arthritis: relation to disease activity

Immunological Medicine

The aim of this study was to find the correlation between severity of dry eye and rheumatoid arth... more The aim of this study was to find the correlation between severity of dry eye and rheumatoid arthritis (RA) disease activity. Forty-two RA patients with dry eye were recruited from Rheumatology Outpatient Clinic in Minia University Hospital. Assessment of RA disease activity was performed using disease activity score (DAS-28). Ocular tests include Schirmer test I, tear film break up time (TBUT) and ocular staining score (OSS) was performed by ophthalmologist to find evidence of ocular dryness. Erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), anti SSA/Ro and anti SSB/La was also tested. Patients with severe dry (OSS ! 3) underwent minor salivary gland biopsy (MSGB) as suspected to have secondary Sj€ ogren's syndrome (SS). Of 42 RA patients, 30 had definite dry eye. DAS-28 did not show significant correlation with any of ocular tests for dryness while the duration of RA was significantly positively correlated with Schirmer test and OSS. The biopsy results of RA patients with severe dry eye show no evidence of SS. The severity of dry eye is not correlated with activity of RA but with its duration.

Research paper thumbnail of SAT0283 CLINICAL and Serological Features of Systemic Sclerosis in Italian and Egyptian Patients

Saturday, 15 June 2019

Ab+ cases, 2 groups were found; one included TNF-a, MCP-1and IP-10, and the other had IFN-b as a ... more Ab+ cases, 2 groups were found; one included TNF-a, MCP-1and IP-10, and the other had IFN-b as a sole component. Conclusion: Cytokine profiles differ among subgroups in myositis. In anti-DDA5+ myositis, IL-15 and IFN-a with strong correlation and IL-6 were characteristic cytokines, while IFN-b was a unique one in anti-ARS+ myositis Disclosure of Interests: None declared

Research paper thumbnail of The distribution and outcome of vasculitic syndromes among Egyptians: A multi-centre study including 630 patients

The Egyptian Rheumatologist

Research paper thumbnail of Ultrasound-guided injection of carpal tunnel syndrome: A comparative study to blind injection

The Egyptian Rheumatologist

Research paper thumbnail of Diagnostic value of anti-annexin A5 antibodies in seropositive versus seronegative antiphospholipid syndrome patients

The Egyptian Rheumatologist

Research paper thumbnail of Asymptomatic Pulmonary Hypertension in Systemic

Research paper thumbnail of Early detection of spondyloarthropathy in patients with psoriasis by using the ultrasonography and magnetic resonance image

European Journal of Rheumatology, 2015

To assess the validity of ultrasound (US) in the early detection of arthritis and enthesitis, wit... more To assess the validity of ultrasound (US) in the early detection of arthritis and enthesitis, with assessment of the validity of magnetic resonance imaging (MRI) in the early detection of sacroiliitis and spondylitis in patients with psoriasis and to compare the findings of clinical examination and conventional radiography. The study included 50 patients with psoriasis and 20 healthy controls. All patients and controls underwent US and power Doppler analyses for the joints of both hands and feet and the entheseal sites. MRI of the lumbosacral spine and sacroiliac joints was performed. Abnormal US findings of arthritis were present in 18% patients, whereas only 6% patients had X-ray abnormalities, the enthesopathy represent 74%, at a higher percentage than clinical and radiological assessment (46, 26% respectively). MRI and radiological study demonstrated evidence of inflammation in the spine in 44% and 16% patients, respectively, and evidence of sacroiliitis in 10% and 6% patients, respectively. Use of newer imaging modalities allows early diagnosis and early initiation of therapy.

Research paper thumbnail of Asymptomatic Pulmonary Hypertension in Systemic Lupus Erythematosus

Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders, 2011

Introduction: Pulmonary arterial hypertension (PAH) is a serious and often fatal complication of ... more Introduction: Pulmonary arterial hypertension (PAH) is a serious and often fatal complication of systemic lupus erythematosus (SLE). Because the diagnosis of PAH often is made years after symptom onset, early diagnostic strategies are essential. Doppler echocardiography currently is considered the noninvasive screening test of choice for evaluating pulmonary hypertension. Aim: Screening for asymptomatic pulmonary hypertension in systemic lupus erythematosus patients using Doppler echocardiography, and correlating it with inflammatory parameters of the disease. Patients and methods: Doppler echocardiography was performed in 74 patients with systemic lupus erythematosus over one year (66 adult and 8 juvenile), adult SLE included 57 patients with adult-onset and 9 patients with childhood-onset. Pulmonary hypertension was diagnosed if the peak systolic pressure gradient at the tricuspid valve was more than 30 mmHg. All patients were subjected to full history taking, rheumatological examination, laboratory studies and chest x-ray. Results: In seventy four SLE patients, the pulmonary hypertension was detected in 8 patients (10.8%), 7 adult-onset SLE patients (aged from 19 to 30 years) and 1 juvenile SLE (aged 12 years). The range of pulmonary artery systolic pressure was 34-61.2 mmHg (43.19 ± 9.28). No significant differences between patients with and those without pulmonary hypertension as regard clinical features. Significantly higher frequencies of rheumatoid factor and anti-cardiolipin antibodies were found in patients with pulmonary hypertension versus those without (P = 0.02, P = 0.008 respectively). Positive rheumatoid factor and ACL were significantly associated with occurrence of PAH in SLE (P = 0.007, P = 0.006 respectively). No significant correlations were found between pulmonary artery pressure, disease duration, SLE Disease Activity Index (SLEDAI), ESR, and anti-ds DNA. Conclusion: Patients with SLE have an increased risk of pulmonary arterial hypertension. Echocardiography should be used as a screening tool in patients at high risk for development of pulmonary hypertension. Positive anti-cardiolipin antibodies and rheumatoid factor were significant predictors of pulmonary hypertension in our study.

Research paper thumbnail of Use of the SS Scale, FIQR, and FIQ VASs for assessment of symptom severity in Egyptian fibromyalgia patients

Egyptian Rheumatology and Rehabilitation, 2014

Research paper thumbnail of Diagnostic Value of Salivary Gland Ultrasonographic Scoring System in Primary Sjogren's Syndrome: A Comparison with Scintigraphy and Biopsy

The Journal of Rheumatology, 2009

Objective.To compare an ultrasonographic (US) scoring system of salivary glands with scintigraphy... more Objective.To compare an ultrasonographic (US) scoring system of salivary glands with scintigraphy and salivary gland biopsy, in order to evaluate its diagnostic value in primary Sjögren’s syndrome (SS).Methods.In 135 patients with suspected SS, the grades of 5 US measures of both parotid and submandibular salivary glands were scored (0–48 scale). Diagnosis of primary SS was established following the American-European Consensus Group criteria of 2002. The patients’ total scintigraphic score (0–12 scale) was determined and the histopathological changes of minor salivary glands graded. Area under the receiver-operating characteristic (ROC) curve was employed to evaluate the diagnostic value of the US scoring system.Results.Primary SS was diagnosed in 107 (79.2%) patients and the remaining 28 subjects (20.8%) constituted the control group. US changes of salivary glands were established in 98/107 patients with SS and in 14/28 controls. Mean US score was 26 in SS patients and 6 in control...

Research paper thumbnail of not me

Cornea, 2009

Cornea. Author manuscript; available in PMC 2010 June 1. ... 1 The Ocular Surface Diseases and Dr... more Cornea. Author manuscript; available in PMC 2010 June 1. ... 1 The Ocular Surface Diseases and Dry Eye Clinic, Division of Cornea and External Disease, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD.