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Papers by Moslim M O H S I N Khalaf

Annals of Parasitology, 2021

The aim of this study was to determine IL-2, IL-4 and IL-10 levels, in patients with giardiosis a... more The aim of this study was to determine IL-2, IL-4 and IL-10 levels, in patients with giardiosis and to compare their interleukins levels with healthy controls. A total of 375 patients (211 males, 164 females) in Thi-Qar Province, southern of Iraq were examined. Twenty-four (16 males, 8 females) patients confirm to have giardiosis and 20 healthy control group were withdrawn (5) ml of venous blood to conduct immunological tests to determine the quantitative for level of IL-2, IL-4 and IL-10 in a manner (ELISA). The result showed, the overall infection rate of G. lamblia was 6.40%, according to gender, higher infection rate was recorded in males 7.58% compared to the females rate 4.87% no significant differences were observed between gender. The highest rates of giardiosis observed in age
group (30–45), which reached 7.04% and there is no significant difference showed in the infection of different ages under study (P≤0.05). The results showed a significant increases in the level of interleukins and the amount of IL-2, IL- 4 and IL-10 in patients (26.90, 17.43 and 14.71), respectively, was higher than those of healthy control (13.32, 10.25 and 10.55). The conclusion of this study demonstrated that the rate of infection was higher in males than in females and the age group (30–45) have the highest infection rates. The levels of interleukins (IL-2, IL-4 and IL10) were increased in the infected patient when compared to healthy persons, from this, we can deduce that pro-inflammatory and antiinflammatory interleukins have an important role in the infection of Giardia lamblia.

Plant Archives, 2020

The current study was designed to determine some immunological and biochemical biomarkers in pati... more The current study was designed to determine some immunological and biochemical biomarkers in patients with thalassemia major (TM) and thalassemia intermedia (TI), 20 patients with thalassemia and 20 healthy volunteers as control group. The results have shown a significant increase in WBCs also a significant decrease in neutrophil activity and IFN- in TM and TI groups as compared to controls. The levels of Hb decrease in TM and TI groups as compared to controls, while a significant increase has been observed in platelets count. The results have also revealed a significant elevation in Iron and ferritin in TM and TI groups when compared with controls while Transferrin was decreased in the patients when compare with controls. The liver enzymes (AST and ALT) have shown significantly elevated activities in TM an TI groups.

World Journal of Pharmaceutical Sciences, 2017

The present study aimed to investigate the effect of dexamethasone and contraceptive pills on glu... more The present study aimed to investigate the effect of dexamethasone and contraceptive pills on glucose level, liver function of female rats. Methods: contraceptive pills (EE 0.03 ml, LE 0.075 ml), and dexamethasone were used, and the animals were treatment for three month. The result indicated a significant increase (p>0.05) of glucose level in the second, third and fourth groups compared with the control group. The results showed a significant increase in liver enzymes (AST, ALT) in the second, third and fourth groups compared with the control group. This study showed that the treatment with dexamethasone caused a damage for liver. No morphological damage was observed in the control group, while (dilated central veins, proliferation of portal and congestion in the sinusoids and enlargement of hepatocytes with, dilated portal spaces) was observed in the second group. In the third group moderate damage (minimal disorganization of the hepatocyte plates, congested sinusoids, central vein, and enlargement hepatocytes was observed .While, the same but moderate changes in the hepatocytes, minimal vacculation of center lobular hepatocytes, enlargement sinusoids, congested central vein and enlargement hepatocytes was observed in the fourth group.

World Journal of Pharmaceutical Sciences, 2014

Cancer continues to be a major health problem for those in developed countries being a leading ca... more Cancer continues to be a major health problem for those in developed countries being a leading cause of death worldwide. Chemotherapy is able to kill some cancer cells especially the more rapidly replicating tumor cells, but they were nonspecific, characterized by low therapeutic index and associated with a wide range of side effects. Therefore the anticancer field still searching for treatments to avoid these side effects. The in vitro method was used to investigate the effect of pure cimetidine on four types of tumor cell lines [HeLa (human cervical cancer cell line, Passages 18-25), Rhabdomyosarcoma (RD, at 75 passages), Ahmad-Majeed-Glioblastoma-Multiform-2005 (AMGM-5, human cerebral glioblastoma multiform at passages 75-84), Ahmed-Mohammed-Nahi-2003 (AMN-3, spontaneous mammary adenocarcinoma at 158 passages) and normal cell line Rat Embryo Fibroblast (REF, at 87 passages)] in different concentrations and at different exposure times by MTT assay. The results showed that cimetidine exerted significant cytotoxic effects with all concentrations used (31.25-1000 µg) on all types of cell lines. Because of cytotoxic activity, good pharmacokinetic characteristics and the safety of drug which used for many years in the treatment of peptic ulcer disease, we can conclude that these characteristics make cimetidine a valuable treatment for many types of cancer.

International Journal of PharmTech Research, 2014

Cancer is one of the most common diseases worldwide, and ranks the second most common cause of de... more Cancer is one of the most common diseases worldwide, and ranks the second most common cause of death following cardiovascular diseases. Chemotherapy is able to kill some cancer cells especially the more rapidly replicating tumor cells, but they were nonspecific, characterized by low therapeutic index and associated with a wide range of side effects. Therefore the anticancer field still searching for treatments to avoid these side effects. The in vitro method was used to investigate the effect of pure sodium valproate on four types of tumor cell lines [HeLa (human cervical cancer cell line, Passages 18-25), Rhabdomyosarcoma (RD, at 75 passages), Ahmad-Majeed-Glioblastoma-Multiform-2005 (AMGM-5, human cerebral glioblastoma multiform at passages 75-84), Ahmed-Mohammed-Nahi-2003 (AMN-3, spontaneous mammary adenocarcinoma at 158 passages) and normal cell line Rat Embryo Fibroblast (REF, at 87 passages)] in different concentrations and at different exposure times by MTT assay. The results showed that sodium valproate induced dose-dependent cytotoxic effects against all the tested cell lines. These effect could be attributed to different mechanisms. Accordingly, sodium valproate should be considered as a good alternative therapy.

Conference Presentations by Moslim M O H S I N Khalaf

International Conference on Promotion of Scientific & Regional Cooperation On Food and Agricultural Sciences., 2018

Scabies is a common disease affecting the parasitic skin that spreads throughout the world, espec... more Scabies is a common disease affecting the parasitic skin that spreads throughout the world, especially in the developing world. This study aimed to detects the frequency of scabies and its relation age, gender and occupations in Dhi Qar, Iraq. The study was performed during the period from December 2017 to May 2018 in patients attending Al-Hussein teaching hospital. Patients were physically examined for scabies as well as microscopic examination of skin scraping was done to confirmed the diagnosis. Scabies diagnosed in 337 patients during the study period. Of this total, 216 (58.3%) were males and 161 (42.7%) were females. Their ages range from 1-70 years. The highest frequency of scabies was occur among patients aged 1-10 years (27.1%) and the incidence rate decreased with the progress of age. The highest rate of scabies was found in student group (34.5%), followed by a housewife and somewhat unemployed, which had higher rates of infection compared with the other groups. In conclusion, scabies were high among males and childhood age, where the disease is decrease with the progression of age. Also, the disease was high prevalent in the students which indicates that the overcrowding is a main factors to scabies spreads in Iraqi populations especially in schools.

Annals of Parasitology, 2021

The aim of this study was to determine IL-2, IL-4 and IL-10 levels, in patients with giardiosis a... more The aim of this study was to determine IL-2, IL-4 and IL-10 levels, in patients with giardiosis and to compare their interleukins levels with healthy controls. A total of 375 patients (211 males, 164 females) in Thi-Qar Province, southern of Iraq were examined. Twenty-four (16 males, 8 females) patients confirm to have giardiosis and 20 healthy control group were withdrawn (5) ml of venous blood to conduct immunological tests to determine the quantitative for level of IL-2, IL-4 and IL-10 in a manner (ELISA). The result showed, the overall infection rate of G. lamblia was 6.40%, according to gender, higher infection rate was recorded in males 7.58% compared to the females rate 4.87% no significant differences were observed between gender. The highest rates of giardiosis observed in age
group (30–45), which reached 7.04% and there is no significant difference showed in the infection of different ages under study (P≤0.05). The results showed a significant increases in the level of interleukins and the amount of IL-2, IL- 4 and IL-10 in patients (26.90, 17.43 and 14.71), respectively, was higher than those of healthy control (13.32, 10.25 and 10.55). The conclusion of this study demonstrated that the rate of infection was higher in males than in females and the age group (30–45) have the highest infection rates. The levels of interleukins (IL-2, IL-4 and IL10) were increased in the infected patient when compared to healthy persons, from this, we can deduce that pro-inflammatory and antiinflammatory interleukins have an important role in the infection of Giardia lamblia.

Plant Archives, 2020

The current study was designed to determine some immunological and biochemical biomarkers in pati... more The current study was designed to determine some immunological and biochemical biomarkers in patients with thalassemia major (TM) and thalassemia intermedia (TI), 20 patients with thalassemia and 20 healthy volunteers as control group. The results have shown a significant increase in WBCs also a significant decrease in neutrophil activity and IFN- in TM and TI groups as compared to controls. The levels of Hb decrease in TM and TI groups as compared to controls, while a significant increase has been observed in platelets count. The results have also revealed a significant elevation in Iron and ferritin in TM and TI groups when compared with controls while Transferrin was decreased in the patients when compare with controls. The liver enzymes (AST and ALT) have shown significantly elevated activities in TM an TI groups.

World Journal of Pharmaceutical Sciences, 2017

The present study aimed to investigate the effect of dexamethasone and contraceptive pills on glu... more The present study aimed to investigate the effect of dexamethasone and contraceptive pills on glucose level, liver function of female rats. Methods: contraceptive pills (EE 0.03 ml, LE 0.075 ml), and dexamethasone were used, and the animals were treatment for three month. The result indicated a significant increase (p>0.05) of glucose level in the second, third and fourth groups compared with the control group. The results showed a significant increase in liver enzymes (AST, ALT) in the second, third and fourth groups compared with the control group. This study showed that the treatment with dexamethasone caused a damage for liver. No morphological damage was observed in the control group, while (dilated central veins, proliferation of portal and congestion in the sinusoids and enlargement of hepatocytes with, dilated portal spaces) was observed in the second group. In the third group moderate damage (minimal disorganization of the hepatocyte plates, congested sinusoids, central vein, and enlargement hepatocytes was observed .While, the same but moderate changes in the hepatocytes, minimal vacculation of center lobular hepatocytes, enlargement sinusoids, congested central vein and enlargement hepatocytes was observed in the fourth group.

World Journal of Pharmaceutical Sciences, 2014

Cancer continues to be a major health problem for those in developed countries being a leading ca... more Cancer continues to be a major health problem for those in developed countries being a leading cause of death worldwide. Chemotherapy is able to kill some cancer cells especially the more rapidly replicating tumor cells, but they were nonspecific, characterized by low therapeutic index and associated with a wide range of side effects. Therefore the anticancer field still searching for treatments to avoid these side effects. The in vitro method was used to investigate the effect of pure cimetidine on four types of tumor cell lines [HeLa (human cervical cancer cell line, Passages 18-25), Rhabdomyosarcoma (RD, at 75 passages), Ahmad-Majeed-Glioblastoma-Multiform-2005 (AMGM-5, human cerebral glioblastoma multiform at passages 75-84), Ahmed-Mohammed-Nahi-2003 (AMN-3, spontaneous mammary adenocarcinoma at 158 passages) and normal cell line Rat Embryo Fibroblast (REF, at 87 passages)] in different concentrations and at different exposure times by MTT assay. The results showed that cimetidine exerted significant cytotoxic effects with all concentrations used (31.25-1000 µg) on all types of cell lines. Because of cytotoxic activity, good pharmacokinetic characteristics and the safety of drug which used for many years in the treatment of peptic ulcer disease, we can conclude that these characteristics make cimetidine a valuable treatment for many types of cancer.

International Journal of PharmTech Research, 2014

Cancer is one of the most common diseases worldwide, and ranks the second most common cause of de... more Cancer is one of the most common diseases worldwide, and ranks the second most common cause of death following cardiovascular diseases. Chemotherapy is able to kill some cancer cells especially the more rapidly replicating tumor cells, but they were nonspecific, characterized by low therapeutic index and associated with a wide range of side effects. Therefore the anticancer field still searching for treatments to avoid these side effects. The in vitro method was used to investigate the effect of pure sodium valproate on four types of tumor cell lines [HeLa (human cervical cancer cell line, Passages 18-25), Rhabdomyosarcoma (RD, at 75 passages), Ahmad-Majeed-Glioblastoma-Multiform-2005 (AMGM-5, human cerebral glioblastoma multiform at passages 75-84), Ahmed-Mohammed-Nahi-2003 (AMN-3, spontaneous mammary adenocarcinoma at 158 passages) and normal cell line Rat Embryo Fibroblast (REF, at 87 passages)] in different concentrations and at different exposure times by MTT assay. The results showed that sodium valproate induced dose-dependent cytotoxic effects against all the tested cell lines. These effect could be attributed to different mechanisms. Accordingly, sodium valproate should be considered as a good alternative therapy.

International Conference on Promotion of Scientific & Regional Cooperation On Food and Agricultural Sciences., 2018

Scabies is a common disease affecting the parasitic skin that spreads throughout the world, espec... more Scabies is a common disease affecting the parasitic skin that spreads throughout the world, especially in the developing world. This study aimed to detects the frequency of scabies and its relation age, gender and occupations in Dhi Qar, Iraq. The study was performed during the period from December 2017 to May 2018 in patients attending Al-Hussein teaching hospital. Patients were physically examined for scabies as well as microscopic examination of skin scraping was done to confirmed the diagnosis. Scabies diagnosed in 337 patients during the study period. Of this total, 216 (58.3%) were males and 161 (42.7%) were females. Their ages range from 1-70 years. The highest frequency of scabies was occur among patients aged 1-10 years (27.1%) and the incidence rate decreased with the progress of age. The highest rate of scabies was found in student group (34.5%), followed by a housewife and somewhat unemployed, which had higher rates of infection compared with the other groups. In conclusion, scabies were high among males and childhood age, where the disease is decrease with the progression of age. Also, the disease was high prevalent in the students which indicates that the overcrowding is a main factors to scabies spreads in Iraqi populations especially in schools.