N. Duran | Mustafa Kemal University (original) (raw)

Papers by N. Duran

Research paper thumbnail of Prevalence of Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus in Pregnant Women

Obstetrics & Gynecology, 2006

The intensive care units (ICUs) are burdened with a high frequency of nosocomial infections often... more The intensive care units (ICUs) are burdened with a high frequency of nosocomial infections often caused by multiresistant nosocomial pathogens. Coagulase-negative staphylococci (CoNS) and Staphylococcus aureus are reported as important causative agents of nosocomial infections. The objective of this study was to identify frequency of methicillin resistant and susceptible staphylococci from the various clinical samples in ICUs, and to investigate resistance patterns against various antibiotics used broadly for treatment. Methods: Originating from four selected ICUs and burn center in a University hospital, a total of 241 staphylococci strains from blood, respiratory tract, urine and wound sites were processed in our central laboratory to assess their occurrence rates and antimicrobial susceptibility profiles. Susceptibility tests of isolates were performed according to disc diffusion method recommended by National Committee for Clinical Laboratory Standards (NCCLS). Results: Staphylococci strains were isolated from 40.4% of the patients in ICUs. The rates of methicillin resistant and susceptible Staphylococcus aureus were 24.1% and 9.96%, respectively. Out of 241 isolates, 14.5% methicillin sensitive CoNS and 15.8% methicillin resistant staphylococci were isolated. The highest staphylococci isolation (47.3 %) was obtained in cardiovascular surgical ICU which is followed by general surgical ICU (45.1%), burn center (39.8%), coronary ICU (39.4%) and internal ICU (33.9%). There is statististically significant difference between surgical ICU and internal ICU. None of the isolated staphyloccocci showed resistance against vancomycin. Penicillin resistance was found to be 100% in methicillin resistant Staphylococcus aureus strains while it was 76% in methicillin sensitive Staphylococcus aureus. There is significant difference between two groups. Conclusion: Frequency of staphylococci was found to be high in patients treated at intensive care units. Antibiotic resistance patterns of methicillin resistant Staphylococcus aureus strains were found to be quite higher than that of methicillin susceptible staphylococcci.

Research paper thumbnail of Cutaneous infection caused by Aspergillus terreus

Journal of Medical Microbiology, 2009

Aspergillus species are widely distributed in nature, and more than 30 species have been reported... more Aspergillus species are widely distributed in nature, and more than 30 species have been reported to be involved in human and animal infection. Cutaneous infections due to Aspergillus terreus are particularly rare. In this report, we describe a case of cutaneous infection caused by A. terreus in a paediatric patient who underwent surgical treatment for an open tibial fracture secondary to an agricultural accident.

Research paper thumbnail of Synthesis, characterization and anti microbial evaluation of novel 1,3,4-oxadiazole containing pyrazolones and 2-thiazolidinone ring systems

Two substituted 1,2,3-triazoles 4 and 6 have been synthesized by the 1,3-dipolar cycloaddition re... more Two substituted 1,2,3-triazoles 4 and 6 have been synthesized by the 1,3-dipolar cycloaddition reaction of 4-azido-8-(trifluoromethyl)quinoline 2 with ethyl acetoacetate and acetylacetone, respectively. The reaction of 2 with ethyl acetoacetate afforded 1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazole-4-carboxylic acid 3 and with acetylacetone afforded 1-{1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazol-4-yl}ethanone 5. Compound 3 is converted into its corresponding acid hydrazide and then condensed with different aromatic aldehydes to yield Schiff's base, N-[1-arylmethylene]-1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazole-4-carbohydrazides 4. Compound 5 is condensed with aromatic aldehydes to obtain [1-aryl-4-{1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazol-4-yl}prop-2-en-1-ones 6. The newly prepared 1,2,3-triazole derivatives 4 and 6 have been characterized by IR, NMR and mass spectral data. These compounds were screened for their antimicrobial activity.

Research paper thumbnail of Performance of QuantiFERON-TB Gold In-Tube test and Tuberculin Skin Test for diagnosis of latent tuberculosis infection in BCG vaccinated health care workers

Medical Science Monitor, 2014

Tuberculin skin test (TST) has been used for years as an aid in diagnosing latent tuberculosis in... more Tuberculin skin test (TST) has been used for years as an aid in diagnosing latent tuberculosis infection (LTBI) but it suffers from a number of well-documented performance and logistic problems. Quantiferon-TB Gold In Tube test (QFT-GIT) has been reported to have better sensitivity and specifity than TST. In this study, it was aimed to compare the performance of a commercial IFN-g release assay (QFT-GIT) with TST in the diagnosis of HCWs at risk for latent TB infection in BCG vaccinated population.

Research paper thumbnail of Prevalence of Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus in Pregnant Women

Obstetrics & Gynecology, 2006

The intensive care units (ICUs) are burdened with a high frequency of nosocomial infections often... more The intensive care units (ICUs) are burdened with a high frequency of nosocomial infections often caused by multiresistant nosocomial pathogens. Coagulase-negative staphylococci (CoNS) and Staphylococcus aureus are reported as important causative agents of nosocomial infections. The objective of this study was to identify frequency of methicillin resistant and susceptible staphylococci from the various clinical samples in ICUs, and to investigate resistance patterns against various antibiotics used broadly for treatment. Methods: Originating from four selected ICUs and burn center in a University hospital, a total of 241 staphylococci strains from blood, respiratory tract, urine and wound sites were processed in our central laboratory to assess their occurrence rates and antimicrobial susceptibility profiles. Susceptibility tests of isolates were performed according to disc diffusion method recommended by National Committee for Clinical Laboratory Standards (NCCLS). Results: Staphylococci strains were isolated from 40.4% of the patients in ICUs. The rates of methicillin resistant and susceptible Staphylococcus aureus were 24.1% and 9.96%, respectively. Out of 241 isolates, 14.5% methicillin sensitive CoNS and 15.8% methicillin resistant staphylococci were isolated. The highest staphylococci isolation (47.3 %) was obtained in cardiovascular surgical ICU which is followed by general surgical ICU (45.1%), burn center (39.8%), coronary ICU (39.4%) and internal ICU (33.9%). There is statististically significant difference between surgical ICU and internal ICU. None of the isolated staphyloccocci showed resistance against vancomycin. Penicillin resistance was found to be 100% in methicillin resistant Staphylococcus aureus strains while it was 76% in methicillin sensitive Staphylococcus aureus. There is significant difference between two groups. Conclusion: Frequency of staphylococci was found to be high in patients treated at intensive care units. Antibiotic resistance patterns of methicillin resistant Staphylococcus aureus strains were found to be quite higher than that of methicillin susceptible staphylococcci.

Research paper thumbnail of Cutaneous infection caused by Aspergillus terreus

Journal of Medical Microbiology, 2009

Aspergillus species are widely distributed in nature, and more than 30 species have been reported... more Aspergillus species are widely distributed in nature, and more than 30 species have been reported to be involved in human and animal infection. Cutaneous infections due to Aspergillus terreus are particularly rare. In this report, we describe a case of cutaneous infection caused by A. terreus in a paediatric patient who underwent surgical treatment for an open tibial fracture secondary to an agricultural accident.

Research paper thumbnail of Synthesis, characterization and anti microbial evaluation of novel 1,3,4-oxadiazole containing pyrazolones and 2-thiazolidinone ring systems

Two substituted 1,2,3-triazoles 4 and 6 have been synthesized by the 1,3-dipolar cycloaddition re... more Two substituted 1,2,3-triazoles 4 and 6 have been synthesized by the 1,3-dipolar cycloaddition reaction of 4-azido-8-(trifluoromethyl)quinoline 2 with ethyl acetoacetate and acetylacetone, respectively. The reaction of 2 with ethyl acetoacetate afforded 1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazole-4-carboxylic acid 3 and with acetylacetone afforded 1-{1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazol-4-yl}ethanone 5. Compound 3 is converted into its corresponding acid hydrazide and then condensed with different aromatic aldehydes to yield Schiff's base, N-[1-arylmethylene]-1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazole-4-carbohydrazides 4. Compound 5 is condensed with aromatic aldehydes to obtain [1-aryl-4-{1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazol-4-yl}prop-2-en-1-ones 6. The newly prepared 1,2,3-triazole derivatives 4 and 6 have been characterized by IR, NMR and mass spectral data. These compounds were screened for their antimicrobial activity.

Research paper thumbnail of Performance of QuantiFERON-TB Gold In-Tube test and Tuberculin Skin Test for diagnosis of latent tuberculosis infection in BCG vaccinated health care workers

Medical Science Monitor, 2014

Tuberculin skin test (TST) has been used for years as an aid in diagnosing latent tuberculosis in... more Tuberculin skin test (TST) has been used for years as an aid in diagnosing latent tuberculosis infection (LTBI) but it suffers from a number of well-documented performance and logistic problems. Quantiferon-TB Gold In Tube test (QFT-GIT) has been reported to have better sensitivity and specifity than TST. In this study, it was aimed to compare the performance of a commercial IFN-g release assay (QFT-GIT) with TST in the diagnosis of HCWs at risk for latent TB infection in BCG vaccinated population.