Graham Ashmead | The Mount Sinai School of Medicine (original) (raw)
Papers by Graham Ashmead
Genetics in medicine open, 2024
Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology, Feb 8, 2024
American Journal of Obstetrics and Gynecology, Dec 31, 2023
American Journal of Obstetrics and Gynecology, Dec 31, 2023
American Journal of Obstetrics and Gynecology, Dec 31, 2023
American Journal of Obstetrics and Gynecology, 2013
American Journal Of Obstetrics & Gynecology Mfm, Mar 1, 2023
American Journal of Obstetrics and Gynecology, Sep 1, 1984
Thrombocytopenia in preeclampsia changes in eclampsia: their frequency and pathogenesis.
Postgraduate obstetrics & gynecology, Jul 1, 2014
American Journal of Obstetrics and Gynecology, Dec 1, 2009
delivery, there were no differences among groups with regard to route of delivery, birthweight, A... more delivery, there were no differences among groups with regard to route of delivery, birthweight, Apgar scores, or intrapartum and postpartum epidural and analgesic use. CONCLUSION: Hypnobirthing was not more effective in improving perceived coping skills during labor than conventional childbirth classes.
Clinical Science, Apr 1, 1993
1. We have studied the transport of Na+ and K+ by erythrocytes during the follicular and luteal p... more 1. We have studied the transport of Na+ and K+ by erythrocytes during the follicular and luteal phases of the human menstrual cycle, and in pregnant compared with non-pregnant women. Venous blood was drawn from 10 healthy young women (not taking any medication or hormones) 1-2 days after menstruation and from the same women 7-9 days after ovulation. For the pregnancy part of the study, blood was drawn from eight other normotensive non-pregnant women and from eight age-matched normotensive pregnant women (36-43 weeks gestation). 2. Intracellular erythrocyte and plasma Na+ and K+ concentrations were measured by flame photometry. The increase in the intracellular Na+ concentration during a 1 h 37 degrees C incubation of fresh whole blood with 0.2 mmol/l ouabain (compared with no ouabain) was measured to determine the rate of active Na+ efflux. The Na(+)-K+ pump rate constant was calculated by dividing the active Na+ efflux rate by the intracellular Na+ concentration. 3. In fresh blood, the intracellular erythrocyte Na+ concentration (P < 0.002) and the plasma K+ concentration (P < 0.01) were both lower in pregnant than in non-pregnant women. The Na(+)-K+ pump rate constant was higher (P < 0.02) during the luteal phase than during the follicular phase, and in pregnant compared with non-pregnant women. 4. We conclude that short-acting hormones in the plasma most probably account for the changes in the Na(+)-K+ pump rate constant during the menstrual cycle.
Development and genetics of pregnancy in utero foetal diagnosis and management maternal-foetal di... more Development and genetics of pregnancy in utero foetal diagnosis and management maternal-foetal disease during pregnancy labour, delivery, neonatal management and pathology medico-legal and statistics.
Journal of Ultrasound in Medicine, Jun 1, 1991
Fetal acardia is a rare but severe congenital anomaly. It involves malformations of the head and ... more Fetal acardia is a rare but severe congenital anomaly. It involves malformations of the head and upper body and an absent or rudimentary nonfunctioning heart. Acardia occurs only in products of monozygotic splitting with an incidence of 1/35,000 deliveries. While the incidence in monozygotic twins is 1 %, the incidence in monozygotic triplets is thought to be three times higher. 1 The four main types of acardia are as follows: (1) Acardius anceps, with the most developed head and thorax; (2) Acardius acephalus, the most common form, with absent head and thorax; (3) Acardius acormus, the most unusual form, with a fetal head attached to the placenta; and (4) Acardius amorphus, a shapeless mass that cannot be recognized as a human form.' The acardiac fetus, however, may not fit any of the above classical types and usually shows other congenital anomalies. 3
American Journal of Obstetrics and Gynecology, 1995
OBJECTIVE: To report a 9-year experience with vaginal birth after cesarean (VBAC) in women with t... more OBJECTIVE: To report a 9-year experience with vaginal birth after cesarean (VBAC) in women with twins in the current pregnancy. STUDY DESIGN: Data were prospectively gathered from labor and delivery records, maternal end neonatal hospital chatS. Women with vertical uterine scars, previous oterina ruptures, unrepaired dehiscences or obstetric contraindicatious to labor were excluded from a trial of labor (TOL). Fullthickness oterine defects requiring intervention were classified as "ruptures"; all others were classified as "debiscences". RESULTS: Between January 1, 1985 and December 31, 1993, at LAC+USC Women's Hospital, 204 women with previous cesarean births were delivered of twins. One hundred eight (53%) underwent repeat cesarean without a TOL, and 96 (47%) underwent a TOL The groups were comparable with respect to maternal age, gravidity, parity, gestaticnal age at delivery and birthweights. Use and success rates cfTOL are summarized below. 204 t~n I gestations I I No TOL-108 (53%) TOL-96 (47%)
PubMed, Apr 1, 1987
Direct access to fetal blood during the second and third trimesters of pregnancy opens new fields... more Direct access to fetal blood during the second and third trimesters of pregnancy opens new fields of prenatal diagnosis and in utero fetal treatment. Percutaneous umbilical blood sampling, a method that involves ultrasonographically guided needle insertion into the umbilical vein, appears to have an acceptable complication rate. This technique has tremendous potential for use in evaluating fetal status.
American Journal of Obstetrics and Gynecology
American Journal of Obstetrics and Gynecology
Topics in Obstetrics & Gynecology, 2017
The antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by arterial an... more The antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by arterial and venous thrombosis, gestational morbidity and presence of elevated and persistently positive serum titers of antiphospholipid antibodies. Antiphospholipid syndrome may exist as an isolated immunologic derangement primary APS (PAPS) or as secondary antiphospholipid syndrome (SAPS) where it occurs in association with autoimmune disease, most commonly SLE. The diagnosis of APS should be suggested whenever patient has history of repeated pregnancy loss without any fetal malformation or foetal death in utero. Other pregnancy complications mainly include intrauterine growth restriction (IUGR), oligohydramnios, preeclampsia, fetal distress, and preterm labor 1. A severe complication of pregnancy, which greatly increases its risk in case of APS, is VTE. Pregnant and postpartum women are approximately 4 to 5 times more likely to develop VTE compared with non pregnant women 2. Many other clinical...
American Journal of Perinatology
Objectives Placenta previa is diagnosed in up to 15% of pregnancies at the anatomy ultrasound and... more Objectives Placenta previa is diagnosed in up to 15% of pregnancies at the anatomy ultrasound and 0.5% persist to term. There is limited data regarding pregnancy outcomes with resolved previa. We aimed to examine patients with resolved placenta previa to determine if abnormal placentation at any time during pregnancy is associated with adverse events during labor. Study Design Patients with placenta previa were identified after second trimester ultrasound, included if placenta previa resolved with the placental edge greater than 2 cm from the internal cervical os, and excluded if placenta previa persisted to term, resolution occurred prior to 20 weeks, patients underwent a prior cesarean delivery or delivered at an outside institution. Time-matched controls were identified among patients with normal placental location. Demographic data and outcomes were collected. Student's t-test, Wilcoxon's rank-sum test, Chi-square, Fisher's exact test, and univariable and multivariab...
Genetics in medicine open, 2024
Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology, Feb 8, 2024
American Journal of Obstetrics and Gynecology, Dec 31, 2023
American Journal of Obstetrics and Gynecology, Dec 31, 2023
American Journal of Obstetrics and Gynecology, Dec 31, 2023
American Journal of Obstetrics and Gynecology, 2013
American Journal Of Obstetrics & Gynecology Mfm, Mar 1, 2023
American Journal of Obstetrics and Gynecology, Sep 1, 1984
Thrombocytopenia in preeclampsia changes in eclampsia: their frequency and pathogenesis.
Postgraduate obstetrics & gynecology, Jul 1, 2014
American Journal of Obstetrics and Gynecology, Dec 1, 2009
delivery, there were no differences among groups with regard to route of delivery, birthweight, A... more delivery, there were no differences among groups with regard to route of delivery, birthweight, Apgar scores, or intrapartum and postpartum epidural and analgesic use. CONCLUSION: Hypnobirthing was not more effective in improving perceived coping skills during labor than conventional childbirth classes.
Clinical Science, Apr 1, 1993
1. We have studied the transport of Na+ and K+ by erythrocytes during the follicular and luteal p... more 1. We have studied the transport of Na+ and K+ by erythrocytes during the follicular and luteal phases of the human menstrual cycle, and in pregnant compared with non-pregnant women. Venous blood was drawn from 10 healthy young women (not taking any medication or hormones) 1-2 days after menstruation and from the same women 7-9 days after ovulation. For the pregnancy part of the study, blood was drawn from eight other normotensive non-pregnant women and from eight age-matched normotensive pregnant women (36-43 weeks gestation). 2. Intracellular erythrocyte and plasma Na+ and K+ concentrations were measured by flame photometry. The increase in the intracellular Na+ concentration during a 1 h 37 degrees C incubation of fresh whole blood with 0.2 mmol/l ouabain (compared with no ouabain) was measured to determine the rate of active Na+ efflux. The Na(+)-K+ pump rate constant was calculated by dividing the active Na+ efflux rate by the intracellular Na+ concentration. 3. In fresh blood, the intracellular erythrocyte Na+ concentration (P < 0.002) and the plasma K+ concentration (P < 0.01) were both lower in pregnant than in non-pregnant women. The Na(+)-K+ pump rate constant was higher (P < 0.02) during the luteal phase than during the follicular phase, and in pregnant compared with non-pregnant women. 4. We conclude that short-acting hormones in the plasma most probably account for the changes in the Na(+)-K+ pump rate constant during the menstrual cycle.
Development and genetics of pregnancy in utero foetal diagnosis and management maternal-foetal di... more Development and genetics of pregnancy in utero foetal diagnosis and management maternal-foetal disease during pregnancy labour, delivery, neonatal management and pathology medico-legal and statistics.
Journal of Ultrasound in Medicine, Jun 1, 1991
Fetal acardia is a rare but severe congenital anomaly. It involves malformations of the head and ... more Fetal acardia is a rare but severe congenital anomaly. It involves malformations of the head and upper body and an absent or rudimentary nonfunctioning heart. Acardia occurs only in products of monozygotic splitting with an incidence of 1/35,000 deliveries. While the incidence in monozygotic twins is 1 %, the incidence in monozygotic triplets is thought to be three times higher. 1 The four main types of acardia are as follows: (1) Acardius anceps, with the most developed head and thorax; (2) Acardius acephalus, the most common form, with absent head and thorax; (3) Acardius acormus, the most unusual form, with a fetal head attached to the placenta; and (4) Acardius amorphus, a shapeless mass that cannot be recognized as a human form.' The acardiac fetus, however, may not fit any of the above classical types and usually shows other congenital anomalies. 3
American Journal of Obstetrics and Gynecology, 1995
OBJECTIVE: To report a 9-year experience with vaginal birth after cesarean (VBAC) in women with t... more OBJECTIVE: To report a 9-year experience with vaginal birth after cesarean (VBAC) in women with twins in the current pregnancy. STUDY DESIGN: Data were prospectively gathered from labor and delivery records, maternal end neonatal hospital chatS. Women with vertical uterine scars, previous oterina ruptures, unrepaired dehiscences or obstetric contraindicatious to labor were excluded from a trial of labor (TOL). Fullthickness oterine defects requiring intervention were classified as "ruptures"; all others were classified as "debiscences". RESULTS: Between January 1, 1985 and December 31, 1993, at LAC+USC Women's Hospital, 204 women with previous cesarean births were delivered of twins. One hundred eight (53%) underwent repeat cesarean without a TOL, and 96 (47%) underwent a TOL The groups were comparable with respect to maternal age, gravidity, parity, gestaticnal age at delivery and birthweights. Use and success rates cfTOL are summarized below. 204 t~n I gestations I I No TOL-108 (53%) TOL-96 (47%)
PubMed, Apr 1, 1987
Direct access to fetal blood during the second and third trimesters of pregnancy opens new fields... more Direct access to fetal blood during the second and third trimesters of pregnancy opens new fields of prenatal diagnosis and in utero fetal treatment. Percutaneous umbilical blood sampling, a method that involves ultrasonographically guided needle insertion into the umbilical vein, appears to have an acceptable complication rate. This technique has tremendous potential for use in evaluating fetal status.
American Journal of Obstetrics and Gynecology
American Journal of Obstetrics and Gynecology
Topics in Obstetrics & Gynecology, 2017
The antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by arterial an... more The antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by arterial and venous thrombosis, gestational morbidity and presence of elevated and persistently positive serum titers of antiphospholipid antibodies. Antiphospholipid syndrome may exist as an isolated immunologic derangement primary APS (PAPS) or as secondary antiphospholipid syndrome (SAPS) where it occurs in association with autoimmune disease, most commonly SLE. The diagnosis of APS should be suggested whenever patient has history of repeated pregnancy loss without any fetal malformation or foetal death in utero. Other pregnancy complications mainly include intrauterine growth restriction (IUGR), oligohydramnios, preeclampsia, fetal distress, and preterm labor 1. A severe complication of pregnancy, which greatly increases its risk in case of APS, is VTE. Pregnant and postpartum women are approximately 4 to 5 times more likely to develop VTE compared with non pregnant women 2. Many other clinical...
American Journal of Perinatology
Objectives Placenta previa is diagnosed in up to 15% of pregnancies at the anatomy ultrasound and... more Objectives Placenta previa is diagnosed in up to 15% of pregnancies at the anatomy ultrasound and 0.5% persist to term. There is limited data regarding pregnancy outcomes with resolved previa. We aimed to examine patients with resolved placenta previa to determine if abnormal placentation at any time during pregnancy is associated with adverse events during labor. Study Design Patients with placenta previa were identified after second trimester ultrasound, included if placenta previa resolved with the placental edge greater than 2 cm from the internal cervical os, and excluded if placenta previa persisted to term, resolution occurred prior to 20 weeks, patients underwent a prior cesarean delivery or delivered at an outside institution. Time-matched controls were identified among patients with normal placental location. Demographic data and outcomes were collected. Student's t-test, Wilcoxon's rank-sum test, Chi-square, Fisher's exact test, and univariable and multivariab...