samantha sartori | Mount Sinai School of Medicine (original) (raw)

Papers by samantha sartori

Research paper thumbnail of TCT-346 The Mega COMBO Collaboration: An Individual Patient Data Pooled Analysis of Patients Undergoing PCI With COMBO Stent

Journal of the American College of Cardiology, 2021

Research paper thumbnail of TCT CONNECT-47 Impact of Sex at Birth on Long-Term Cardiovascular Outcomes of Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome

Journal of the American College of Cardiology, 2020

Research paper thumbnail of Safety and Efficacy of the Bioabsorbable Polymer Everolimus Eluting Stents Compared to the 2ND Generation Durable Polymer Everolimus Eluting Stents in Complex Coronary Lesions

Journal of the American College of Cardiology, 2019

Research paper thumbnail of Predictors of 1 Year Net Adverse Cardiovascular Events (Nace) Among Acs Patients Undergoing Pci with Clopidogrel or Prasugrel: Analysis from the Prometheus Registry

Journal of the American College of Cardiology, 2016

Research paper thumbnail of TCT-379 Independent and Combined Effect of Chronic Kidney Disease and Diabetes Mellitus in Women Undergoing Percutaneous Coronary Intervention with Drug-Eluting Stents: Results from a Patient-Level Pooled Analysis of Randomized Controlled Trials

Journal of the American College of Cardiology, 2015

Research paper thumbnail of TCT CONNECT-378 Sex Disparities Among Patients Undergoing Complex Percutaneous Coronary Intervention (PCI): Insights From a Single-Center Large-Volume PCI Registry

Journal of the American College of Cardiology, 2020

Research paper thumbnail of SSartori

Research paper thumbnail of Abstract 84: Impact of Education on Dual Antiplatelet Therapy Adherence

Circulation: Cardiovascular Quality and Outcomes, 2012

Background: Lack of education is associated with adverse outcomes following percutaneous coronary... more Background: Lack of education is associated with adverse outcomes following percutaneous coronary intervention (PCI). Whether or not this is due to medication non-compliance, which is a risk factor for cardiac events, is unclear. Methods: PARIS (Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients) is a multi-center, multinational, prospective registry of patients that have undergone stent implantation. The primary outcome is non-adherence to dual antiplatelet therapy (DAPT) defined as discontinuation, interruption, or disruption. Independently adjudicated outcomes were measured at 30 days after procedure. Discontinuation was defined as stopping DAPT because therapy was no longer needed, in contrast to interruption (stopping DAPT on under physician guidance because of a procedure or surgery), and disruption (stopping DAPT due to bleeding or non-compliance). Results: Among 5033 patients, the average age was 64 years, 74.5% were male, 40.9% presented with ACS, and 8...

Research paper thumbnail of TCT-89 Tradeoff between Myocardial Infarction and Bleeding in Relation to Bleeding Risk: insights from PARIS registry

Journal of the American College of Cardiology, 2017

Research paper thumbnail of Use of prasugrel vs clopidogrel and outcomes in patients with and without diabetes mellitus presenting with acute coronary syndrome undergoing percutaneous coronary intervention

International Journal of Cardiology, 2018

Research paper thumbnail of White Blood Cell Count and Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention in the Contemporary Era

Circulation: Cardiovascular Interventions, 2017

Background— Elevated white blood cell (WBC) count is associated with increased major adverse card... more Background— Elevated white blood cell (WBC) count is associated with increased major adverse cardiovascular events (MACE) in the setting of acute coronary syndrome. The aim of this study was to evaluate whether similar associations persist in an all-comers population of patients undergoing percutaneous coronary intervention in the contemporary era. Methods and Results— In the multicenter, prospective, observational PARIS study (Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients Registry), 4222 patients who underwent percutaneous coronary intervention in the United States and Europe between July 1, 2009, and December 2, 2010, were evaluated. The associations between baseline WBC and MACE (composite of cardiac death, stent thrombosis, spontaneous myocardial infarction, or target lesion revascularization) at 24-month follow-up were analyzed using multivariable Cox regression. Patients with higher WBC were more often younger, smokers, and with less comorbid risk fac...

Research paper thumbnail of Acute and 30-Day Outcomes in Women After TAVR: Results From the WIN-TAVI (Women's INternational Transcatheter Aortic Valve Implantation) Real-World Registry

JACC. Cardiovascular interventions, Aug 8, 2016

The study sought to examine the safety and performance of transcatheter aortic valve replacement ... more The study sought to examine the safety and performance of transcatheter aortic valve replacement (TAVR) using an all-female registry and to further explore the potential impact of female sex-specific characteristics on clinical outcomes after TAVR. Although women comprise 50% of patients with symptomatic severe aortic stenosis undergoing TAVR, the optimal treatment strategy remains undetermined. The WIN-TAVI (Women's INternational Transcatheter Aortic Valve Implantation) registry is a multinational, prospective, observational registry of women undergoing TAVR for aortic stenosis, conducted without any external funding. The primary endpoint was the Valve Academic Research Consortium (VARC)-2 early safety endpoint at 30 days (composite of mortality, stroke, major vascular complication, life-threatening bleeding, stage 2 or 3 acute kidney injury, coronary artery obstruction, or repeat procedure for valve-related dysfunction). Between January 2013 and December 2015, 1,019 women were...

Research paper thumbnail of Abstract 13775: Dual vs. Triple Antithrombotic Therapy After Coronary Stenting in Patients With Non-Valvular Atrial Fibrillation

Circulation, Nov 26, 2013

Research paper thumbnail of Comment: Is renal denervation an effective treatment for hypertension? Comparison of recent meta-analysis and a multinational registry

Blood pressure monitoring, Jan 4, 2015

We compared the impact of renal denervation (RDN) on blood pressures using results available from... more We compared the impact of renal denervation (RDN) on blood pressures using results available from a recent comprehensive meta-analysis and an international registry. The meta-analysis summarized recent trials in which RDN was compared with control groups that were treated only with antihypertensive medication; the registry only included patients treated with RDN. Both publications presented pretreatment pressures and changes 6 months postbaseline. Significant reductions in office systolic pressure and 24 h ambulatory systolic pressure were observed in both groups of the meta-analysis and the registry. However, the magnitude of blood pressure reduction with RDN and medical treatment was comparable in both the meta-analysis and registry. RDN has not been shown to be superior to medical management of hypertension in this combined experience of nearly 2000 hypertensive patients.

Research paper thumbnail of Safety and Efficacy of New-Generation Drug-Eluting Stents in Women at High Risk for Atherothrombosis: From the Women in Innovation and Drug-Eluting Stents Collaborative Patient-Level Pooled Analysis

Circulation. Cardiovascular interventions, 2016

The safety and efficacy of new-generation drug-eluting stents (DES) in women with multiple athero... more The safety and efficacy of new-generation drug-eluting stents (DES) in women with multiple atherothrombotic risk (ATR) factors is unclear. We pooled patient-level data for women enrolled in 26 randomized trials. Study population was categorized based on the presence or absence of high ATR, which was defined as having history of diabetes mellitus, prior percutaneous or surgical coronary revascularization, or prior myocardial infarction. The primary end point was major adverse cardiovascular events defined as a composite of all-cause mortality, myocardial infarction, or target lesion revascularization at 3 years of follow-up. Out of 10 449 women included in the pooled database, 5333 (51%) were at high ATR. Compared with women not at high ATR, those at high ATR had significantly higher risk of major adverse cardiovascular events (15.8% versus 10.6%; adjusted hazard ratio: 1.53; 95% confidence interval: 1.34-1.75; P=0.006) and all-cause mortality. In high-ATR risk women, the use of new-...

Research paper thumbnail of Effect of Chronic Kidney Disease in Women Undergoing Percutaneous Coronary Intervention With Drug-Eluting Stents

JACC: Cardiovascular Interventions, 2016

Research paper thumbnail of Efficacy and safety of routine thrombus aspiration in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: An updated systematic review and meta-analysis of randomized controlled trials

Catheterization and Cardiovascular Interventions, 2015

Randomized clinical trials evaluating the role of thrombus aspiration (TA) in patients undergoing... more Randomized clinical trials evaluating the role of thrombus aspiration (TA) in patients undergoing primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) have yielded contrasting results. Therefore, the efficacy and safety of TA in STEMI is unclear. We sought to evaluate the efficacy and safety of TA during PPCI for STEMI compared with conventional PPCI alone. We included study-level data from 25 randomized, controlled trials, involving 21,733 patients with STEMI and PPCI. The primary efficacy endpoint was major adverse cardiac events (MACE) according to study definitions; the primary safety endpoint was stroke. The mean weighted follow-up time across studies was 8.2 months. Compared with conventional PPCI, TA was associated with significant lower risk for MACE [relative risk (RR): 0.91; 95% confidence interval (CI): 0.83-1.00; P = 0.042). However, this benefit in MACE was counterbalanced by a significant increase in the risk for stroke (RR: 1.58; 95% CI: 1.11-2.25; P = 0.011). There were no differences in the risk of myocardial infarction (RR: 0.94; 95% CI: 0.78-1.12; P = 0.486), target vessel revascularization (RR: 0.93; 95% CI: 0.82-1.04; P = 0.2), and definite or probable stent thrombosis (RR: 0.84; 95% CI: 0.66-1.07; P = 0.148). TA was associated with an ostensible lower risk for all-cause mortality, which did not reach statistical significance (RR: 0.88; 95% CI: 0.78-1.00; P = 0.059). Compared with conventional PPCI for STEMI, adjunctive TA reduces the risk of subsequent MACE. However, the benefit in MACE is counterbalanced by an increased risk in stroke. Considering the above potential risks and benefits, TA should be considered in selected patients lesions rather than routinely. © 2015 Wiley Periodicals, Inc.

Research paper thumbnail of Antithrombotic Strategy Variability In ATrial Fibrillation and Obstructive Coronary Disease Revascularized with PCI - Rationale and study design of the prospective observational multicenter AVIATOR 2 Registry

American Heart Journal, 2015

Research paper thumbnail of Balancing the Risk of Bleeding and Stroke in Patients with Atrial Fibrillation after Percutaneous Coronary Intervention (from the AVIATOR-registry)

The American Journal of Cardiology, 2015

Patients with atrial fibrillation (AF) who underwent percutaneous coronary intervention (PCI) are... more Patients with atrial fibrillation (AF) who underwent percutaneous coronary intervention (PCI) are at elevated risk for bleeding and thromboembolic ischemic events. Currently, guidelines on antithrombotic treatment for these patients are based on weak consensus. We describe patterns and determinants of antithrombotic prescriptions in this population. The Antithrombotic Strategy Variability in Atrial Fibrillation and Obstructive Coronary Disease Revascularized with PCI Registry was an international observational study of 859 consecutive patients with AF who underwent PCI from 2009 to 2011. Patients were stratified by treatment at discharge with either dual antiplatelet therapy (DAPT; aspirin plus clopidogrel) or triple therapy (TT; warfarin plus DAPT). Bleeding and thromboembolism risks were assessed by the HAS-BLED and CHADS2 scores, respectively, and predictors of TT prescription at discharge were identified. Major adverse cardiovascular events and clinically relevant bleeding (Bleeding Academic Research Consortium score ≥2) at 1-year follow-up were compared across antithrombotic regimens. Compared with patients on DAPT (n = 488; 57%), those given TT (n = 371; 43%) were older, with higher CHADS2 scores, lower left ventricular ejection fraction, and more often had permanent AF, single-vessel coronary artery disease, and bare-metal stents. In multivariate analysis, increasing thromboembolic risk (CHADS2) was associated with a higher rate of TT prescription at discharge (intermediate vs low CHADS2: odds ratio 2.2, 95% confidence interval [CI] 2.0 to 3.3, p <0.01; high vs low CHADS2: odds ratio 1.6, 95% CI 2.6 to 4.3, p <0.01 for TT). However, there was no significant association between bleeding risk and TT prescription in the overall cohort or within each CHADS2 risk stratum. The rates of major adverse cardiovascular events were similar for patients discharged on TT or DAPT (20% vs 17%, adjusted hazard ratio 0.8, 95% CI 0.5 to 1.1, p = 0.19), whereas the rate of Bleeding Academic Research Consortium ≥2 bleeding was higher in patients discharged on TT (11.5% vs 6.4%, adjusted hazard ratio 1.8, 95% CI 1.1 to 2.9, p = 0.02). In conclusion, the choice of the intensity of antithrombotic therapy correlated more closely with the risk of ischemic rather than bleeding events in this cohort of patients with AF who underwent PCI.

Research paper thumbnail of Impact of Left Ventricular Dysfunction on Outcomes in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: Insights from the Aviator Registry

Journal of the American College of Cardiology, 2015

Research paper thumbnail of TCT-346 The Mega COMBO Collaboration: An Individual Patient Data Pooled Analysis of Patients Undergoing PCI With COMBO Stent

Journal of the American College of Cardiology, 2021

Research paper thumbnail of TCT CONNECT-47 Impact of Sex at Birth on Long-Term Cardiovascular Outcomes of Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome

Journal of the American College of Cardiology, 2020

Research paper thumbnail of Safety and Efficacy of the Bioabsorbable Polymer Everolimus Eluting Stents Compared to the 2ND Generation Durable Polymer Everolimus Eluting Stents in Complex Coronary Lesions

Journal of the American College of Cardiology, 2019

Research paper thumbnail of Predictors of 1 Year Net Adverse Cardiovascular Events (Nace) Among Acs Patients Undergoing Pci with Clopidogrel or Prasugrel: Analysis from the Prometheus Registry

Journal of the American College of Cardiology, 2016

Research paper thumbnail of TCT-379 Independent and Combined Effect of Chronic Kidney Disease and Diabetes Mellitus in Women Undergoing Percutaneous Coronary Intervention with Drug-Eluting Stents: Results from a Patient-Level Pooled Analysis of Randomized Controlled Trials

Journal of the American College of Cardiology, 2015

Research paper thumbnail of TCT CONNECT-378 Sex Disparities Among Patients Undergoing Complex Percutaneous Coronary Intervention (PCI): Insights From a Single-Center Large-Volume PCI Registry

Journal of the American College of Cardiology, 2020

Research paper thumbnail of SSartori

Research paper thumbnail of Abstract 84: Impact of Education on Dual Antiplatelet Therapy Adherence

Circulation: Cardiovascular Quality and Outcomes, 2012

Background: Lack of education is associated with adverse outcomes following percutaneous coronary... more Background: Lack of education is associated with adverse outcomes following percutaneous coronary intervention (PCI). Whether or not this is due to medication non-compliance, which is a risk factor for cardiac events, is unclear. Methods: PARIS (Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients) is a multi-center, multinational, prospective registry of patients that have undergone stent implantation. The primary outcome is non-adherence to dual antiplatelet therapy (DAPT) defined as discontinuation, interruption, or disruption. Independently adjudicated outcomes were measured at 30 days after procedure. Discontinuation was defined as stopping DAPT because therapy was no longer needed, in contrast to interruption (stopping DAPT on under physician guidance because of a procedure or surgery), and disruption (stopping DAPT due to bleeding or non-compliance). Results: Among 5033 patients, the average age was 64 years, 74.5% were male, 40.9% presented with ACS, and 8...

Research paper thumbnail of TCT-89 Tradeoff between Myocardial Infarction and Bleeding in Relation to Bleeding Risk: insights from PARIS registry

Journal of the American College of Cardiology, 2017

Research paper thumbnail of Use of prasugrel vs clopidogrel and outcomes in patients with and without diabetes mellitus presenting with acute coronary syndrome undergoing percutaneous coronary intervention

International Journal of Cardiology, 2018

Research paper thumbnail of White Blood Cell Count and Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention in the Contemporary Era

Circulation: Cardiovascular Interventions, 2017

Background— Elevated white blood cell (WBC) count is associated with increased major adverse card... more Background— Elevated white blood cell (WBC) count is associated with increased major adverse cardiovascular events (MACE) in the setting of acute coronary syndrome. The aim of this study was to evaluate whether similar associations persist in an all-comers population of patients undergoing percutaneous coronary intervention in the contemporary era. Methods and Results— In the multicenter, prospective, observational PARIS study (Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients Registry), 4222 patients who underwent percutaneous coronary intervention in the United States and Europe between July 1, 2009, and December 2, 2010, were evaluated. The associations between baseline WBC and MACE (composite of cardiac death, stent thrombosis, spontaneous myocardial infarction, or target lesion revascularization) at 24-month follow-up were analyzed using multivariable Cox regression. Patients with higher WBC were more often younger, smokers, and with less comorbid risk fac...

Research paper thumbnail of Acute and 30-Day Outcomes in Women After TAVR: Results From the WIN-TAVI (Women's INternational Transcatheter Aortic Valve Implantation) Real-World Registry

JACC. Cardiovascular interventions, Aug 8, 2016

The study sought to examine the safety and performance of transcatheter aortic valve replacement ... more The study sought to examine the safety and performance of transcatheter aortic valve replacement (TAVR) using an all-female registry and to further explore the potential impact of female sex-specific characteristics on clinical outcomes after TAVR. Although women comprise 50% of patients with symptomatic severe aortic stenosis undergoing TAVR, the optimal treatment strategy remains undetermined. The WIN-TAVI (Women's INternational Transcatheter Aortic Valve Implantation) registry is a multinational, prospective, observational registry of women undergoing TAVR for aortic stenosis, conducted without any external funding. The primary endpoint was the Valve Academic Research Consortium (VARC)-2 early safety endpoint at 30 days (composite of mortality, stroke, major vascular complication, life-threatening bleeding, stage 2 or 3 acute kidney injury, coronary artery obstruction, or repeat procedure for valve-related dysfunction). Between January 2013 and December 2015, 1,019 women were...

Research paper thumbnail of Abstract 13775: Dual vs. Triple Antithrombotic Therapy After Coronary Stenting in Patients With Non-Valvular Atrial Fibrillation

Circulation, Nov 26, 2013

Research paper thumbnail of Comment: Is renal denervation an effective treatment for hypertension? Comparison of recent meta-analysis and a multinational registry

Blood pressure monitoring, Jan 4, 2015

We compared the impact of renal denervation (RDN) on blood pressures using results available from... more We compared the impact of renal denervation (RDN) on blood pressures using results available from a recent comprehensive meta-analysis and an international registry. The meta-analysis summarized recent trials in which RDN was compared with control groups that were treated only with antihypertensive medication; the registry only included patients treated with RDN. Both publications presented pretreatment pressures and changes 6 months postbaseline. Significant reductions in office systolic pressure and 24 h ambulatory systolic pressure were observed in both groups of the meta-analysis and the registry. However, the magnitude of blood pressure reduction with RDN and medical treatment was comparable in both the meta-analysis and registry. RDN has not been shown to be superior to medical management of hypertension in this combined experience of nearly 2000 hypertensive patients.

Research paper thumbnail of Safety and Efficacy of New-Generation Drug-Eluting Stents in Women at High Risk for Atherothrombosis: From the Women in Innovation and Drug-Eluting Stents Collaborative Patient-Level Pooled Analysis

Circulation. Cardiovascular interventions, 2016

The safety and efficacy of new-generation drug-eluting stents (DES) in women with multiple athero... more The safety and efficacy of new-generation drug-eluting stents (DES) in women with multiple atherothrombotic risk (ATR) factors is unclear. We pooled patient-level data for women enrolled in 26 randomized trials. Study population was categorized based on the presence or absence of high ATR, which was defined as having history of diabetes mellitus, prior percutaneous or surgical coronary revascularization, or prior myocardial infarction. The primary end point was major adverse cardiovascular events defined as a composite of all-cause mortality, myocardial infarction, or target lesion revascularization at 3 years of follow-up. Out of 10 449 women included in the pooled database, 5333 (51%) were at high ATR. Compared with women not at high ATR, those at high ATR had significantly higher risk of major adverse cardiovascular events (15.8% versus 10.6%; adjusted hazard ratio: 1.53; 95% confidence interval: 1.34-1.75; P=0.006) and all-cause mortality. In high-ATR risk women, the use of new-...

Research paper thumbnail of Effect of Chronic Kidney Disease in Women Undergoing Percutaneous Coronary Intervention With Drug-Eluting Stents

JACC: Cardiovascular Interventions, 2016

Research paper thumbnail of Efficacy and safety of routine thrombus aspiration in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: An updated systematic review and meta-analysis of randomized controlled trials

Catheterization and Cardiovascular Interventions, 2015

Randomized clinical trials evaluating the role of thrombus aspiration (TA) in patients undergoing... more Randomized clinical trials evaluating the role of thrombus aspiration (TA) in patients undergoing primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) have yielded contrasting results. Therefore, the efficacy and safety of TA in STEMI is unclear. We sought to evaluate the efficacy and safety of TA during PPCI for STEMI compared with conventional PPCI alone. We included study-level data from 25 randomized, controlled trials, involving 21,733 patients with STEMI and PPCI. The primary efficacy endpoint was major adverse cardiac events (MACE) according to study definitions; the primary safety endpoint was stroke. The mean weighted follow-up time across studies was 8.2 months. Compared with conventional PPCI, TA was associated with significant lower risk for MACE [relative risk (RR): 0.91; 95% confidence interval (CI): 0.83-1.00; P = 0.042). However, this benefit in MACE was counterbalanced by a significant increase in the risk for stroke (RR: 1.58; 95% CI: 1.11-2.25; P = 0.011). There were no differences in the risk of myocardial infarction (RR: 0.94; 95% CI: 0.78-1.12; P = 0.486), target vessel revascularization (RR: 0.93; 95% CI: 0.82-1.04; P = 0.2), and definite or probable stent thrombosis (RR: 0.84; 95% CI: 0.66-1.07; P = 0.148). TA was associated with an ostensible lower risk for all-cause mortality, which did not reach statistical significance (RR: 0.88; 95% CI: 0.78-1.00; P = 0.059). Compared with conventional PPCI for STEMI, adjunctive TA reduces the risk of subsequent MACE. However, the benefit in MACE is counterbalanced by an increased risk in stroke. Considering the above potential risks and benefits, TA should be considered in selected patients lesions rather than routinely. © 2015 Wiley Periodicals, Inc.

Research paper thumbnail of Antithrombotic Strategy Variability In ATrial Fibrillation and Obstructive Coronary Disease Revascularized with PCI - Rationale and study design of the prospective observational multicenter AVIATOR 2 Registry

American Heart Journal, 2015

Research paper thumbnail of Balancing the Risk of Bleeding and Stroke in Patients with Atrial Fibrillation after Percutaneous Coronary Intervention (from the AVIATOR-registry)

The American Journal of Cardiology, 2015

Patients with atrial fibrillation (AF) who underwent percutaneous coronary intervention (PCI) are... more Patients with atrial fibrillation (AF) who underwent percutaneous coronary intervention (PCI) are at elevated risk for bleeding and thromboembolic ischemic events. Currently, guidelines on antithrombotic treatment for these patients are based on weak consensus. We describe patterns and determinants of antithrombotic prescriptions in this population. The Antithrombotic Strategy Variability in Atrial Fibrillation and Obstructive Coronary Disease Revascularized with PCI Registry was an international observational study of 859 consecutive patients with AF who underwent PCI from 2009 to 2011. Patients were stratified by treatment at discharge with either dual antiplatelet therapy (DAPT; aspirin plus clopidogrel) or triple therapy (TT; warfarin plus DAPT). Bleeding and thromboembolism risks were assessed by the HAS-BLED and CHADS2 scores, respectively, and predictors of TT prescription at discharge were identified. Major adverse cardiovascular events and clinically relevant bleeding (Bleeding Academic Research Consortium score ≥2) at 1-year follow-up were compared across antithrombotic regimens. Compared with patients on DAPT (n = 488; 57%), those given TT (n = 371; 43%) were older, with higher CHADS2 scores, lower left ventricular ejection fraction, and more often had permanent AF, single-vessel coronary artery disease, and bare-metal stents. In multivariate analysis, increasing thromboembolic risk (CHADS2) was associated with a higher rate of TT prescription at discharge (intermediate vs low CHADS2: odds ratio 2.2, 95% confidence interval [CI] 2.0 to 3.3, p <0.01; high vs low CHADS2: odds ratio 1.6, 95% CI 2.6 to 4.3, p <0.01 for TT). However, there was no significant association between bleeding risk and TT prescription in the overall cohort or within each CHADS2 risk stratum. The rates of major adverse cardiovascular events were similar for patients discharged on TT or DAPT (20% vs 17%, adjusted hazard ratio 0.8, 95% CI 0.5 to 1.1, p = 0.19), whereas the rate of Bleeding Academic Research Consortium ≥2 bleeding was higher in patients discharged on TT (11.5% vs 6.4%, adjusted hazard ratio 1.8, 95% CI 1.1 to 2.9, p = 0.02). In conclusion, the choice of the intensity of antithrombotic therapy correlated more closely with the risk of ischemic rather than bleeding events in this cohort of patients with AF who underwent PCI.

Research paper thumbnail of Impact of Left Ventricular Dysfunction on Outcomes in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: Insights from the Aviator Registry

Journal of the American College of Cardiology, 2015