Mange Ram Yadav | The M.S.University Of Baroda-Vadodara (original) (raw)
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Open Access by Mange Ram Yadav
Bentham Science Publishers
Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used for the treatment of chronic inflam... more Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used for the treatment of chronic inflammatory diseases suffer from several undesired side effects, the most important being gastrointestinal (GI) irritation and ulceration. The prodrug designing is one of the several strategies used to overcome this drawback. The rationale behind the prodrug concept is to achieve temporary blockade of the free carboxylic group present in the NSAIDs till their systemic absorption. In this paper, a review on the concept of prodrugs designing of NSAIDs to improve their efficacy and reduce the toxicity is being presented.
Papers by Mange Ram Yadav
Indian drugs, 2003
... INIST-CNRS. 2, Allée du Parc de Brabois CS 10310 F-54519 Vandoeuvre-lès-Nancy Cedex France Ph... more ... INIST-CNRS. 2, Allée du Parc de Brabois CS 10310 F-54519 Vandoeuvre-lès-Nancy Cedex France Phone: +33 (0)3 83 50 46 64 Fax: +33 (0)3 83 50 46 66. ... Auteur(s) / Author(s). SARATHY KP ; GIRIDHAR R. ; YADAV MR ; Résumé / Abstract. ...
Journal of the American Chemical Society, 2006
One of the primary objectives in the design of protein inhibitors is to shape the three-dimension... more One of the primary objectives in the design of protein inhibitors is to shape the three-dimensional structures of small molecules to be complementary to the binding site of a target protein. In the course of our efforts to discover potent inhibitors of Bcl-2 family proteins, we found a unique folded conformation adopted by tethered aromatic groups in the ligand that significantly enhanced binding affinity to Bcl-XL. This finding led us to design compounds that were biased by nonbonding interactions present in a urea tether to adopt this bioactive, folded motif. To characterize the key interactions that induce the desired conformational bias, a series of substituted N,N′-diarylureas were prepared and analyzed using X-ray crystallography and quantum mechanical calculations. Stabilizing π-stacking interactions and destabilizing steric interactions were predicted to work in concert in two of the substitution patterns to promote the bioactive conformation as a global energy minimum and result in a high target binding affinity. Conversely, intramolecular hydrogen bonding present in the third substitution motif promotes a less active, extended conformer as the energetically favored geometry. These findings were corroborated when the inhibition constant of binding to Bcl-X L was determined for fully elaborated analogues bearing these structural motifs. Finally, we obtained the NMR solution structure of the disubstituted N,N′-diarylurea bound to Bcl-XL demonstrating the folded conformation of the urea motif engaged in extensive π-interactions with the protein.
![Research paper thumbnail of Pyrido[1,2-a]pyrimidin-4-ones as antiplasmodial falcipain-2 inhibitors](https://attachments.academia-assets.com/99264449/thumbnails/1.jpg)
](Bioorganic & Medicinal Chemistry, 2012
Plasmodium falciparum cysteine protease falcipain-2 (FP-2) is a promising target for antimalarial... more Plasmodium falciparum cysteine protease falcipain-2 (FP-2) is a promising target for antimalarial chemotherapy and inhibition of this protease affects the growth of parasite adversely. A series of pyrido[1,2-a]pyrimidin-4-ones were synthesized and evaluated for their in vitro FP-2 inhibitory potential. Compounds (14,17) showed excellent FP-2 inhibition and can serve as lead compounds for further development of potent FP-2 inhibitors as potential antimalarial drugs.
Molecular Diversity, 2021
In this contribution, we report the design, synthesis and cytotoxicity studies of a series of N-[... more In this contribution, we report the design, synthesis and cytotoxicity studies of a series of N-[3-(benzimidazol-2-yl-amino)phenyl]amine and N-[3-(benzoxazol-2-ylamino)phenyl]amine derivatives. In vitro cytotoxicity assay of 26 selected compounds was carried out at National Cancer Institute (NCI), USA. Out of them, compounds 10e (NSC D-762842/1) and 11s (NSC D-764942/1) have shown remarkable cytotoxicity with GI50 values ranging between "0.589-14.3 µM" and "0.276-12.3 µM," respectively, in the representative nine subpanels of human tumor cell lines. Further, flow cytometry analysis demonstrated that compound 10e exerted cell cycle arrest at G2/M phase and showed dose-dependent enhancement in apoptosis in K-562 leukemia cancer cells.
European Journal of Medicinal Chemistry, 2006
3D-QSAR studies of some tricyclicpiperazinyl derivatives as farnesyltransferase inhibitors were p... more 3D-QSAR studies of some tricyclicpiperazinyl derivatives as farnesyltransferase inhibitors were performed by comparative molecular field analysis (CoMFA) and comparative molecular similarity indices (CoMSIA) methods to rationalize the structural requirements responsible for the inhibitory activity of these compounds. The global minimum energy conformer of the template molecule 35, the most active and pharmacokinetically stable molecule of the series, was obtained by simulated annealing method and used to build structures of the molecules in the dataset. The CoMFA model obtained after the removal of outliers produced statistically significant results with cross-validated and conventional correlation coefficients of 0.550 and 0.969, respectively. The combination of steric, electrostatic, hydrogen bond acceptor and hydrophobic fields in CoMSIA gave the best results with cross-validated and conventional correlation coefficients of 0.611 and 0.986, respectively. The predictive ability of CoMFA and CoMSIA were determined using a test set of 24 tricyclicpiperazinyl derivatives giving predictive correlation coefficients of 0.543 and 0.663, respectively, indicating good predictive power. Further the robustness of the model was verified by bootstrapping analysis. Based on the CoMFA and CoMSIA analysis we have identified some key features in the tricyclicpiperazinyl series that are responsible for farnesyltransferase inhibitory activity that may be used to design more potent tricyclicpiperazinyl derivatives and predict their activity prior to synthesis.
ChemInform, 2010
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Indian journal of experimental biology, 1996
Gas liquid chromatographic analysis of fixed oil of O. sanctum revealed the presence of five fatt... more Gas liquid chromatographic analysis of fixed oil of O. sanctum revealed the presence of five fatty acids (stearic, palmitic, oleic, linoleic and linolenic acids). The triglyceride fraction of the oil showed higher protection compared to fixed oil against carrageenam-induced paw edema and acetic acid-induced writhings in rats and mice, respectively. The pharmacological activity of the fixed oil could be attributed to its triglyceride fraction or the fatty acids.
Bollettino chimico farmaceutico, 2004
A non-bitter chloroquine suspension formulation for pediatric use was prepared in the form of an ... more A non-bitter chloroquine suspension formulation for pediatric use was prepared in the form of an ion-pair of chloroquine with pamoic acid. Various parameters involved in the formulation of a stable and palatable suspension have been optimized. The suspension was characterized for particle size analysis, viscosity, physical and chemical stability and taste. Release of chloroquine from the ion-pair conducted as dissolution rate studies in simulated gastric media showed near to 100% release instantaneously. In-vivo bioavailability study conducted in albino rats indicated comparable bioavailability of chloroquine from the suspension with that of chloroquine phosphate syrup taken as standard. Stability study conducted over a period of 3 months showed the intactness of the ion-pair and the tasteless behavior of the suspension throughout the period of storage.
Progress in Medicinal Chemistry, 1979
Page 47. Progress in Medicinal ChemistryVol. 16, edited by GP Ellis and GB West © Elsevier/North... more Page 47. Progress in Medicinal ChemistryVol. 16, edited by GP Ellis and GB West © Elsevier/North-Holland Biomedical Press1979 2 Heterosteroids and Drug Research HARKISHAN SINGH, M. Pharm., Ph. D. VIJAY K. KAPOOR, M. Pharm., Ph. ...
Mini-Reviews in Medicinal Chemistry, 2007
The aim of this review is precisely to give a comprehensive account of the large volume of work c... more The aim of this review is precisely to give a comprehensive account of the large volume of work carried out on 1,4-diazepines regardless of the degree of unsaturation in the diazepine system. This review mainly emphasizes recent work on the diazepines also including earlier work.
Journal of Advanced Pharmaceutical Technology & Research, 2013
Bentham Science Publishers
Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used for the treatment of chronic inflam... more Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used for the treatment of chronic inflammatory diseases suffer from several undesired side effects, the most important being gastrointestinal (GI) irritation and ulceration. The prodrug designing is one of the several strategies used to overcome this drawback. The rationale behind the prodrug concept is to achieve temporary blockade of the free carboxylic group present in the NSAIDs till their systemic absorption. In this paper, a review on the concept of prodrugs designing of NSAIDs to improve their efficacy and reduce the toxicity is being presented.
Indian drugs, 2003
... INIST-CNRS. 2, Allée du Parc de Brabois CS 10310 F-54519 Vandoeuvre-lès-Nancy Cedex France Ph... more ... INIST-CNRS. 2, Allée du Parc de Brabois CS 10310 F-54519 Vandoeuvre-lès-Nancy Cedex France Phone: +33 (0)3 83 50 46 64 Fax: +33 (0)3 83 50 46 66. ... Auteur(s) / Author(s). SARATHY KP ; GIRIDHAR R. ; YADAV MR ; Résumé / Abstract. ...
Journal of the American Chemical Society, 2006
One of the primary objectives in the design of protein inhibitors is to shape the three-dimension... more One of the primary objectives in the design of protein inhibitors is to shape the three-dimensional structures of small molecules to be complementary to the binding site of a target protein. In the course of our efforts to discover potent inhibitors of Bcl-2 family proteins, we found a unique folded conformation adopted by tethered aromatic groups in the ligand that significantly enhanced binding affinity to Bcl-XL. This finding led us to design compounds that were biased by nonbonding interactions present in a urea tether to adopt this bioactive, folded motif. To characterize the key interactions that induce the desired conformational bias, a series of substituted N,N′-diarylureas were prepared and analyzed using X-ray crystallography and quantum mechanical calculations. Stabilizing π-stacking interactions and destabilizing steric interactions were predicted to work in concert in two of the substitution patterns to promote the bioactive conformation as a global energy minimum and result in a high target binding affinity. Conversely, intramolecular hydrogen bonding present in the third substitution motif promotes a less active, extended conformer as the energetically favored geometry. These findings were corroborated when the inhibition constant of binding to Bcl-X L was determined for fully elaborated analogues bearing these structural motifs. Finally, we obtained the NMR solution structure of the disubstituted N,N′-diarylurea bound to Bcl-XL demonstrating the folded conformation of the urea motif engaged in extensive π-interactions with the protein.
Bioorganic & Medicinal Chemistry, 2012
Plasmodium falciparum cysteine protease falcipain-2 (FP-2) is a promising target for antimalarial... more Plasmodium falciparum cysteine protease falcipain-2 (FP-2) is a promising target for antimalarial chemotherapy and inhibition of this protease affects the growth of parasite adversely. A series of pyrido[1,2-a]pyrimidin-4-ones were synthesized and evaluated for their in vitro FP-2 inhibitory potential. Compounds (14,17) showed excellent FP-2 inhibition and can serve as lead compounds for further development of potent FP-2 inhibitors as potential antimalarial drugs.
Molecular Diversity, 2021
In this contribution, we report the design, synthesis and cytotoxicity studies of a series of N-[... more In this contribution, we report the design, synthesis and cytotoxicity studies of a series of N-[3-(benzimidazol-2-yl-amino)phenyl]amine and N-[3-(benzoxazol-2-ylamino)phenyl]amine derivatives. In vitro cytotoxicity assay of 26 selected compounds was carried out at National Cancer Institute (NCI), USA. Out of them, compounds 10e (NSC D-762842/1) and 11s (NSC D-764942/1) have shown remarkable cytotoxicity with GI50 values ranging between "0.589-14.3 µM" and "0.276-12.3 µM," respectively, in the representative nine subpanels of human tumor cell lines. Further, flow cytometry analysis demonstrated that compound 10e exerted cell cycle arrest at G2/M phase and showed dose-dependent enhancement in apoptosis in K-562 leukemia cancer cells.
European Journal of Medicinal Chemistry, 2006
3D-QSAR studies of some tricyclicpiperazinyl derivatives as farnesyltransferase inhibitors were p... more 3D-QSAR studies of some tricyclicpiperazinyl derivatives as farnesyltransferase inhibitors were performed by comparative molecular field analysis (CoMFA) and comparative molecular similarity indices (CoMSIA) methods to rationalize the structural requirements responsible for the inhibitory activity of these compounds. The global minimum energy conformer of the template molecule 35, the most active and pharmacokinetically stable molecule of the series, was obtained by simulated annealing method and used to build structures of the molecules in the dataset. The CoMFA model obtained after the removal of outliers produced statistically significant results with cross-validated and conventional correlation coefficients of 0.550 and 0.969, respectively. The combination of steric, electrostatic, hydrogen bond acceptor and hydrophobic fields in CoMSIA gave the best results with cross-validated and conventional correlation coefficients of 0.611 and 0.986, respectively. The predictive ability of CoMFA and CoMSIA were determined using a test set of 24 tricyclicpiperazinyl derivatives giving predictive correlation coefficients of 0.543 and 0.663, respectively, indicating good predictive power. Further the robustness of the model was verified by bootstrapping analysis. Based on the CoMFA and CoMSIA analysis we have identified some key features in the tricyclicpiperazinyl series that are responsible for farnesyltransferase inhibitory activity that may be used to design more potent tricyclicpiperazinyl derivatives and predict their activity prior to synthesis.
ChemInform, 2010
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Indian journal of experimental biology, 1996
Gas liquid chromatographic analysis of fixed oil of O. sanctum revealed the presence of five fatt... more Gas liquid chromatographic analysis of fixed oil of O. sanctum revealed the presence of five fatty acids (stearic, palmitic, oleic, linoleic and linolenic acids). The triglyceride fraction of the oil showed higher protection compared to fixed oil against carrageenam-induced paw edema and acetic acid-induced writhings in rats and mice, respectively. The pharmacological activity of the fixed oil could be attributed to its triglyceride fraction or the fatty acids.
Bollettino chimico farmaceutico, 2004
A non-bitter chloroquine suspension formulation for pediatric use was prepared in the form of an ... more A non-bitter chloroquine suspension formulation for pediatric use was prepared in the form of an ion-pair of chloroquine with pamoic acid. Various parameters involved in the formulation of a stable and palatable suspension have been optimized. The suspension was characterized for particle size analysis, viscosity, physical and chemical stability and taste. Release of chloroquine from the ion-pair conducted as dissolution rate studies in simulated gastric media showed near to 100% release instantaneously. In-vivo bioavailability study conducted in albino rats indicated comparable bioavailability of chloroquine from the suspension with that of chloroquine phosphate syrup taken as standard. Stability study conducted over a period of 3 months showed the intactness of the ion-pair and the tasteless behavior of the suspension throughout the period of storage.
Progress in Medicinal Chemistry, 1979
Page 47. Progress in Medicinal ChemistryVol. 16, edited by GP Ellis and GB West © Elsevier/North... more Page 47. Progress in Medicinal ChemistryVol. 16, edited by GP Ellis and GB West © Elsevier/North-Holland Biomedical Press1979 2 Heterosteroids and Drug Research HARKISHAN SINGH, M. Pharm., Ph. D. VIJAY K. KAPOOR, M. Pharm., Ph. ...
Mini-Reviews in Medicinal Chemistry, 2007
The aim of this review is precisely to give a comprehensive account of the large volume of work c... more The aim of this review is precisely to give a comprehensive account of the large volume of work carried out on 1,4-diazepines regardless of the degree of unsaturation in the diazepine system. This review mainly emphasizes recent work on the diazepines also including earlier work.
Journal of Advanced Pharmaceutical Technology & Research, 2013
European Journal of Medicinal Chemistry, 2012
A series of 4,6-diaryl-2-aminopyrimidines was developed as antiplatelet agents and their potency ... more A series of 4,6-diaryl-2-aminopyrimidines was developed as antiplatelet agents and their potency was evaluated by in vitro assay. Compound 14k was found to be two times more potent than aspirin. These encouraging results could be helpful for the development of new antiplatelet compounds.