Anastasia A. Zabolotneva | MSU (original) (raw)

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Papers by Anastasia A. Zabolotneva

Research paper thumbnail of Evolutionary Acquisition of Multifunctionality by Glycolytic Enzymes

Rossijskij fiziologičeskij žurnal im. I.M. Sečenova, 2023

Research paper thumbnail of Reconstruction of the Metabolic Activity of the Intestinal Microbiota in Children and Adults with Obesity and its Relationship with the Representation of Alkylresorcinols in Feces

Žurnal èvolûcionnoj biohimii i fiziologii, Jul 1, 2023

Research paper thumbnail of Molecular orchestra of microbiotic metabolites in the scenario of carcinogenesis

Research paper thumbnail of The role of microbiotic metabolites in carcinogenesis

Èndokrinnaâ hirurgiâ, Dec 21, 2023

Research paper thumbnail of The role of tryptophan metabolites in the development of autoreactivity

Èndokrinnaâ hirurgiâ, Dec 27, 2023

Research paper thumbnail of Genetic and therapeutic landscapes in cohort of pancreatic adenocarcinomas: next-generation sequencing and machine learning for full tumor exome analysis

Research paper thumbnail of Alkylresorcinols as a New Type of Gut Microbiota Regulators Influencing Immune Therapy Efficiency in Lung Cancer Treatment

Advanced Gut & Microbiome Research, Dec 22, 2023

Research paper thumbnail of Lactate: a New Look at the Role of an Evolutionarily Ancient Metabolite

Journal of Evolutionary Biochemistry and Physiology, Nov 1, 2022

Research paper thumbnail of Современное понимание молекулярных механизмов адипогенеза и пластичности жировой ткани

Uspekhi sovremennoĭ biologii, 2021

Research paper thumbnail of Role of Tryptophan Metabolites and Short-Chain Fatty Acids in Pathogenesis of Autoimmune Diseases

Journal of Evolutionary Biochemistry and Physiology

Research paper thumbnail of Supplementation of a high-fat diet with pentadecylresorcinol increases the representation of Akkermansia muciniphila in the mouse small and large intestines and may protect against complications caused by imbalanced nutrition

Research Square (Research Square), Feb 28, 2024

Supplementation of a high-fat diet with pentadecylresorcinol increases the representation of Akke... more Supplementation of a high-fat diet with pentadecylresorcinol increases the representation of Akkermansia muciniphila in the mouse small and large intestines and may protect against complications caused by imbalanced nutrition

Research paper thumbnail of Reviewed by

doi: 10.3389/fgene.2013.00247 A systematic experimental evaluation of microRNA markers of human b... more doi: 10.3389/fgene.2013.00247 A systematic experimental evaluation of microRNA markers of human bladder cancer

Research paper thumbnail of Molecular Ensembles of Microbiotic Metabolites in Carcinogenesis

Biokhimiya, Jul 1, 2023

The mechanisms of carcinogenesis are extremely complex and involve multiple components that contr... more The mechanisms of carcinogenesis are extremely complex and involve multiple components that contribute to the malignant cell transformation, tumor growth, and metastasis. In recent decades, there has been a growing interest in the role of symbiotic human microbiota in the regulation of metabolism and functioning of host immune system. The symbiosis between a macroorganism and its microbiota has given rise to the concept of a holoorganism. Interactions between the components of a holoorganism have formed in the process of coevolution, resulting in the acquisition by microbiotic metabolites of a special role of signaling molecules and main regulators of molecular interactions in the holoorganism. As elements of signaling pathways in the host organism, bacterial metabolites have become essential participants in various physiological and pathological processes, including tumor growth. At the same time, signaling metabolites often exhibit multiple effects and impact both the functions of the host cells and metabolic activity and composition of the microbiome. This review discusses the role of microbiotic metabolites in the induction and prevention of malignant transformation of cells in the host organism and their impact on the efficacy of anticancer therapy, with special emphasis on the involvement of some components of the microbial metabolite molecular ensemble in the initiation and progression of tumor growth.

Research paper thumbnail of How many antiviral small interfering RNAs may be encoded by the mammalian genomes?

Biology Direct, Nov 8, 2010

Background: The discovery of RNA interference phenomenon (RNAi) and understanding of its mechanis... more Background: The discovery of RNA interference phenomenon (RNAi) and understanding of its mechanisms has revolutionized our views on many molecular processes in the living cell. Among the other, RNAi is involved in silencing of transposable elements and in inhibition of virus infection in various eukaryotic organisms. Recent experimental studies demonstrate few cases of viral replication suppression via complementary interactions between the mammalian small RNAs and viral transcripts. Presentation of the hypothesis: It was found that >50% of the human genome is transcribed in different cell types and that these transcripts are mainly not associated with known protein coding genes, but represent noncoding RNAs of unknown functions. We propose a hypothesis that mammalian DNAs encode thousands RNA motifs that may serve for antiviral protection. We also presume that the evolutional success of some groups of genomic repeats and, in particular, of transposable elements (TEs) may be due to their ability to provide antiviral RNA motifs to the host organism. Intense genomic repeat propagation into the genome would inevitably cause bidirectional transcription of these sequences, and the resulting double-stranded RNAs may be recognized and processed by the RNA interference enzymatic machinery. Provided that these processed target motifs may be complementary to viral transcripts, fixation of the repeats into the host genome may be of a considerable benefit to the host. It fits with our bioinformatical data revealing thousands of 21-28 bp long motifs identical between human DNA and human-pathogenic adenoviral and herpesviral genomes. Many of these motifs are transcribed in human cells, and the transcribed part grows proportionally to their lengths. Many such motifs are included in human TEs. For example, one 23 nt-long motif that is a part of human abundant Alu retrotransposon, shares sequence identity with eight human adenoviral genomes. Testing the hypothesis: This hypothesis could be tested on various mammalian species and viruses infecting mammalian cells.

Research paper thumbnail of Tryptophan metabolites in serum and feces of patients with non-small cell lung cancer

Âkutskij medicinskij žurnal, 2021

Research paper thumbnail of Evolutionary View on Lactate-Dependent Mechanisms of Maintaining Cancer Cells Stemness and Reprimitivization <sup></sup&gt

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of Reconstruction of Metabolic Activity of the Gut Microbiota in Children and Adults with Obesity and Its Relationship with the Representation of Alkylresorcinols in Stool Samples

Journal of Evolutionary Biochemistry and Physiology

Research paper thumbnail of Coupling features of intestinal and serum indole pools in obesity

Problems of Biological Medical and Pharmaceutical Chemistry

Research paper thumbnail of Regulatory role and anticarcinogenic properties of certain vitamins’ active derivatives and vitamin-like substances

Problems of Nutrition

Vitamins are low-molecular compounds consisting of an essential part of the human diet. After ent... more Vitamins are low-molecular compounds consisting of an essential part of the human diet. After entering the human organism vitamins or their precursors can undergo chemical modification, changing their biological properties and regulatory activity. For many decades, vitamins were considered mainly as precursors of enzyme cofactors, and hypovitaminosis was interpreted as a deficiency of a particular metabolite resulting from enzyme's insufficient activity. However, with the development of molecular biology techniques and breakthrough in understanding of gene expression regulation and cell signaling mechanisms, as well as in molecular mechanisms of diseases associated with impaired functions, it became clear that there are significantly more active forms of vitamins, and their functions in the human body are more diverse than it had been suggested previously. The purpose of this review was to consider vitamins' and vitamins' derivatives regulatory and anti-tumor role and their potential for clinical application as main or adjuvant drugs for malignant neoplasms treatment. Material and methods. The present review is based on the results of literature analysis conducted in the Scopus, PubMed, Science Direct databases for the keywords «vitamin A AND cancer», «retinoids AND cancer», «vitamin D AND cancer», «vitamins AND cancer», «vitamins AND cancer». The search depth was 6 years (2016-2021). Results. Active forms of hydrophilic and lipophilic vitamins are key participants in the processes of chromatin remodeling, genome stability maintaining, covalent modification of proteins, including signaling and regulatory ones, and also act as chemical messengers themselves. Therefore, vitamin deficiency is associated with autoimmune and chronic diseases such as cancer, atherosclerosis, diabetes mellitus, etc. This review considers the regulatory role of active forms of vitamins, their derivatives and vitamin-like substances as well as their involvement in the process of carcinogenesis. Conclusions. Modern studies confirm the high therapeutic potential of vitamins: the use of pharmacological doses of vitamins or their derivatives may help to prevent or fight non-communicable diseases, including cancer.

Research paper thumbnail of Accepted Manuscript

Transcriptional regulation of human-specific SVAF1 retrotransposons by

Research paper thumbnail of Evolutionary Acquisition of Multifunctionality by Glycolytic Enzymes

Rossijskij fiziologičeskij žurnal im. I.M. Sečenova, 2023

Research paper thumbnail of Reconstruction of the Metabolic Activity of the Intestinal Microbiota in Children and Adults with Obesity and its Relationship with the Representation of Alkylresorcinols in Feces

Žurnal èvolûcionnoj biohimii i fiziologii, Jul 1, 2023

Research paper thumbnail of Molecular orchestra of microbiotic metabolites in the scenario of carcinogenesis

Research paper thumbnail of The role of microbiotic metabolites in carcinogenesis

Èndokrinnaâ hirurgiâ, Dec 21, 2023

Research paper thumbnail of The role of tryptophan metabolites in the development of autoreactivity

Èndokrinnaâ hirurgiâ, Dec 27, 2023

Research paper thumbnail of Genetic and therapeutic landscapes in cohort of pancreatic adenocarcinomas: next-generation sequencing and machine learning for full tumor exome analysis

Research paper thumbnail of Alkylresorcinols as a New Type of Gut Microbiota Regulators Influencing Immune Therapy Efficiency in Lung Cancer Treatment

Advanced Gut & Microbiome Research, Dec 22, 2023

Research paper thumbnail of Lactate: a New Look at the Role of an Evolutionarily Ancient Metabolite

Journal of Evolutionary Biochemistry and Physiology, Nov 1, 2022

Research paper thumbnail of Современное понимание молекулярных механизмов адипогенеза и пластичности жировой ткани

Uspekhi sovremennoĭ biologii, 2021

Research paper thumbnail of Role of Tryptophan Metabolites and Short-Chain Fatty Acids in Pathogenesis of Autoimmune Diseases

Journal of Evolutionary Biochemistry and Physiology

Research paper thumbnail of Supplementation of a high-fat diet with pentadecylresorcinol increases the representation of Akkermansia muciniphila in the mouse small and large intestines and may protect against complications caused by imbalanced nutrition

Research Square (Research Square), Feb 28, 2024

Supplementation of a high-fat diet with pentadecylresorcinol increases the representation of Akke... more Supplementation of a high-fat diet with pentadecylresorcinol increases the representation of Akkermansia muciniphila in the mouse small and large intestines and may protect against complications caused by imbalanced nutrition

Research paper thumbnail of Reviewed by

doi: 10.3389/fgene.2013.00247 A systematic experimental evaluation of microRNA markers of human b... more doi: 10.3389/fgene.2013.00247 A systematic experimental evaluation of microRNA markers of human bladder cancer

Research paper thumbnail of Molecular Ensembles of Microbiotic Metabolites in Carcinogenesis

Biokhimiya, Jul 1, 2023

The mechanisms of carcinogenesis are extremely complex and involve multiple components that contr... more The mechanisms of carcinogenesis are extremely complex and involve multiple components that contribute to the malignant cell transformation, tumor growth, and metastasis. In recent decades, there has been a growing interest in the role of symbiotic human microbiota in the regulation of metabolism and functioning of host immune system. The symbiosis between a macroorganism and its microbiota has given rise to the concept of a holoorganism. Interactions between the components of a holoorganism have formed in the process of coevolution, resulting in the acquisition by microbiotic metabolites of a special role of signaling molecules and main regulators of molecular interactions in the holoorganism. As elements of signaling pathways in the host organism, bacterial metabolites have become essential participants in various physiological and pathological processes, including tumor growth. At the same time, signaling metabolites often exhibit multiple effects and impact both the functions of the host cells and metabolic activity and composition of the microbiome. This review discusses the role of microbiotic metabolites in the induction and prevention of malignant transformation of cells in the host organism and their impact on the efficacy of anticancer therapy, with special emphasis on the involvement of some components of the microbial metabolite molecular ensemble in the initiation and progression of tumor growth.

Research paper thumbnail of How many antiviral small interfering RNAs may be encoded by the mammalian genomes?

Biology Direct, Nov 8, 2010

Background: The discovery of RNA interference phenomenon (RNAi) and understanding of its mechanis... more Background: The discovery of RNA interference phenomenon (RNAi) and understanding of its mechanisms has revolutionized our views on many molecular processes in the living cell. Among the other, RNAi is involved in silencing of transposable elements and in inhibition of virus infection in various eukaryotic organisms. Recent experimental studies demonstrate few cases of viral replication suppression via complementary interactions between the mammalian small RNAs and viral transcripts. Presentation of the hypothesis: It was found that >50% of the human genome is transcribed in different cell types and that these transcripts are mainly not associated with known protein coding genes, but represent noncoding RNAs of unknown functions. We propose a hypothesis that mammalian DNAs encode thousands RNA motifs that may serve for antiviral protection. We also presume that the evolutional success of some groups of genomic repeats and, in particular, of transposable elements (TEs) may be due to their ability to provide antiviral RNA motifs to the host organism. Intense genomic repeat propagation into the genome would inevitably cause bidirectional transcription of these sequences, and the resulting double-stranded RNAs may be recognized and processed by the RNA interference enzymatic machinery. Provided that these processed target motifs may be complementary to viral transcripts, fixation of the repeats into the host genome may be of a considerable benefit to the host. It fits with our bioinformatical data revealing thousands of 21-28 bp long motifs identical between human DNA and human-pathogenic adenoviral and herpesviral genomes. Many of these motifs are transcribed in human cells, and the transcribed part grows proportionally to their lengths. Many such motifs are included in human TEs. For example, one 23 nt-long motif that is a part of human abundant Alu retrotransposon, shares sequence identity with eight human adenoviral genomes. Testing the hypothesis: This hypothesis could be tested on various mammalian species and viruses infecting mammalian cells.

Research paper thumbnail of Tryptophan metabolites in serum and feces of patients with non-small cell lung cancer

Âkutskij medicinskij žurnal, 2021

Research paper thumbnail of Evolutionary View on Lactate-Dependent Mechanisms of Maintaining Cancer Cells Stemness and Reprimitivization <sup></sup&gt

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of Reconstruction of Metabolic Activity of the Gut Microbiota in Children and Adults with Obesity and Its Relationship with the Representation of Alkylresorcinols in Stool Samples

Journal of Evolutionary Biochemistry and Physiology

Research paper thumbnail of Coupling features of intestinal and serum indole pools in obesity

Problems of Biological Medical and Pharmaceutical Chemistry

Research paper thumbnail of Regulatory role and anticarcinogenic properties of certain vitamins’ active derivatives and vitamin-like substances

Problems of Nutrition

Vitamins are low-molecular compounds consisting of an essential part of the human diet. After ent... more Vitamins are low-molecular compounds consisting of an essential part of the human diet. After entering the human organism vitamins or their precursors can undergo chemical modification, changing their biological properties and regulatory activity. For many decades, vitamins were considered mainly as precursors of enzyme cofactors, and hypovitaminosis was interpreted as a deficiency of a particular metabolite resulting from enzyme's insufficient activity. However, with the development of molecular biology techniques and breakthrough in understanding of gene expression regulation and cell signaling mechanisms, as well as in molecular mechanisms of diseases associated with impaired functions, it became clear that there are significantly more active forms of vitamins, and their functions in the human body are more diverse than it had been suggested previously. The purpose of this review was to consider vitamins' and vitamins' derivatives regulatory and anti-tumor role and their potential for clinical application as main or adjuvant drugs for malignant neoplasms treatment. Material and methods. The present review is based on the results of literature analysis conducted in the Scopus, PubMed, Science Direct databases for the keywords «vitamin A AND cancer», «retinoids AND cancer», «vitamin D AND cancer», «vitamins AND cancer», «vitamins AND cancer». The search depth was 6 years (2016-2021). Results. Active forms of hydrophilic and lipophilic vitamins are key participants in the processes of chromatin remodeling, genome stability maintaining, covalent modification of proteins, including signaling and regulatory ones, and also act as chemical messengers themselves. Therefore, vitamin deficiency is associated with autoimmune and chronic diseases such as cancer, atherosclerosis, diabetes mellitus, etc. This review considers the regulatory role of active forms of vitamins, their derivatives and vitamin-like substances as well as their involvement in the process of carcinogenesis. Conclusions. Modern studies confirm the high therapeutic potential of vitamins: the use of pharmacological doses of vitamins or their derivatives may help to prevent or fight non-communicable diseases, including cancer.

Research paper thumbnail of Accepted Manuscript

Transcriptional regulation of human-specific SVAF1 retrotransposons by