Magdalena E Grzybowska | Medical University of Gdańsk (original) (raw)

Papers by Magdalena E Grzybowska

Neurourology and Urodynamics, 2016

Neurourology and Urodynamics, 2017

International Journal of Environmental Research and Public Health, Apr 26, 2022

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Neurourology and Urodynamics, 2015

Neurourology and Urodynamics, 2019

International Urogynecology Journal

Ginekologia Polska, Mar 31, 2021

This article is available in open access under Creative Common Attribution-Non-Commercial-No Deri... more This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.

Cel pracy. Celem publikacji bylo opracowanie przez Sekcje Uroginekologii Polskiego Towarzystwa Gi... more Cel pracy. Celem publikacji bylo opracowanie przez Sekcje Uroginekologii Polskiego Towarzystwa Ginekologow i Poloznikow (PTGiP) interdyscyplinarnych rekomendacji dotyczących leczenia pecherza nadreaktywnego na podstawie dostepnych wiarygodnych danych literaturowych, przy wykorzystaniu doświadczenia ekspertow i elementow codziennej praktyki. Material i metody. Dokonano przeglądu wcześniejszych rekomendacji Sekcji Uroginekologii PTGiP oraz literatury przedmiotu z uwzglednieniem aktualnych miedzynarodowych wytycznych obejmujących zagadnienia zespolu pecherza nadreaktywnego, nietrzymania moczu, naglącego nietrzymania moczu i mieszanego nietrzymania moczu. Wyniki. Niniejsze zalecenia przedstawiają mozliwości postepowania z pacjentką z pecherzem nadreaktywnym. Wyroznione zostaly cztery linie leczenia: pierwsza linia — edukacja pacjentki, terapia behawioralna polączona z cwiczeniami mieśni dna miednicy; druga linia — farmakoterapia; trzecia linia — iniekcje z toksyny botulinowej oraz stymulacja nerwu piszczelowego; w tej grupie ujeto rowniez stymulacje nerwow krzyzowych, ktora jednak, jak dotąd, jest stosowana w bardzo wyselekcjonowanej grupie pacjentow; czwarta linia — postepowanie chirurgiczne. Opracowanie poszerzono o omowienie podstawowych dostepnych badan stanowiących poparcie przedstawionych rekomendacji oraz ukazujących rozne aspekty stosowanej terapii. Uwzglednione zostaly tez problemy istotne w codziennej praktyce klinicznej związane z farmakoterapią pecherza nadreaktywnego. Wnioski. Autorzy dokonali usystematyzowanego przeglądu obecnie dostepnych zalecen i analizy postepowania z pacjentkami z pecherzem nadreaktywnym (w tym z naglącym nietrzymaniem moczu). Wydając zalecenia dotyczące mozliwych opcji postepowania terapeutycznego, PTGiP jednocześnie pragnie podkreślic potrzebe zindywidualizowanego podejścia do terapii pacjentek z pecherzem nadreaktywnym.

Scientific Reports, Jul 29, 2022

Cyclophosphamide (CYP) damages all mucosal defence lines and induces hemorrhagic cystitis (HC) le... more Cyclophosphamide (CYP) damages all mucosal defence lines and induces hemorrhagic cystitis (HC) leading to detrusor overactivity. Patients who undergo combined chemio-radiotherapy are at higher risk of HC. Potentilla chinensis extract (PCE) prevent oxidative stress-dependent diseases. Thus, the aim of the study was to investigate the effect of PCE on urinary bladder function in CYPinduced HC in preclinical study. 60 rats were divided into 4 groups, as follows: I-control, II-rats with CYP-induced HC, III-rats received PCE in dose of 500 mg/kg, and IV-rats with CYP-induced HC which received PCE in dose of 500 mg/kg. PCE or vehicle were administered orally for 14 days. The cystometry was performed 3 days after the last dose of the PCE. Next, urothelium thickness and oedema measurement and biochemical analyses were performed. Cyclophosphamide induced hemorrhagic cystitis. PCE had no influence on the urinary bladder function and micturition cycles in normal rats. PCE diminished the severity of CYP-induced hemorrhagic cystitis. In the urothelium the cyclophosphamide induced the elevation of CGRP, TNF-α, IL-6, IL-1β, OTC 3, NIT, and MAL. Also, the level of T-H protein, HB-EGF, and ZO1 was decreased. Moreover, the level of ROCK1 and VAChT in detrusor muscle increased. cyclophosphamide caused an increased concentration of BDNF and NGF in the urine. In turn, PCE in cyclophosphamide-induced hemorrhagic cystitis caused a reversal of the described biochemical changes within urothelium, detrusor muscle and urine. PCE attenuates detrusor overactivity. In conclusion, our results revealed that PCE attenuates detrusor overactivity in case of cyclophosphamide-induced hemorrhagic cystitis. The potential properties of PCE appear to be important in terms of preventing of oxidative stress-dependent dysfunction of urinary bladder. PCE may become a potential supportive treatment in patient to whom cyclophosphamide-based chemotherapy is used. Chemotherapy based on oxazophorine alkylating agents (cyclophosphamide-CYP or ifosfamide) and radiotherapy in the area of urinary bladder play role in hemorrhagic cystitis (HC) pathogenesis. Patients who undergo combined chemio-radiotherapy are at higher risk of HC development 1. CYP treatment damages all mucosal

Frontiers in Molecular Biosciences

The aim of the current study was to determine if phytomedicine (Urox®) would reverse retinyl acet... more The aim of the current study was to determine if phytomedicine (Urox®) would reverse retinyl acetate (RA)–induced changes characteristic of bladder overactivity. There were 60 rats divided into the following 4 groups: I—control, II—received RA to induce detrusor overactivity (DO), III—received Urox (840 mg daily for 14 days), and IV—received combination of RA and Urox®. The cystometry was performed 2 days after the last dose of Urox®. Next, urothelium thickness and biochemical parameter measurements were performed. In group IV, a decrease in basal pressure and detrusor overactivity index was noted when compared to group II. Furthermore, in group IV the following parameters were increased: threshold pressure, voided volume, intercontraction interval, and bladder compliance in comparison with group II. There were significant elevations in c-Fos expression in the neuronal voiding centers in group II, while the expression of c-Fos in group IV was normalized. No significant changes in th...

Health and Quality of Life Outcomes, 2021

Purpose Urogenital Distress Inventory-6 (UDI-6), Incontinence Impact Questionnaire-7 (IIQ-7) and ... more Purpose Urogenital Distress Inventory-6 (UDI-6), Incontinence Impact Questionnaire-7 (IIQ-7) and The International Consultation on Incontinence (ICIQ-SF) Short Form are used to diagnose individuals with urinary incontinence (UI) and to assess the impact of the dysfunction on patient quality of life. While ICIQ-SF has fixed cutoff values—UDI-6 and IIQ-7 do not. We aimed to find the cutoff scores for UDI-6 and IIQ-7 in women with UI. Methods The study involved 205 women aged between 31 and 83 years—155 with, and 50 without UI symptoms. All participants completed all three questionnaires: ICIQ-SF, UDI-6 and IIQ-7. Patients were categorized according to their ICIQ-SF scores, as symptomatic ICIQ-SF ≥ 6 (n = 134) and asymptomatic ICIQ < 6 (n = 60). The Receiver Operating Characteristics (ROC) curve was used to test how well UDI-6 allowed a discrimination between patients suffering from UI and those who do not. Area under Curve (AUC) statistic was calculated to measure the UDI-6 and IIQ...

Ginekologia Polska, Nov 30, 2021

Healthcare, May 21, 2021

Journal of Clinical Medicine, May 10, 2022

Pain Research & Management, Jul 11, 2020

Purpose. e aim of the research was to conduct an assessment of the prevalence of dysmenorrhea and... more Purpose. e aim of the research was to conduct an assessment of the prevalence of dysmenorrhea and associated factors among Polish women. Patients and Methods. A cross-sectional study was conducted among Polish women using an online questionnaire. e mean age of the participants was 23 ± 4 years. Out of the total of 1,317 women who took part in the study, 1,127 were included in the analysis, and 190 were excluded due to incomplete answers. e questionnaire consisted of 19 questions that were grouped into three parts. e first concerned sociodemographic data such as age, weight, education, and residence (urban or rural). e second part of the questionnaire pertained to the factors of dysmenorrhea (premenstrual syndrome, age of menarche, and family history of dysmenorrhea.). In the third part, the women were asked about their diet, alcohol intake, cigarette smoking, and physical activity. Results. Dysmenorrhea affected 94% of the interviewed women. Dysmenorrhea was most likely to occur among respondents whose mothers had a history of dysmenorrhea (p < 0.005). Significant relationship between the occurrence of dysmenorrhea among respondents and their sisters was also observed (p < 0.005). e prevalence of premenstrual syndrome (PMS) was significantly higher in women reporting dysmenorrhea (p < 0.005). Other significant factors associated with dysmenorrhea were age of menarche (p < 0.005), stress frequency (p � 0.005), lack of physical activity (p � 0.037), and self-esteem (p � 0.042). However, in the respondents, no significant relationship was observed between dysmenorrhea and diet, smoking, body mass index, and alcohol intake. Conclusion. e study points to the fact that the problem of dysmenorrhea affects many Polish women. Women with dysmenorrhea were characterized with a family history of dysmenorrhea, occurrence of PMS, early age of menarche, stressful lifestyle, lack of physical activity, and low self-esteem. We suggest that further assessment of factors contributing for dysmenorrhea among women is necessary.

International Journal of Environmental Research and Public Health, Feb 13, 2020

Dysmenorrhea often significantly reduces the quality of women's life and is still an important pu... more Dysmenorrhea often significantly reduces the quality of women's life and is still an important public health problem. Despite numerous studies, the pathomechanism of dysmenorrhea is not fully understood. Previous research indicates the complexity of biochemical reactions between the endocrine, vascular, and immune systems. Prostaglandins play a major role in the pathomechanism of dysmenorrhea. In contrast, cytokines and other proinflammatory factors in primary dysmenorrhea are less studied. In addition to the applied pharmacotherapy, more and more studies proving the effectiveness of non-pharmacological methods appear. Therefore, the present work contains a review of the latest research concerning factors involved in dysmenorrhea, as well as therapeutic options. In the literature search, authors used online databases, PubMed, and clinitrials.gov and browsed through individual gynecology, physiotherapy journals and books.

Proceedings of The 3rd International Electronic Conference on Environmental Research and Public Health —Public Health Issues in the Context of the COVID-19 Pandemic, Jan 11, 2021

Introduction: In spite of many studies, the pathomechanism of dysmenorrhea (DM) remains unclear. ... more Introduction: In spite of many studies, the pathomechanism of dysmenorrhea (DM) remains unclear. The study aimed to evaluate the levels of progesterone and 17-beta estradiol and the severity of dysmenorrhea in six young women, including three after the use of manual therapy and the other three after the administration of ibuprofen. Material and methods: In six patients aged 22±2, gynecological and physiotherapeutic examinations were completed. Moreover, a twofold determination of progesterone and 17-beta estradiol levels were carried out. The intensity of dysmenorrhea was assessed in the numerical pain rating scale (NPRS). The patients were dichotomized into two subgroups. Subgroup A (n=3) was subjected to manual therapy (3 x 45 min), while in subgroup B (n=3), the patients were administered ibuprofen 3 x 400 mg/24 h during menstruation. Results: Lower progesterone levels were detected in the blood of the 3 women from subgroup A after manual therapy and in 2 of the women from subgroup B after administrating ibuprofen. After the therapy, the level of 17-beta estradiol was higher in each woman from subgroup A and in one woman from subgroup B. In subgroup A, dysmenorrhea was reduced on average from 8 down to 3 points in the NPRS and duration time was shortened by one day on average. In subgroup B, dysmenorrhea was decreased on average from 8 to 3 points in the NPRS, yet no changes in its duration time were observed. Conclusions: It has been demonstrated that manual therapy alleviated dysmenorrhea to a similar degree as ibuprofen. However, only the manual therapy exerted an effect on the shortening of dysmenorrhea duration time. The use of manual therapy probably influenced the diminution of progesterone levels.

Journal of Clinical Medicine

Perineal pain occurs in 97% of women with episiotomy or first- and second-degree perineal tears o... more Perineal pain occurs in 97% of women with episiotomy or first- and second-degree perineal tears on the first day after delivery. The study aimed to assess the impact of capacitive and resistive energy transfer (TECAR) on perineal pain and discomfort in the first two postpartum days. The prospective randomized double-blind study was performed with the pain and discomfort assessment using the Visual Analogue Scale at baseline and after both TECAR interventions. Characteristics data, delivery information, and the number of painkillers taken were collected. The assumed significance level was α < 0.05. The study included 121 women with a mean age of 30.7 ± 4.2 years and a median BMI of 26.1 kg/m2 (24.1; 28.9). Pain reduction at rest, when walking, and discomfort reduction when walking were significantly higher in the TECAR group compared to the sham group (p < 0.05). After the first TECAR intervention, significant reduction in all measured parameters was observed in the study group...