Daksha Prabhat | Maharashtra University 0f Health Science (original) (raw)
Papers by Daksha Prabhat
Annals of pathology and laboratory medicine, Nov 1, 2023
PubMed, Jul 1, 1997
Primary adenocarcinoma is a rare tumour involving the fallopian tube. Two such cases are reported... more Primary adenocarcinoma is a rare tumour involving the fallopian tube. Two such cases are reported; the first case was associated with papillary carcinoma of the paratubal cysts and the second occurred in a young female.
DOAJ (DOAJ: Directory of Open Access Journals), Mar 7, 2000
ABSTRACT Two cases of plasma cell leukaemia--a rare form of leukaemia are described. Both cases p... more ABSTRACT Two cases of plasma cell leukaemia--a rare form of leukaemia are described. Both cases presented with anaemia and hepatosplenomegaly. Investigations revealed leucocytosis with increased plasma cells (> 20%). Skeletal survey revealed a few osteolytic lesions in both cases.
NATIONAL JOURNAL OF LABORATORY MEDICINE
Although eosinophilia is a recognised associated feature of Hodgkin’s Lymphoma, hypereosinophilia... more Although eosinophilia is a recognised associated feature of Hodgkin’s Lymphoma, hypereosinophilia is seldom the presenting feature in the patient. Here, the authors report an unusual case of a 21-year-old male patient who presented to the General Medicine outpatient department of the hospital with a history of multiple episodes of left-sided pleural effusion in addition to mediastinal and cervical lymphadenopathy. Baseline investigations revealed hypereosinophilia which was persistent despite Diethylcarbamazine (DEC) and steroid therapy. Computer Tomography (CT) guided biopsy of an anterior mediastinal mass, likely to be thymus, led to the diagnosis of Hodgkin's Lymphoma. The patient was transferred to the Haematology department where he was started on Adriamycin, Bleomycin, Vinblastine and Dacarbazine (ABVD) chemotherapy regimen. Despite the fact that blood eosinophilia is an associated finding, it is rare for a patient to present with it. The authors also discuss the discrepan...
Maternal Mortality - Lessons Learnt from Autopsy, 2022
Annals of Pathology and Laboratory Medicine, 2019
With this backdrop, the current study was planned to study hematology histograms in relation with... more With this backdrop, the current study was planned to study hematology histograms in relation with major blood cell components and cases of acute febrile illness. Materials and Methods Ethics: Prior approval was taken from Institutional Ethics Committee before commencing the study. A written informed consent was taken from patients. Methodology: It was a cross sectional observational study conducted over 200 consecutively collected samples in the Department of Pathology of a tertiary care hospital in Mumbai, Maharashtra. Blood samples received for routine complete blood count in the hematology laboratory of
International Journal of Research in Medical Sciences, 2019
Background: Hematolymphoid malignancies (HLM) are primary cancers of blood, bone marrow and lymph... more Background: Hematolymphoid malignancies (HLM) are primary cancers of blood, bone marrow and lymphoid organs associated with high mortality. Clinically undetected cases, diagnosed primarily at autopsy, are common.Methods: Cases of HLMs at autopsy performed in our hospital from 1st January 2009 to 30th June 2017 were analysed. Gross and microscopic findings at autopsy along with clinical parameters were studied. Special stains and immunohistochemistry (IHC) were performed wherever possible.Results: There were 49 cases of HLMs (0.98 %) among 4971 autopsies conducted during the study period, occurring predominantly in males (70 %). Fifteen (30.61 %) were primarily diagnosed at autopsy. There were 26 lymphomas and 19 leukemias; three patients had multiple myeloma and one patient had Langherhan cell histiocytosis. Non-Hodgkin’s lymphoma was the commonest (24 patients). Nine were diffuse large B-cell lymphoma; rare sub-types included angiotrophic lymphoma, post-renal lymphoproliferative di...
Journal of postgraduate medicine
Epithelial neoplasms are uncommon lesions affecting the sino-nasal tract. There are hardly any re... more Epithelial neoplasms are uncommon lesions affecting the sino-nasal tract. There are hardly any reports in the Indian literature. To study the incidence, mode of presentation and histological types of sino-nasal epithelial tumours in the surgical pathology material. Retrospective retrieval of all sino-nasal tumours and analysis of epithelial tumours. All sino-nasal epithelial tumours, biopsied or surgically excised over a period of ten years, were studied. The tumours were classified as benign or malignant. The histology was correlated with the clinical presentation and investigations. In ten years, there were 120 sino-nasal tumours representing 0.14% of all the surgical specimens received. Sixty-nine epithelial tumours (59.2%) outnumbered the non-epithelial tumours and were diagnosed on the basis of histopathology. Twenty were benign and 49 malignant; occurring predominantly in males. Benign lesions included four squamous papillomas and 16 inverted papillomas, with recurrence in thr...
Indian Journal of Medical and Paediatric Oncology, 2014
Context: The pathology of classic Burkitt lymphoma (BL) remains a challenge despite being a well-... more Context: The pathology of classic Burkitt lymphoma (BL) remains a challenge despite being a well-defined entity, in view of the significant overlap with atypical BL and B-cell lymphoma intermediate between DLBL (diffuse large B cell lymphoma) and BL. They are difficult to be segregated in resource-limited setups which lack molecular testing facilities. This is further affected by interobserver variability and experience of the reporting pathologist. Aims: The aim of our study was to quantitate variability among a group of pathologists with an interest in lymphomas (albeit with variable levels of experience) and quantitate the benefit of joint discussions as a tool to increase accuracy and reduce interobserver variability of pathologists, in the diagnosis of BL in a resource-limited setup. Materials and Methods: A set of 25 non-Hodgkin lymphoma cases in which a diagnosis of BL was entertained were circulated to 14 participating pathologist within the Mumbai lymphoma study group. A pr...
Annals of Pathology and Laboratory Medicine, 2019
A Clinico-Hematological Study of Cases of Leucoerythroblastic Reaction With this backdrop, the pr... more A Clinico-Hematological Study of Cases of Leucoerythroblastic Reaction With this backdrop, the present study was planned to study the hematological changes, especially peripheral blood smear (PBS) findings in LER cases. Materials and methods Ethics: Prior approval was taken from Institutional Ethics Committee before commencing the study. A written informed consent was taken from patients or guardian/ parents as applicable. Methodology: The present study was an observational, cross-sectional study conducted over two years of duration
Indian journal of pathology & microbiology, 2002
Among the surgically excised or biopsied sinonasal tumours in a span of ten years, the neurogenic... more Among the surgically excised or biopsied sinonasal tumours in a span of ten years, the neurogenic tumours formed 6.7% of all sinonasal tumours. They were eight in number, three schwannomas, two neurofibromas and three malignant schwannomas with occurrence in a wide age range and no gender predilection. Nasal obstruction and epistaxis were common modes of presentation with a unilateral location. The diagnosis of benign neurogenic tumours do not pose difficulty. However, malignant schwannoma should be considered when one encounters a cellular spindle cell lesion in sinonasal region.
Pathology, 2014
An 8.5-year-old girl presented with breast development, irregular uterine bleeding, and a spurt i... more An 8.5-year-old girl presented with breast development, irregular uterine bleeding, and a spurt in height during the previous 9 months. She also complained of rapid increase of abdominal girth and body weight (4 kg). No remarkable past history or family history was noted. Her height (143 cm), breast development (Tanner stage 3), and pubic hair (Tanner stage 2) were compatible with precocious puberty. Laboratory examinations showed microcytic hypochromic anemia (Hb 9.2 g/dL), and serum estradiol was 138 pg/mL. LH and FSH were in the undetectable level even after a LH-RH (100 μg) injection. Ovarian tumor markers including CEA, CA19-9, CA125, α-fetoprotein, and hCG were within the normal range. Magnetic resonance imaging revealed a giant multilocular cystic tumor (25 × 14 × 10 cm) in the lower abdomen.Tumor resection was performed. The tumor originated from the right ovary and contained 3500 × mL of yellowish serous fluid. The left ovary was grossly normal. The resected right ovarian tumor was multilocular cystic, measuring 16.0 × cm in the greatest dimension, with occasional foci of whitish yellow elevated components in the cystic wall.
Acta Dermato-Venereologica, 1999
Indian Journal of Medical and Paediatric Oncology, 2014
Context: The pathology of classic Burkitt lymphoma (BL) remains a challenge despite being a well-... more Context: The pathology of classic Burkitt lymphoma (BL) remains a challenge despite being a well-defined entity, in view of the significant overlap with atypical BL and B-cell lymphoma intermediate between DLBL (diffuse large B cell lymphoma) and BL. They are difficult to be segregated in resource-limited setups which lack molecular testing facilities. This is further affected by interobserver variability and experience of the reporting pathologist. Aims: The aim of our study was to quantitate variability among a group of pathologists with an interest in lymphomas (albeit with variable levels of experience) and quantitate the benefit of joint discussions as a tool to increase accuracy and reduce interobserver variability of pathologists, in the diagnosis of BL in a resource-limited setup. Materials and Methods: A set of 25 non-Hodgkin lymphoma cases in which a diagnosis of BL was entertained were circulated to 14 participating pathologist within the Mumbai lymphoma study group. A proforma recorded the morphologic and immunohistochemical features perceived during the initial independent diagnosis followed by a consensus meeting for discussion on morphology and additional information pertinent to the case.Statistical analysis and Results:
Annals of pathology and laboratory medicine, Nov 1, 2023
PubMed, Jul 1, 1997
Primary adenocarcinoma is a rare tumour involving the fallopian tube. Two such cases are reported... more Primary adenocarcinoma is a rare tumour involving the fallopian tube. Two such cases are reported; the first case was associated with papillary carcinoma of the paratubal cysts and the second occurred in a young female.
DOAJ (DOAJ: Directory of Open Access Journals), Mar 7, 2000
ABSTRACT Two cases of plasma cell leukaemia--a rare form of leukaemia are described. Both cases p... more ABSTRACT Two cases of plasma cell leukaemia--a rare form of leukaemia are described. Both cases presented with anaemia and hepatosplenomegaly. Investigations revealed leucocytosis with increased plasma cells (> 20%). Skeletal survey revealed a few osteolytic lesions in both cases.
NATIONAL JOURNAL OF LABORATORY MEDICINE
Although eosinophilia is a recognised associated feature of Hodgkin’s Lymphoma, hypereosinophilia... more Although eosinophilia is a recognised associated feature of Hodgkin’s Lymphoma, hypereosinophilia is seldom the presenting feature in the patient. Here, the authors report an unusual case of a 21-year-old male patient who presented to the General Medicine outpatient department of the hospital with a history of multiple episodes of left-sided pleural effusion in addition to mediastinal and cervical lymphadenopathy. Baseline investigations revealed hypereosinophilia which was persistent despite Diethylcarbamazine (DEC) and steroid therapy. Computer Tomography (CT) guided biopsy of an anterior mediastinal mass, likely to be thymus, led to the diagnosis of Hodgkin's Lymphoma. The patient was transferred to the Haematology department where he was started on Adriamycin, Bleomycin, Vinblastine and Dacarbazine (ABVD) chemotherapy regimen. Despite the fact that blood eosinophilia is an associated finding, it is rare for a patient to present with it. The authors also discuss the discrepan...
Maternal Mortality - Lessons Learnt from Autopsy, 2022
Annals of Pathology and Laboratory Medicine, 2019
With this backdrop, the current study was planned to study hematology histograms in relation with... more With this backdrop, the current study was planned to study hematology histograms in relation with major blood cell components and cases of acute febrile illness. Materials and Methods Ethics: Prior approval was taken from Institutional Ethics Committee before commencing the study. A written informed consent was taken from patients. Methodology: It was a cross sectional observational study conducted over 200 consecutively collected samples in the Department of Pathology of a tertiary care hospital in Mumbai, Maharashtra. Blood samples received for routine complete blood count in the hematology laboratory of
International Journal of Research in Medical Sciences, 2019
Background: Hematolymphoid malignancies (HLM) are primary cancers of blood, bone marrow and lymph... more Background: Hematolymphoid malignancies (HLM) are primary cancers of blood, bone marrow and lymphoid organs associated with high mortality. Clinically undetected cases, diagnosed primarily at autopsy, are common.Methods: Cases of HLMs at autopsy performed in our hospital from 1st January 2009 to 30th June 2017 were analysed. Gross and microscopic findings at autopsy along with clinical parameters were studied. Special stains and immunohistochemistry (IHC) were performed wherever possible.Results: There were 49 cases of HLMs (0.98 %) among 4971 autopsies conducted during the study period, occurring predominantly in males (70 %). Fifteen (30.61 %) were primarily diagnosed at autopsy. There were 26 lymphomas and 19 leukemias; three patients had multiple myeloma and one patient had Langherhan cell histiocytosis. Non-Hodgkin’s lymphoma was the commonest (24 patients). Nine were diffuse large B-cell lymphoma; rare sub-types included angiotrophic lymphoma, post-renal lymphoproliferative di...
Journal of postgraduate medicine
Epithelial neoplasms are uncommon lesions affecting the sino-nasal tract. There are hardly any re... more Epithelial neoplasms are uncommon lesions affecting the sino-nasal tract. There are hardly any reports in the Indian literature. To study the incidence, mode of presentation and histological types of sino-nasal epithelial tumours in the surgical pathology material. Retrospective retrieval of all sino-nasal tumours and analysis of epithelial tumours. All sino-nasal epithelial tumours, biopsied or surgically excised over a period of ten years, were studied. The tumours were classified as benign or malignant. The histology was correlated with the clinical presentation and investigations. In ten years, there were 120 sino-nasal tumours representing 0.14% of all the surgical specimens received. Sixty-nine epithelial tumours (59.2%) outnumbered the non-epithelial tumours and were diagnosed on the basis of histopathology. Twenty were benign and 49 malignant; occurring predominantly in males. Benign lesions included four squamous papillomas and 16 inverted papillomas, with recurrence in thr...
Indian Journal of Medical and Paediatric Oncology, 2014
Context: The pathology of classic Burkitt lymphoma (BL) remains a challenge despite being a well-... more Context: The pathology of classic Burkitt lymphoma (BL) remains a challenge despite being a well-defined entity, in view of the significant overlap with atypical BL and B-cell lymphoma intermediate between DLBL (diffuse large B cell lymphoma) and BL. They are difficult to be segregated in resource-limited setups which lack molecular testing facilities. This is further affected by interobserver variability and experience of the reporting pathologist. Aims: The aim of our study was to quantitate variability among a group of pathologists with an interest in lymphomas (albeit with variable levels of experience) and quantitate the benefit of joint discussions as a tool to increase accuracy and reduce interobserver variability of pathologists, in the diagnosis of BL in a resource-limited setup. Materials and Methods: A set of 25 non-Hodgkin lymphoma cases in which a diagnosis of BL was entertained were circulated to 14 participating pathologist within the Mumbai lymphoma study group. A pr...
Annals of Pathology and Laboratory Medicine, 2019
A Clinico-Hematological Study of Cases of Leucoerythroblastic Reaction With this backdrop, the pr... more A Clinico-Hematological Study of Cases of Leucoerythroblastic Reaction With this backdrop, the present study was planned to study the hematological changes, especially peripheral blood smear (PBS) findings in LER cases. Materials and methods Ethics: Prior approval was taken from Institutional Ethics Committee before commencing the study. A written informed consent was taken from patients or guardian/ parents as applicable. Methodology: The present study was an observational, cross-sectional study conducted over two years of duration
Indian journal of pathology & microbiology, 2002
Among the surgically excised or biopsied sinonasal tumours in a span of ten years, the neurogenic... more Among the surgically excised or biopsied sinonasal tumours in a span of ten years, the neurogenic tumours formed 6.7% of all sinonasal tumours. They were eight in number, three schwannomas, two neurofibromas and three malignant schwannomas with occurrence in a wide age range and no gender predilection. Nasal obstruction and epistaxis were common modes of presentation with a unilateral location. The diagnosis of benign neurogenic tumours do not pose difficulty. However, malignant schwannoma should be considered when one encounters a cellular spindle cell lesion in sinonasal region.
Pathology, 2014
An 8.5-year-old girl presented with breast development, irregular uterine bleeding, and a spurt i... more An 8.5-year-old girl presented with breast development, irregular uterine bleeding, and a spurt in height during the previous 9 months. She also complained of rapid increase of abdominal girth and body weight (4 kg). No remarkable past history or family history was noted. Her height (143 cm), breast development (Tanner stage 3), and pubic hair (Tanner stage 2) were compatible with precocious puberty. Laboratory examinations showed microcytic hypochromic anemia (Hb 9.2 g/dL), and serum estradiol was 138 pg/mL. LH and FSH were in the undetectable level even after a LH-RH (100 μg) injection. Ovarian tumor markers including CEA, CA19-9, CA125, α-fetoprotein, and hCG were within the normal range. Magnetic resonance imaging revealed a giant multilocular cystic tumor (25 × 14 × 10 cm) in the lower abdomen.Tumor resection was performed. The tumor originated from the right ovary and contained 3500 × mL of yellowish serous fluid. The left ovary was grossly normal. The resected right ovarian tumor was multilocular cystic, measuring 16.0 × cm in the greatest dimension, with occasional foci of whitish yellow elevated components in the cystic wall.
Acta Dermato-Venereologica, 1999
Indian Journal of Medical and Paediatric Oncology, 2014
Context: The pathology of classic Burkitt lymphoma (BL) remains a challenge despite being a well-... more Context: The pathology of classic Burkitt lymphoma (BL) remains a challenge despite being a well-defined entity, in view of the significant overlap with atypical BL and B-cell lymphoma intermediate between DLBL (diffuse large B cell lymphoma) and BL. They are difficult to be segregated in resource-limited setups which lack molecular testing facilities. This is further affected by interobserver variability and experience of the reporting pathologist. Aims: The aim of our study was to quantitate variability among a group of pathologists with an interest in lymphomas (albeit with variable levels of experience) and quantitate the benefit of joint discussions as a tool to increase accuracy and reduce interobserver variability of pathologists, in the diagnosis of BL in a resource-limited setup. Materials and Methods: A set of 25 non-Hodgkin lymphoma cases in which a diagnosis of BL was entertained were circulated to 14 participating pathologist within the Mumbai lymphoma study group. A proforma recorded the morphologic and immunohistochemical features perceived during the initial independent diagnosis followed by a consensus meeting for discussion on morphology and additional information pertinent to the case.Statistical analysis and Results: