Gholamreza Kheirabadi | Isfahan University of Medical Sciences (original) (raw)

Papers by Gholamreza Kheirabadi

Substance Use & Misuse

Research Square (Research Square), Jan 14, 2021

Background: An unplanned pregnancy may be followed by increased depression and anxiety. The aim o... more Background: An unplanned pregnancy may be followed by increased depression and anxiety. The aim of the present study was to evaluate the mediating role of partner's emotional reaction to pregnancy (PERP) on the relationship between pregnancy planning and prenatal mental health. Methods: This cross-sectional study was conducted on 303 healthy Iranian pregnant women during their third trimester. The levels of depression and anxiety were measured using the Edinburgh Postnatal Depression Scale and the State-Trait Anxiety Inventory. The PERP score was also measured using a researcher-made questionnaire. The data were analyzed using the plug-in application PROCESS macro. Results: The results showed that PERP score was reversely related to pregnancy planning and prenatal depression and anxiety. The direct effect of the pregnancy planning on depression (c=-.05) and anxiety levels (c=-.02) were not signi cant; but the indirect effect of pregnancy planning on depression (Point Estimate=-.379, CI:-.523 to-.250) and anxiety levels (Point Estimate=-.560, CI:-.741 to-.385) with the mediating role of PERP were signi cant. Conclusions: The results indicated that the effect of pregnancy planning on prenatal mental health is mediated by PERP, and in unplanned pregnancy women need to receive positive reaction of their partners toward pregnancy so that they can preserve their mental health.

Journal of Substance Use, Mar 11, 2021

ABSTRACT Background Since addiction is a common problem in the general population, successful add... more ABSTRACT Background Since addiction is a common problem in the general population, successful addiction treatment requires multidimensional and long-term interventions. This study aimed to investigate the effectiveness of Transactional Analysis on primary maladaptive schemas, interpersonal problems, and treatment acceptance in patients under Methadone Maintenance Treatment (MMT) Methods This study was quasi-experimental with a pretest, posttest, and a control group. Twenty-four male MMT patients were selected from an outpatient addiction clinic and randomly assigned to the intervention and control groups, but due to attrition, each group included 11 patients. The data were collected by the Young Schema Questionnaire – Short Form Version 3 (YSQ-S3), Inventory of Interpersonal Problems-32 (IIP-32), and the Stages of Change, Readiness and Treatment Eagerness Scale (SOCRATES). The intervention group underwent ten sessions of Transactional Analysis intervention, and the data were analyzed using aanalysis of variance (ANOVA) Results The results revealed that Transactional Analysis intervention significantly influenced interpersonal problems and readiness for treatment. The mean scores of Abandonment in the control group, Vulnerability to harm, and Entitlement in the intervention group were significantly different, but other variables did not differ significantly Conclusion Transactional Analysis Intervention can positively influence interpersonal problems and readiness for treatment in patients under MMT.

International Journal of Pediatrics, 2020

Background: Non-suicidal self-injury (NSSI) refers to the intentional damage of one's own body wi... more Background: Non-suicidal self-injury (NSSI) refers to the intentional damage of one's own body without a suicidal intent, which involves common behaviors such as cutting, burning, scratching, and hitting the body. Identifying factors associated with the development and continuity of NSSI is a research priority, as prevention is crucial. The aim of the current study was to determine factors associated with NSSI in Iran. Materials and Methods: In this systematic review, Persian databases including Barakat Knowledge Network System, Magiran, SID, and international databases including Scopus, Medline, and Web of Science were searched for relevant publications in English and Persian by using the following Medical Subject Headings search terms: "behavior self-injurious" OR "deliberate self-harm" OR "deliberate self-harm" OR "self-destructive behavior" OR "non-suicidal self-injury" AND "Iran": from 1983 until September 2019. Two independent reviewers studied the full text of the articles and extracted the main results. The results of studies were classified and presented descriptively with a narrative approach. Results: A total of 334 articles were found of which 18 articles (n= 17343) met the inclusion criteria and were reviewed. More than half of the reviewed articles were cross-sectional (n=16). Three main themes were identified: factors associated with baseline characteristics (such as age and gender); mental disorders (such as depression); and psycho-social factors associated with mental disorders (such as self-concept disturbance). Conclusion: The meaning of identified main themes shows that the most important factor in occurrence of NSSI in Iranian patients is mental health status. Since the majority of studies were cross-sectional, the data do not yet justify risk factors. Therefore, longitudinal studies with adequate methodological qualities are recommended in future studies.

Journal of Research in Medical Sciences, 2019

It has been suggested that immune system impairment is affected by the pathogenesis of major depr... more It has been suggested that immune system impairment is affected by the pathogenesis of major depression, and there is an association between depression and activation of the innate inflammatory immune response, including changes in the ability of immune cells in expressing inflammatory cytokines. [4] In addition, there is an association between inflammatory markers and depression symptoms such as fatigue, poor cognitive function, and sleep disorders. [5-7] Elevated total number of white blood cells and number and Background: Involvement of the immune system is one of the issues raised in the pathophysiology of depression. BCL2 and BAX genes are related to immune system regulation. We investigated the BCL2 and BAX expression as a probable mechanism of immune system involvement in depression. Materials and Methods: This case-control study was conducted on 28 patients with major depression (case) and 28 nondepressed individuals (control) within the age range of 18-55 years in the Isfahan University of Medical Sciences. Clinical interviews, based on the Diagnostic and Statistical Manual of Mental Disorders, were conducted to detect depression, and Beck's Depression Inventory was used to measure the severity of depression in the individuals. In addition, a real-time polymerase chain reaction was employed to compare the level of Bax and Bcl-2 gene expression in peripheral blood lymphocytes. The multivariate covariance analysis was used to explore the correlation between BCL2 and BAX gene expression and to control the effect of duration and severity of depression. Results: The results showed that none of the variables including group membership, the duration of depression, and the severity of depression were not significantly correlated with the expression of BCL2 and BAX genes. Furthermore, there was no statistically significant relationship between the Bax and Bcl-2 genes expression in case and control groups (P > 0.05). Conclusion: Depression may have no impact on Bax and Bcl-2 gene expression in patients with major depression. Studies with larger sample size are recommended.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, Feb 28, 2023

Objective: Brain-derived neurotrophic factor (BDNF) and high sensitive C-reactive protein (hs-CRP... more Objective: Brain-derived neurotrophic factor (BDNF) and high sensitive C-reactive protein (hs-CRP) have been reported to play roles in depression and bipolar disorder (BD). However, the probable discriminatory properties of these biologic markers are less investigated. We aimed to assess the serum BDNF and hs-CRP levels among Iranian patients with major depressive disorder (MDD) and BD during a depressive episode and investigate the optimum cutoff point for differential diagnosis of BD and MDD. Methods: We recruited 30 patients with MDD, 30 with BD in depressive mood and 30 healthy comparators. Blood sample was taken from each participant to measure BDNF and hs-CRP levels. We also used receiver operating characteristic (ROC) curve analysis to find an optimal cutoff point for differentiating MDD from BD according to pre-defined variables. Results: The mean age of total study population was 37.3 ± 5.0 years (males: 49%). BDNF was significantly lower in patients with BD, followed by MDD subjects and healthy controls 541.0 ± 601.0 pg/ml vs. 809.5 ± 433.3 pg/ml vs. 1,482.1 ± 519.8, respectively, p ＜ 0.001). The area under curve of ROC curve analysis for BD versus MDD was 0.704 (95% confidence interval: 0.564−0.844, p = 0.007). We also found that the BDNF cutoff value of 504 could appropriately distinguished BD from MDD (sensitivity: 73%, specificity: 70%). No significant association were identified in terms of hs-CRP levels. Conclusion: Patients suffering from BD had lowest BDNF levels compared to MDD or healthy adults and this biomarker could play a practical role differentiating MDD from BD. Several studies are required confirming our outcomes.

International Journal of Medical Research and Health Sciences, May 1, 2016

This study was conducted in 2015 with goal of analysis of the effects of a support program based ... more This study was conducted in 2015 with goal of analysis of the effects of a support program based on psychosocial needs of families on care burdens of family caregivers of patients with ischemic heart disease hospitalized in Chamran heart ward of Isfahan University of Medical Sciences. This study in terms of purpose is functional and in terms of data gathering is Field survey. The population of this study consisted of 64 patients with ischemic heart disease (32 people in experimental group and 32 people in control group) who were referred to inner heart wards of Chamran hospital. Data collection tools were 2 questionnaires; Psychosocial Needs Assessment questionnaire and Care Burden questionnaire. Results of study showed that in the control group the mean score of the Care burdens was a significant difference between three times (p< 0.05). Apart from the physical realm there was no significant difference observed between control groups. The results showed that immediately after the intervention (p<0/001) and one month after intervention (p<0.001) the average score of the overall Care burdens and areas of (physical, emotional, social, developmental and time) in control group was significantly higher than experimental group and there was a significant difference between the two groups. The results also showed that findings revealed that before intervention, there was no significant difference between the two experimental and control groups in average of overall Care burdens and areas of (physical, emotional, social, developmental and time) of caregivers of patients with ischemic heart disease.

Journal of education and health promotion, 2016

Introduction: The process of assisted reproductive treatment is a stressful situation in the trea... more Introduction: The process of assisted reproductive treatment is a stressful situation in the treatment of infertile couples and it would harm the mental health of women. Fertile women who started infertility treatment due to male factor infertility have reported to experience less stress and depression than other women before the assisted reproductive process but considering the cultural and social factors and also the etiology of the assisted reproductive process, it could affect the metal health of these women. Therefore, this study was conducted to evaluate the mental health of fertile women who undergo assisted reproductive treatment due to male factor infertility. Materials and Methods: This study was a prospective study on 70 fertile women who underwent assisted reproductive treatment due to male factor infertility. The exclusion criterion was to stop super ovulation induction. To assess mental health, anxiety and depression dimensions of the general health questionnaire were used. Before starting ovulation induction and after oocyte harvesting, the general health questionnaire was filled by women who were under treatment. Data were analyzed using multi-variable linear regression, paired t-test, and Chi-square. Results: The results showed that the mean score of depression and anxiety before ovulation induction and after oocyte harvesting were not significantly different; but the rate of mental health disorder in the depression dimension was significantly decreased after oocytes harvesting (31.7% vs. 39.7%). Also, there was a significant relation between the level of anxiety and depression before ovulation induction and after oocyte harvesting (P < 0.05). The anxiety level after oocyte harvesting had a positive and significant correlation with the economic situation (P < 0.05). Conclusion: This study revealed that the process of assisted reproductive treatment does not affect the mental health in fertile women independently, but these women start assisted reproductive process with high levels of depression and anxiety. Therefore, prior to the assisted reproductive treatment mental health consultation is needed.

Advanced Biomedical Research, 2023

PubMed, Dec 17, 2022

Background: Drug use is known as an important underlying factor in the occurrence of risky sexual... more Background: Drug use is known as an important underlying factor in the occurrence of risky sexual behaviors. The present study was conducted to identify the factors associated with the involvement of women drug users in risky sexual behaviors. Materials and methods: This review was conducted by searching databases of ISI Web of Science, Scopus, Science Direct, Cochrane, PubMed, Scientific Information Database (SID), the Iranian Magazine Database (Magiran), the Iranian Research Institute for Information Science and Technology (IranDoc), and the Iranian Medical Articles Database (IranMedex) and searching through the Google Scholar engine. All the articles published in English and Persian using the keywords including substance use, drug users, addiction, substance use disorders, substance-related disorders, sexual risks, high-risk sexual behavior, HIV risk behavior, unsafe sex, unprotected sex, and risky sex were searched from January 2000 to December 2020. After reviewing the articles, out of 110 articles, 21 articles were selected for final evaluation. Results: Factors related to the involvement of women drug users in risky sexual behaviors were divided into five categories: individual factors, factors related to drug use, inter-personal relationships, gender discrimination, and socio-economic factors. Conclusions: The results can be used in the field of women's social harms in finding strategies and designing the necessary interventions to prevent risky sexual behaviors in women drug users in different societies and cultural contexts. Also, the results can be used by all researchers who want to study the relationship between these factors and the involvement of women drug users in risky sexual behaviors.

Reproductive Health, Jun 1, 2020

Background: Drug use is an important underlying factor in risky sexual behaviors. Risky sexual be... more Background: Drug use is an important underlying factor in risky sexual behaviors. Risky sexual behaviors can lead to STIs and HIV/AIDS, especially in women. For better understanding of the relationship between drug use and risky sexual behaviors in women, it is necessary to identify the process of the formation of these behaviors that is a multidimensional process influenced by multiple socio-cultural factors. Therefore, the present study aims to explore the process of risky sexual behaviors formation in women drug users. Methods: This is a grounded theory qualitative study with Corbin and Strauss approach. The participants of the study are women drug users with risky sexual behaviors who, using purposeful sampling method, will be selected from the Counseling and Harm Reduction centers for vulnerable women, the Drug Rehabilitation centers affiliated to the Isfahan University of Medical Sciences, Therapeutic Community Rehabilitation centers, Drop in Centers affiliated to the Welfare Organization, Medium-term Residential centers (women's camps), and Women's Empowerment centers in Isfahan, Iran. Sampling will continue using snowball method and the strategy of maximum variation in terms of the age, occupation, education, duration of the drug use, and type of the drug. During the sampling process, theoretical sampling will gradually replace purposeful sampling, so that sampling will proceed based on the emergence of the theory and for understanding of the concept and, then, the next participants will be selected. Sampling will continue until data saturation is reached. Data will be collected using individual semi-structured in-depth interviews, observation, field notes, and memo writing. Data will be coded as they are collected, and the analysis will be performed at three levels of open, axial, and selective coding and based on the constant comparative analysis. The four criteria of credibility, dependability, transferability and confirmability will be used to ensure the trustworthiness of the data. Discussion: The findings of the present study are expected to provide a better understanding of the process of risky sexual behaviors formation in women drug users. The findings may also lead to the identification of the barriers and factors contributing to the formation of such behaviors and, finally, will promote the reproductive and sexual health of these women. This study can also provide the guide and the ground for designing and conducting further studies in the related areas through using various qualitative and quantitative methods.

DOAJ (DOAJ: Directory of Open Access Journals), 2021

Background: A low level of vitamin B6 may theoretically cause symptoms of depression. Aims: To in... more Background: A low level of vitamin B6 may theoretically cause symptoms of depression. Aims: To investigate the effect of vitamin B6 on the prevention of postpartum depression (PPD) among mothers at risk for PPD. Methods: This single-blind, placebo-controlled clinical trial was conducted on 81 pregnant women who were at risk of PPD from February to July 2016 at six selected health centers in Isfahan, Iran. A simple random sampling method was adopted. Forty cases and 41 controls received 80 mg vitamin B6 and placebo, respectively from the 28 th week until the end of pregnancy. The risk of PPD was assessed as the main inclusion criteria using a structured clinical interview using hospital anxiety-depressive scale (HADS), social support appraisals scale (SS-A), and Holmes and Rahe life change and stress evaluation questionnaire (HRLCSEQ). The Edinburgh postpartum depression scale (EPDS) was used to assess the rate of depression prior to and 1.5 months after the intervention (end of pregnancy). Data were analyzed using SPSS 20 and statistical tests (Chi-square, independent t-test, Mann-Whitney's, and Exact Fisher Test). Results: Forty-three subjects were assigned to each group and the final analysis comprised 81 subjects (40 in the case and 41 in the control groups), the mean age of the case and control groups being 5.8 ± 29.6 and 4.6 ± 28.2, respectively. The mean depression score was 10.4 ± 1.4 in the case and 9.3 ± 4.2 in control groups (P = 0.34) before and 4.2 ± 2.7 in the case and 10.4 ± 3.4 in control groups (P < 0.001) after intervention. Conclusions: Vitamin B6 has a positive effect on reducing postpartum depression scores among mothers at risk for PPD. These may be clinically useful for preventing PPD in high-risk women.

Qom University of Medical Sciences Journal, May 1, 2020

Background and Objectives: Postpartum depression is a mood disorder that weakens the relationship... more Background and Objectives: Postpartum depression is a mood disorder that weakens the relationship between couple and between mother and child and has negative effects on health, quality of life of the affected and family members. Depression in women is highly affected by social and demographic risk factors. The purpose of the present study was to investigate the congenital risk factors for postpartum depression in Natanz city. Methods: The current study is a descriptive study in which 673 women who referred to Natanz health centers in 2018, were examined two weeks to two months after their delivery. The research tools were 2 questionnaires of standard Edinburgh and demographic information. Results: The overall prevalence of depression in the study population was obtained to be 7.1%. Maternal illness and preterm birth and sex of baby, were among the factors associated with postpartum depression. The mother's age, education, occupation, wanted or unwanted pregnancy, type of baby feeding, the birth rate, type of delivery, mother's thyroid disease, and baby hospitalization, were not related to maternal depression. Conclusion: Investigating the factors related to postpartum depression in this research will help the health team for better planning to manage this disorder, and to prevent the disorder, educational and supportive programs should be implemented during pregnancy and after delivery for the mother and those around her, and by timely referral of mothers at risk of postpartum depression, the complications of this disorder could be prevented to some extent.

We present a global experience-sampling method (ESM) study aimed at describing, predicting, and u... more We present a global experience-sampling method (ESM) study aimed at describing, predicting, and understanding individual differences in well-being during times of crisis such as the COVID-19 pandemic. This international ESM study is a collaborative effort of over 60 interdisciplinary researchers from around the world in the “Coping with Corona” (CoCo) project. The study comprises trait-, state-, and daily-level data of 7,490 participants from over 20 countries (total ESM measurements = 207,263; total daily measurements = 73,295) collected between October 2021 and August 2022. We provide a brief overview of the theoretical background and aims of the study, present the applied methods (including a description of the study design, data collection procedures, data cleaning, and final sample), and discuss exemplary research questions to which these data can be applied. We end by inviting collaborations on the CoCo dataset.

Current Psychosomatic Research

Background and Objective: The perception of illness can affect a person’s mental health and abili... more Background and Objective: The perception of illness can affect a person’s mental health and ability to cope with illnesses. Meanwhile, personality traits can affect an individual’s lifestyle and quality of life (QoL). This study aims to investigate the role of illness perception as a mediator between personality variables and QoL in patients with a heart attack. Materials & Methods: This was a cross-sectional study conducted on 193 patients with a heart attack at least 6 to 12 months before the study. The patients were selected via the available sampling method from the cardiovascular clinics of Shahid Chamran, Al-Zahra, and Khurshid hospitals in Isfahan City, Iran. The participants were evaluated using the scale of disease perception, the QoL questionnaire, and the 5-factor personality questionnaire. The data were analyzed by the path analysis method. Results: In this study, 128(66.32%) participants were male and 66(33.68%) were female, with an mean age of 61.4±10.7 years. In the p...

Military Caring Sciences

Introduction: The importance of the Air Force's ability to protect and defend any country is obvi... more Introduction: The importance of the Air Force's ability to protect and defend any country is obvious. The well-performed air force depends on the capabilities, mental and physical health of staff. Family as an environmental factor plays a significant role in the development and maintenance of mental health disorders. Objective: This study aimed to investigate the relationship between family function and stress, anxiety and depression in Isfahan Air Force pilots during 2019-2020. Materials and Methods: In this descriptive study, 120 military air force pilots completed the standard family functioning (FAD), anxiety, stress and depression (DASS) questionnaires. After excluding invalid questionnaires, data were collected from 103 individuals and analyzed in SPSS20. The significant level is considered 0.05. Results: Linear regression analysis showed that the family function was scored 0.16, 0.05 and 0.05 in in depression, anxiety and stress, respectively. The family function was a significant predictor of depression, anxiety and stress in participants. The results showed that based on beta coefficients, each 0.25, 0.24 and 0.24 change in family performance score resulted in a significant change in participants' depression, anxiety and stress scores, respectively (P <0.05). Discussion and Conclusion: Based on results of this study, it can be concluded that decreasing family function increases anxiety, depression and stress in pilots. Therefore military families should be considred.

Journal of Psychiatry, 2017

Journal of Clinical Psychopharmacology, 2021

Background Methamphetamine addiction is a global issue. Buprenorphine might have beneficial roles... more Background Methamphetamine addiction is a global issue. Buprenorphine might have beneficial roles in reducing craving to methamphetamine use via altering neurotransmission signaling and dopaminergic system-related reward mechanisms. Procedures This clinical trial was performed in 2019 to 2020 in Khorshid Hospital, Isfahan, Iran. The study was conducted on patients with methamphetamine use disorder. The intervention group received sublingual buprenorphine for 8 weeks, and the other group also received placebo tablets. Patients were followed up and visited every month for the next 4 months. Both groups were treated simultaneously by matrix program for 2 months and observed for the next 4 months. Patients filled out the Cocaine Craving Questionnaire-Brief (CCQ-Brief) every week during intervention time (first 2 months) and every month during follow up visits (4 months). The Depression Anxiety Stress Scale (DASS-21) was also filled out before and after interventions for all of the patie...

Journal of Substance Use, Aug 15, 2022

International archives of health sciences, 2020

Aims: Hypertension is a serious health problem that requires lifelong treatment. The patient'... more Aims: Hypertension is a serious health problem that requires lifelong treatment. The patient's nonadherence with antihypertensive medications is the major factor in treatment failure. Previous studies have suggested that adherence may be related to psychological factors consisting of personality traits. Materials and Methods: This cross-sectional study included 194 hypertensive patients referred to Alzahra Cardiovascular Clinic. The patients were asked to complete two questionnaires, including the NEO Big Five and adherence questionnaire. Results: Statistical analyses showed a significant negative correlation between neuroticism and medical adherence (CC = −0.148, PV = 0.002, CI = −0.240/−0.056), and extroversion had a significant positive correlation (CC = 0.161, PV = 0.001, CI = 0.260/0.052). The other aspects of personality traits had no significant correlation with medical adherence. Conclusion: Neuroticism may be a negative predictor and extroversion may be a positive predictor of medical adherence in hypertensive patients.