SAMANTHA Dsouza | Father Muller Medical College and hospital (original) (raw)
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Background: Despite the advances in breast cancer treatment, it has a higher rate of mortality. T... more Background: Despite the advances in breast cancer treatment, it has a higher rate of mortality. The response of treatment varies significantly; this could be due to the various subtypes that determine the course of the disease. In this study, we evaluated patients who were treated definitively and had developed organ-specific metastasis and local recurrence according to biological subtype. Materials and Methods: Out of 856 patients who were diagnosed to have carcinoma breast from the year January 2015 to January 2020, 468 patients were treated definitively, out of which 55 patients developed recurrent or metastatic disease after completion of treatment. Results: The most frequent subgroup for relapse was triple-negative breast cancer (TNBC) 23 (41.8%). Twenty-two (40%) had multiple metastases at the time of first distant recurrence. The most common site of distant recurrence was bone 28 patients (50.9%) with maximum incidence in Luminal B subgroup (23.6%), followed by liver metastasis 23 patients (41.81%) with the highest incidence seen among TNBC (18%), followed by lung 19 (34.5%) patients with maximum incidence in TNBC (16.3%) followed by brain 5 (9%) patients. Locoregional recurrence was observed in 13 patients, out of which 8 (61.5%) patients had TNBC molecular subgroup. Conclusion: Our results demonstrate an association between molecular subtype and pattern of recurrence.
The success of any hard work comes from the constant encouragement and support of the people apar... more The success of any hard work comes from the constant encouragement and support of the people apart from the effort of the person who has done it. The satisfaction and the euphoria that accompanies the successful completion of any task would be incomplete without the mention of the person who made it possible. The only way in which we can express our gratitude to these people is by mentioning their name in the reports. First and foremost, I would like to thank the lord for his blessings, for being my guiding light and strength throughout the course. I express my sincere gratitude to my guide DR. DONALD J. FERNANDES Professor and Head of the Department, Department of Radiotherapy, Father Muller Medical College, Kankanady, Mangalore. Without his valuable suggestions, technical expertise and constant encouragement it would not have been possible to achieve this goal.
Background: Despite the advances in breast cancer treatment, it has a higher rate of mortality. T... more Background: Despite the advances in breast cancer treatment, it has a higher rate of mortality. The response of treatment varies significantly; this could be due to the various subtypes that determine the course of the disease. In this study, we evaluated patients who were treated definitively and had developed organ-specific metastasis and local recurrence according to biological subtype. Materials and Methods: Out of 856 patients who were diagnosed to have carcinoma breast from the year January 2015 to January 2020, 468 patients were treated definitively, out of which 55 patients developed recurrent or metastatic disease after completion of treatment. Results: The most frequent subgroup for relapse was triple-negative breast cancer (TNBC) 23 (41.8%). Twenty-two (40%) had multiple metastases at the time of first distant recurrence. The most common site of distant recurrence was bone 28 patients (50.9%) with maximum incidence in Luminal B subgroup (23.6%), followed by liver metastasis 23 patients (41.81%) with the highest incidence seen among TNBC (18%), followed by lung 19 (34.5%) patients with maximum incidence in TNBC (16.3%) followed by brain 5 (9%) patients. Locoregional recurrence was observed in 13 patients, out of which 8 (61.5%) patients had TNBC molecular subgroup. Conclusion: Our results demonstrate an association between molecular subtype and pattern of recurrence.
The success of any hard work comes from the constant encouragement and support of the people apar... more The success of any hard work comes from the constant encouragement and support of the people apart from the effort of the person who has done it. The satisfaction and the euphoria that accompanies the successful completion of any task would be incomplete without the mention of the person who made it possible. The only way in which we can express our gratitude to these people is by mentioning their name in the reports. First and foremost, I would like to thank the lord for his blessings, for being my guiding light and strength throughout the course. I express my sincere gratitude to my guide DR. DONALD J. FERNANDES Professor and Head of the Department, Department of Radiotherapy, Father Muller Medical College, Kankanady, Mangalore. Without his valuable suggestions, technical expertise and constant encouragement it would not have been possible to achieve this goal.