mahdi shahri | Mashhad University of Medical Sciences, Mashhad. Iran. (original) (raw)
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Purpose: To evaluate the correlation of Bcl-2 and Bax protein expressions with biochemical failur... more Purpose: To evaluate the correlation of Bcl-2 and Bax protein expressions with biochemical failure-free survival in patients with advanced or metastatic prostate @@@@@@@@@@@@@@@@@@@@@€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Materials and Methods: This retrospective study was performed on patients with therapy. Samples were analyzed immunohistochemically for Bax and Bcl-2 expression. The H-score was calculated for each sample based on intensity and per-Results: Thirty-seven patients (13 metastatic and 24 locally advanced) were eligi-tween Bax expression and Gleason score, high Bcl-2 expression (H-score > 85) P months and 16 (range, 9 to 26) months, respectively. High Bcl-2 expression (P = @@@@@@@@@@@@@@@@@ P of lower biochemical progression-free survival. Conclusion: High Bcl-2 expression was associated with higher Gleason scores @@@@@@@@@@@@@@@@@ androgen deprivation therapy.
Journal of Research in Medical Sciences the Official Journal of Isfahan University of Medical Sciences, Nov 1, 2010
Bronchial leiomyoma is extremely rare. To date less than 60 cases have been reported in the world... more Bronchial leiomyoma is extremely rare. To date less than 60 cases have been reported in the world literature. The presented case here is a 30 year old woman who had been treated for bronchial asthma for several years. Her chest radiograph showed bulluos emphysematous changes in the right lung and computer tomography scan found the tumor in the right main bronchus near carina. Diagnosis was made by histological and immunohistochemical examination of the specimens obtained during bronchoscopy. The patient was treated by bonchoscopic resection of the 3 centimetre firm tumor and its removal through a tracheostomy incision.
Indian Journal of Pathology and Microbiology, 2013
Lung cancer is the leading cause of cancer death worldwide. In addition to smoking, a variety of ... more Lung cancer is the leading cause of cancer death worldwide. In addition to smoking, a variety of other contributing factors, including viral infection, have been suggested in tumorigenesis. Epstein Barr virus (EBV), which is linked to various malignancies, seems to be a good candidate. The aim of this study was to investigate the association of EBV with lung carcinomas. A total number of 90 formalin fixed paraffin embedded lung tissue samples including 48 cases of lung cancers (18 squamous cell carcinomas [SCCs], 18 adenocarcinomas and 12 small cell carcinomas) and 42 non-tumoral samples (control group), were retrieved from the pathology archive. Following deoxyribonucleic acid extraction, polymerase chain reaction (PCR) was performed using an EBV-Eph PCR kit. The positive cases were studied immunohistochemically for the expression of EBV-late membrane protein-1 (EBV-LMP-1) in tumoral tissues. The t-test and Fisher exact test were used and P < 0.05 was considered statistically significant. Five of our cases, including four SCCs and one adenocarcinoma and two control samples showed a positive reaction in PCR. All positive tumoral cases showed diffuse staining with LMP-1 in immunohistochemistry. We found a significant difference in the presence of the EBV genome in cases of lung SCC compared to other lung lesions (P = 0.02). According to our data, EBV is not at major play in the non-lymphoepithelioma-like cancers of the lung in general, but may have a role in the tumorigenesis of some lung SCCs.
Purpose: To evaluate the correlation of Bcl-2 and Bax protein expressions with biochemical failur... more Purpose: To evaluate the correlation of Bcl-2 and Bax protein expressions with biochemical failure-free survival in patients with advanced or metastatic prostate @@@@@@@@@@@@@@@@@@@@@€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€€ Materials and Methods: This retrospective study was performed on patients with therapy. Samples were analyzed immunohistochemically for Bax and Bcl-2 expression. The H-score was calculated for each sample based on intensity and per-Results: Thirty-seven patients (13 metastatic and 24 locally advanced) were eligi-tween Bax expression and Gleason score, high Bcl-2 expression (H-score > 85) P months and 16 (range, 9 to 26) months, respectively. High Bcl-2 expression (P = @@@@@@@@@@@@@@@@@ P of lower biochemical progression-free survival. Conclusion: High Bcl-2 expression was associated with higher Gleason scores @@@@@@@@@@@@@@@@@ androgen deprivation therapy.
Journal of Research in Medical Sciences the Official Journal of Isfahan University of Medical Sciences, Nov 1, 2010
Bronchial leiomyoma is extremely rare. To date less than 60 cases have been reported in the world... more Bronchial leiomyoma is extremely rare. To date less than 60 cases have been reported in the world literature. The presented case here is a 30 year old woman who had been treated for bronchial asthma for several years. Her chest radiograph showed bulluos emphysematous changes in the right lung and computer tomography scan found the tumor in the right main bronchus near carina. Diagnosis was made by histological and immunohistochemical examination of the specimens obtained during bronchoscopy. The patient was treated by bonchoscopic resection of the 3 centimetre firm tumor and its removal through a tracheostomy incision.
Indian Journal of Pathology and Microbiology, 2013
Lung cancer is the leading cause of cancer death worldwide. In addition to smoking, a variety of ... more Lung cancer is the leading cause of cancer death worldwide. In addition to smoking, a variety of other contributing factors, including viral infection, have been suggested in tumorigenesis. Epstein Barr virus (EBV), which is linked to various malignancies, seems to be a good candidate. The aim of this study was to investigate the association of EBV with lung carcinomas. A total number of 90 formalin fixed paraffin embedded lung tissue samples including 48 cases of lung cancers (18 squamous cell carcinomas [SCCs], 18 adenocarcinomas and 12 small cell carcinomas) and 42 non-tumoral samples (control group), were retrieved from the pathology archive. Following deoxyribonucleic acid extraction, polymerase chain reaction (PCR) was performed using an EBV-Eph PCR kit. The positive cases were studied immunohistochemically for the expression of EBV-late membrane protein-1 (EBV-LMP-1) in tumoral tissues. The t-test and Fisher exact test were used and P < 0.05 was considered statistically significant. Five of our cases, including four SCCs and one adenocarcinoma and two control samples showed a positive reaction in PCR. All positive tumoral cases showed diffuse staining with LMP-1 in immunohistochemistry. We found a significant difference in the presence of the EBV genome in cases of lung SCC compared to other lung lesions (P = 0.02). According to our data, EBV is not at major play in the non-lymphoepithelioma-like cancers of the lung in general, but may have a role in the tumorigenesis of some lung SCCs.