PETER OLABODE | University of Abuja,Abuja.Nigeria (original) (raw)

Papers by PETER OLABODE

Journal of US-China Medical Science, 2017

Epithelioid haemangioendothelioma is a rare vascular tumor, described for the first time in 1975 ... more Epithelioid haemangioendothelioma is a rare vascular tumor, described for the first time in 1975 by Dail and Liebow as an aggressive bronchoalveolar cell carcinoma. It represents 1% of all vascular tumours, due to its heterogeneous presentation, it is often misdiagnosed and not suitably treated. The etiology is still a dilemma. Most of the times it affects lung, liver and bones, although this kind of tumor may involve the head and neck area, breast, lymph nodes, mediastinum, brain and meninges, the spine, skin, abdomen and many other sites. Mesentery involvement is very rare. We report a case of 22-year old female student, who presented with recurrent abdominal pain of four month duration and one month duration of abdominal swelling that was later histopathological diagnosed to be epithelioid haemangioendothelioma.

Journal of Urology, 2021

specifically developed for use with a fiberoptic cystoscope, participants also used the ES for ri... more specifically developed for use with a fiberoptic cystoscope, participants also used the ES for rigid cystoscopy, rigid and flexible ureteroscopy, and laparoscopy. CONCLUSIONS: The Endockscope System is an inexpensive and practical advance that empowers urologists in underserved countries to successfully expand their endoscopic services.

Nature, 2017

Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Reported he... more Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Reported here is an extensive molecular characterization of 228 primary cervical cancers, the largest comprehensive genomic study of cervical cancer to date. We observed striking APOBEC mutagenesis patterns and identified SHKBP1, ERBB3, CASP8, HLA-A, and TGFBR2 as novel significantly mutated genes in cervical cancer. We also discovered novel amplifications in immune targets CD274/PD-L1 and PDCD1LG2/PD-L2, and the BCAR4 lncRNA that has been associated with response to lapatinib. HPV integration was observed in all HPV18-related cases and 76% of HPV16-related cases, and was associated with structural aberrations and increased target gene expression. We identified a unique set of endometrial-like cervical cancers, comprised predominantly of HPV-negative tumors with high frequencies of KRAS, ARID1A, and PTEN mutations. Integrative clustering of 178 samples identified Keratin-low Squamous, Keratin-high Squamous, and Adenocarcinoma-rich subgroups. These molecular analyses reveal new potential therapeutic targets for cervical cancers. Cervical cancer accounts for 528,000 new cases and 266,000 deaths worldwide each year, more than any other gynecologic tumor 1. Ninety-five percent of cases are caused by persistent infections with carcinogenic human papillomaviruses (HPV) 2. Effective prophylactic vaccines against the most important carcinogenic HPV types are available, but uptake remains poor. Although early cervical cancer can be treated with surgery or radiation, metastatic cervical cancer is incurable and new therapeutic approaches are needed 3. While most HPV infections are cleared within months, some persist and express viral oncogenes that inactivate p53 and Rb, leading to increased genomic instability, accumulation of somatic mutations, and in some cases integration of HPV into the host genome 4. The association with cancer risk and histological subtypes varies substantially among carcinogenic HPV types, but the reasons for these differences are poorly understood. Further, clinically relevant cervical cancer patient subgroups have yet to be identified. Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:

Epithelioid haemangioendothelioma is a rare vascular tumor, described for the first time in 1975 ... more Epithelioid haemangioendothelioma is a rare vascular tumor, described for the first time in 1975 by Dail and Liebow as an aggressive bronchoalveolar cell carcinoma. It represents 1% of all vascular tumours, due to its heterogeneous presentation, it is often misdiagnosed and not suitably treated. The etiology is still a dilemma. Most of the times it affects lung, liver and bones, although this kind of tumor may involve the head and neck area, breast, lymph nodes, mediastinum, brain and meninges, the spine, skin, abdomen and many other sites. Mesentery involvement is very rare. We report a case of 22-year old female student, who presented with recurrent abdominal pain of four month duration and one month duration of abdominal swelling that was later histopathological diagnosed to be epithelioid haemangioendothelioma.

Journal of US-China Medical Science, 2017

Epithelioid haemangioendothelioma is a rare vascular tumor, described for the first time in 1975 ... more Epithelioid haemangioendothelioma is a rare vascular tumor, described for the first time in 1975 by Dail and Liebow as an aggressive bronchoalveolar cell carcinoma. It represents 1% of all vascular tumours, due to its heterogeneous presentation, it is often misdiagnosed and not suitably treated. The etiology is still a dilemma. Most of the times it affects lung, liver and bones, although this kind of tumor may involve the head and neck area, breast, lymph nodes, mediastinum, brain and meninges, the spine, skin, abdomen and many other sites. Mesentery involvement is very rare. We report a case of 22-year old female student, who presented with recurrent abdominal pain of four month duration and one month duration of abdominal swelling that was later histopathological diagnosed to be epithelioid haemangioendothelioma.

Journal of Urology, 2021

specifically developed for use with a fiberoptic cystoscope, participants also used the ES for ri... more specifically developed for use with a fiberoptic cystoscope, participants also used the ES for rigid cystoscopy, rigid and flexible ureteroscopy, and laparoscopy. CONCLUSIONS: The Endockscope System is an inexpensive and practical advance that empowers urologists in underserved countries to successfully expand their endoscopic services.

Nature, 2017

Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Reported he... more Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Reported here is an extensive molecular characterization of 228 primary cervical cancers, the largest comprehensive genomic study of cervical cancer to date. We observed striking APOBEC mutagenesis patterns and identified SHKBP1, ERBB3, CASP8, HLA-A, and TGFBR2 as novel significantly mutated genes in cervical cancer. We also discovered novel amplifications in immune targets CD274/PD-L1 and PDCD1LG2/PD-L2, and the BCAR4 lncRNA that has been associated with response to lapatinib. HPV integration was observed in all HPV18-related cases and 76% of HPV16-related cases, and was associated with structural aberrations and increased target gene expression. We identified a unique set of endometrial-like cervical cancers, comprised predominantly of HPV-negative tumors with high frequencies of KRAS, ARID1A, and PTEN mutations. Integrative clustering of 178 samples identified Keratin-low Squamous, Keratin-high Squamous, and Adenocarcinoma-rich subgroups. These molecular analyses reveal new potential therapeutic targets for cervical cancers. Cervical cancer accounts for 528,000 new cases and 266,000 deaths worldwide each year, more than any other gynecologic tumor 1. Ninety-five percent of cases are caused by persistent infections with carcinogenic human papillomaviruses (HPV) 2. Effective prophylactic vaccines against the most important carcinogenic HPV types are available, but uptake remains poor. Although early cervical cancer can be treated with surgery or radiation, metastatic cervical cancer is incurable and new therapeutic approaches are needed 3. While most HPV infections are cleared within months, some persist and express viral oncogenes that inactivate p53 and Rb, leading to increased genomic instability, accumulation of somatic mutations, and in some cases integration of HPV into the host genome 4. The association with cancer risk and histological subtypes varies substantially among carcinogenic HPV types, but the reasons for these differences are poorly understood. Further, clinically relevant cervical cancer patient subgroups have yet to be identified. Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:

Epithelioid haemangioendothelioma is a rare vascular tumor, described for the first time in 1975 ... more Epithelioid haemangioendothelioma is a rare vascular tumor, described for the first time in 1975 by Dail and Liebow as an aggressive bronchoalveolar cell carcinoma. It represents 1% of all vascular tumours, due to its heterogeneous presentation, it is often misdiagnosed and not suitably treated. The etiology is still a dilemma. Most of the times it affects lung, liver and bones, although this kind of tumor may involve the head and neck area, breast, lymph nodes, mediastinum, brain and meninges, the spine, skin, abdomen and many other sites. Mesentery involvement is very rare. We report a case of 22-year old female student, who presented with recurrent abdominal pain of four month duration and one month duration of abdominal swelling that was later histopathological diagnosed to be epithelioid haemangioendothelioma.