Dipten Laskar | Nagaland University (original) (raw)
Articles by Dipten Laskar
North-east India is part of Indo-Burma hotspot and among the richest bird zones in India. Tripura... more North-east India is part of Indo-Burma hotspot and among the richest bird zones in India. Tripura lies in the border of Indo-Burma global biodiversity hotspot area but very poorly covered by ornithological works. Avifauna of Tripura state is known by 277 species but there is lack of information about their distribution, particularly in and around Agartala city, which is the capital of Tripura state and is a tourist destination along the border of Bangladesh for its natural landscapes, inland water species, and strong presence of green flora with a view to enhance its value for tourist attraction and naturalists. A study was conducted to record the species of birds that occur in and around the City. In the present study 73 bird species were recorded from Agartala city and its adjacent areas belonging to 41 families and 14 orders.
Papers by Dipten Laskar
Bioinformation, Jan 31, 2023
Staphylococcus aureus is an opportunistic pathogen that causes variety of infections range from m... more Staphylococcus aureus is an opportunistic pathogen that causes variety of infections range from mild skin diseases to life-threatening sepsis. It is also notorious for acquiring resistance to numerous antibiotics. Parvulin-type peptidyl-prolyl cis-trans isomerase (PPiase) domain containing PrsA protein is considered as an essential folding factor for secreted proteins of Gram-positive bacteria. Therefore, it is considered as a potential target for anti-staphylococcal drug discovery. Juglone, plant-derived 1,4-naphthoquinone, shows confirmed antitumor and antibacterial activities. Destruction of bacterial biofilm, inhibition of enzyme expression, degradation of nucleic acids, and other pathways are likely the major possible mechanisms for Staphylococcus aureus inactivation by juglone. Selective inhibition of parvulin type PPiase by juglone has been proven biochemically. However, detail structural information of parvulin-juglone interaction and mechanism of enzymatic inhibition till unexplored. Past hypothesis on inactivation of parvulin type PPiase due to covalent attachment of juglone molecules to its cysteine residues is not acceptable for the S. aureus PrsA parvulin domain as that lacks cysteine. Docking studies showed that juglone binds to the active site residues of S. aureus PrsA parvulin domain involved in enzymatic reaction. Active site conserved histidine residue of parvulin may be involved in juglone interaction as it was found to be the common interactive residue in majority of docking complexes. Data shows Juglone possibly inhibits parvulin type PPiase through competitive inhibition mechanism. Subtle differences of juglone interactions with other orthologous parvulin domains will help to develop semisynthetic drug with higher specificity against S. aureus.
South African Journal of Botany
Bioinformation
Staphylococcus aureus is an opportunistic pathogen that causes variety of infections range from m... more Staphylococcus aureus is an opportunistic pathogen that causes variety of infections range from mild skin diseases to life-threatening sepsis. It is also notorious for acquiring resistance to numerous antibiotics. Parvulin-type peptidyl-prolyl cis-trans isomerase (PPiase) domain containing PrsA protein is considered as an essential folding factor for secreted proteins of Gram-positive bacteria. Therefore, it is considered as a potential target for anti-staphylococcal drug discovery. Juglone, plant-derived 1,4-naphthoquinone, shows confirmed antitumor and antibacterial activities. Destruction of bacterial biofilm, inhibition of enzyme expression, degradation of nucleic acids, and other pathways are likely the major possible mechanisms for Staphylococcus aureus inactivation by juglone. Selective inhibition of parvulin type PPiase by juglone has been proven biochemically. However, detail structural information of parvulin-juglone interaction and mechanism of enzymatic inhibition till u...
North-east India is part of Indo-Burma hotspot and among the richest bird zones in India. Tripura... more North-east India is part of Indo-Burma hotspot and among the richest bird zones in India. Tripura lies in the border of Indo-Burma global biodiversity hotspot area but very poorly covered by ornithological works. Avifauna of Tripura state is known by 277 species but there is lack of information about their distribution, particularly in and around Agartala city, which is the capital of Tripura state and is a tourist destination along the border of Bangladesh for its natural landscapes, inland water species, and strong presence of green flora with a view to enhance its value for tourist attraction and naturalists. A study was conducted to record the species of birds that occur in and around the City. In the present study 73 bird species were recorded from Agartala city and its adjacent areas belonging to 41 families and 14 orders.
Bioinformation, Jan 31, 2023
Staphylococcus aureus is an opportunistic pathogen that causes variety of infections range from m... more Staphylococcus aureus is an opportunistic pathogen that causes variety of infections range from mild skin diseases to life-threatening sepsis. It is also notorious for acquiring resistance to numerous antibiotics. Parvulin-type peptidyl-prolyl cis-trans isomerase (PPiase) domain containing PrsA protein is considered as an essential folding factor for secreted proteins of Gram-positive bacteria. Therefore, it is considered as a potential target for anti-staphylococcal drug discovery. Juglone, plant-derived 1,4-naphthoquinone, shows confirmed antitumor and antibacterial activities. Destruction of bacterial biofilm, inhibition of enzyme expression, degradation of nucleic acids, and other pathways are likely the major possible mechanisms for Staphylococcus aureus inactivation by juglone. Selective inhibition of parvulin type PPiase by juglone has been proven biochemically. However, detail structural information of parvulin-juglone interaction and mechanism of enzymatic inhibition till unexplored. Past hypothesis on inactivation of parvulin type PPiase due to covalent attachment of juglone molecules to its cysteine residues is not acceptable for the S. aureus PrsA parvulin domain as that lacks cysteine. Docking studies showed that juglone binds to the active site residues of S. aureus PrsA parvulin domain involved in enzymatic reaction. Active site conserved histidine residue of parvulin may be involved in juglone interaction as it was found to be the common interactive residue in majority of docking complexes. Data shows Juglone possibly inhibits parvulin type PPiase through competitive inhibition mechanism. Subtle differences of juglone interactions with other orthologous parvulin domains will help to develop semisynthetic drug with higher specificity against S. aureus.
South African Journal of Botany
Bioinformation
Staphylococcus aureus is an opportunistic pathogen that causes variety of infections range from m... more Staphylococcus aureus is an opportunistic pathogen that causes variety of infections range from mild skin diseases to life-threatening sepsis. It is also notorious for acquiring resistance to numerous antibiotics. Parvulin-type peptidyl-prolyl cis-trans isomerase (PPiase) domain containing PrsA protein is considered as an essential folding factor for secreted proteins of Gram-positive bacteria. Therefore, it is considered as a potential target for anti-staphylococcal drug discovery. Juglone, plant-derived 1,4-naphthoquinone, shows confirmed antitumor and antibacterial activities. Destruction of bacterial biofilm, inhibition of enzyme expression, degradation of nucleic acids, and other pathways are likely the major possible mechanisms for Staphylococcus aureus inactivation by juglone. Selective inhibition of parvulin type PPiase by juglone has been proven biochemically. However, detail structural information of parvulin-juglone interaction and mechanism of enzymatic inhibition till u...