Kazuyo Tsushita | Nagoya University (original) (raw)
Papers by Kazuyo Tsushita
GHM Open
Individuals with diabetes who have inadequate glycemic control develop diabetes-related microvasc... more Individuals with diabetes who have inadequate glycemic control develop diabetes-related microvascular complications, including retinopathy and nephropathy, and have a 2-to 3-fold increased risk of incident cardiovascular disease (CVD) (1,2). Early detection of diabetes and its complications and ensuring adequate (3)
Nutrition & Diabetes
Following publication, the authors asked to add the following institution to the affiliations of ... more Following publication, the authors asked to add the following institution to the affiliations of author Madoka Matsushita: Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine Both the PDF and HTML versions of the Article have been updated accordingly.
Circulation Reports
of obesity has been increasing in Japan in recent decades, government-led prevention programs in ... more of obesity has been increasing in Japan in recent decades, government-led prevention programs in Japan have started to reverse the obesity epidemic since 2008. All health insurers in Japan must provide a lifestyle modification program for metabolic syndrome after health checkups. As part of the initial counseling in this program, participants set personalized goals: 3-5% reductions in body weight (BW) and a 3-cm reduction in waist circumference (WC). 7 A previous study showed greater improvements in body mass index (BMI), WC, and blood pressure (BP) among program participants than non-participants over a period of 3 years. 8 C hronic non-communicable diseases (NCDs) are the leading cause of death in Russia and worldwide. 1,2 Obesity is closely associated with other risk factors for chronic NCDs, 3 particularly hypertension. 4 These risk factors also determine the occurrence of cardiovascular diseases, cancer, and diabetes. 5 Currently, approximately one-quarter of adult men and one-third of adult women in Russia are obese. 4 Japan has the greatest longevity in the world, 6 and the prevalence of obesity among the Japanese population is significantly lower than in Russia. Although the prevalence
Geriatrics & Gerontology International
Journal of Diabetes Science and Technology
Environmental Health and Preventive Medicine
Background: To let the early elderly live well, understanding how lifestyle and psychosocial fact... more Background: To let the early elderly live well, understanding how lifestyle and psychosocial factors related to a decline in competence in daily living is important. Methods: We investigated the associations between lifestyle and psychosocial factors at age 64 years and a decline in the Tokyo Metropolitan Institute of Gerontology Index of Competence score of ≥ 2 points at age 70 years among the participants in comprehensive medical checkups living in a city in Japan. Multivariable logistic regression analyses were performed separately for men and women. Results: Of the 1113 eligible men and 1203 eligible women, 110 men and 80 women showed a deteriorated competence in daily living during the 6 years. In men, risk was increased with ≥ 2 nighttime awakenings (multivariable odds ratio [mOR] 2.14, 95% confidence interval [CI] 1.19-3.86) and living alone (mOR 4.68, 95% CI 1.22-18.0), whereas risk was significantly decreased with a medium or fast gait (mOR 0.37 and 0.21, 95% CI 0.21-0.67 and 0.08-0.58) and high academic achievement (mOR 0.32 and 0.43, 95% CI 0.19-0.53 and 0.25-0.72). In women, risk was decreased with high life satisfaction (mOR 0.39, 95% CI 0.16-0.91) and participation in community activities (mOR 0.50, 95% CI 0.29-0.86) but increased with depressive mood (mOR 1.86, 95% CI 1.09-3.18). Conclusion: Living alone for men and low life satisfaction for women at age 64 years were markedly associated with the risk of a subsequent declining competence in daily living.
Clinical and Experimental Nephrology
Journal of atherosclerosis and thrombosis, 2018
All health insurers in Japan are mandated to provide Specific Health Checkups and Specific Health... more All health insurers in Japan are mandated to provide Specific Health Checkups and Specific Health Guidance (SHG) focusing on metabolic syndrome (MetS) in middle-aged adults, beginning in 2008; intensive HG for individuals who have abdominal obesity and two or more additional MetS risk factors, and motivational HG for individuals with one risk factor. The aim of this study is to describe medium-term changes in health indexes for intensive and motivational HG groups using the National Database. We compared changes of risk factors and initiation of pharmacological therapy over 3 yr between participants (n=31,790) and nonparticipants (n=189,726) who were eligible for SHG in 2008. Body weight reduction in intensive HG was 1.98 kg (participants) vs 0.42 kg (nonparticipants) in men (p＜0.01) and 2.25 vs 0.68 kg in women (p＜0.01) after 1 yr. In motivational HG, the respective reduction was 1.40 vs 0.30 kg in men (p＜0.01) and 1.53 vs 0.42 kg in women (p＜0.01). Waist circumference reduction wa...
Journal of epidemiology, Jan 24, 2018
Most studies of plasma adiponectin (APN) and mortality among community-dwelling elderly focus on ... more Most studies of plasma adiponectin (APN) and mortality among community-dwelling elderly focus on cardiovascular disease, but data on the relationship between plasma APN and cancer mortality is exiguous. We investigated whether APN is associated with cancer mortality in community-dwelling elderly people. We conducted a case-cohort study within the New Integrated Suburban Seniority Investigation (NISSIN) Project using a randomly drawn sub-cohort of 697 subjects (351 men and 346 women; mean age 64.5 [standard deviation, 0.5] years) among whom we compared cases of all-cause death (n = 269) and cancer death (n = 149) during a mean follow-up duration of 10.8 (standard deviation, 3.7) years. Associations between APN and mortality were assessed using weighted Cox regression analyses. We observed significant positive associations between the APN concentration and cancer death in the first and third APN tertiles compared with the second APN tertile (hazard ratio [HR], 1.67; 95% confidence int...
Journal of Diabetes Investigation
The beta-3 adrenergic receptor (ADRB3), primarily expressed in adipose tissue, is involved in the... more The beta-3 adrenergic receptor (ADRB3), primarily expressed in adipose tissue, is involved in the regulation of energy metabolism. The present study hypothesized that ADRB3 (Trp64Arg, rs4994) polymorphisms modulate the effects of lifestyle intervention on weight and metabolic parameters in patients with impaired glucose tolerance. Data were analyzed from 112 patients with impaired glucose tolerance in the Japan Diabetes Prevention Program, a lifestyle intervention trial, randomized to either an intensive lifestyle intervention group or usual care group. Changes in weight and metabolic parameters were measured after the 6-month intervention. The ADRB3 polymorphisms were determined using the polymerase chain reaction restriction fragment length polymorphism method. Non-carriers showed a greater weight reduction compared with the carriers in both the lifestyle intervention group and usual care group, and a greater increase of high-density lipoprotein cholesterol levels than the carriers only in the lifestyle intervention group. ADRB3 polymorphisms could influence the effects of lifestyle interventions on weight and lipid parameters in impaired glucose tolerance patients.
Nihon Naika Gakkai Zasshi
あいち健康の森健康科学総合センター 113 th Scientific Meeting of the Japanese Society of Internal Medicine：Panel Di... more あいち健康の森健康科学総合センター 113 th Scientific Meeting of the Japanese Society of Internal Medicine：Panel Discussion：Obesity disease and metabolic syndrome-from pathophysiology to concept of management；6. Practice and evaluation of lifestyle intervention on program.
Circulation, Mar 25, 2014
Nihon Naika Gakkai Zasshi, Apr 10, 2011
Nagoya journal of medical science, 2015
Sarcopenia, defined as the loss of muscle mass accompanied by weakness, is an important factor le... more Sarcopenia, defined as the loss of muscle mass accompanied by weakness, is an important factor leading to frailty and is a growing concern in the aging Japanese society. Muscle mass can be calculated by dual-energy X-ray absorptiometry (DXA), but results differ between devices produced by different manufactures. Thus, cross-calibration is needed to compare body composition results in multicenter trials or when scanners are replaced. The purpose of this study was to perform an in vivo calibration of total body scans between pencil-beam (DPX-NT, GE Healthcare) and fan-beam (QDR-4500C, Hologic Inc.) DXA units. A total 30 subjects (15 women, 15 men, mean age = 35 years, range 22-49 years) were recruited. The lumbar bone mineral density (BMD), femoral neck BMD, appendicular fat and lean body mass, and the appendicular skeletal muscle mass index (ASMI) were highly correlated (r = 0.979-0.993, r(2) = 0.889-0.977). The conversion formulas were as follows: lumbar BMD, Y = -0.08 + 1.16X (X = ...
Nippon Kōshū Eisei Zasshi Japanese Journal of Public Health, Jun 1, 2009
Journal of Epidemiology, 2015
Background: Regular physical activity contributes to the prevention of cancer, cardiovascular dis... more Background: Regular physical activity contributes to the prevention of cancer, cardiovascular disease, and other chronic diseases. However, the frequency of physical activity often declines with age, particularly among the elderly. Thus, we investigated the effects of daily walking on mortality among younger-elderly men (65-74 years) with or without major critical diseases (heart disease, cerebrovascular disease, or cancer). Methods: We assessed 1239 community-dwelling men aged 64/65 years from the New Integrated Suburban Seniority Investigation Project. We estimated hazard ratios (HRs) of all-cause mortality and 95% confidence intervals (CIs) according to daily walking duration and adjusted for potential confounders, including survey year, marital status, work status, education, smoking and drinking status, BMI, regular exercise, regular sports, sleeping time, medical status, disease history, and functional capacity. Results: For men without critical diseases, mortality risk declined linearly with increased walking time after adjustment for confounders (P trend = 0.018). Walking ≥2 hours/day was significantly associated with lower all-cause mortality (HR 0.49; 95% CI, 0.27-0.90). For men with critical diseases, walking 1-2 hours/day showed a protective effect on mortality compared with walking <0.5 hours/day after adjustment for confounders (HR 0.29; 95% CI, 0.06-1.20). Walking ≥2 hours/day showed no benefit on mortality in men with critical diseases, even after adjustment for confounders. Conclusions: Different duration of daily walking was associated with decreased mortality for younger-elderly men with or without critical diseases, independent of sociodemographic and lifestyle factors, BMI, medical status, disease history, and functional capacity. Incorporating regular walking into daily lives of younger-elderly men may improve longevity and successful aging.
Japanese journal of MHTS, 2001
Japanese journal of MHTS, 1994
Health Evaluation and Promotion, 2011
ANTI-AGING MEDICINE, 2011
Body weight gain or obesity has been reported to increase the risk of developing lifestyle-relate... more Body weight gain or obesity has been reported to increase the risk of developing lifestyle-related diseases. However, few longitudinal studies have examined the relationship between body shape change and health, and the few that do exist used body shapes reported by the subjects. We investigated whether or not maintaining a "youthful" body shape helps prevent the development of lifestyle-related diseases in healthy women. Changes in body shape in a group of healthy women were evaluated over 30 years starting from sometime in their 20s by visually judging pictures of the subjects and using body shape vectors. Subjects were classified into two groups: a group of 12 (mean age: 44.9±5.1 years) who were judged to have maintained their youthful body shape (maintained group) and a group of 16 (mean age: 47.5±6.1 years) who were judged not to have maintained their shape (non-maintained group). Body size and composition measurements were then compared with biochemical markers that measure the risk of developing lifestyle-related diseases. Mean body weight in the maintained group was 4.0 kg less than in the non-maintained group, while body fat mass was 4.6 kg less. In addition, the maintained group showed better scores for biochemical and pulse wave velocity tests. Taken together, our results suggest that women who maintain their youthful body shape into their later years have a reduced risk of the lifestyle-related diseases that frequently accompany age.
GHM Open
Individuals with diabetes who have inadequate glycemic control develop diabetes-related microvasc... more Individuals with diabetes who have inadequate glycemic control develop diabetes-related microvascular complications, including retinopathy and nephropathy, and have a 2-to 3-fold increased risk of incident cardiovascular disease (CVD) (1,2). Early detection of diabetes and its complications and ensuring adequate (3)
Nutrition & Diabetes
Following publication, the authors asked to add the following institution to the affiliations of ... more Following publication, the authors asked to add the following institution to the affiliations of author Madoka Matsushita: Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine Both the PDF and HTML versions of the Article have been updated accordingly.
Circulation Reports
of obesity has been increasing in Japan in recent decades, government-led prevention programs in ... more of obesity has been increasing in Japan in recent decades, government-led prevention programs in Japan have started to reverse the obesity epidemic since 2008. All health insurers in Japan must provide a lifestyle modification program for metabolic syndrome after health checkups. As part of the initial counseling in this program, participants set personalized goals: 3-5% reductions in body weight (BW) and a 3-cm reduction in waist circumference (WC). 7 A previous study showed greater improvements in body mass index (BMI), WC, and blood pressure (BP) among program participants than non-participants over a period of 3 years. 8 C hronic non-communicable diseases (NCDs) are the leading cause of death in Russia and worldwide. 1,2 Obesity is closely associated with other risk factors for chronic NCDs, 3 particularly hypertension. 4 These risk factors also determine the occurrence of cardiovascular diseases, cancer, and diabetes. 5 Currently, approximately one-quarter of adult men and one-third of adult women in Russia are obese. 4 Japan has the greatest longevity in the world, 6 and the prevalence of obesity among the Japanese population is significantly lower than in Russia. Although the prevalence
Geriatrics & Gerontology International
Journal of Diabetes Science and Technology
Environmental Health and Preventive Medicine
Background: To let the early elderly live well, understanding how lifestyle and psychosocial fact... more Background: To let the early elderly live well, understanding how lifestyle and psychosocial factors related to a decline in competence in daily living is important. Methods: We investigated the associations between lifestyle and psychosocial factors at age 64 years and a decline in the Tokyo Metropolitan Institute of Gerontology Index of Competence score of ≥ 2 points at age 70 years among the participants in comprehensive medical checkups living in a city in Japan. Multivariable logistic regression analyses were performed separately for men and women. Results: Of the 1113 eligible men and 1203 eligible women, 110 men and 80 women showed a deteriorated competence in daily living during the 6 years. In men, risk was increased with ≥ 2 nighttime awakenings (multivariable odds ratio [mOR] 2.14, 95% confidence interval [CI] 1.19-3.86) and living alone (mOR 4.68, 95% CI 1.22-18.0), whereas risk was significantly decreased with a medium or fast gait (mOR 0.37 and 0.21, 95% CI 0.21-0.67 and 0.08-0.58) and high academic achievement (mOR 0.32 and 0.43, 95% CI 0.19-0.53 and 0.25-0.72). In women, risk was decreased with high life satisfaction (mOR 0.39, 95% CI 0.16-0.91) and participation in community activities (mOR 0.50, 95% CI 0.29-0.86) but increased with depressive mood (mOR 1.86, 95% CI 1.09-3.18). Conclusion: Living alone for men and low life satisfaction for women at age 64 years were markedly associated with the risk of a subsequent declining competence in daily living.
Clinical and Experimental Nephrology
Journal of atherosclerosis and thrombosis, 2018
All health insurers in Japan are mandated to provide Specific Health Checkups and Specific Health... more All health insurers in Japan are mandated to provide Specific Health Checkups and Specific Health Guidance (SHG) focusing on metabolic syndrome (MetS) in middle-aged adults, beginning in 2008; intensive HG for individuals who have abdominal obesity and two or more additional MetS risk factors, and motivational HG for individuals with one risk factor. The aim of this study is to describe medium-term changes in health indexes for intensive and motivational HG groups using the National Database. We compared changes of risk factors and initiation of pharmacological therapy over 3 yr between participants (n=31,790) and nonparticipants (n=189,726) who were eligible for SHG in 2008. Body weight reduction in intensive HG was 1.98 kg (participants) vs 0.42 kg (nonparticipants) in men (p＜0.01) and 2.25 vs 0.68 kg in women (p＜0.01) after 1 yr. In motivational HG, the respective reduction was 1.40 vs 0.30 kg in men (p＜0.01) and 1.53 vs 0.42 kg in women (p＜0.01). Waist circumference reduction wa...
Journal of epidemiology, Jan 24, 2018
Most studies of plasma adiponectin (APN) and mortality among community-dwelling elderly focus on ... more Most studies of plasma adiponectin (APN) and mortality among community-dwelling elderly focus on cardiovascular disease, but data on the relationship between plasma APN and cancer mortality is exiguous. We investigated whether APN is associated with cancer mortality in community-dwelling elderly people. We conducted a case-cohort study within the New Integrated Suburban Seniority Investigation (NISSIN) Project using a randomly drawn sub-cohort of 697 subjects (351 men and 346 women; mean age 64.5 [standard deviation, 0.5] years) among whom we compared cases of all-cause death (n = 269) and cancer death (n = 149) during a mean follow-up duration of 10.8 (standard deviation, 3.7) years. Associations between APN and mortality were assessed using weighted Cox regression analyses. We observed significant positive associations between the APN concentration and cancer death in the first and third APN tertiles compared with the second APN tertile (hazard ratio [HR], 1.67; 95% confidence int...
Journal of Diabetes Investigation
The beta-3 adrenergic receptor (ADRB3), primarily expressed in adipose tissue, is involved in the... more The beta-3 adrenergic receptor (ADRB3), primarily expressed in adipose tissue, is involved in the regulation of energy metabolism. The present study hypothesized that ADRB3 (Trp64Arg, rs4994) polymorphisms modulate the effects of lifestyle intervention on weight and metabolic parameters in patients with impaired glucose tolerance. Data were analyzed from 112 patients with impaired glucose tolerance in the Japan Diabetes Prevention Program, a lifestyle intervention trial, randomized to either an intensive lifestyle intervention group or usual care group. Changes in weight and metabolic parameters were measured after the 6-month intervention. The ADRB3 polymorphisms were determined using the polymerase chain reaction restriction fragment length polymorphism method. Non-carriers showed a greater weight reduction compared with the carriers in both the lifestyle intervention group and usual care group, and a greater increase of high-density lipoprotein cholesterol levels than the carriers only in the lifestyle intervention group. ADRB3 polymorphisms could influence the effects of lifestyle interventions on weight and lipid parameters in impaired glucose tolerance patients.
Nihon Naika Gakkai Zasshi
あいち健康の森健康科学総合センター 113 th Scientific Meeting of the Japanese Society of Internal Medicine：Panel Di... more あいち健康の森健康科学総合センター 113 th Scientific Meeting of the Japanese Society of Internal Medicine：Panel Discussion：Obesity disease and metabolic syndrome-from pathophysiology to concept of management；6. Practice and evaluation of lifestyle intervention on program.
Circulation, Mar 25, 2014
Nihon Naika Gakkai Zasshi, Apr 10, 2011
Nagoya journal of medical science, 2015
Sarcopenia, defined as the loss of muscle mass accompanied by weakness, is an important factor le... more Sarcopenia, defined as the loss of muscle mass accompanied by weakness, is an important factor leading to frailty and is a growing concern in the aging Japanese society. Muscle mass can be calculated by dual-energy X-ray absorptiometry (DXA), but results differ between devices produced by different manufactures. Thus, cross-calibration is needed to compare body composition results in multicenter trials or when scanners are replaced. The purpose of this study was to perform an in vivo calibration of total body scans between pencil-beam (DPX-NT, GE Healthcare) and fan-beam (QDR-4500C, Hologic Inc.) DXA units. A total 30 subjects (15 women, 15 men, mean age = 35 years, range 22-49 years) were recruited. The lumbar bone mineral density (BMD), femoral neck BMD, appendicular fat and lean body mass, and the appendicular skeletal muscle mass index (ASMI) were highly correlated (r = 0.979-0.993, r(2) = 0.889-0.977). The conversion formulas were as follows: lumbar BMD, Y = -0.08 + 1.16X (X = ...
Nippon Kōshū Eisei Zasshi Japanese Journal of Public Health, Jun 1, 2009
Journal of Epidemiology, 2015
Background: Regular physical activity contributes to the prevention of cancer, cardiovascular dis... more Background: Regular physical activity contributes to the prevention of cancer, cardiovascular disease, and other chronic diseases. However, the frequency of physical activity often declines with age, particularly among the elderly. Thus, we investigated the effects of daily walking on mortality among younger-elderly men (65-74 years) with or without major critical diseases (heart disease, cerebrovascular disease, or cancer). Methods: We assessed 1239 community-dwelling men aged 64/65 years from the New Integrated Suburban Seniority Investigation Project. We estimated hazard ratios (HRs) of all-cause mortality and 95% confidence intervals (CIs) according to daily walking duration and adjusted for potential confounders, including survey year, marital status, work status, education, smoking and drinking status, BMI, regular exercise, regular sports, sleeping time, medical status, disease history, and functional capacity. Results: For men without critical diseases, mortality risk declined linearly with increased walking time after adjustment for confounders (P trend = 0.018). Walking ≥2 hours/day was significantly associated with lower all-cause mortality (HR 0.49; 95% CI, 0.27-0.90). For men with critical diseases, walking 1-2 hours/day showed a protective effect on mortality compared with walking <0.5 hours/day after adjustment for confounders (HR 0.29; 95% CI, 0.06-1.20). Walking ≥2 hours/day showed no benefit on mortality in men with critical diseases, even after adjustment for confounders. Conclusions: Different duration of daily walking was associated with decreased mortality for younger-elderly men with or without critical diseases, independent of sociodemographic and lifestyle factors, BMI, medical status, disease history, and functional capacity. Incorporating regular walking into daily lives of younger-elderly men may improve longevity and successful aging.
Japanese journal of MHTS, 2001
Japanese journal of MHTS, 1994
Health Evaluation and Promotion, 2011
ANTI-AGING MEDICINE, 2011
Body weight gain or obesity has been reported to increase the risk of developing lifestyle-relate... more Body weight gain or obesity has been reported to increase the risk of developing lifestyle-related diseases. However, few longitudinal studies have examined the relationship between body shape change and health, and the few that do exist used body shapes reported by the subjects. We investigated whether or not maintaining a "youthful" body shape helps prevent the development of lifestyle-related diseases in healthy women. Changes in body shape in a group of healthy women were evaluated over 30 years starting from sometime in their 20s by visually judging pictures of the subjects and using body shape vectors. Subjects were classified into two groups: a group of 12 (mean age: 44.9±5.1 years) who were judged to have maintained their youthful body shape (maintained group) and a group of 16 (mean age: 47.5±6.1 years) who were judged not to have maintained their shape (non-maintained group). Body size and composition measurements were then compared with biochemical markers that measure the risk of developing lifestyle-related diseases. Mean body weight in the maintained group was 4.0 kg less than in the non-maintained group, while body fat mass was 4.6 kg less. In addition, the maintained group showed better scores for biochemical and pulse wave velocity tests. Taken together, our results suggest that women who maintain their youthful body shape into their later years have a reduced risk of the lifestyle-related diseases that frequently accompany age.