Iyad Ali | An-Najah National University (original) (raw)

Papers by Iyad Ali

Drug Metabolism and Drug Interactions, 2020

Objectives A “potential drug-drug interaction” (pDDI) is the possibility one drug has to alter th... more Objectives A “potential drug-drug interaction” (pDDI) is the possibility one drug has to alter the effects of another when both are administered simultaneously. Intensive care unit (ICU) patients are especially prone to these pDDIs. This study aimed to determine the frequency and severity of pDDIs during the hospitalization of patients in the ICU. Methods This study was conducted retrospectively in three hospitals, including both governmental and non-governmental hospitals in Nablus, Palestine, over the course of six months; starting in January 2018 and ending in June 2018. The sample size included 232 ICU patients, and medications prescribed during the hospitalization of these patients were evaluated for pDDIs using the drugs.com application. Results A total of 167 patients (72%) were found to have at least one pDDI, while the total number of pDDIs in the study was 422, resulting in an average of 1.82 pDDIs per patient. Out of the total identified pDDIs, 41 interactions (9.7%) were...

Background: Metabolic syndrome (MS) is a cluster of the most dangerous cardiac risk factors and i... more Background: Metabolic syndrome (MS) is a cluster of the most dangerous cardiac risk factors and is associated with high mortality. Ethnic differences in metabolic syndrome (MS) criteria and prevalence rates have been reported. The purpose of this study was to investigate the MS prevalence among patients with schizophrenia in Palestine. Methods: We recruited 250 patients with schizophrenia from 4 psychiatric primary healthcare centers in Northern Palestine. The MS prevalence was assessed based on National Cholesterol Education Program Adult Treatment

The photodynamic action of riboflavin is generally considered to involve the generation of reacti... more The photodynamic action of riboflavin is generally considered to involve the generation of reactive oxygen species, whose production is enhanced when Cu(II) is present in the reaction. In the present study we report that photoactivated riboflavin causes K loss from fresh human red blood cells (RBC) in a time dependent manner. Addition of Cu(II) further enhances the K loss and also leads to significant hemolysis. Riboflavin in a 2:1 stoichiometry with Cu(II) leads to maximum K loss and up to 45 % hemolysis. Bathocuproine, a specific Cu(I)-sequestering agent, when present in the reaction, inhibits the hemolysis completely. Free radical scavengers like superoxide dismutase, potassium iodide and mannitol inhibited the hemolysis up to 55 % or more. However, thiourea was the most effective scavenger showing 90 % inhibition. These results suggest that K leakage and hemolysis of human RBC are basically free radical mediated reactions. ß 2000

Complete blood count (CBC) test is one of the recommended tools to demonstrate the prevalence of ... more Complete blood count (CBC) test is one of the recommended tools to demonstrate the prevalence of unhealthy lifestyle and poor diet. The objective of this work was to employ the hemoglobin level as a tool to evaluate the quality of lifestyle and diet of schizophrenic patients in Palestine. Cross sectional study was conducted at governmental primary psychiatric health care centers in northern West-Bank of Palestine. Two hundred and fifty patients were selected by convenience sampling method. The components of CBC were evaluated using blood samples donated by schizophrenic patients. A pretested self-administered questionnaire was used to retrieve personal information of participants. Descriptive statistical methods and regression analysis were used to analyze the data. Data have shown that 55.9% of female patients and 13.7% of the male patients suffered from anemia. Regression analysis showed that gender was a significant factor associated with the prevalence of anemia among schizophre...

Sesame oil has many cosmeceutical and pharmaceutical benefits. These can be exploited to produce ... more Sesame oil has many cosmeceutical and pharmaceutical benefits. These can be exploited to produce cosmeceuticals such as sunscreens and wound healing creams according to their sun protection factor (SPF) value and β-sitosterol content. The aim of this study was to assess the quality of sesame oil available on the Palestinian market for cosmeceutical and pharmaceutical use. A phytochemical qualitative analysis was executed using standard tests like Molisch's test, Fehling's test and Benedict's test. Moreover, 2,2-diphenyl-1-picrylhydrazyl (DPPH) inhibition percentage and elastase inhibition percentage calculations were applied using the standard references Trolox and oleanolic acid. Furthermore, the β-sitosterol (w/w) component was measured for each oil type. The DPPH inhibition, elastase inhibition and SPF values of Indian, Turkish and Palestinian sesame oil were (6.7±0.64 µg/mL, 9.3±0.37 µg/mL, 9.77±0.44 µg/mL), (50.11±0.70 µg/ mL, 56.23±0.37 µg/mL, 79.43±0.48 µg/mL) and (3.2, 3.0, 2.2), respectively. In addition, the β-sitosterol concentrations were Turkish 0.194% w/w, Palestinian 0.196% w/w and Indian 0.153% w/w. The results show that Indian sesame oil was the strongest antioxidant and had the highest elastase inhibition activity and SPF value for use in sunscreens and anti-ageing products. Turkish and Palestinian sesame oils are best used in wound healing creams.

Reactive oxygen species (ROS) participate in many chemical reactions leading to damage in several... more Reactive oxygen species (ROS) participate in many chemical reactions leading to damage in several molecular species including lipids, proteins, and nucleic acids and this can cause oxidative stress [1, 2].Oxidative stress can lead to hypertension, cancer, atherosclerosis, diabetes, Alzheimer, Parkinson and other diseases [3, 4]. Antioxidant are known as substances that can prevent oxidation process and delay or inhibit cellular damage due to their free radical scavenging property [5, 6]. Several health benefits can be achieved by consumption of a diet that is rich in fruits and vegetables. An alternative way to consume proper amounts of nutrients is to consume beverages such as juices. During the last few years, the demand for these beverages has been rising all over the world [7]. Such diet can provide not only essential nutrients but also phytochemicals that are very important for promoting health and preventing from diseases [8]. Consumption of fruits and vegetables is found to be strongly associated with reduction of risk of many common diseases such as cardiovascular disease, Alzheimer disease, diabetes, cancer, cataracts, and age-related functional decline [9, 10]. Many studies found that fruits and vegetables can supply a wide variety of antioxidant compounds that are very important for human health. Preventive effect of individual antioxidant in a dietary supplement is found to be less effective when it is taken through diet in fruits and vegetables [11]. Thus, the health-promoting effects of dietary fruits and vegetables probably reflects a complex interaction among many naturally occurring compounds, which has not been duplicated by consumption of isolated antioxidant compounds [7].

Marmara Pharmaceutical Journal, 2017

The food composition tables, which are necessary tools for nutritional and epidemiological studie... more The food composition tables, which are necessary tools for nutritional and epidemiological studies, are representative of food stuffs consumed in only raw state. These studies don't take into consideration the facts that, the concentration of nutrients and their biological activity may be changed by processing methods. The aim of this study is to investigate the influence of processing/storing conditions on the free radical scavenging activity of different fruit juices. Free radical scavenging activity of fruit juices was determined by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method. Different types of fruit juices showed different values of scavenging activity. The free radical scavenging activity was quite stable when fruit juices were incubated at 4 o C for 4 days. When the freshly squeezed fruit juices were incubated under the sun light for 4 days, orange juice retains its scavenging activity. Lemon juices, mandarin and grapefruits lost more than 70% of their scavenging activit...

BMC Complementary Medicine and Therapies, 2021

Background Microbial resistance, diabetes mellitus, and obesity are global health care problems t... more Background Microbial resistance, diabetes mellitus, and obesity are global health care problems that have posed a serious threat to both human and environmental ecosystems. The goals of the present investigations are to investigate the phytoconstituents, antilipase, anti-α-amylase, and antimicrobial activity of Orobanche aegyptiaca Pers. (OA) from Palestine. Methods Identification of the phytoconstituents of OA plant petroleum ether, methylene chloride, chloroform, acetone, and methanol extracts were conducted using pharmacopeia’s methods, while porcine pancreatic lipase and α–amylase inhibitory activities were examined using p-nitrophenyl butyrate and 3,5-dinitro salicylic acid methods, respectively. Moreover, the antimicrobial activity was evaluated utilizing broth microdilution assay against eight bacterial and fungal strains. Results The phytochemical screening results showed that the methanol extract of the OA plant is rich in phytochemical components, also this extract has pow...

BioMed Research International, 2020

Pellitory plant (Parietaria judaica (PJ)) is one of the most widely used Arabian traditional medi... more Pellitory plant (Parietaria judaica (PJ)) is one of the most widely used Arabian traditional medicinal plants due to its ability to cure several infectious diseases and other illnesses. The current study is aimed at assessing the phytoconstituents, antilipase, antiamylase, antimicrobial, and cytotoxic characters of the Pellitory plant (Parietaria judaica (PJ)). Phytochemical screening and procyanidin detection were conducted according to the standard phytochemical procedures. Porcine pancreatic lipase and α-amylase inhibitory activities were carried out using p-nitrophenyl butyrate and dinitrosalicylic acid assays, respectively. In addition, antimicrobial activity was determined utilizing a microdilution assay against several bacterial and fungal strains. Besides, the cytotoxic effect against HeLa cell line was tested employing 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay. The quantitative test results revealed that the methano...

Heliyon, 2020

Background: Respiratory distress syndrome (RDS), a consequence of lung immaturity, is a serious c... more Background: Respiratory distress syndrome (RDS), a consequence of lung immaturity, is a serious complication of preterm birth and the primary cause of early neonatal mortality. Administration of antenatal steroids is a standard care method for mothers with anticipated preterm labor. However, the gestational age range at which antenatal corticosteroids (ACS) provide benefit has been subjected to debate. This study aimed to find the prevalence of ACS use in patients that developed/did not develop RDS. Methods: This cross-sectional study was conducted at Rafidia governmental surgical hospital. It is based on the data obtained from the files of mothers who gave birth to premature babies and from a face-to-face interview. One hundred and twenty-eight data collection forms were completed over a period of seven months. Results: Approximately 64% of mothers, mothers who gave birth to premature babies, were given ACS, and about 33% of premature neonates developed RDS. Mothers who gave birth to newborns with RDS have lower odds of being administered ACS by 44% (OR ¼ 0.44, CI ¼ 0.202-0.94, p value ¼ 0.034). However, the association became statistically not significant after adjusting gestational age, birth weight, gender, mother's age, intrauterine growth restriction (IUGR), mode of delivery and gestational hypertension (OR ¼ 0.462, CI ¼ 0.137-1.56, p value ¼ 0.212). Higher risk of RDS was significantly associated with lower gestational age (p-value < 0.001) and IUGR after adjustment (p value ¼ 0.035). However, no significant association could be found between RDS and mode of delivery (p value ¼ 0.730), maternal age (p value ¼ 0.63) and gender of the baby (p value ¼ 0.22). Conclusions: the overall prevalence of RDS in preterm infants was 33.3% and the identified risk factors were lower gestational age and IUGR. We showed that the administration of ACS wasn't significantly associated with the development of RDS after adjusting gestational age, birth weight, gender, mother's age, IUGR, mode of delivery and gestational hypertension, as the administration of ACS didn't fully meet the international guidelines.

Jordan Journal of Pharmaceutical Sciences, 2017

Stroke Research and Treatment, 2019

Background/Aim. Stroke or cerebrovascular accident is defined as sudden or sub acute onset of foc... more Background/Aim. Stroke or cerebrovascular accident is defined as sudden or sub acute onset of focal neurologic deficit, caused by the interruption of blood flow to parts of the brain. In this study, we aimed to investigate the prevalence of dyslipidemia and hyperglycemia among stroke patients in Palestine. Materials and Methods. A total of 70 patients with stroke were included in a cross-sectional study between November 2017 and February 2018. Stroke patients were diagnosed based on a CT scan reviewed by a neurologist. Fasting venous blood samples were collected to measure the lipid profile (cholesterol, low-density lipoproteins (LDL), triacylglycerol (TAG), high-density lipoproteins (HDL)), fasting blood glucose (FBG), and glycosylated hemoglobin (HbA1c) levels. An interview-based questionnaire, included background data, past medical history, family history, and other risk factors for stroke, was filled for each patient. Results. Based on our results, 28.57% of patients had high LD...

Journal of Lipids, 2019

Introduction. Dyslipidemia is the most important modifiable risk factor that leads to cardiovascu... more Introduction. Dyslipidemia is the most important modifiable risk factor that leads to cardiovascular diseases. The screening for dyslipidemia in Palestine is not established in primary health care centers for healthy people. Our study aims to determine the prevalence of dyslipidemia among healthy undiagnosed adult men in Palestine in order to assess the need for screening and preventive programs for dyslipidemia. Materials and Methods. A cross-sectional observational study was carried out in 10 secondary schools at Nablus municipality (Palestine) from August 2017 to February 2018. The study included 140 teachers based on sample calculations. The age of participants ranged between 24 and 60 years. A questionnaire was used to collect demographic data about the lifestyle, past medical, and family histories. Serum lipid profile, and fasting blood glucose levels for each participant were measured. Lipoprotein levels were categorized based on the adult treatment panel III criteria. Result...

Drug design, development and therapy, 2017

Orlistat is an irreversible inhibitor of the lipase enzyme that prevents trigylcerides from being... more Orlistat is an irreversible inhibitor of the lipase enzyme that prevents trigylcerides from being digested, thereby inhibiting triglyceride hydrolysis and absorption. The resultant reduced calorie uptake enables a positive effect on weight control. Systemic absorption of the drug is, therefore, not necessary for its mode of action. An alternative in vitro study (pharmacodynamic) has been introduced for this drug, as in vivo bioavailability studies are irrelevant with regard to the achievement of the product's intended purposes. To develop a new validated high-performance liquid chromatography (HPLC) method for the analysis of orlistat and to assess the potency and equivalence of three orlistat formulations using the pharmacodynamic method as a surrogate indicator of pharmaceutical interchangeability. A new HPLC method was developed for the analysis and for the dissolution studies of orlistat in capsules. Pancreatic lipase activity was measured for three different capsule product...

Marmara Pharmaceutical Journal, 2017

Preservation methods may affect total phenols, flavonoids contents, and antioxidant capacity of m... more Preservation methods may affect total phenols, flavonoids contents, and antioxidant capacity of many vegetables and fruits. These effects may cause degradation of antioxidant compounds, formation of new products, or destruction of the active metabolites. This study investigated the effects of different preservation methods, such as canning and freezing, on total flavonoids, total phenols, and antioxidant activity on grapevine leaves, which can be consumed either as medicine or food. Phytochemical screening was performed by using standard analytical methods; antioxidant activity was assayed by using 2,2-diphenyl-1-picryl-hydrazylhydrate reagent method; and total flavonoids and total phenols content were determined by using the rutin reference standard method and by Folin-Ciocalteu's method, respectively. The phytochemical content of all the studied grapevine leaf extracts were same. Fresh leaf extract showed the highest antioxidant capacity as well as total phenols and flavonoids contents. This was followed by the frozen leaf extract, while the canned leaf extract showed lower antioxidant capacity and reduced phenolic and flavonoids contents. Canning and freezing preservation methods of these leaves had no deleterious effects on total antioxidant capacity as well as total phenols and flavonoid contents. Therefore these methods can be used for preparing nutraceutical, cosmeceutical, and pharmaceutical supplements. However, the preservation of V. vinifera leaves by canning is economically and environmentally favored over freezing. In addition the storing, handling, and maintenance of canned leaves is easier than fresh and frozen leaves.

An Najah University Journal For Research Natural Sciences, Sep 17, 2014

Background: Reactive oxygen species (ROS) are formed as a natural byproduct of the normal metabol... more Background: Reactive oxygen species (ROS) are formed as a natural byproduct of the normal metabolism of oxygen and have important roles in cell signaling and homeostasis. However, during times of oxidative stress, ROS levels can rise dramatically. This may result in significant damage to cell structures. In this work we are interested to show the effect of different ROS on the morphology of fresh human RBCs. Methods: The RBCs were incubated with different reaction mixtures at room temperature and exposed to cool fluorescent light (800 lux). Then, cells were isolated and scanned by a scanning electron microscope. Results: When incubated with photoilluminated riboflavin, RBCs lost their biconcave shape and adopted a spherocytes shape. The formation of spherocytes is usually associated with spectrin deficiency. In the presence of Cu(II) and riboflavin, RBCs appeared with spikes of different sizes on their surface showing the formation of "acanthocytes", which is usually prevalent in abetalipoprotienemia. Moreover, addition of NaN 3 to riboflavin-Cu(II) system resulted in completely damaged RBCs. Away from the above combinations, when RBCs are incubated with ‫ـــــــــــــ‬ ‫ـــ‬ ‫ـ‬ ‫ــــــــــــــــــــــــــ‬ ‫ــــــــــــــــــ‬ ‫ـــــــ‬ ‫ـــــــ‬ ‫ـــــــــ‬ ‫ــــــ‬ "Morphological Perturbation of ......" An-Najah Univ. J. Res. (N. Sc.) Vol. 29, 2015 ‫ــــــــــــــــــــــــــــــــــــــــــ‬ ‫ـ‬ ‫ـــــــ‬ ‫ـ‬ ‫ـــــ‬ ‫ـ‬ ‫ـــ‬ ‫ـ‬ ‫ـــــــــــــــ‬ riboflavin-aminophylline combination, they appeared with spikes of equal lengths and sizes on their surface "echinocytes", which usually appear in different diseases like pyruvate kinase deficiency and uremia. Conclusion: Red blood cells undergo different morphological changes when incubated in each of the above combinations, most probably due to the formation of different ROS and these ROS could be involved in different pathological consequences.

European Journal of Psychology and Educational Studies, 2014

than the comparator groups in the general population [7] keeping in mind that poor diet, smoking,... more than the comparator groups in the general population [7] keeping in mind that poor diet, smoking, and excess weight are potentially modifiable factors associated with increased physical morbidity and mortality. [7] There was a negative (beneficial) relationship between pulses, fish and seafood intake, and prevalence of depression among schizophrenic clients. [8] The prevalence of smoking in schizophrenia patients greatly exceeds that in the general population. [9,10] Furthermore, heavy cigarette smoking is intimately associated with schizophrenia and it may have implications in the underlying neurobiology of the disease. [11] People with schizophrenia tended to take only small amounts of exercise. [12] The reason for this has not been demonstrated, but factors such as features of the illness, sedative medication, and lack of opportunity and general motivation may be relevant. [7,13] The relative risk of atherosclerosis in physically inactive individuals is higher than in those who are more active. Nevertheless, the specific mechanism by which physical Researchers have observed that nutritional deficiencies correlate with some mental disorders. [6] People with schizophrenia were reported to make significantly poorer dietary choices, do less exercise, and smoke more heavily

Saudi Pharmaceutical Journal

It has been suggested that Lys 234 residue participates in β-lactamase catalysis by acting as an ... more It has been suggested that Lys 234 residue participates in β-lactamase catalysis by acting as an electrostatic anchor for the C-3 carboxylate of penicillin. The aim of the present work is to test the role of the carboxylate group at C-3 in binding with the enzyme. A novel penicillin derivative, 3-aminomethyl-6-phenylacetamidopenicillanate, was prepared in which the carboxylic acid group at C-3 was replaced by an amino group. This was achieved by the reduction of a mixed anhydride of penicillin G to obtain 6-phenylacetamidopenicillanyl alcohol. The behavior of the alcoholic function in reacting with acidic components, following Mitsunobu reaction, was investigated, and 3-di-tert-butoxycarbonylaminomethyl-6-phenylacetamidopenicillanate was prepared as a crude product. After purification using column chromatography, the crude product undergoes deprotection of the amino group to produce the desired compound 3-aminomethyl-6-phenylacetamidopenicillanate. The hydrolysis of this compound by...

Indian journal of biochemistry & biophysics, 2006

Riboflavin (RF) upon irradiation with fluorescent light generates reactive oxygen species like su... more Riboflavin (RF) upon irradiation with fluorescent light generates reactive oxygen species like superoxide anion, singlet and triplet oxygen, flavin radicals and substantial amounts of hydrogen peroxide (H2O2). H2O2 can freely penetrate cell membrane and react with a transition metal ion like Cu(ll), generating hydroxyl radical via the modified metal-catalyzed Haber-Weiss reaction. Earlier, it was reported that trypsin-chymotrypsin mixture served as an indirect antioxidant and decreased free radical generation. Thus, in the present study, we used photoilluminated RF as a source of ROS to investigate the effect of free radicals on the activity of trypsin. We also compared the damaging effect of photoilluminated RF and RF-Cu(ll) system using trypsin as a target molecule. RF caused fragmentation of trypsin and the effect was further enhanced, when Cu(II) was added to the reaction. Results obtained with various ROS scavengers suggested that superoxide radical, singlet and triplet oxygen ...

Drug Metabolism and Drug Interactions, 2020

Marmara Pharmaceutical Journal, 2017

BMC Complementary Medicine and Therapies, 2021

BioMed Research International, 2020

Heliyon, 2020

Jordan Journal of Pharmaceutical Sciences, 2017

Stroke Research and Treatment, 2019

Journal of Lipids, 2019

Drug design, development and therapy, 2017

Marmara Pharmaceutical Journal, 2017

An Najah University Journal For Research Natural Sciences, Sep 17, 2014

European Journal of Psychology and Educational Studies, 2014

Saudi Pharmaceutical Journal

Indian journal of biochemistry & biophysics, 2006