Abdulmojeed Yakubu | Nasarawa State University, Keffi (original) (raw)

Papers by Abdulmojeed Yakubu

Research paper thumbnail of Genetic Diversity of Rabbit (Oryctolagus cuniculus) Population in South Eastern Nigeria Using Microsatellite Markers

Tropical Animal Science Journal, Aug 21, 2021

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Research paper thumbnail of Editorial: Technologies in smallholder poultry development: characterization, utilization, conservation, and improvement

Frontiers in Genetics

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Research paper thumbnail of Sequence analysis of exon 1 and intron 1 of growth hormone gene in six chicken genotypes raised in tropical environment

Biotehnologija u stocarstvu

Alpha % Growth hormone gene % Nigerian indigenous chicken % SNPs KR nema Chicken growth hormone (... more Alpha % Growth hormone gene % Nigerian indigenous chicken % SNPs KR nema Chicken growth hormone (cGH) is a polypeptide hormone secreted by the pituitary gland which is responsible for several functions such as tissue growth and reproduction in chickens. This study was conducted to characterize six chicken genotypes using exon 1 and intron 1 regions of cGH gene sequences. One hundred and thirty-four (134) chickens comprising Normal feather (19), Naked neck (21), Frizzle feather (8), Arbor Acre (24), FUNAAB Alpha-1 (dihybrid) (31), and FUNAAlpha-2 (trihybrid) (31) were used for the study. Blood samples were collected from the birds into EDTA bottles for DNA extraction. The exon 1 and intron 1 regions of cGH were amplified using published primers. The product of the polymerase chain reaction was subjected to Sanger sequencing. DnaSP5 software was used to determine the diversity indices and MEGA6 software was used to determine the phylogenetic relationships among the six chicken genotyp...

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Research paper thumbnail of Exploiting morphobiometric and genomic variability of African indigenous camel populations-A review

Frontiers in Genetics

Camels (Camelus dromedarius) in Africa are adapted to arid and the semi-arid environmental condit... more Camels (Camelus dromedarius) in Africa are adapted to arid and the semi-arid environmental conditions, and are valuable for meat, milk and fiber production. On account of the growing demand for camels in this continent, there is a need for knowledge on their phenotypic and genetic diversity. This is fundamental to sustainable herd management and utilization including the design of appropriate breeding and conservation strategies. We reviewed studies on the phenotypic and genetic characterization, breeding objectives, systems of production, productive and reproductive performances, and pathways for the sustainable rearing and use of camels in Africa. The morphological and genetic diversity, productive and reproductive abilities of African camels suggest the existence of genetic variations that can be utilized for breeds/ecotypes’ genetic improvement and conservation. Possible areas of intervention include the establishment of open nucleus and community-based breeding schemes and util...

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Research paper thumbnail of Heterozygous Single-Nucleotide Polymorphism Genotypes at Heat Shock Protein 70 Gene Potentially Influence Thermo-Tolerance Among Four Zebu Breeds of Nigeria

Frontiers in Genetics

Genetic variants at heat shock protein 70 gene and their influence on heat stress (HS) tolerance ... more Genetic variants at heat shock protein 70 gene and their influence on heat stress (HS) tolerance were studied among selected Nigeria zebu, namely, 25 White Fulani (WF), 21 Sokoto Gudali (SG), 21 Red Bororo (RB), and 23 Ambala (AM). Detection of single nucleotide polymorphism (SNP) followed by determination of genotype and genotypic frequency was made among the selected breeds. The heat tolerance coefficient (HTC) was determined from thermo-related parameters including body temperature, rectal temperature, and respiratory rate. Thermo-Tolerance was evaluated through the SNP–thermo-parameter relationship. Statistical analyses were done using the GLM procedure in SAS. A quantitative real-time/high-resolution melting-based assay detected twelve genetic variants. Five of these were common and shared across all breeds of cattle. Of the remaining seven variants, three were specifically identified in AM, two in SG, and two in RB. Also, SNPs were evaluated and four unique SNPs (C151T, C146T,...

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Research paper thumbnail of Multivariate characterisation of morpho-biometric traits of indigenous helmeted Guinea fowl (Numida meleagris) in Nigeria

PLOS ONE

This study was conducted to characterise phenotypically helmeted Guinea fowls in three agro-ecolo... more This study was conducted to characterise phenotypically helmeted Guinea fowls in three agro-ecologies in Nigeria using multivariate approach. Eighteen biometric characters, four morphological indices and eleven qualitative physical traits were investigated in a total of 569 adult birds (158 males and 411 females). Descriptive statistics, non-parametric Kruskal–Wallis H test followed by the Mann–Whitney U and Dunn-Bonferroni tests for post hoc, Multiple Correspondence Analysis (MCA), Univariate Analysis, Canonical Discriminant Analysis, Categorical Principal Component Analysis and Decision Trees were employed to discern the effects of agro-ecological zone and sex on the morphostructural parameters. Agro-ecology had significant effect (P<0.05; P<0.01) on all the colour traits. In general, the most frequently observed colour phenotype of Guinea fowl had pearl plumage colour (54.0%), pale red skin colour (94.2%), black shank colour (68.7%), brown eye colour (49.7%), white earlobe ...

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Research paper thumbnail of Myostatin Gene Sequence in Helmeted Guinea Fowl Breeds

Social Science Research Network, 2022

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Research paper thumbnail of Evaluation of Polymorphisms at Heat Shock Protein 90 Gene by High Resolution Melting Assays for Potential Heat Tolerance among Nigerian Zebu Cattle Breeds

American Journal of Animal and Veterinary Sciences, 2020

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Research paper thumbnail of Comparison of five mathematical models that describe growth in tropically adapted dual-purpose breeds of chicken

Journal of Applied Animal Research, 2021

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Research paper thumbnail of Farmers' Choice of Breeding Stock and Trait Preferences in Tropically-Adapted in Five Agro-Ecological Zones in Nigeria

A Paper Presented at the 44th Annual Conference of the Nigerian Society for Animal Production fro... more A Paper Presented at the 44th Annual Conference of the Nigerian Society for Animal Production from March 17 – 21, 2019 Abuja, Nigeria.

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Research paper thumbnail of Multivariate Characterization of Morpho-biometric Traits of Indigenous Helmeted Guinea Fowl (Numida meleagris) in Nigeria

This study was embarked upon to characterise phenotypically helmeted guinea fowls in three agro-e... more This study was embarked upon to characterise phenotypically helmeted guinea fowls in three agro-ecologies in Nigeria using multivariate approach. Eighteen biometric characters, four morphological indices and eleven qualitative (phaneroptic) traits were investigated in a total of 569 adult birds (158 males and 411 females). Descriptive statistics, non-parametric Kruskal–Wallis H test followed by the Mann–Whitney U test for post hoc, Multiple Correspondence Analysis (MCA), General Linear Model, Canonical Discriminant Analysis, Categorical Principal Component Analysis and Decision Trees were employed to discern the effects of agro-ecological zone and sex on the morphostructural parameters. Agro-ecology had significant effect (P<0.05; P <0.01) on all the colour traits. In general, the most frequently observed colour phenotype of guinea fowl had pearl plumage colour (54.0%), pale red skin colour (94.2%), black shank colour (68.7%), brown eye colour (49.7%), white earlobe colour (54...

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Research paper thumbnail of Genetic conservation through effective utilization of the improved indigenous chicken breeds by rural households in Nigeria

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Research paper thumbnail of Bioinformatics analysis of beta-casein gene in some selected mammalian species

Research Opinions in Animal & Veterinary Sciences, 2014

This study investigates in silico the genetic diversity of CSN2 on its evolutionary and different... more This study investigates in silico the genetic diversity of CSN2 on its evolutionary and differentiation within and among species and also examines the attendant effects of polymorphism on the functionality of CSN2. A total of 22 CNS2 gene sequences with corresponding amino acids belonging to 8 species [cattle (3), buffalo (3), camel (3), goat (3), horse (1), rabbit (3), rat (3) and mice (3) were retrieved from Genbank (www.ncbi.nlm.nih.gov). All sequences were trimmed to equal length (501bp) corresponding to the same region. Sequences alignment, translation and comparison were done with ClustalW using IUB substitution matrix, gap open penalty of 15 and gap extension penalty of 6.66. The alignment revealed high polymorphism of CNS2 sequences within and among species. The Dxy inferred using p-distance revealed a maximum value of 0.68 between horse and goat and a minimum value of 0.03 between cattle and buffalo. The hypothesis of strict neutral evolution was rejected for both genes as ...

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Research paper thumbnail of Principal component regression of carcass traits in meat line funaab alpha chicken genotype

This study aimed to assess the relationship among carcass traits of meat line FUNAAB Alpha chicke... more This study aimed to assess the relationship among carcass traits of meat line FUNAAB Alpha chicken genotype, to identify the components that defined bled weight in them using multivariate principal component regression. A total of 14 different carcass traits from sixty-eight birds were recorded and subjected to one-way analysis of variance to vet for sex effect. Phenotypic relationships among the carcass traits were also established to pave way for the principal component analysis. The results reveal significant effects between the traits measured. The male significantly (P<0.05) had greater mean values for the traits measured. Correlations among the considered carcass traits were found to be positive and significant ranging from r = 0.406 (LrWt) - 0.981 (EdWt) for the female chicken; r = 0.330 (Head Wt) - 0.978 (BdWt) for the male chicken. The extracted components PC1 to PC7 contributed 95.66% with PC1 accounting for 68.68% of the variability in the original parameters. Communal...

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Research paper thumbnail of Sequence analyses of insulin-like growth factor 1 gene in Nigerian indigenous and arbor acre chickens

Genetika, 2021

Alpha % Indigenous chicken % Gene % Sequence KR nema The chicken Insulin-like growth factor 1 (IG... more Alpha % Indigenous chicken % Gene % Sequence KR nema The chicken Insulin-like growth factor 1 (IGF1) is a candidate gene for growth, body composition and metabolism, skeletal characteristics and growth of adipose tissue and fat deposition in chickens. It is mapped to 165.95 cM on chromosome 1 and composed of four exons and three introns, spanning more than 50 kb. Genomic DNA was extracted from blood samples collected from the experimental birds using Qiagen DNA extraction kits. Polymersae chain reaction (PCR) was carried out using established primers. The PCR amplicon involving 5?untranslated region were sequenced. The sequences were analysed to identify polymorphisms, their genetic diversities and evolutionary relationships among three strains of Nigerian indigenous chickens [Frizzle Feathered (7), Normal Feathered (19) and Naked Neck (19), and the Arbor Acre broiler chicken (17)]. Nucleotide sequences generated were edited and aligned using Codon Code Aligner. Diversity analysis w...

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Research paper thumbnail of Characterisation of indigenous helmeted guinea fowls in Nigeria for meat and egg production

World's Poultry Science Journal, 2021

SUMMARY There is increasing interest in sustainable poultry production in developing economies. T... more SUMMARY There is increasing interest in sustainable poultry production in developing economies. This review provides an insight into guinea fowl production in Nigeria as a means of additional high-quality poultry meat and egg production. Under the smallholder scavenging system, flock size of the four investigated plumages (Pearl, Lavender, Black and White) of indigenous helmeted guinea fowl in Nigeria typically ranges from 6 to 9 birds per household, 14-week mean live weight from 917 to 975 g, dressed weight at this age from 700 to 737 g and dressing percentage from 74 to 76%. Under the backyard system of production, mean egg number is typically about 80 eggs per hen/annum while under intensive management it can be up to 147 eggs per hen/annum and egg weight from 29 to 38 g. Under smallholder conditions, hatchability of fertile eggs can range from 70 to 86% while under improved housing and rearing conditions it can be as high as 89%. The present information could be exploited in formulating appropriate management strategies and breeding decisions for sustainable production of hybrid improved guinea fowls, thereby contributing to food security in Nigeria.

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Research paper thumbnail of Evolutionary Pattern of Interferon Alpha Genes in Bovidae and Genetic Diversity of IFNAA in the Bovine Genome

Frontiers in Immunology, 2020

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Research paper thumbnail of Farmers’ choice of genotypes and trait preferences in tropically adapted chickens in five agro-ecological zones in Nigeria

Tropical Animal Health and Production, 2019

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Research paper thumbnail of Application of computational algorithms to assess the functionality of non-synonymous substitutions in MHC DRB gene of Nigerian goats

Genetika, 2017

The Major Histocompatibility Complex (MHC) contains highly variable multi-gene families, which pl... more The Major Histocompatibility Complex (MHC) contains highly variable multi-gene families, which play a key role in the adaptive immune response within vertebrates. Among the Capra MHC class II genes, the expressed DRB locus is highly polymorphic, particularly in exon 2, which encodes the antigen-binding site. Models of variable non-synonymous/synonymous rate ratios among sites may provide important insights into functional constraints at different amino acid sites and may be used to detect sites under positive selection. Many non-synonymous single nucleotide polymorphisms (nsSNPs) at the DRB locus in goats are suspected to impact protein function. This study, therefore, aimed at comparing the efficiency of six computational approaches to predict the likelihood of a particular non-synonymous (amino acid change) coding SNP to cause a functional impact on the protein. This involved the use of PANTHER, SNAP, SIFT, PolyPhen-2, PROVEAN and nsSNPAnalyzer bioinformatics analytical tools in d...

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Research paper thumbnail of Association of SNP variants of MHC Class II DRB gene with thermo-physiological traits in tropical goats

Tropical Animal Health and Production, 2016

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Research paper thumbnail of Genetic Diversity of Rabbit (Oryctolagus cuniculus) Population in South Eastern Nigeria Using Microsatellite Markers

Tropical Animal Science Journal, Aug 21, 2021

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Research paper thumbnail of Editorial: Technologies in smallholder poultry development: characterization, utilization, conservation, and improvement

Frontiers in Genetics

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Research paper thumbnail of Sequence analysis of exon 1 and intron 1 of growth hormone gene in six chicken genotypes raised in tropical environment

Biotehnologija u stocarstvu

Alpha % Growth hormone gene % Nigerian indigenous chicken % SNPs KR nema Chicken growth hormone (... more Alpha % Growth hormone gene % Nigerian indigenous chicken % SNPs KR nema Chicken growth hormone (cGH) is a polypeptide hormone secreted by the pituitary gland which is responsible for several functions such as tissue growth and reproduction in chickens. This study was conducted to characterize six chicken genotypes using exon 1 and intron 1 regions of cGH gene sequences. One hundred and thirty-four (134) chickens comprising Normal feather (19), Naked neck (21), Frizzle feather (8), Arbor Acre (24), FUNAAB Alpha-1 (dihybrid) (31), and FUNAAlpha-2 (trihybrid) (31) were used for the study. Blood samples were collected from the birds into EDTA bottles for DNA extraction. The exon 1 and intron 1 regions of cGH were amplified using published primers. The product of the polymerase chain reaction was subjected to Sanger sequencing. DnaSP5 software was used to determine the diversity indices and MEGA6 software was used to determine the phylogenetic relationships among the six chicken genotyp...

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Research paper thumbnail of Exploiting morphobiometric and genomic variability of African indigenous camel populations-A review

Frontiers in Genetics

Camels (Camelus dromedarius) in Africa are adapted to arid and the semi-arid environmental condit... more Camels (Camelus dromedarius) in Africa are adapted to arid and the semi-arid environmental conditions, and are valuable for meat, milk and fiber production. On account of the growing demand for camels in this continent, there is a need for knowledge on their phenotypic and genetic diversity. This is fundamental to sustainable herd management and utilization including the design of appropriate breeding and conservation strategies. We reviewed studies on the phenotypic and genetic characterization, breeding objectives, systems of production, productive and reproductive performances, and pathways for the sustainable rearing and use of camels in Africa. The morphological and genetic diversity, productive and reproductive abilities of African camels suggest the existence of genetic variations that can be utilized for breeds/ecotypes’ genetic improvement and conservation. Possible areas of intervention include the establishment of open nucleus and community-based breeding schemes and util...

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Research paper thumbnail of Heterozygous Single-Nucleotide Polymorphism Genotypes at Heat Shock Protein 70 Gene Potentially Influence Thermo-Tolerance Among Four Zebu Breeds of Nigeria

Frontiers in Genetics

Genetic variants at heat shock protein 70 gene and their influence on heat stress (HS) tolerance ... more Genetic variants at heat shock protein 70 gene and their influence on heat stress (HS) tolerance were studied among selected Nigeria zebu, namely, 25 White Fulani (WF), 21 Sokoto Gudali (SG), 21 Red Bororo (RB), and 23 Ambala (AM). Detection of single nucleotide polymorphism (SNP) followed by determination of genotype and genotypic frequency was made among the selected breeds. The heat tolerance coefficient (HTC) was determined from thermo-related parameters including body temperature, rectal temperature, and respiratory rate. Thermo-Tolerance was evaluated through the SNP–thermo-parameter relationship. Statistical analyses were done using the GLM procedure in SAS. A quantitative real-time/high-resolution melting-based assay detected twelve genetic variants. Five of these were common and shared across all breeds of cattle. Of the remaining seven variants, three were specifically identified in AM, two in SG, and two in RB. Also, SNPs were evaluated and four unique SNPs (C151T, C146T,...

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Research paper thumbnail of Multivariate characterisation of morpho-biometric traits of indigenous helmeted Guinea fowl (Numida meleagris) in Nigeria

PLOS ONE

This study was conducted to characterise phenotypically helmeted Guinea fowls in three agro-ecolo... more This study was conducted to characterise phenotypically helmeted Guinea fowls in three agro-ecologies in Nigeria using multivariate approach. Eighteen biometric characters, four morphological indices and eleven qualitative physical traits were investigated in a total of 569 adult birds (158 males and 411 females). Descriptive statistics, non-parametric Kruskal–Wallis H test followed by the Mann–Whitney U and Dunn-Bonferroni tests for post hoc, Multiple Correspondence Analysis (MCA), Univariate Analysis, Canonical Discriminant Analysis, Categorical Principal Component Analysis and Decision Trees were employed to discern the effects of agro-ecological zone and sex on the morphostructural parameters. Agro-ecology had significant effect (P<0.05; P<0.01) on all the colour traits. In general, the most frequently observed colour phenotype of Guinea fowl had pearl plumage colour (54.0%), pale red skin colour (94.2%), black shank colour (68.7%), brown eye colour (49.7%), white earlobe ...

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Research paper thumbnail of Myostatin Gene Sequence in Helmeted Guinea Fowl Breeds

Social Science Research Network, 2022

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Research paper thumbnail of Evaluation of Polymorphisms at Heat Shock Protein 90 Gene by High Resolution Melting Assays for Potential Heat Tolerance among Nigerian Zebu Cattle Breeds

American Journal of Animal and Veterinary Sciences, 2020

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Research paper thumbnail of Comparison of five mathematical models that describe growth in tropically adapted dual-purpose breeds of chicken

Journal of Applied Animal Research, 2021

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Research paper thumbnail of Farmers' Choice of Breeding Stock and Trait Preferences in Tropically-Adapted in Five Agro-Ecological Zones in Nigeria

A Paper Presented at the 44th Annual Conference of the Nigerian Society for Animal Production fro... more A Paper Presented at the 44th Annual Conference of the Nigerian Society for Animal Production from March 17 – 21, 2019 Abuja, Nigeria.

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Research paper thumbnail of Multivariate Characterization of Morpho-biometric Traits of Indigenous Helmeted Guinea Fowl (Numida meleagris) in Nigeria

This study was embarked upon to characterise phenotypically helmeted guinea fowls in three agro-e... more This study was embarked upon to characterise phenotypically helmeted guinea fowls in three agro-ecologies in Nigeria using multivariate approach. Eighteen biometric characters, four morphological indices and eleven qualitative (phaneroptic) traits were investigated in a total of 569 adult birds (158 males and 411 females). Descriptive statistics, non-parametric Kruskal–Wallis H test followed by the Mann–Whitney U test for post hoc, Multiple Correspondence Analysis (MCA), General Linear Model, Canonical Discriminant Analysis, Categorical Principal Component Analysis and Decision Trees were employed to discern the effects of agro-ecological zone and sex on the morphostructural parameters. Agro-ecology had significant effect (P<0.05; P <0.01) on all the colour traits. In general, the most frequently observed colour phenotype of guinea fowl had pearl plumage colour (54.0%), pale red skin colour (94.2%), black shank colour (68.7%), brown eye colour (49.7%), white earlobe colour (54...

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Research paper thumbnail of Genetic conservation through effective utilization of the improved indigenous chicken breeds by rural households in Nigeria

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Bioinformatics analysis of beta-casein gene in some selected mammalian species

Research Opinions in Animal & Veterinary Sciences, 2014

This study investigates in silico the genetic diversity of CSN2 on its evolutionary and different... more This study investigates in silico the genetic diversity of CSN2 on its evolutionary and differentiation within and among species and also examines the attendant effects of polymorphism on the functionality of CSN2. A total of 22 CNS2 gene sequences with corresponding amino acids belonging to 8 species [cattle (3), buffalo (3), camel (3), goat (3), horse (1), rabbit (3), rat (3) and mice (3) were retrieved from Genbank (www.ncbi.nlm.nih.gov). All sequences were trimmed to equal length (501bp) corresponding to the same region. Sequences alignment, translation and comparison were done with ClustalW using IUB substitution matrix, gap open penalty of 15 and gap extension penalty of 6.66. The alignment revealed high polymorphism of CNS2 sequences within and among species. The Dxy inferred using p-distance revealed a maximum value of 0.68 between horse and goat and a minimum value of 0.03 between cattle and buffalo. The hypothesis of strict neutral evolution was rejected for both genes as ...

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Research paper thumbnail of Principal component regression of carcass traits in meat line funaab alpha chicken genotype

This study aimed to assess the relationship among carcass traits of meat line FUNAAB Alpha chicke... more This study aimed to assess the relationship among carcass traits of meat line FUNAAB Alpha chicken genotype, to identify the components that defined bled weight in them using multivariate principal component regression. A total of 14 different carcass traits from sixty-eight birds were recorded and subjected to one-way analysis of variance to vet for sex effect. Phenotypic relationships among the carcass traits were also established to pave way for the principal component analysis. The results reveal significant effects between the traits measured. The male significantly (P<0.05) had greater mean values for the traits measured. Correlations among the considered carcass traits were found to be positive and significant ranging from r = 0.406 (LrWt) - 0.981 (EdWt) for the female chicken; r = 0.330 (Head Wt) - 0.978 (BdWt) for the male chicken. The extracted components PC1 to PC7 contributed 95.66% with PC1 accounting for 68.68% of the variability in the original parameters. Communal...

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Research paper thumbnail of Sequence analyses of insulin-like growth factor 1 gene in Nigerian indigenous and arbor acre chickens

Genetika, 2021

Alpha % Indigenous chicken % Gene % Sequence KR nema The chicken Insulin-like growth factor 1 (IG... more Alpha % Indigenous chicken % Gene % Sequence KR nema The chicken Insulin-like growth factor 1 (IGF1) is a candidate gene for growth, body composition and metabolism, skeletal characteristics and growth of adipose tissue and fat deposition in chickens. It is mapped to 165.95 cM on chromosome 1 and composed of four exons and three introns, spanning more than 50 kb. Genomic DNA was extracted from blood samples collected from the experimental birds using Qiagen DNA extraction kits. Polymersae chain reaction (PCR) was carried out using established primers. The PCR amplicon involving 5?untranslated region were sequenced. The sequences were analysed to identify polymorphisms, their genetic diversities and evolutionary relationships among three strains of Nigerian indigenous chickens [Frizzle Feathered (7), Normal Feathered (19) and Naked Neck (19), and the Arbor Acre broiler chicken (17)]. Nucleotide sequences generated were edited and aligned using Codon Code Aligner. Diversity analysis w...

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Research paper thumbnail of Characterisation of indigenous helmeted guinea fowls in Nigeria for meat and egg production

World's Poultry Science Journal, 2021

SUMMARY There is increasing interest in sustainable poultry production in developing economies. T... more SUMMARY There is increasing interest in sustainable poultry production in developing economies. This review provides an insight into guinea fowl production in Nigeria as a means of additional high-quality poultry meat and egg production. Under the smallholder scavenging system, flock size of the four investigated plumages (Pearl, Lavender, Black and White) of indigenous helmeted guinea fowl in Nigeria typically ranges from 6 to 9 birds per household, 14-week mean live weight from 917 to 975 g, dressed weight at this age from 700 to 737 g and dressing percentage from 74 to 76%. Under the backyard system of production, mean egg number is typically about 80 eggs per hen/annum while under intensive management it can be up to 147 eggs per hen/annum and egg weight from 29 to 38 g. Under smallholder conditions, hatchability of fertile eggs can range from 70 to 86% while under improved housing and rearing conditions it can be as high as 89%. The present information could be exploited in formulating appropriate management strategies and breeding decisions for sustainable production of hybrid improved guinea fowls, thereby contributing to food security in Nigeria.

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Research paper thumbnail of Evolutionary Pattern of Interferon Alpha Genes in Bovidae and Genetic Diversity of IFNAA in the Bovine Genome

Frontiers in Immunology, 2020

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Research paper thumbnail of Farmers’ choice of genotypes and trait preferences in tropically adapted chickens in five agro-ecological zones in Nigeria

Tropical Animal Health and Production, 2019

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Research paper thumbnail of Application of computational algorithms to assess the functionality of non-synonymous substitutions in MHC DRB gene of Nigerian goats

Genetika, 2017

The Major Histocompatibility Complex (MHC) contains highly variable multi-gene families, which pl... more The Major Histocompatibility Complex (MHC) contains highly variable multi-gene families, which play a key role in the adaptive immune response within vertebrates. Among the Capra MHC class II genes, the expressed DRB locus is highly polymorphic, particularly in exon 2, which encodes the antigen-binding site. Models of variable non-synonymous/synonymous rate ratios among sites may provide important insights into functional constraints at different amino acid sites and may be used to detect sites under positive selection. Many non-synonymous single nucleotide polymorphisms (nsSNPs) at the DRB locus in goats are suspected to impact protein function. This study, therefore, aimed at comparing the efficiency of six computational approaches to predict the likelihood of a particular non-synonymous (amino acid change) coding SNP to cause a functional impact on the protein. This involved the use of PANTHER, SNAP, SIFT, PolyPhen-2, PROVEAN and nsSNPAnalyzer bioinformatics analytical tools in d...

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Research paper thumbnail of Association of SNP variants of MHC Class II DRB gene with thermo-physiological traits in tropical goats

Tropical Animal Health and Production, 2016

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