AbdElkarim A. Abdrabo | AL-Neelain University (original) (raw)

Papers by AbdElkarim A. Abdrabo

Matrix science medica, 2022

American Journal of Medicine and Medical Sciences, 2014

The objective of this study is to evaluate the levels of gamma-glutamyltransferase and highly sen... more The objective of this study is to evaluate the levels of gamma-glutamyltransferase and highly sensitive C-reactive protein in patients with metabolic disorders in Sudan. Material and method: A case control hospital based study was carried out at Atbara-River Nile State-Sudan. Total of 294 participants, 194 patients were with at least one of the metabolic disorders (Diabetic, Obese, or Hypertensive) were enrolled in this study together with 100 healthy control subjects during the period from October to November 2013. For all participants, body mass index (BMI), gamma-glutamyltransferase (GGT) and highly sensitive C-reactive protein (hs-CRP) were measured using standard methods. Result: A significant elevation of GGT levels was observed in all patients (diabetic, hypertensive, and obese). Levels of hs-CRP significantly increased in obese and diabetic. While in hypertensive patients insignificant elevation was observed. Conclusion: patients with metabolic disorders, included in this study, have significantly elevated GGT levels and hs-CRP except hypertensive.

Journal of Medical and Life Science (Print), Mar 1, 2022

Background: More than 70 million couples worldwide are affected by infertility. With a male facto... more Background: More than 70 million couples worldwide are affected by infertility. With a male factor infertility account for about half of the cases. Semen analysis is critical for determining male fertility potential. Objective: To estimate the prevalence of abnormal semen parameters among Sudanese Patients Fertility Center in Khartoum city, Sudan. Materials and methods: This is a retrospective cross-sectional study conducted on 2585 males who were referred to the fertility Center in Khartoum, in 2018, to evaluate the semen quality (sperm count, motility, and morphology) according to World Health Organization (WHO) criteria. The descriptive statistics and frequency studies were conducted using the SPSS version (23). Results: There is a higher prevalence of abnormal semen parameters 86.8 % (sperm count 14.9% -sperm motility 0.7% -morphology 40.7% and 30.5% is a combination of two or more abnormal sperm counts). Sperm motility and morphology and only 13.2% showed normal semen parameters according to WHO criteria. the finding of this study revealed there is low semen quality. It shows a high prevalence of low sperm count, abnormal motility, and morphology according to the WHO criteria.

The quality of formalin, boric acid, domestic bleach and carbol fuchsin were investigated as pres... more The quality of formalin, boric acid, domestic bleach and carbol fuchsin were investigated as preservatives of Schistosoma haematobium ova for three weeks. Urine specimens obtained from patients included in a survey conducted in the Maio area in Khartoum the urine specimen was divided into 4 aliquots within 12h of the collection into the four preservatives mentioned above and were processed after one week, two week and three week of wet preparation of 14 positive specimens (a total of 217 processed samples) after concentration by centrifugation. We found that all fixatives give good morphological characteristics for S. Haematobium with some morphological changes, and crystal formation with formalin, boric acid and domestic bleach which appear after the first week. Formalin is aldehyde base fixative, domestic bleach is oxidizing agents based fixative, both have action of cross linking in preservation of samples which may cause these morphological changes. Carbol fuchsin gave the same morphological appearance during the three weeks. According to this result, we conclude that non-cross linking alcohol based fixatives such as carbol fuchsin gave good preservation for the morphology of S. Haematobium ova as the morphological characters did not change during preservation time.

Pan African Medical Journal

Pakistan Journal of Medical and Health Sciences

Background: Breast cancer (BC) is problem in developed and developing nations and is linked to a ... more Background: Breast cancer (BC) is problem in developed and developing nations and is linked to a high mortality rate. Objective: In this study, we determined the relationships between osteopontin level, hormonal status, stage, BMI, and age in BC patients. Materials and Methods: In a cross sectional 178 BC patients, ages ranged from 28 to 95 were randomly enrolled. Body mass index were estimated. Plasma osteopontin were measured. Results: From total of 178 BC patients, 54 (30.3 %) were trilpe negative, 124 (69.7%.) were hormone receptor positive. 86 (48.3%) had high plasma OPN level and 92 (51.7%) with OPN ≤ 55. Chi square analyses show that osteopontin was significantly associated with triple negative breast cancer and tumor stage with (P = 0.002 and 0.011), and (odd ratio 1.653,1.604) respectively. Conclusion: High OPN associated with hormone receptor and tumor stage in breast cancer patients. Keywords: Osteopontin, BC, Hormone, Receptors

This case control study, 100 pregnant women (50 normal pregnant, 50 pre-eclamptic women of age ra... more This case control study, 100 pregnant women (50 normal pregnant, 50 pre-eclamptic women of age ranging between 16-38 years and having gestational age between 26 to 36 weeks. This study carried in Midwives Hospital, Omdurman from January to march 2015. In the subjects serum concentrations of iron and TIBC were estimated using ferrozine method using Bio-System. Ferritin and Transferrin were estimated using immune Enzymometric Assay (TOSOH-A1A-360).

Background: A number of studies have been published in recent years showing a significant associa... more Background: A number of studies have been published in recent years showing a significant association between leukemia and low plasma cholesterol levels. Objectives: We measured lipids profile which includes plasma total cholesterol, low density (LDL) and high density (HDL) lipoproteins in patients with leukemia in comparison with age and sex matched controls. Materials and Methods: The study included 50 normal healthy controls and 100 patients with leukemia (64 acute and 36 of them are chronic). Cholesterol profile was estimated using spectrophotometer method. Results: Mean ± SD of total cholesterol, LDL and HDL in leukemic patients were (120.86 ± 23.04, 29.47 ± 10.76, 29.38 ± 8.45mg/dl) respectively, while the mean ± SD of healthy person were (168.00 ± 14.73, 61.94 ± 14.64, 62.50 ± 10.60mg/dl) respectively. This result show highly significant difference which was lower in the leukemic patients compared to the control with P value (0.000). Conclusion: This study concluded that the ...

Journal of Biomedical and Pharmaceutical Research, Aug 5, 2013

BACKGROUND: Previous data suggest possible effects of postmenopause on serum lipids profile and u... more BACKGROUND: Previous data suggest possible effects of postmenopause on serum lipids profile and uric acidwhich are established risk factors for cardiovascular system.AIM: to evaluate the changes that may occur on serum lipids profile and uric acid measurements inpostmenopausal Sudanese women.MATERIALS AND METHODS The study involved 150 females. The studies subjects were grouped according to theirmenstrual status to women at age of menarche (75 women) their age ranged between (45 – 90 years, mean of59.1), and women at age after menopause (75 women) aged between (25 – 49 years, mean 35.9). Following atleast 12 hours fasting, serum total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL),and uric acid were measured.RESULTS: lipids measurements were significantly different in both groups; HDL-cholesterol was significantly less inpostmenopausal women (M±SD = 45.2±13.76 mg/dl) compared to women at age of menarche (M±SD = 51.8±14.9mg/dl, P = 0.032). TC, LDL, and UA concentrations are significantly increased in postmenopausal women (171±19.6mg/dl, 120.5±19 mg/dl and 5.0±0.8 mg/dl) compared with women at age of menarche (149.2±25.7 mg/dl and94.7±10.1 mg/dl, and 3.66±0.7, P = 0.000, 0.002, and 0.001 respectively).CONCLUSION: two possible cardiovascular risk factors may present in postmenopausal women hyperlipidaemiaand increased uric acid, so screening is necessary to women at this age.

Objective: To estimate serum levels of zinc and magnesium among Sudanese children under 5 years w... more Objective: To estimate serum levels of zinc and magnesium among Sudanese children under 5 years with protein energy malnutrition (PEM), in comparison with apparently healthy volunteers. Materials and methods: A cross- sectional hospital based study conducted during the period from May to September 2013. Children with PEM were chosen from Omdurman Teaching Hospital for Pediatric. The studied populations consist of 90 subjects: Fifty children patients less than five years with PEM. Forty apparently healthy subjects matching age and sex were also included as control. Results: We found significantly low serum zinc and magnesium levels in PEM types [kwashiorkor: zinc = (0.31mg/dl), magnesium = (1.09 mg/dl), marasmus: zinc = (0.31mg/dl), magnesium = (0.99 mg/dl), marasmic-kwashiorkor: zinc = (0.33 mg/dl), magnesium = (0.98mg/dl)] patients as compared to control [zinc = (0.76 mg/dl), magnesium = ( 1.92 mg/dl)], P <0.05 Conclusion: This findings can be concluded to that PEM is associated...

The objective of this study is to shed more light on the role of trace metals and their mode of a... more The objective of this study is to shed more light on the role of trace metals and their mode of action in hyperthyroidism and hypothyroidism. The content of the trace elements Zinc and Manganese (Zn and Mn) in the serum of patients was determined (Forty patients with hyperthyroidism (26 females and 14 males) and hypothyroidism (23 females and 17 males) were participated in this study. Serum zinc and manganese were determined using flame atomic absorption spectrophotometer technique. The study showed that serum zinc and manganese levels of hyperthyroidism patients were significantly lower (p<0.05) compared to reference range (zinc level is (0.5 to 1.2, mean 0.85 mg/l) and manganese is (0.3 to 0.9, mean 0.6 mg/l), While a significant increase in serum manganese level and decrease in serum zinc levels in patients with hypothyroidism (p<0.05). The present study confirmed significant changes in the levels of serum Zn, Mn in hyperthyroidism and hypothyroidism patients and these changes may be related to pathophysiology of thyroid disease.

Effect of cigarette smoking on serum thyroid hormones i.e. thyroxin (T3) and triiodothyronine (T4... more Effect of cigarette smoking on serum thyroid hormones i.e. thyroxin (T3) and triiodothyronine (T4) and their regulatory hormone i.e. thyrotrophin (TSH) was evaluated in healthy smoker individuals and compared with non smoker individuals. Enzyme linked immunosorbant assay (ELISA) was used to estimate level of T3, T4 and TSH. The results of study showed that the (Mean ± SD) of T3, T4 and TSH were (1.21±0.26), (6.3±2.0) and (1.27±0.7) respectively in smokers which was not significantly differ when compared with nonsmokers (Mean ± SD) of T3, T4 and TSH were (1.31±0.27), ( 6.0±0.7) and (1.33±0.6) respectively. The study indicated no significant variations in thyroid hormones and their regulatory hormones in smokers and non smoker individuals.

Reports of Biochemistry and Molecular Biology

Background: Diabetes-related vascular complications linked to increase in the expression of VEGF ... more Background: Diabetes-related vascular complications linked to increase in the expression of VEGF and its receptors. It helps to accelerate tissue damage inflicted by hyperglycemia, which is potential risk for diabetic complications. The study aimed to assess VEGF genetic polymorphism and its correlation with glucose and HbA1C level among Sudanese patients with diabetic retinopathy and nephropathy. Methods: A case-control study was conducted among a total of 252 subjects and divided into four groups of 63 subjects each. Glucose and HBA1c were measured then the VEGF gene was amplified using polymerase chain reaction. The data were analyzed using SPSS. Results: The HBA1c, and blood glucose levels had significantly (P value≤0.00001) highest mean in the DR group, DN group followed by DM. There is a non-significant correlation between VEGF Genotypes and HbA1c, and blood glucose levels (P value≤0.102, 0.173) Patients with GC genotypes will be 74.6%, and 54% higher at risk to develop DR, and DN respectively and 40 % lower at risk to develop DM than those without GC genotype. While patients with CC genotypes will be 22.2% higher at risk of developing DM and 9.5%, 12.2% higher at risk of developing DR and DN respectively. Conclusions: The VEGF +405G/C gene polymorphism is linked to diabetic retinopathy, and diabetic nephropathy in type 2 Sudanese diabetics, and the presence of the GC genotypes and G allele is a significant predictor for retinopathy. There is no significant relation between HbA1C serum levels, blood glucose, and the VEGF +405G/C gene polymorphism.

Zagazig university medical journal, May 19, 2022

Background: The association between serum 25-Hydroxy vitamin D (25-OH vitamin D) levels in hypoth... more Background: The association between serum 25-Hydroxy vitamin D (25-OH vitamin D) levels in hypothyroid subjects with and without thyroid peroxidase (TPO) antibodies is controversial. There is increasing evidence that 25-OH vitamin D level is associated with autoimmune diseases. The study aimed to assess serum 25-OH vitamin D levels among hypothyroidism Sudanese patients with and without thyroid peroxidase (TPO) antibodies. Methods: analytical cross-sectional conducted at The Center for Diabetes and Endocrinology in Khartoum from February to October 2020. Sixty subjects with hypothyroidism were recruited from the follow-up clinic. Other sixty age and sex-matched subjects were selected as control. Thyroid function tests (TSH, FT4, and FT3) were measured using TOSOH AIA 360 system analyzer, and serum 25-OH vitamin D level was measured using a semiautomatic I-Chroma-II reader and thyroid peroxidase antibodies (TPO antibodies) were measured in both cases and controls using ELISA technique. The results were analyzed using SPSS version 21. Results: TSH was significantly increased in both TPO antibodies positive and TPO antibodies negative hypothyroid subjects than in the control (22.3±4.44), (10.5±2.55) (3.42±0.75), respectively, with a P-value of 0.000. The level of 25-OH Vitamin D was lower among hypothyroid subjects than in the control. Subjects with positive TPO antibody had lower 25-OH vitamin D levels than the TPO-antibody negative subjects compared to control (7.45±4.50 ̽) (10.5±7.18) (48.8±10.0), respectively, with a P-value of 0.000. Females 46 (77%) were more than males 14(23%). Conclusions: 25-OH vitamin D level was low in patients with hypothyroidism. Subjects with positive TPOantibodies had lower serum 25-OH vitamin D compared to TPO-antibody negative subjects.

Background: Hepatotoxicity is a potential complication from the usage of various illicit drugs, b... more Background: Hepatotoxicity is a potential complication from the usage of various illicit drugs, but information on this scare in the medical literature Objective: The aim of this study was to study the assessment of Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST) and Alkaline Phosphatase (ALP) in chronic Marijuana abusers. Methodology: This is a case control study, conducted in Khartoum State at Alribat Hospital, during May to August 2015.A 120 blood sample was collected, 60 samples of abuse people as case study, 60 samples as control group. The age and sex was matched, which ranged between 18-60 years. Plasma concentration of ALT, AST and ALP were estimated using PS MINDRAY full automation 380. Results: (The means SD) of plasma ALT, AST, and ALP in marijuana abuse people respectively, were (31.1±17.5), (26.9±8.2), (77.1±32.8) IU/ml while in the control group, respectively were (59.7±10.5), (63.7±12.4), (169.4±14.2). Conclusion: This study concludes that chronic abu...

Kidney transplantation is the treatment of choice for end-stage renal disease (ESRD). Restoration... more Kidney transplantation is the treatment of choice for end-stage renal disease (ESRD). Restoration of renal function after kidney transplantation rectifies many of the disturbances that lead to renal osteodystrophy, bone disease and cardiovascular disease and an increased risk of morbidity and mortality. Identifying patients at risk and evaluating for this complication is imperative because early intervention may slow or arrest the progression of both bone and cardiac disease. Helping physician and renal transplant center to creating a successful treatment plan. The objective of this study was to evaluate calcium, phosphorus and parathyroid hormone concentrations in renaltransplantation in Sudanese patient. This study was case control hospital based study, conducted in Sudanese renal transplantation association, Khartoum state. During June to July 2013.The study involved a control group (n= 50) matched for age with a renaltransplantation patient (n= 50). The ages ranged in both group...

Pregnancy-induced hypertension (PIH) continues to be a major obstetric problem in present day hea... more Pregnancy-induced hypertension (PIH) continues to be a major obstetric problem in present day healthcare practice. Normal thyroid hormone level is essential in maintaining the normal fetal development.

Background: All available contraceptive methods have both advantages and disadvantages and it is ... more Background: All available contraceptive methods have both advantages and disadvantages and it is up to the health provider to make a rational choice. Objective: The aim of this study was to estimate the lipid profile [HDL, LDL, VLDL, cholesterol and triglyceride] on implantable Sudanese women and control. Methodology: These studies were case control study, carried out at Omdurman Maternity Hospital, department of family planning center, Khartoum, Sudan, during the period January-May 2015. The blood sample was collected from 70 patients with age ranged between 18-40 year, and 70 from normal female as control groups. Serum cholesterol, triglyceride and HDL were estimated by Mindray for chemistry analyzer. And LDL, VLDL was obtained through calculation. Result: The (mean±SD) of serum cholesterol, triglyceride, HDL, VLDL and LDL in patient respectively, were (143.34±61.66), (100.01±22.42), (44.25±8.37), (20.00±4), (105.0±14.4). While the mean±SD of serum cholesterol, triglyceride, HDL, ...

Article History Received: 01.11.2018 Accepted: 08.11.2018 Published: 30.11.2018 Abstract: Diabete... more Article History Received: 01.11.2018 Accepted: 08.11.2018 Published: 30.11.2018 Abstract: Diabetes mellitus is a metabolic disorder resulting from insufficient insulin secretion, inefficient insulin action or both which lead to increased blood glucose, Diabetes is the most common cause of End Stage Renal Disease (ESRD). Approximately 40% of patients with type 1 and 15% of patients with type 2 Diabetes eventually develop ESRD. The aim of this study was to assess the level of serum Cystatin-C and Creatinine among Sudanese patients with diabetes mellitus. a cross-sectional study was conducted during the period from May to Jun 2017, sixty samples from diagnosed patients with diabetes mellitus (admitted to Eltayeb said make in Khartoum state) as cases, the level of serum Cystatin-C and Creatinine were measured by I-chroma device and Mindray BS 120 method, Data analysis was carried out by SPSS version 16. The level of serum Cystatin-C and serum Creatinine showed significantly increased in...