Greg Allison | Rutgers at Newark (original) (raw)
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AIDS, 2003
Osteonecrosis has been increasingly associated with HIV disease throughout the 1990s, and the inc... more Osteonecrosis has been increasingly associated with HIV disease throughout the 1990s, and the incidence appears to be rising. The hip is most commonly involved and often bilaterally. Although anecodotal reports suggest an association between osteonecrosis and highly active antiretroviral therapy, controlled epidemiologic studies do not support a direct link. Many patients with osteonecrosis have established risk factors, some of which may be related to HIV disease or its therapy, including corticosteroid use and hyperlipidemia. Alcoholism, hypercoagulability, megesterol acetate use, immune reconstitution, and other factors may also contribute. Plain radiographs and magnetic resonance imaging are the cornerstones of diagnosis. Management is dependent on the stage of bone disease and ranges from observation to total joint arthroplasty. Clinicians may help to prevent HIV-associated osteonecrosis by encouraging patients to limit their exposure to the established risk factors for the disease.
Journal of Biological Chemistry, 2000
AIDS, 2003
ABSTRACT Osteonecrosis has been increasingly associated with HIV disease throughout the 1990s, an... more ABSTRACT Osteonecrosis has been increasingly associated with HIV disease throughout the 1990s, and the incidence appears to be rising. The hip is most commonly involved and often bilaterally. Although anecodotal reports suggest an association between osteonecrosis and highly active antiretroviral therapy, controlled epidemiologic studies do not support a direct link. Many patients with osteonecrosis have established risk factors, some of which may be related to HIV disease or its therapy, including corticosteroid use and hyperlipidemia. Alcoholism, hypercoagulability, megesterol acetate use, immune reconstitution, and other factors may also contribute. Plain radiographs and magnetic resonance imaging are the cornerstones of diagnosis. Management is dependent on the stage of bone disease and ranges from observation to total joint arthroplasty. Clinicians may help to prevent HIV-associated osteonecrosis by encouraging patients to limit their exposure to the established risk factors for the disease.
Human Resources Director Joe Bremgartner will facilitate the presentation by Board members of the... more Human Resources Director Joe Bremgartner will facilitate the presentation by Board members of the following awards: . The Bridge Builder Reaches out to the community The Instructor Excels at teaching. The Playmaker Supports others. The Innovator Changes making a difference. The Conductor Creates harmony. Champion of Differences Celebrates diversity. The Sparkplug Ignites and energizes individuals and groups. The Trailblazer Leadership beyond the district. The Unsung Hero Goes the extra mile. The Dream Team Above and beyond.
Osteoarthritis and Cartilage
The damage to cartilage collagen is a central event in the pathogenesis of cartilage aging and os... more The damage to cartilage collagen is a central event in the pathogenesis of cartilage aging and osteoarthritis (OA). We have previously developed an in vitro model of cartilage degradation which shows that chondrocyte-dependent lipid peroxidation mediates cartilage collagen degradation. The goal of our study was to investigate the role of vitamin C in this degradation model and to investigate effect of chondrocyte-dependent lipid peroxidation in the oxidation of cartilage collagen. We studied primary articular chondrocytes. Effect of vitamin C was investigated in the previously described model. Serum-free stimulated and unstimulated chondrocyte-matrix extracts were subjected to SDS-PAGE and immunoblot analysis. Malondialdehyde (MDA)-protein oxidation of cartilage proteins was demonstrated by the reactivity of chondrocyte extracts to a monoclonal antibody, MDA2, which detects MDA-lysine adducts. Vitamin C treatment of chondrocyte cultures resulted in significant enhanced incorporation...
Osteoarthritis and cartilage, 2003
AIDS, 2003
Osteonecrosis has been increasingly associated with HIV disease throughout the 1990s, and the inc... more Osteonecrosis has been increasingly associated with HIV disease throughout the 1990s, and the incidence appears to be rising. The hip is most commonly involved and often bilaterally. Although anecodotal reports suggest an association between osteonecrosis and highly active antiretroviral therapy, controlled epidemiologic studies do not support a direct link. Many patients with osteonecrosis have established risk factors, some of which may be related to HIV disease or its therapy, including corticosteroid use and hyperlipidemia. Alcoholism, hypercoagulability, megesterol acetate use, immune reconstitution, and other factors may also contribute. Plain radiographs and magnetic resonance imaging are the cornerstones of diagnosis. Management is dependent on the stage of bone disease and ranges from observation to total joint arthroplasty. Clinicians may help to prevent HIV-associated osteonecrosis by encouraging patients to limit their exposure to the established risk factors for the disease.
Journal of Biological Chemistry, 2000
AIDS, 2003
ABSTRACT Osteonecrosis has been increasingly associated with HIV disease throughout the 1990s, an... more ABSTRACT Osteonecrosis has been increasingly associated with HIV disease throughout the 1990s, and the incidence appears to be rising. The hip is most commonly involved and often bilaterally. Although anecodotal reports suggest an association between osteonecrosis and highly active antiretroviral therapy, controlled epidemiologic studies do not support a direct link. Many patients with osteonecrosis have established risk factors, some of which may be related to HIV disease or its therapy, including corticosteroid use and hyperlipidemia. Alcoholism, hypercoagulability, megesterol acetate use, immune reconstitution, and other factors may also contribute. Plain radiographs and magnetic resonance imaging are the cornerstones of diagnosis. Management is dependent on the stage of bone disease and ranges from observation to total joint arthroplasty. Clinicians may help to prevent HIV-associated osteonecrosis by encouraging patients to limit their exposure to the established risk factors for the disease.
Human Resources Director Joe Bremgartner will facilitate the presentation by Board members of the... more Human Resources Director Joe Bremgartner will facilitate the presentation by Board members of the following awards: . The Bridge Builder Reaches out to the community The Instructor Excels at teaching. The Playmaker Supports others. The Innovator Changes making a difference. The Conductor Creates harmony. Champion of Differences Celebrates diversity. The Sparkplug Ignites and energizes individuals and groups. The Trailblazer Leadership beyond the district. The Unsung Hero Goes the extra mile. The Dream Team Above and beyond.
Osteoarthritis and Cartilage
The damage to cartilage collagen is a central event in the pathogenesis of cartilage aging and os... more The damage to cartilage collagen is a central event in the pathogenesis of cartilage aging and osteoarthritis (OA). We have previously developed an in vitro model of cartilage degradation which shows that chondrocyte-dependent lipid peroxidation mediates cartilage collagen degradation. The goal of our study was to investigate the role of vitamin C in this degradation model and to investigate effect of chondrocyte-dependent lipid peroxidation in the oxidation of cartilage collagen. We studied primary articular chondrocytes. Effect of vitamin C was investigated in the previously described model. Serum-free stimulated and unstimulated chondrocyte-matrix extracts were subjected to SDS-PAGE and immunoblot analysis. Malondialdehyde (MDA)-protein oxidation of cartilage proteins was demonstrated by the reactivity of chondrocyte extracts to a monoclonal antibody, MDA2, which detects MDA-lysine adducts. Vitamin C treatment of chondrocyte cultures resulted in significant enhanced incorporation...
Osteoarthritis and cartilage, 2003