David Truong | Ho Chi Minh City Open University (original) (raw)
Papers by David Truong
Molecular Imaging and Biology, 2005
Many considerations, involving understanding and selection of multiple experimental parameters, a... more Many considerations, involving understanding and selection of multiple experimental parameters, are required to perform MicroPET studies properly. The large number of these parameters/variables and their complicated interdependence make their optimal choice nontrivial. We have a developed kinetic imaging system (KIS), an integrated software system, to assist the planning, design, and data analysis of MicroPET studies. The system serves multiple functions—education, virtual experimentation, experimental design, and image analysis of simulated/experimental data—and consists of four main functional modules—“Dictionary,” “Virtual Experimentation,” “Image Analysis,” and “Model Fitting.” The “Dictionary” module provides didactic information on tracer kinetics, pharmacokinetic, MicroPET imaging, and relevant biological/pharmacological information. The “Virtual Experimentation” module allows users to examine via computer simulations the effect of biochemical/pharmacokinetic parameters on tissue tracer kinetics. It generates dynamic MicroPET images based on the user's assignment of kinetics or kinetic parameters to different tissue organs in a 3-D digital mouse phantom. Experimental parameters can be adjusted to investigate the design options of a MicroPET experiment. The “Image Analysis” module is a full-fledged image display/manipulation program. The “Model Fitting” module provides model-fitting capability for measured/simulated tissue kinetics. The system can be run either through the Web or as a stand-alone process. With KIS, radiotracer characteristics, administration method, dose level, imaging sequence, and image resolution-to-noise tradeoff can be evaluated using virtual experimentation. KIS is designed for biology/pharmaceutical scientists to make learning and applying tracer kinetics fun and easy.
![Research paper thumbnail of Movement correction of [18F]FDDNP PET studies for brain amyloid imaging](https://a.academia-assets.com/images/blank-paper.jpg)
](2-(l-{6-[(2-[18F]fluoroethyl)(methyl)amino]-2-naph- thyl}ethylidene)malononitrile ([18F]FDDNP) PE... more 2-(l-{6-[(2-[18F]fluoroethyl)(methyl)amino]-2-naph- thyl}ethylidene)malononitrile ([18F]FDDNP) PET studies for imaging neuronal concentration of beta-amyloid plaques and neurofibrillary tangles, the neuropathological hallmarks of Alzheimer's disease (AD), usually requires a 1-2 hour dynamic scan to measure the kinetics of the tracer in brain tissue. It is difficult for the subject to keep his or her head stationary during the entire data acquisition period. Thus, the reliability of the acquired kinetic data could be severely compromised. Furthermore, misalignment between transmission (TX) and emission (EM) scans due to head movement could introduce errors in attenuation correction (AC) and physiological parameters. In this study, we have developed an image-based procedure for head movement correction that takes a TX image and coregisters it to its corresponding non-AC EM frame before reconstruction of the dynamic image and then realigns all the now proper AC EM frames to a common reference frame. Effects of head movement on tracer time-activity curves and distribution volume ratio (DVR) parametric images are also investigated. The proposed movement correction procedure is done with [18F]FDDNP as a case in point but has the potential to be used in a wide variety of dynamic brain PET studies.
Internet advertising, aka Web advertising or online advertising, is a fast growing business. It h... more Internet advertising, aka Web advertising or online advertising, is a fast growing business. It has already proved to be significantly important in digital economics. For example, it is vitally important for both web search engines and online content providers and publishers because web advertising provides them with major sources of revenue. Its presence is increasingly important for the whole media industry due to the influence of the Web. For advertisers, it is a smarter alternative to traditional marketing media such as TVs and newspapers. As the web evolves and data collection continues, the design of methods for more targeted, interactive, and friendly advertising may have a major impact on the way our digital economy evolves, and to aid societal development.
Molecular Imaging and Biology, 2005
Many considerations, involving understanding and selection of multiple experimental parameters, a... more Many considerations, involving understanding and selection of multiple experimental parameters, are required to perform MicroPET studies properly. The large number of these parameters/variables and their complicated interdependence make their optimal choice nontrivial. We have a developed kinetic imaging system (KIS), an integrated software system, to assist the planning, design, and data analysis of MicroPET studies. The system serves multiple functions—education, virtual experimentation, experimental design, and image analysis of simulated/experimental data—and consists of four main functional modules—“Dictionary,” “Virtual Experimentation,” “Image Analysis,” and “Model Fitting.” The “Dictionary” module provides didactic information on tracer kinetics, pharmacokinetic, MicroPET imaging, and relevant biological/pharmacological information. The “Virtual Experimentation” module allows users to examine via computer simulations the effect of biochemical/pharmacokinetic parameters on tissue tracer kinetics. It generates dynamic MicroPET images based on the user's assignment of kinetics or kinetic parameters to different tissue organs in a 3-D digital mouse phantom. Experimental parameters can be adjusted to investigate the design options of a MicroPET experiment. The “Image Analysis” module is a full-fledged image display/manipulation program. The “Model Fitting” module provides model-fitting capability for measured/simulated tissue kinetics. The system can be run either through the Web or as a stand-alone process. With KIS, radiotracer characteristics, administration method, dose level, imaging sequence, and image resolution-to-noise tradeoff can be evaluated using virtual experimentation. KIS is designed for biology/pharmaceutical scientists to make learning and applying tracer kinetics fun and easy.
2-(l-{6-[(2-[18F]fluoroethyl)(methyl)amino]-2-naph- thyl}ethylidene)malononitrile ([18F]FDDNP) PE... more 2-(l-{6-[(2-[18F]fluoroethyl)(methyl)amino]-2-naph- thyl}ethylidene)malononitrile ([18F]FDDNP) PET studies for imaging neuronal concentration of beta-amyloid plaques and neurofibrillary tangles, the neuropathological hallmarks of Alzheimer's disease (AD), usually requires a 1-2 hour dynamic scan to measure the kinetics of the tracer in brain tissue. It is difficult for the subject to keep his or her head stationary during the entire data acquisition period. Thus, the reliability of the acquired kinetic data could be severely compromised. Furthermore, misalignment between transmission (TX) and emission (EM) scans due to head movement could introduce errors in attenuation correction (AC) and physiological parameters. In this study, we have developed an image-based procedure for head movement correction that takes a TX image and coregisters it to its corresponding non-AC EM frame before reconstruction of the dynamic image and then realigns all the now proper AC EM frames to a common reference frame. Effects of head movement on tracer time-activity curves and distribution volume ratio (DVR) parametric images are also investigated. The proposed movement correction procedure is done with [18F]FDDNP as a case in point but has the potential to be used in a wide variety of dynamic brain PET studies.
Internet advertising, aka Web advertising or online advertising, is a fast growing business. It h... more Internet advertising, aka Web advertising or online advertising, is a fast growing business. It has already proved to be significantly important in digital economics. For example, it is vitally important for both web search engines and online content providers and publishers because web advertising provides them with major sources of revenue. Its presence is increasingly important for the whole media industry due to the influence of the Web. For advertisers, it is a smarter alternative to traditional marketing media such as TVs and newspapers. As the web evolves and data collection continues, the design of methods for more targeted, interactive, and friendly advertising may have a major impact on the way our digital economy evolves, and to aid societal development.