Metin Donma | Namik Kemal University (original) (raw)

Papers by Metin Donma

Journal of Human Hypertension

Aimns-To investigate the effect of pregnancy on serum concentrations of lipids, lipoproteins, and... more Aimns-To investigate the effect of pregnancy on serum concentrations of lipids, lipoproteins, and apolipoproteins. Methods-Fasting serum concentrations of total cholesterol, triglyceride, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), apolipoproteins AI, AII, and B, and lipoprotein (a) were measured in 178 women with normal glucose tolerance in the second and third trimesters of pregnancy and in a control group of 58 nonpregnant women of similar age. Data were analysed using the unpaired t test and by one-way analysis of variance. Results-The pregnant women had significantly higher concentrations of total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, and apolipoproteins AI and B (p < 0 001) and apolipoprotein AII (p = 0.003) than the control women.

$Research paper thumbnail of A rare association: Unilateral fibromatosis colli and contralateral clavicle fracture in a newborn$

International Journal of Pediatric Otorhinolaryngology Extra, 2015

ABSTRACT Fibromatosis colli (FC) is a cause of muscular torticollis that can be diagnosed by care... more ABSTRACT Fibromatosis colli (FC) is a cause of muscular torticollis that can be diagnosed by careful physical examination. In most of the cases, follow up and exercise is enough for treatment, although rare cases require surgical intervention. Clavicle fracture can be a complication of struggling vaginal parturition and usually treated by close follow up. This case was reported and discussed as a rare association that is not found in the literature and the first case diagnosed in the newborn period with unilateral FC associated with contralateral clavicle fracture in a non-macrosomic infant who was treated with dramatic response to physical therapy.

Cumhuriyet Medical Journal, 2013

Ultrasound in Medicine & Biology, 2005

To determine optimal sonographic fetal weight estimation formula for male and female infants, a p... more To determine optimal sonographic fetal weight estimation formula for male and female infants, a prospective study has been performed. Uncomplicated pregnancies and 465 newborns were evaluated. Measurements included birth weight, length and head circumference in addition to fetal head circumference, femur length, abdominal circumference and biparietal diameter. Actual weights were compared with estimated weights calculated by ten different formula. Estimated fetal weight obtained from all formula, except those of Merz, Warsof and Ferrero, tended to be lower than the measured birth weight. The smallest mean differences were obtained with Hadlock 1, Hadlock 2, Hadlock 4 and Shepard formula (19 g-85 g), whereas Merz and Woo produced largest mean differences (110 g-364 g). Intraclass correlation coefficients (ICCs) generated with Hadlock 1 and Hadlock 2 formula were identical (0.90). ICCs obtained with Hadlock 3 and Hadlock 4, Shepard, Merz, Warsof and Campbell formula varied between 0.84 and 0.88. Hadlock 1 and 2 formula gave the closest approximation of birth weight in Turkish population.

Medical Hypotheses, 2006

Helicobacter pylori (HP) acquired in childhood is an important risk factor for gastric carcinoma.... more Helicobacter pylori (HP) acquired in childhood is an important risk factor for gastric carcinoma. Once colonization is established, infection may be carried for life. The relationship between food intake and HP infection, the presence of metals and phytochemicals closely associated with oxidative stress within everyday diet are important topics to be considered. The possible anti-HP effects of phytochemicals, prooxidant effects exerted in the presence of metal species, intimate relations between some metals and HP, bivalent effects of some metal species in cancer, interactions between metal species and phytochemicals in HP infection are the topics, which require further research. Formulas or diets enriched with phytochemicals and metals against HP and, which are devoid of metals known to favour the growth of HP, may be suggested as the supplements to the classical treatment regimens. The importance of collective consideration of HP, metal species and phytochemicals should be emphasized.

Journal of the American College of Cardiology, 2013

Background: Down syndrome (DS) is a genetic disorder that results in extra genetic material from ... more Background: Down syndrome (DS) is a genetic disorder that results in extra genetic material from chromosome 21 and seen in patients with congenital heart defects (CHD). Approximately 40%-50% of patients with Down syndrome have a heart defect. CHD affects 6-8 babies in every 1000 live births and connect to fetal loss. It was reported that the frequencies of CHD were ranging from 16-65% in DS.

Although the premature tooth exfoliation (PTE) can be associated with some systemic diseases such... more Although the premature tooth exfoliation (PTE) can be associated with some systemic diseases such as changes in immune system or connective tissue disorders, we didn't find any report on this disorder and hypophosphatemic rickets. In bone metabolic disorders, there are a few reports on hypophosphatasia and PTE [1][2][3] . Although, some factors such as severe oral infection can predispose PTE in HR patients, we recommend a study on prevalence of PTE and its related factors in HR patients in future.

Iranian journal of pediatrics, 2013

This study was designed to determine the current age-related hepatitis A virus (HAV) seroprevalan... more This study was designed to determine the current age-related hepatitis A virus (HAV) seroprevalance, vaccination status of children and to evaluate the epidemiological shift in HAV serostatus living in Tekirdağ, which is located in Thrace region, the European part of Turkey. Children 6 months-12 years of age with simple health problems were included. Blood samples were studied for HAV IgM and IgG collectively. A questionnaire addressing several characteristics of subjects was administered to obtain basic descriptive data on HAV epidemiology. Vaccination status of the children was recorded according to the immunization cards. The overall anti-HAV IgM and anti-HAV IgG prevalance in children aged 6 months - 12 years was 3.3% and 25.4% respectively. Maximum hepatitis A IgM positivity was in the 7-12 years age group 4.8% (n= 12; P<0.001) and maximum hepatitis A IgG positivity in the same age group was 34% (n = 85; P<0.001). HAV vaccination rate among patients aged more than 2 years...

Inflammation, 2015

The aim of this prospective case control study is to determine CD4(+), CD25(+), and FoxP3(+) T re... more The aim of this prospective case control study is to determine CD4(+), CD25(+), and FoxP3(+) T regulatory cells (Tregs) and T helper cells (Ths) in obese, asthmatic, asthmatic obese, and healthy children. Obese (n = 40), asthmatic (n = 40), asthmatic obese (n = 40), and healthy children (n = 40) were included in this study. Blood samples collected from children were marked with CD4, CD25, ve Foxp3 in order to detect Tregs and Ths by flow cytometric method. Statistical analyses were performed. p ≤ 0.05 was chosen as meaningful threshold. Tregs exhibiting anti-inflammatory nature were significantly lower in obese (0.16 %; p ≤ 0.001), asthmatic (0.25 %; p ≤ 0.01), and asthmatic obese (0.29 %; p ≤ 0.05) groups than control group (0.38 %). Ths were counted higher in asthma group than control (p ≤ 0.01) and obese (p ≤ 0.001) groups. T cell immunity plays important roles in chronic inflammatory diseases such as obesity and asthma pathogeneses. Decreased numbers of Tregs found in obese, asthmatic, and asthmatic obese children might represent a challenge of these cells.

Urology, 2013

To investigate the relation between copeptin, arginine vasopressin (AVP), and nocturnal enuresis ... more To investigate the relation between copeptin, arginine vasopressin (AVP), and nocturnal enuresis (NE). Forty-four patients with NE and 44 healthy children aged between 6 and 14 years were enrolled. Patients with nonmonosymptomatic and secondary NE were excluded from the study. A small questionnaire, filled by parents, collected information about sociodemographic characteristics. Blood was obtained for plasma AVP and copeptin concentrations. Copeptin levels were significantly lower in patient group (3.74 ± 1.44 pg/mL) than the control group (16.57 ± 3.91 pg/mL), whereas AVP levels were not significantly different between groups. Copeptin levels were significantly lower in patients (3.17 ± 1.15 pg/mL) who had bed-wetting 2 or more nights a week, which is considered as severe bed-wetting, than the patients (4.95 ± 1.24 pg/mL) who had bed-wetting 1 night or less than 1 night a week. This study demonstrates the presence of decreased levels of copeptin in patients with NE compared with healthy patients. AVP levels were not different between groups. To our knowledge, this is the first report assessing the relationship between copeptin and NE.

Tuberculin Skin Test in Children, 2013

Pediatric Hematology-Oncology, 2012

Iron deficiency (IDA) and beta thalassemia trait (TT) are the most common causes of hypochromia a... more Iron deficiency (IDA) and beta thalassemia trait (TT) are the most common causes of hypochromia and microcytosis. Many indices have been defined to quickly discriminate these similar entities via parameters obtained from automated blood cell analyzers. However, studies in the pediatric age group are scarce and their results are controversial. We calculated eight discrimination indices [Mentzer Index (MI), England and Fraser Index (E&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;F), Srivastava Index (S), Green and King Index (G&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;K), Shine and Lal Index (S&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;L), red blood cell (RBC) count, RBC distribution width, and red blood cell distribution width Index (RDWI)] in 100 patients. We calculated sensitivity (SENS), specificity (SPEC), positive and negative predictive value (PPV and NPV), and Youden&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s Index (YI) of each discrimination index. None of the discrimination indices showed a SENS and SPEC of 100%. The highest SENS was obtained with S&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;L (87.1%), while the highest SPEC was obtained with E&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;F formula (100%). The highest YI value was obtained with E&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;F formula (58.1%). In our study, none of the formulas appears reliable in discriminating between TT and IDA patients. The evaluation of iron status and measurement of hemoglobin A(2) (HbA(2)) remain the most reliable investigations to differentiate between TT and IDA patients.

Pacing and Clinical Electrophysiology, 2013

The aim of our study is to investigate the effects of low birth weight (LBW) on atrial conduction... more The aim of our study is to investigate the effects of low birth weight (LBW) on atrial conduction and ventricular repolarization in children by using P-wave dispersion (Pw-d) and QT dispersion (QT-d) analyses. These effects have not yet been studied in detail in LBW children. Fifty LBW children and 70 normal birth weight (NBW) children were enrolled in this cross-sectional controlled study. The Pw-d and QT-d of the LBW and NBW children were investigated. Independent Student&amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s t-test, Mann-Whitney U test, and χ(2) test were performed to compare these two groups. Stepwise multiple regression analysis was performed to investigate whether there was a relationship between P-wave indices, QT derivatives, anthropometric and clinical features, and echocardiographic parameters. Age, gender, body mass index, waist circumferences, systolic and diastolic blood pressure, and echocardiographic measurements were similar between the LBW group and the NBW group (all P values &amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05). The following findings were recorded for the LBW and NBW groups, respectively: the Pw-d (30 [10-50] ms vs 30 [10-50] ms, P = 0.977), QT-d (20 [10-50] ms vs 30 [15-50] ms, P = 0.561), and QTc-d (26 [14-54] ms vs 33 [17-62] ms, P = 0.866). No significant difference was found in Pw-d, QT-d, and QTc-d in comparison between the groups (all P values &amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; 0.05). Pw-d was related to left atrial diameter and QTc-d was associated with left ventricle mass index even though they were within the normal range. Compared with the NBW group, no significant difference was found in both atrial conduction and ventricular repolarization features in LBW children.

Angiology, 2013

We measured brachial artery flow-mediated dilatation (FMD) and common carotid intima-media thickn... more We measured brachial artery flow-mediated dilatation (FMD) and common carotid intima-media thickness (cIMT) in overweight (n = 67) and normal weight children (n = 115, controls). Age at examination ranged from 72 to 182 months (mean 123 ± 27). Compared to controls, the overweight children had increased weight, waist and hip circumference, systolic and diastolic blood pressures (all P &amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .001), right and left mean cIMT (mm; 0.58 [0.42-0.68] vs 0.44 [0.3-0.64], P &amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .001 and 0.56 [0.32-0.70] vs 0.44 [0.3-0.60], P &amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .001), respectively, and decreased FMD (%; 6.25 [3.33-19.05] vs 7.69 [3.45-16], P &amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; .001). The cIMT and FMD were closely related to the serum insulin concentrations. Age, waist circumferences, and serum triglycerides were independent predictive risk factors for increased cIMT, and fasting glucose and BMI were independent predictive variables for decreased FMD. Overweight children are also potentially at risk of early atherosclerosis as much as obese children.

The Turkish journal of pediatrics

Jacobsen syndrome (JS), a rare disorder with multiple dysmorphic features, is caused by the termi... more Jacobsen syndrome (JS), a rare disorder with multiple dysmorphic features, is caused by the terminal deletion of chromosome 11q. Typical features include mild to moderate psychomotor retardation, trigonocephaly, facial dysmorphism, cardiac defects, and thrombocytopenia, though none of these features are invariably present. The estimated occurrence of JS is about 1/100,000 births. The female/male ratio is 2:1. The patient admitted to our clinic at 3.5 years of age with a cardiac murmur and facial anomalies. Facial anomalies included trigonocephaly with bulging forehead, hypertelorism, telecanthus, downwardslanting palpebral fissures, and a carp-shaped mouth. The patient also had strabismus. An echocardiogram demonstrated perimembranous aneurysmatic ventricular septal defect and a secundum atrial defect. The patient was <3rd percentile for height and weight and showed some developmental delay. Magnetic resonance imaging (MRI) showed hyperintensive gliotic signal changes in perivent...