Bahram Bibak | North Khorasan University of Medical Sciences, Bojnurd, Iran (original) (raw)

Papers by Bahram Bibak

journal of north khorasan university of medical sciences, Sep 1, 2022

journal of north khorasan university of medical sciences, Sep 1, 2014

journal of north khorasan university of medical sciences, Mar 1, 2013

journal of north khorasan university of medical sciences, Mar 1, 2013

journal of north khorasan university of medical sciences, Mar 1, 2014

Background & Objectives: analysis of service quality from the perspective of the customer has gen... more Background & Objectives: analysis of service quality from the perspective of the customer has generated much attention. This study was performed to determine the quality gap in educational services at North Khorasan University of Medical Sciences, based on students'perceptions and expectations. Material & Methods: In this cross-sectional descriptiveanalytical study, 175 students were selected by stratified random sampling method, were studied in the year 2011. The data were collected using a valid and reliable questionaire based on the SERVQUAL (science quality) instrument. Data were analyzed by SPSS-16 software.and presented with descriptive and analytic statistic Results: The findings indicated that there was a negative gap in five dimensions of services. The smallest gap with-1/62±1/0 belonged to "reliability" dimension and the largest gap with-2/2±1/3 to "assurance ". Senior students evaluated more all aspects of the service gap than other students (p<0/05). Conclusion: Based on our results, from student's points of view, the educational services quality is under the acceptable level in the university, thus, in order to improve quality of educational services, considering what stated above especially "assurance" dimension, reconsidering new strategies is demanded .

Research in Pharmaceutical Sciences, 2022

journal of north khorasan university of medical sciences, Jun 1, 2014

journal of north khorasan university of medical sciences, Sep 1, 2012

Background & Objective: Schizophrenia is considered as one of the most extreme mental illnesses i... more Background & Objective: Schizophrenia is considered as one of the most extreme mental illnesses in the area of psychiatry which is characterized by social and occupational incompetence. Support and care of these patients has always been on the part of families. The imposed burden includes physical, mental, social and economic problems being experienced by caregiver of the family. The present study aimed at investigating the burden experienced by schizophrenic patients at Imam Reza Hospital in the city of Bojnurd. Material & Methods: This is a descriptive-analytical study conducted on 75 family caregivers visiting Imam Reza Hospital. Data collection methods included demographic questionnaire, and Zarit Questionnaire which measured degree of experienced burden by caregivers. Reliability and validity of both questionnaires had already been established. Then, data were fed into SPSS 14 for analysis. Results: 12.2% of caregivers experienced low burden, 36.4% average burden, and 51.5% high burden. The perceived burden among women was significantly higher (P=0.003) than that of men. There was significant relationship (p=0.03) between the obtained score of caregiving and age of caregivers while the relationship between caregiving score and age of patients was not significant (p>0.05) but was negative. Younger patients imposed higher burden on the caregivers. Conclusion: Taking care of schizophrenic patients put immense pressure on family especially on caregivers. Therefore, it can be said that the mental pressure imposed by such patients threatens caregivers' mental health, hence reduction in quality of care and support. Consequently, family centered programs are recommended for decreasing the burden incurred by schizophrenic patients.

Journal of North Khorasan University of Medical Sciences

Journal of North Khorasan University of Medical Sciences

Background & Objectives: sinusitis is a common upper respiratory tract infection and antibiotics ... more Background & Objectives: sinusitis is a common upper respiratory tract infection and antibiotics almost always are selected empirically based on sensitivity of microorganisms to antibacterial agents. Finding alternative agents with herbal origin to broad spectrum antibiotics for treatment of sinusitis could be a valuable and safe therapeutic method. Viola Odorata contains some antimicrobial agents which can open a new horizon for controlling and treating microbial infections of upper respiratory tract. Materials & Methods: The herb which was collected from north Khorasan province was macerated and water and methanolic extracts were obtained. The antibacterial potency was evaluated by disc and well diffusion method. Results: for water extract, Inhibition zone of Staphylococcus epidermidis in well and disc diffusion method were (11 &12 millimeters) respectively. For methanol extract were (13 &15 mm) respectively. Also inhibition zone of Staphylococcus eureous was (11 &12 mm) with water extract and (11 & 13 mm) in methanol extract. Two extract didn't have any effect on Entrobacter aeroginosa. Conclusion: as it can be seen, water extracts have the smallest inhibition zone, so it can be concluded that these extracts do not contain strong antimicrobial factors. On the other hand methanolic extracts with large inhibition zones should have effective and strong antimicrobial agents.

Journal of North Khorasan University of Medical Sciences

Background & Objectives: Nowadays it is very desirable to investigate and discover new antibacter... more Background & Objectives: Nowadays it is very desirable to investigate and discover new antibacterial and anticancer agents from natural products and medicinal plants. In this regard, the current study is conducted in order to explore the antibacterial and antioxidant properties of a rare plant named Uvaria grandiflora Roxb. Material & Methods: The antibacterial disc diffusion method, the DPPH radical scavenging test and the preliminary phytochemical screening were performed for six different extracts obtained by hexane, chloroform and ethanol. Results: Data exhibited the stem bark and leaves ethanolic extract of the plant, have high amounts of flavonoids and polyphenols and therefore they have strongly inhibited Staphylococcus aureus and Bacillus cereus growth at the concentration of 2mg/disc. These samples illustrated the highest radical scavenging activity with the percentages of 95.32% and 86.38% at the concentration of 100µg/ml, respectively. Conclusion: Following the results, it was concluded that the flavonoids and poly-phenols play crucial roles in the properties of Uvaria grandiflora Roxb., thus more investigations and isolations are recommended.

Journal of Asian Natural Products Research, 2012

This article may be used for research, teaching, and private study purposes. Any substantial or s... more This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae, and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand, or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material. Reviews on 1,4-naphthoquinones from Diospyros L.

Journal of North Khorasan University of Medical Sciences, 2012

Avicenna journal of phytomedicine, Oct 4, 2022

Biomedicine & Pharmacotherapy

Background and Objective: Ulcerative colitis is a group of chronic inflammatory disorders of unkn... more Background and Objective: Ulcerative colitis is a group of chronic inflammatory disorders of unknown etiology that affects the digestive system. Aloe vera is used in many situations such as wound healing. The purpose of this study was to evaluate the effect of aqueous extract of this plant on the gastric acid secretion and colonic histopathology in acute ulcerative colitis model induced by acetic acid in rats. Materials and Methods: This experimental study was performed on 32 Wistar rats weighing 200-250g. Animals were randomly divided into four groups including intact, acetic acid-induced colitis group, the groups treated with Aloe Vera (8 days) and treated with sulfasalazine. The animals were anesthetized with ether, and then colitis was induced with acetic acid. After treatment, biopsies of 10 cm distal parts of the colon were removed for histopathological studies. To compare the histopathologic quantitative features, the grading system (Bita 2012) was used. The gastric acid concentration was measured by titration method. The results were expressed as Mean±SEM and P<0.05 was regarded as significant. Results: Treatment with aqueous extract of Aloe Vera did not reduce the gastric acid. Histopathological results indicated an inflammatory response in the ulcerative colitis group. Aloe Vera reduced the severity of symptoms of ulcerative colitis histopathology, although its efficiency was less than sulfasalazine. Conclusion: Regarding the improving effect of Aloe vera, it seems to be useful for the treatment of colonic disorders. However, for determination of the effective dose of this plant in decreasing gastric acid secretions, further research is recommended.

International Immunopharmacology

Current Medicinal Chemistry

In terms of frequency and aggressiveness, glioblastoma multiforme (GBM) is undoubtedly the most f... more In terms of frequency and aggressiveness, glioblastoma multiforme (GBM) is undoubtedly the most frequent and fatal primary brain tumor. Despite advances in clinical management, the response to current treatments is dismal, with a 2-year survival rate varying between 6 and 12 percent. Metformin, a derivative of biguanide widely used in treating type 2 diabetes, has been shown to extend the lifespan of patients with various malignancies. There is limited evidence available on the long-term survival of GBM patients who have taken metformin. This research examined the literature to assess the connection between metformin's anticancer properties and GBM development. Clinical findings, together with the preclinical data from animal models and cell lines, are included in the present review. This comprehensive review covers not only the association of hyperactivation of the AMPK pathway with the anticancer activity of metformin but also other mechanisms underpinning its role in apoptosi...

journal of north khorasan university of medical sciences, Sep 1, 2022

journal of north khorasan university of medical sciences, Sep 1, 2014

journal of north khorasan university of medical sciences, Mar 1, 2013

journal of north khorasan university of medical sciences, Mar 1, 2013

journal of north khorasan university of medical sciences, Mar 1, 2014

Background & Objectives: analysis of service quality from the perspective of the customer has gen... more Background & Objectives: analysis of service quality from the perspective of the customer has generated much attention. This study was performed to determine the quality gap in educational services at North Khorasan University of Medical Sciences, based on students'perceptions and expectations. Material & Methods: In this cross-sectional descriptiveanalytical study, 175 students were selected by stratified random sampling method, were studied in the year 2011. The data were collected using a valid and reliable questionaire based on the SERVQUAL (science quality) instrument. Data were analyzed by SPSS-16 software.and presented with descriptive and analytic statistic Results: The findings indicated that there was a negative gap in five dimensions of services. The smallest gap with-1/62±1/0 belonged to "reliability" dimension and the largest gap with-2/2±1/3 to "assurance ". Senior students evaluated more all aspects of the service gap than other students (p<0/05). Conclusion: Based on our results, from student's points of view, the educational services quality is under the acceptable level in the university, thus, in order to improve quality of educational services, considering what stated above especially "assurance" dimension, reconsidering new strategies is demanded .

Research in Pharmaceutical Sciences, 2022

journal of north khorasan university of medical sciences, Jun 1, 2014

journal of north khorasan university of medical sciences, Sep 1, 2012

Background & Objective: Schizophrenia is considered as one of the most extreme mental illnesses i... more Background & Objective: Schizophrenia is considered as one of the most extreme mental illnesses in the area of psychiatry which is characterized by social and occupational incompetence. Support and care of these patients has always been on the part of families. The imposed burden includes physical, mental, social and economic problems being experienced by caregiver of the family. The present study aimed at investigating the burden experienced by schizophrenic patients at Imam Reza Hospital in the city of Bojnurd. Material & Methods: This is a descriptive-analytical study conducted on 75 family caregivers visiting Imam Reza Hospital. Data collection methods included demographic questionnaire, and Zarit Questionnaire which measured degree of experienced burden by caregivers. Reliability and validity of both questionnaires had already been established. Then, data were fed into SPSS 14 for analysis. Results: 12.2% of caregivers experienced low burden, 36.4% average burden, and 51.5% high burden. The perceived burden among women was significantly higher (P=0.003) than that of men. There was significant relationship (p=0.03) between the obtained score of caregiving and age of caregivers while the relationship between caregiving score and age of patients was not significant (p>0.05) but was negative. Younger patients imposed higher burden on the caregivers. Conclusion: Taking care of schizophrenic patients put immense pressure on family especially on caregivers. Therefore, it can be said that the mental pressure imposed by such patients threatens caregivers' mental health, hence reduction in quality of care and support. Consequently, family centered programs are recommended for decreasing the burden incurred by schizophrenic patients.

Journal of North Khorasan University of Medical Sciences

Journal of North Khorasan University of Medical Sciences

Background & Objectives: sinusitis is a common upper respiratory tract infection and antibiotics ... more Background & Objectives: sinusitis is a common upper respiratory tract infection and antibiotics almost always are selected empirically based on sensitivity of microorganisms to antibacterial agents. Finding alternative agents with herbal origin to broad spectrum antibiotics for treatment of sinusitis could be a valuable and safe therapeutic method. Viola Odorata contains some antimicrobial agents which can open a new horizon for controlling and treating microbial infections of upper respiratory tract. Materials & Methods: The herb which was collected from north Khorasan province was macerated and water and methanolic extracts were obtained. The antibacterial potency was evaluated by disc and well diffusion method. Results: for water extract, Inhibition zone of Staphylococcus epidermidis in well and disc diffusion method were (11 &12 millimeters) respectively. For methanol extract were (13 &15 mm) respectively. Also inhibition zone of Staphylococcus eureous was (11 &12 mm) with water extract and (11 & 13 mm) in methanol extract. Two extract didn't have any effect on Entrobacter aeroginosa. Conclusion: as it can be seen, water extracts have the smallest inhibition zone, so it can be concluded that these extracts do not contain strong antimicrobial factors. On the other hand methanolic extracts with large inhibition zones should have effective and strong antimicrobial agents.

Journal of North Khorasan University of Medical Sciences

Background & Objectives: Nowadays it is very desirable to investigate and discover new antibacter... more Background & Objectives: Nowadays it is very desirable to investigate and discover new antibacterial and anticancer agents from natural products and medicinal plants. In this regard, the current study is conducted in order to explore the antibacterial and antioxidant properties of a rare plant named Uvaria grandiflora Roxb. Material & Methods: The antibacterial disc diffusion method, the DPPH radical scavenging test and the preliminary phytochemical screening were performed for six different extracts obtained by hexane, chloroform and ethanol. Results: Data exhibited the stem bark and leaves ethanolic extract of the plant, have high amounts of flavonoids and polyphenols and therefore they have strongly inhibited Staphylococcus aureus and Bacillus cereus growth at the concentration of 2mg/disc. These samples illustrated the highest radical scavenging activity with the percentages of 95.32% and 86.38% at the concentration of 100µg/ml, respectively. Conclusion: Following the results, it was concluded that the flavonoids and poly-phenols play crucial roles in the properties of Uvaria grandiflora Roxb., thus more investigations and isolations are recommended.

Journal of Asian Natural Products Research, 2012

This article may be used for research, teaching, and private study purposes. Any substantial or s... more This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae, and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand, or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material. Reviews on 1,4-naphthoquinones from Diospyros L.

Journal of North Khorasan University of Medical Sciences, 2012

Avicenna journal of phytomedicine, Oct 4, 2022

Biomedicine & Pharmacotherapy

Background and Objective: Ulcerative colitis is a group of chronic inflammatory disorders of unkn... more Background and Objective: Ulcerative colitis is a group of chronic inflammatory disorders of unknown etiology that affects the digestive system. Aloe vera is used in many situations such as wound healing. The purpose of this study was to evaluate the effect of aqueous extract of this plant on the gastric acid secretion and colonic histopathology in acute ulcerative colitis model induced by acetic acid in rats. Materials and Methods: This experimental study was performed on 32 Wistar rats weighing 200-250g. Animals were randomly divided into four groups including intact, acetic acid-induced colitis group, the groups treated with Aloe Vera (8 days) and treated with sulfasalazine. The animals were anesthetized with ether, and then colitis was induced with acetic acid. After treatment, biopsies of 10 cm distal parts of the colon were removed for histopathological studies. To compare the histopathologic quantitative features, the grading system (Bita 2012) was used. The gastric acid concentration was measured by titration method. The results were expressed as Mean±SEM and P<0.05 was regarded as significant. Results: Treatment with aqueous extract of Aloe Vera did not reduce the gastric acid. Histopathological results indicated an inflammatory response in the ulcerative colitis group. Aloe Vera reduced the severity of symptoms of ulcerative colitis histopathology, although its efficiency was less than sulfasalazine. Conclusion: Regarding the improving effect of Aloe vera, it seems to be useful for the treatment of colonic disorders. However, for determination of the effective dose of this plant in decreasing gastric acid secretions, further research is recommended.

International Immunopharmacology

Current Medicinal Chemistry

In terms of frequency and aggressiveness, glioblastoma multiforme (GBM) is undoubtedly the most f... more In terms of frequency and aggressiveness, glioblastoma multiforme (GBM) is undoubtedly the most frequent and fatal primary brain tumor. Despite advances in clinical management, the response to current treatments is dismal, with a 2-year survival rate varying between 6 and 12 percent. Metformin, a derivative of biguanide widely used in treating type 2 diabetes, has been shown to extend the lifespan of patients with various malignancies. There is limited evidence available on the long-term survival of GBM patients who have taken metformin. This research examined the literature to assess the connection between metformin's anticancer properties and GBM development. Clinical findings, together with the preclinical data from animal models and cell lines, are included in the present review. This comprehensive review covers not only the association of hyperactivation of the AMPK pathway with the anticancer activity of metformin but also other mechanisms underpinning its role in apoptosi...