Luca Pastore | Private - Academia.edu (original) (raw)
Papers by Luca Pastore
PLoS Medicine, 2008
The Learning Forum discusses an important clinical problem of relevance to a general medical audi... more The Learning Forum discusses an important clinical problem of relevance to a general medical audience.
fungating mass on the dorsum of the tongue (Figure 1), which had lasted for an unknown period of ... more fungating mass on the dorsum of the tongue (Figure 1), which had lasted for an unknown period of time. The lesion had a roughened and irregular surface, with areas of white keratosis admixed with areas of necrosis. It felt indurated on palpation. Two additional smaller exophytic lesions were observed on the dorsum of the tongue: one adjacent to the main mass and the other on the apex. Both showed surface nodularity and minimal surface keratin production. The surrounding mucosa demonstrated hyperkeratosis and a pebbled surface. Interlacing white keratotic striae were observed on the right buccal mucosa (Figure 2), while the mucosa of the left cheek had an erosive area bordered by fine, white radiating striae (not shown in figure). A skin examination revealed polygonal, flat-topped papules covered with a fine network of white lines on the legs (Figure
Recenti progressi in medicina, 2004
The dramatic improvement in knowledge concerning celiac disease (CD) has disclosed the pattern of... more The dramatic improvement in knowledge concerning celiac disease (CD) has disclosed the pattern of the associated clinical manifestations and the often atypical or silent presentation of this disease, which makes clinical diagnosis difficult. Also oral manifestations, mostly recurrent apthous stomatitis (RAS) and dental enamel hypoplasia, are atypical signs of CD. Our opinion about the possibility of performing mass-screening to reveal atypical or silent CD is in agreement whit who is asserting that a sistematical case-finding is, at present, the most suitable epidemiological approach. So, we think that patients affected by RAS, or dental enamel hypoplasia, should be considered, even in the absence of any gastrointestinal symptom, at-risk subjects, and should therefore undergo diagnostic procedure for CD.
Recenti Progressi in Medicina, Oct 1, 2004
Oral Oncology Supplement, 2007
Journal of Dental Research, 2008
Celiac disease (CD) is a lifelong immune-mediated disorder caused by the ingestion of wheat glute... more Celiac disease (CD) is a lifelong immune-mediated disorder caused by the ingestion of wheat gluten in genetically susceptible persons. Most cases of CD are atypical and remain undiagnosed, which exposes the individuals to the risk of life-threatening complications. Serologic endomysial and tissue transglutaminase antibody tests are used to screen at-risk individuals, although a firm diagnosis requires demonstration of characteristic histopathologic
Igiene e sanita pubblica
In dental healthcare surgeries, both workers and patients are regularly exposed to various infect... more In dental healthcare surgeries, both workers and patients are regularly exposed to various infectious agents. It is essential therefore that dental healthcare workers have a good knowledge of disinfection systems and that dentists' surgeries be effectively managed so as to reduce or even eliminate the risk of cross infections. In order to evaluate infectious risk prevention methods and describe the procedures used by dental healthcare workers on a daily basis, a sample of dentists who work in public surgeries were asked to anonymously fill up a questionnaire. The results of this survey show that dental healthcare workers are sufficiently well-informed about the infectious hazards present in the workplace and are aware of the high risk of exposure to infections but seem to be especially concerned about blood-borne infections (hepatitis, AIDS). Only 67.5%, however, are immunised against HBV. Individual safety devices are used correctly while there seems to be a lack of knowledge a...
International journal of immunopathology and pharmacology
The possibility of the non-parenteral Hepatitis C Virus (HCV) transmission is supported by the de... more The possibility of the non-parenteral Hepatitis C Virus (HCV) transmission is supported by the demonstration that the actual virus is present in several body fluids, including saliva. From a review of the literature many investigators have found the presence of HCV-RNA in saliva, however, widely contrasting results emerge, with detection rates ranging from 0-100%. To further examine HCV salivary shedding, saliva samples were collected from 46 chronically HCV-infected patients and tested for HCV-RNA and occult blood. Quantification and genotyping of serum HCV-RNA were also carried out for each patient. HCV-RNA was detected in 39.13% of the saliva samples. The viral salivary shedding was significantly related to viraemia levels, serum viral genotype and the presence of salivary occult blood. Our findings indicate that the HCV salivary shedding occurs in about one third of HCV infected patients, but seem to suggest that it is unlikely when the serum viral genotype is 3a. Moreover, bloo...
International journal of immunopathology and pharmacology
Squamous cell carcinoma (SCC) of the lip is a relatively common malignancy of the head and neck r... more Squamous cell carcinoma (SCC) of the lip is a relatively common malignancy of the head and neck region. Tumour thickness, grading and perineural invasion are significant prognostic indicators. However, there is still the need of new reliable biological markers able to predict the prognosis of the single cases with an unfavourable biological behaviour unpredictable by the classic clinical-pathological parameters. 32 cases of (SCC) of the lower lip were analysed for their clincopathologic features, and immunohistochemical expression of Fas/FasL in neoplastic cells and in inflammatory infiltrate. Moreover the density and phenotype of tumour-infiltrating lymphocytes (TIL) were analysed. The results were related with the follow-up of the patients ranging from 2 to 6 years. The cases with over-expression of Fas/FasL in neoplastic cells and Fas+ in T cells preferentially showed a more aggressive clinical behaviour (P<0.01). Moreover we found an alteration of the normal expression of CD4...
Recenti progressi in medicina, 2004
The dramatic improvement in knowledge concerning celiac disease (CD) has disclosed the pattern of... more The dramatic improvement in knowledge concerning celiac disease (CD) has disclosed the pattern of the associated clinical manifestations and the often atypical or silent presentation of this disease, which makes clinical diagnosis difficult. Also oral manifestations, mostly recurrent apthous stomatitis (RAS) and dental enamel hypoplasia, are atypical signs of CD. Our opinion about the possibility of performing mass-screening to reveal atypical or silent CD is in agreement whit who is asserting that a sistematical case-finding is, at present, the most suitable epidemiological approach. So, we think that patients affected by RAS, or dental enamel hypoplasia, should be considered, even in the absence of any gastrointestinal symptom, at-risk subjects, and should therefore undergo diagnostic procedure for CD.
autoantibodies are used to screen and follow up on patients with CD, diagnostic confirmation is s... more autoantibodies are used to screen and follow up on patients with CD, diagnostic confirmation is still based on the histological examination of the small intestinal mucosa. Although the small intestinal mucosa is the main site of the gut involved in CD, other mucosal surfaces (such as gastric, rectal, ileal, and esophageal) belonging to the gastrointestinal tract and the gut-associated lymphoid tissue (GALT) can also be involved. A site that could be studied less invasively is the mouth, as it is the first part of the gastrointestinal system and a part of the GALT. Indeed, not only have various oral ailments been reported as possible atypical aspects of CD, but it has been also demonstrated that inflammatory changes occur after oral supramucosal application and a submucosal injection of gliadin into the oral mucosa of CD patients. However, to date, only two studies have assessed the capacity of the oral mucosa of untreated CD patients to EMA and anti-tTG antibodies. In this paper, we will review studies that evaluate the capacity of the oral mucosa to produce specific CD autoantibodies. Discrepancies in sensitivity from the two studies have revealed that biopsy is still not an adequate procedure for the routine diagnostic purposes of CD patients, and a more in-depth evaluation on a larger sample size with standardized collection and analysis methods is merited. However, the demonstration of immunological reactivity to the gluten ingestion of the oral mucosa of CD, in terms of IgA EMA and anti-tTG production, needs to be further evaluated in order to verify whether the oral mucosa is colonized by lymphocytes activated in the intestine or if gluten could stimulate naïve lymphocytes directly in the oral mucosa. This would have important implications for the pathogenesis, diagnosis, and treatment of CD.
Oral Oncology Supplement, 2005
Carclnoma's is one of two nlaln causes of premature inortahty an Serbia as an nmch of the rest of... more Carclnoma's is one of two nlaln causes of premature inortahty an Serbia as an nmch of the rest of Europe. Tobacco use and alcohohc dependence are one of tile ctnef preventable causes of oral cancer chseases. We surveyed three diagnoses: Carcinoma planocellulare nmcosae buccae, Ca planocellulare linguae (without baseos otis) and Ca planocellulare labll otis llffenoris and superloris. at Stomatologlcal Faculty, m Chnlc of Maxflofaclal Surgery m Belgrade. There were 357 patients m total, but sample of 214 histories of (hseases were approachable, selected mid investigated. Results: Tins study has shown that there were two-tied (62.15%) pahents who had smoked cigarettes and two-fifth (42.52%) who were alcohohc depended. One-third of them (34.11) had practiced both habits. There were stalastlcal difference related on that habits by gender and by mentioned chseases. So, 66.21% of men were smokers and 54.05°,; had alcohol used. Both (tobacco and alcohol) were mcldenced 46.62%. More than half (53.03%) of women patients were smokers mad one-sixth (16.66%) of them had alcohol used. Both of bad habits were mcldenced m 6.060,'0. The inost statistical difference was between results of tobacco use and alcohol prevalence of Ca linguae and Ca buccae by gender. Conelusion: The prevalence of tobacco and alcohol use among patients with researched diseases is higher than among total adult population m Serbia, men (52.9°,'0) women (36.92,3). The negative health consequences of these rlsc factors have been recognized.
Radiotherapy and Oncology, 2007
New England Journal of Medicine, 2007
Maturitas, 2007
Burning mouth syndrome associated to vulvodynia (Vulvostomatodynia) is a rare condition and is of... more Burning mouth syndrome associated to vulvodynia (Vulvostomatodynia) is a rare condition and is often difficult to diagnose and treat. Tongue, lips, vestibule and others mucosal sites may be affected by a tiresome burning sensation, especially in menopausal and postmenopausal women. Patients seldom report genital symptoms to the dentist and dentists do not generally investigate about genital symptoms. Delays in diagnosis may affect the quality of life. We report the clinical features of five new cases of vulvostomatodynia. A thorough multidisciplinary medical management is necessary to improve symptoms and prevent from psychologic distress. Counselling and an understanding between patient and clinician/therapist are important for long-term results.
Journal of Periodontology, 2005
Lichen planus with simultaneous oral and genital involvement in males is a quite rare condition a... more Lichen planus with simultaneous oral and genital involvement in males is a quite rare condition and often difficult to diagnose. The prevalence, treatment options, and management for this condition are far from being established, and research in this area primarily relies on anecdotes. We present the clinical features of eight cases of peno-gingival lichen planus and propose a management algorithm for this condition based on the best available published evidence. Personal medical history was collected for all cases. Following careful examination of the oral and genital mucosae, pathology was obtained, previous treatments and duration of mucosal lesions ascertained, treatment initiated, and response evaluated at 8 weeks on both oral and genital lesions. The first-line drug was topical clobetasol propionate 0.05% cream in all cases; in case of failure, topical cyclosporin was used. A review of the literature on treatment options for this rare condition was performed based upon standard literature review practices. Five cases presented gingival lesions that clinically resembled lichen planus. Glans penis was involved in all patients. All patients responded to treatment except for one. Oral candidiasis was the only observed side effect. Genital lichen planus may be suspected in males when atrophic-erosive gingival lichen planus is found. A thorough multidisciplinary medical management and active early treatment are necessary to improve symptoms and prevent genital sequelae and, given the risk of squamous cell carcinoma, as a preventative strategy, although this area still needs investigation. Therapeutic trials relating to the treatment of peno-gingival lichen planus may be undertaken considering that current management relies exclusively on observations of case reports.
Journal of Oral and Maxillofacial Surgery, 2007
Journal of Clinical Gastroenterology, 2008
Cancer Investigation, 2007
P63 is the protein codified by p63 gene, a p53 gene homolog, known for its pivotal role in cell c... more P63 is the protein codified by p63 gene, a p53 gene homolog, known for its pivotal role in cell cycle regulation, and involved in the tumor differentiation. Aims of the present study were to assess the frequency and pattern of p63 protein expression in oral squamous cell carcinoma (OSCC) in relation to the main tumour characteristics and to verify whether p63 can be considered a marker of prognosis in patients with OSCC. In a retrospective study, a cohort of 64 OSCC patients was investigated for p63 protein expression and its cellular localization by immunohistochemistry (monoclonal mouse anti-human p63 protein-clone 4A4). After grouping by p63 expression, OSCCs were statistically analyzed for the variables age, gender, histological grading (G), TNM, staging, recurrence, and overall survival rate. The overall frequency of p63 overexpressed was of 57.8 percent. Various p63 staining patterns were observed according to G score, with a significant correlation between p63 overexpression and the lowest G score (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.0001). No statistically significant difference was found between p63 pattern expression and age, sex, staging. OSCC patients with p63 overexpressed were found to have a poorer survival rate with respect to OSCCs with a normal pattern of expression (P = 0.024). On the basis of these results, it is possible to suggest p63 pattern expression as a reliable indicator of histological grading and an early marker of poor prognosis.
British Journal of Dermatology, 2006
such as metronidazole. Ciclosporin inhibits interleukin (IL)-2 production. Barnadas et al. report... more such as metronidazole. Ciclosporin inhibits interleukin (IL)-2 production. Barnadas et al. report a patient who developed angiomatous lesions after anti-IL-2 therapy. 2 Angiomatous lesions have also been reported in patients in whom IL-2 levels are low, e.g. those with extensive burns and chronic mucocutaneous candidiasis. 5 Treatment appears extremely difficult. Shave, excision, cryotherapy and electrocautery have all been unsuccessful in the three previously published cases. 2-4 Curettage and cautery and radiotherapy were unsuccessful in our patient. Thalidomide is antiangiogenic and can be helpful in GVHD, but failed when given to two of the three patients reported. 2-4 Our patient also received thalidomide: no change was noted clinically, and the drug was stopped because of nausea and fatigue.
PLoS Medicine, 2008
The Learning Forum discusses an important clinical problem of relevance to a general medical audi... more The Learning Forum discusses an important clinical problem of relevance to a general medical audience.
fungating mass on the dorsum of the tongue (Figure 1), which had lasted for an unknown period of ... more fungating mass on the dorsum of the tongue (Figure 1), which had lasted for an unknown period of time. The lesion had a roughened and irregular surface, with areas of white keratosis admixed with areas of necrosis. It felt indurated on palpation. Two additional smaller exophytic lesions were observed on the dorsum of the tongue: one adjacent to the main mass and the other on the apex. Both showed surface nodularity and minimal surface keratin production. The surrounding mucosa demonstrated hyperkeratosis and a pebbled surface. Interlacing white keratotic striae were observed on the right buccal mucosa (Figure 2), while the mucosa of the left cheek had an erosive area bordered by fine, white radiating striae (not shown in figure). A skin examination revealed polygonal, flat-topped papules covered with a fine network of white lines on the legs (Figure
Recenti progressi in medicina, 2004
The dramatic improvement in knowledge concerning celiac disease (CD) has disclosed the pattern of... more The dramatic improvement in knowledge concerning celiac disease (CD) has disclosed the pattern of the associated clinical manifestations and the often atypical or silent presentation of this disease, which makes clinical diagnosis difficult. Also oral manifestations, mostly recurrent apthous stomatitis (RAS) and dental enamel hypoplasia, are atypical signs of CD. Our opinion about the possibility of performing mass-screening to reveal atypical or silent CD is in agreement whit who is asserting that a sistematical case-finding is, at present, the most suitable epidemiological approach. So, we think that patients affected by RAS, or dental enamel hypoplasia, should be considered, even in the absence of any gastrointestinal symptom, at-risk subjects, and should therefore undergo diagnostic procedure for CD.
Recenti Progressi in Medicina, Oct 1, 2004
Oral Oncology Supplement, 2007
Journal of Dental Research, 2008
Celiac disease (CD) is a lifelong immune-mediated disorder caused by the ingestion of wheat glute... more Celiac disease (CD) is a lifelong immune-mediated disorder caused by the ingestion of wheat gluten in genetically susceptible persons. Most cases of CD are atypical and remain undiagnosed, which exposes the individuals to the risk of life-threatening complications. Serologic endomysial and tissue transglutaminase antibody tests are used to screen at-risk individuals, although a firm diagnosis requires demonstration of characteristic histopathologic
Igiene e sanita pubblica
In dental healthcare surgeries, both workers and patients are regularly exposed to various infect... more In dental healthcare surgeries, both workers and patients are regularly exposed to various infectious agents. It is essential therefore that dental healthcare workers have a good knowledge of disinfection systems and that dentists' surgeries be effectively managed so as to reduce or even eliminate the risk of cross infections. In order to evaluate infectious risk prevention methods and describe the procedures used by dental healthcare workers on a daily basis, a sample of dentists who work in public surgeries were asked to anonymously fill up a questionnaire. The results of this survey show that dental healthcare workers are sufficiently well-informed about the infectious hazards present in the workplace and are aware of the high risk of exposure to infections but seem to be especially concerned about blood-borne infections (hepatitis, AIDS). Only 67.5%, however, are immunised against HBV. Individual safety devices are used correctly while there seems to be a lack of knowledge a...
International journal of immunopathology and pharmacology
The possibility of the non-parenteral Hepatitis C Virus (HCV) transmission is supported by the de... more The possibility of the non-parenteral Hepatitis C Virus (HCV) transmission is supported by the demonstration that the actual virus is present in several body fluids, including saliva. From a review of the literature many investigators have found the presence of HCV-RNA in saliva, however, widely contrasting results emerge, with detection rates ranging from 0-100%. To further examine HCV salivary shedding, saliva samples were collected from 46 chronically HCV-infected patients and tested for HCV-RNA and occult blood. Quantification and genotyping of serum HCV-RNA were also carried out for each patient. HCV-RNA was detected in 39.13% of the saliva samples. The viral salivary shedding was significantly related to viraemia levels, serum viral genotype and the presence of salivary occult blood. Our findings indicate that the HCV salivary shedding occurs in about one third of HCV infected patients, but seem to suggest that it is unlikely when the serum viral genotype is 3a. Moreover, bloo...
International journal of immunopathology and pharmacology
Squamous cell carcinoma (SCC) of the lip is a relatively common malignancy of the head and neck r... more Squamous cell carcinoma (SCC) of the lip is a relatively common malignancy of the head and neck region. Tumour thickness, grading and perineural invasion are significant prognostic indicators. However, there is still the need of new reliable biological markers able to predict the prognosis of the single cases with an unfavourable biological behaviour unpredictable by the classic clinical-pathological parameters. 32 cases of (SCC) of the lower lip were analysed for their clincopathologic features, and immunohistochemical expression of Fas/FasL in neoplastic cells and in inflammatory infiltrate. Moreover the density and phenotype of tumour-infiltrating lymphocytes (TIL) were analysed. The results were related with the follow-up of the patients ranging from 2 to 6 years. The cases with over-expression of Fas/FasL in neoplastic cells and Fas+ in T cells preferentially showed a more aggressive clinical behaviour (P<0.01). Moreover we found an alteration of the normal expression of CD4...
Recenti progressi in medicina, 2004
The dramatic improvement in knowledge concerning celiac disease (CD) has disclosed the pattern of... more The dramatic improvement in knowledge concerning celiac disease (CD) has disclosed the pattern of the associated clinical manifestations and the often atypical or silent presentation of this disease, which makes clinical diagnosis difficult. Also oral manifestations, mostly recurrent apthous stomatitis (RAS) and dental enamel hypoplasia, are atypical signs of CD. Our opinion about the possibility of performing mass-screening to reveal atypical or silent CD is in agreement whit who is asserting that a sistematical case-finding is, at present, the most suitable epidemiological approach. So, we think that patients affected by RAS, or dental enamel hypoplasia, should be considered, even in the absence of any gastrointestinal symptom, at-risk subjects, and should therefore undergo diagnostic procedure for CD.
autoantibodies are used to screen and follow up on patients with CD, diagnostic confirmation is s... more autoantibodies are used to screen and follow up on patients with CD, diagnostic confirmation is still based on the histological examination of the small intestinal mucosa. Although the small intestinal mucosa is the main site of the gut involved in CD, other mucosal surfaces (such as gastric, rectal, ileal, and esophageal) belonging to the gastrointestinal tract and the gut-associated lymphoid tissue (GALT) can also be involved. A site that could be studied less invasively is the mouth, as it is the first part of the gastrointestinal system and a part of the GALT. Indeed, not only have various oral ailments been reported as possible atypical aspects of CD, but it has been also demonstrated that inflammatory changes occur after oral supramucosal application and a submucosal injection of gliadin into the oral mucosa of CD patients. However, to date, only two studies have assessed the capacity of the oral mucosa of untreated CD patients to EMA and anti-tTG antibodies. In this paper, we will review studies that evaluate the capacity of the oral mucosa to produce specific CD autoantibodies. Discrepancies in sensitivity from the two studies have revealed that biopsy is still not an adequate procedure for the routine diagnostic purposes of CD patients, and a more in-depth evaluation on a larger sample size with standardized collection and analysis methods is merited. However, the demonstration of immunological reactivity to the gluten ingestion of the oral mucosa of CD, in terms of IgA EMA and anti-tTG production, needs to be further evaluated in order to verify whether the oral mucosa is colonized by lymphocytes activated in the intestine or if gluten could stimulate naïve lymphocytes directly in the oral mucosa. This would have important implications for the pathogenesis, diagnosis, and treatment of CD.
Oral Oncology Supplement, 2005
Carclnoma's is one of two nlaln causes of premature inortahty an Serbia as an nmch of the rest of... more Carclnoma's is one of two nlaln causes of premature inortahty an Serbia as an nmch of the rest of Europe. Tobacco use and alcohohc dependence are one of tile ctnef preventable causes of oral cancer chseases. We surveyed three diagnoses: Carcinoma planocellulare nmcosae buccae, Ca planocellulare linguae (without baseos otis) and Ca planocellulare labll otis llffenoris and superloris. at Stomatologlcal Faculty, m Chnlc of Maxflofaclal Surgery m Belgrade. There were 357 patients m total, but sample of 214 histories of (hseases were approachable, selected mid investigated. Results: Tins study has shown that there were two-tied (62.15%) pahents who had smoked cigarettes and two-fifth (42.52%) who were alcohohc depended. One-third of them (34.11) had practiced both habits. There were stalastlcal difference related on that habits by gender and by mentioned chseases. So, 66.21% of men were smokers and 54.05°,; had alcohol used. Both (tobacco and alcohol) were mcldenced 46.62%. More than half (53.03%) of women patients were smokers mad one-sixth (16.66%) of them had alcohol used. Both of bad habits were mcldenced m 6.060,'0. The inost statistical difference was between results of tobacco use and alcohol prevalence of Ca linguae and Ca buccae by gender. Conelusion: The prevalence of tobacco and alcohol use among patients with researched diseases is higher than among total adult population m Serbia, men (52.9°,'0) women (36.92,3). The negative health consequences of these rlsc factors have been recognized.
Radiotherapy and Oncology, 2007
New England Journal of Medicine, 2007
Maturitas, 2007
Burning mouth syndrome associated to vulvodynia (Vulvostomatodynia) is a rare condition and is of... more Burning mouth syndrome associated to vulvodynia (Vulvostomatodynia) is a rare condition and is often difficult to diagnose and treat. Tongue, lips, vestibule and others mucosal sites may be affected by a tiresome burning sensation, especially in menopausal and postmenopausal women. Patients seldom report genital symptoms to the dentist and dentists do not generally investigate about genital symptoms. Delays in diagnosis may affect the quality of life. We report the clinical features of five new cases of vulvostomatodynia. A thorough multidisciplinary medical management is necessary to improve symptoms and prevent from psychologic distress. Counselling and an understanding between patient and clinician/therapist are important for long-term results.
Journal of Periodontology, 2005
Lichen planus with simultaneous oral and genital involvement in males is a quite rare condition a... more Lichen planus with simultaneous oral and genital involvement in males is a quite rare condition and often difficult to diagnose. The prevalence, treatment options, and management for this condition are far from being established, and research in this area primarily relies on anecdotes. We present the clinical features of eight cases of peno-gingival lichen planus and propose a management algorithm for this condition based on the best available published evidence. Personal medical history was collected for all cases. Following careful examination of the oral and genital mucosae, pathology was obtained, previous treatments and duration of mucosal lesions ascertained, treatment initiated, and response evaluated at 8 weeks on both oral and genital lesions. The first-line drug was topical clobetasol propionate 0.05% cream in all cases; in case of failure, topical cyclosporin was used. A review of the literature on treatment options for this rare condition was performed based upon standard literature review practices. Five cases presented gingival lesions that clinically resembled lichen planus. Glans penis was involved in all patients. All patients responded to treatment except for one. Oral candidiasis was the only observed side effect. Genital lichen planus may be suspected in males when atrophic-erosive gingival lichen planus is found. A thorough multidisciplinary medical management and active early treatment are necessary to improve symptoms and prevent genital sequelae and, given the risk of squamous cell carcinoma, as a preventative strategy, although this area still needs investigation. Therapeutic trials relating to the treatment of peno-gingival lichen planus may be undertaken considering that current management relies exclusively on observations of case reports.
Journal of Oral and Maxillofacial Surgery, 2007
Journal of Clinical Gastroenterology, 2008
Cancer Investigation, 2007
P63 is the protein codified by p63 gene, a p53 gene homolog, known for its pivotal role in cell c... more P63 is the protein codified by p63 gene, a p53 gene homolog, known for its pivotal role in cell cycle regulation, and involved in the tumor differentiation. Aims of the present study were to assess the frequency and pattern of p63 protein expression in oral squamous cell carcinoma (OSCC) in relation to the main tumour characteristics and to verify whether p63 can be considered a marker of prognosis in patients with OSCC. In a retrospective study, a cohort of 64 OSCC patients was investigated for p63 protein expression and its cellular localization by immunohistochemistry (monoclonal mouse anti-human p63 protein-clone 4A4). After grouping by p63 expression, OSCCs were statistically analyzed for the variables age, gender, histological grading (G), TNM, staging, recurrence, and overall survival rate. The overall frequency of p63 overexpressed was of 57.8 percent. Various p63 staining patterns were observed according to G score, with a significant correlation between p63 overexpression and the lowest G score (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.0001). No statistically significant difference was found between p63 pattern expression and age, sex, staging. OSCC patients with p63 overexpressed were found to have a poorer survival rate with respect to OSCCs with a normal pattern of expression (P = 0.024). On the basis of these results, it is possible to suggest p63 pattern expression as a reliable indicator of histological grading and an early marker of poor prognosis.
British Journal of Dermatology, 2006
such as metronidazole. Ciclosporin inhibits interleukin (IL)-2 production. Barnadas et al. report... more such as metronidazole. Ciclosporin inhibits interleukin (IL)-2 production. Barnadas et al. report a patient who developed angiomatous lesions after anti-IL-2 therapy. 2 Angiomatous lesions have also been reported in patients in whom IL-2 levels are low, e.g. those with extensive burns and chronic mucocutaneous candidiasis. 5 Treatment appears extremely difficult. Shave, excision, cryotherapy and electrocautery have all been unsuccessful in the three previously published cases. 2-4 Curettage and cautery and radiotherapy were unsuccessful in our patient. Thalidomide is antiangiogenic and can be helpful in GVHD, but failed when given to two of the three patients reported. 2-4 Our patient also received thalidomide: no change was noted clinically, and the drug was stopped because of nausea and fatigue.