Dr.Ewies Fawzy | National Research Centre (original) (raw)
Papers by Dr.Ewies Fawzy
The reactions of 5-azido-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde (azidopyrazole) with severa... more The reactions of 5-azido-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde (azidopyrazole) with several classes of organophosphorus reagents: phosphonium ylides, Wittig-Horner reagents, dialkylphosphonates, trialkylphosphites, tris(dialkylamino)phosphines, triph-enylstibine, triphenylarsine, and Lawesson's reagent are reported. Structural reasoning for the new products was based on compatible analytical and spectral data. The cytotoxic activity of most of the new products was evaluated against human breast carcinoma cell line (MCF7) and human hepatocellular carcinoma cell line(HepG2). Certain tested compounds showed promising results.
![Research paper thumbnail of Synthesis of Novel Alkyl (dialkoxyphosphoryl)-1H-indole-3-yl)acetate, Dialkoxyphosphoryl[2,3-b]indole-3-carboxylate and Dialkyl methylphosphonate Derivatives Using Wittig-Horner Reagents and their Antimicrobial Activity](https://attachments.academia-assets.com/42532353/thumbnails/1.jpg)
](Research Journal of Pharmaceutical, Biological and Chemical Sciences
The reaction of diazoisatin with five derivatives of Wittig-Horner reagents; trialkylphosphonoace... more The reaction of diazoisatin with five derivatives of Wittig-Horner reagents; trialkylphosphonoacetates, diethyl(pyrrolidinomethyl)phosphonate, diethyl (1,3-dioxoisoindolin-2-yl) methylphosphonate, (diethylphospho) acetonitrile and diethyl 4-methoxybenzylphosphonate has been reported. Some of the prepared products were screened for their antimicrobial activity.
Reactions of 3-amino-4-aminoximidofurazan (AAOF) with Wittig-Horner reagents, trial-kylphosphites... more Reactions of 3-amino-4-aminoximidofurazan (AAOF) with Wittig-Horner reagents, trial-kylphosphites, trisdialkylaminophosphines as well as the thiating Lawesson and Japanese reagents were studied. Elemental analysis and spectroscopic measurements were in good accord with the structures postulated for the new products. The antitumor activities of certain selected new compounds were screened, in vitro, against a panel of five (liver; HepG2; breast; MCF-7; lung; A549; colon; HCT116; and prostate PC3) human solid tu-mor cell lines.
3-Methyl-2-benzothiazolinone hydrazone condensed with some selected aldehydes to give the corresp... more 3-Methyl-2-benzothiazolinone hydrazone condensed with some selected aldehydes to give the corresponding Schiff bases. Cyclizing the obtained Schiff base derivatives with thioglycolic acid afforded the respective thiazolylideneaminothiazolidenones. Condensation of 3-methyl-2-benzothiazolinone hydrazone with ethyl cyanoacetate yielded a mixture of the bishydrazine and the cyanoacetohydrazide derivatives. Meanwhile, its condensation with ethyl acetoacetate produced a mixture of the monoketone and the β-diketone derivatives. Besides, the reaction of the starting hydrazone with malononitrile afforded a mixture of the cyanomethylylidene and cyanomethyl hydrazone derivatives beside the bishydrazine derivative. Elementary and spectroscopic measurements were in good accord with the structures postulated for the new compounds. The antitumor activities of certain selected new compounds were screened, in vitro, against a panel of four (liver, HepG2; breast, MCF-7; lung, A549; and colon; HCT116) human solid tumor cell lines. The cells that showed better activity were HepG2 and MCF-7. Structure-activity relationship (SAR) was also discussed.
5,6-Diphenyl-3-thioxo-2,3-dihydropyridazine-4-carbonitrile (1) reacted with Wittig-Horner reagent... more 5,6-Diphenyl-3-thioxo-2,3-dihydropyridazine-4-carbonitrile (1) reacted with
Wittig-Horner reagents 2a-g in presence of sodium alkoxide to afford new pyridazine
derivatives with antitumor activity.
![Research paper thumbnail of Reaction of 1,1-Bis(Diphenylphosphino)Methane with O-Quinones and Naphtho[2,1-B]Furan-1,2-Dione. Novel Synthesis of Bis(Diphenylphosphoryl) Derivatives and their Antimicrobial Activity](https://attachments.academia-assets.com/35256441/thumbnails/1.jpg)
](The reaction of 1,1-bis(diphenylphosphino)methane with substituted o-quinones afforded the novel ... more The reaction of 1,1-bis(diphenylphosphino)methane with substituted o-quinones afforded the novel 6-[bis(diphenylphosphoryl)methyl]-, and 6-[bis(diphenyl phosphoryl)methylidene derivatives. Moreover, 1,1-bis(diphenylphosphino)methane reacts with 3,4,5,6-tetrabromo-o-benzoquinone to give only the new 6-[bis(diphenylphosphoryl)methyl] derivative. Mechanisms accounting for the formation of the new products are discussed. The antimicrobial activity of some of the newly synthesized compounds was also examined
The reactions are reported of 4-(furan-3-ylcarbonyl)-1,5-diphenylpyrrolidine-2,3-dione with six c... more The reactions are reported of 4-(furan-3-ylcarbonyl)-1,5-diphenylpyrrolidine-2,3-dione with six classes of organophosphorus
reagents: carboalkoxymethylene triphenylphosphoranes, triphenyl (phenylimino)-λ5
-phosphane, trialkylphosphonoacetates,
trialkylphosphites, tris (dialkylamino)phosphines, and Lawesson’s reagent. Several of the products showed antitumour activity.
![Research paper thumbnail of Synthesis of Novel Alkyl (dialkoxyphosphoryl)-1H-indole-3-yl)acetate, Dialkoxyphosphoryl[2,3-b]indole-3-carboxylate and Dialkyl methyl phosphonate Derivatives Using Wittig-Horner Reagents and their Antimicrobial Activity.](https://attachments.academia-assets.com/35081626/thumbnails/1.jpg)
](The reaction of diazoisatin with five derivatives of Wittig-Horner reagents; trialkylphosphonoace... more The reaction of diazoisatin with five derivatives of Wittig-Horner reagents; trialkylphosphonoacetates,
diethyl(pyrrolidinomethyl)phosphonate, diethyl (1,3-dioxoisoindolin-2-yl) methylphosphonate,
(diethylphospho) acetonitrile and diethyl 4-methoxybenzylphosphonate has been reported. Some of the
prepared products were screened for their antimicrobial activity.
3-(4-Nitrobenzylidene)-5-phenylfuran-2(3H)-one 2 was prepared and converted into a variet... more 3-(4-Nitrobenzylidene)-5-phenylfuran-2(3H)-one 2 was prepared and converted into a variety of heterocyclic systems of
synthetic and biological importance via reaction with nitrogen nucleophiles. Benzylamine reacted with the furanone 2; the
product was found to depend on the reaction conditions. Thus, at room temperature the open-chain N-benzylamide 3 was
obtained, whereas under refluxing conditions the 3-(4-Nitrobenzylidene)-5-phenyl-1-benzyl-2(3H)-pyrrolone 4 was obtained.
Hydrazine hydrate affected ring opening of the furanone to give the corresponding acid hydrazide 5. The latter was used as
key starting materials for the synthesis of aminotriazole 17 and 1,3,4-oxadiazole derivatives 15a-c. The structural elucidation
of products is reported and also some of the products were screened for their antimicrobial activity.
Review by Dr.Ewies Fawzy
The present review represents a board description for the methods used in the synthesis of chromo... more The present review represents a board description for the methods used in the synthesis of chromones
and some of its derivatives. The rigid bicyclic chromone fragment has been classified as a privileged
structure in drug discovery, due to its use in a wide variety of pharmacologically active compounds;
few examples as therapeutic agents chromones are used as scaffolds for the development of bioactive
compounds, the application in medicinal chemistry, such as preparation of fluorescence probes, due to
photochemical properties of chromones have been also mentioned. This review is limited to the work
done during the last ten years.
Phase-transfer Catalysis (PTC) can increase yields, reduce cycle times, eliminate hazardous or ex... more Phase-transfer Catalysis (PTC) can increase yields, reduce cycle times, eliminate hazardous or expensive reagents and solvents, and provide numerous other benefits to organic chemical manufacturers, so that much effort has been directed toward the coupling of phase-transfer catalysis with asymmetric synthesis. There are hundreds of industrial applications of PTC for a variety of processes of organic synthesis and major advantages of PTC in industrial applications; which easily recognized in the given examples. Also, many synthetic approaches of PTC are discussed in this review.
Organoarsenic compounds have been known for over 200 years and in that time have given insight i... more Organoarsenic compounds have been known for over 200 years and in that time have given insight into important theoretical topics in chemistry from valency to aromaticity. They have also proved to have beneficial pharmacological effects. Organoarsenic compounds are produced industrially with uses as insecticides, herbicides, and fungicides. In general these applications are declining in step with growing concerns about their impact on the environment and human health. The parent compound is arsine. Despite their toxicity, organoarsenic biomolecules are well known.
Thesis Chapters by Dr.Ewies Fawzy
The reaction of 5(4H)-oxazolones with tetraethyl methanediylbis(phosphonate) afforded new 1,1-bis... more The reaction of 5(4H)-oxazolones with tetraethyl methanediylbis(phosphonate) afforded new
1,1-bisphosphonate and 1,1-bisphosphonic acid derivatives. Moreover, 5(4H)-oxazolones reacted
with Wittig reagents to give the corresponding heterocyclic products. Treatment of 5(4H)-oxazolones
with trisdialkylaminophosphanes gave the corresponding N-(1-dialkylcarbamoyl)-2-phenylvinylbenzamides.
Mechanisms accounting for the formation of the new products are discussed. The
biological activity of the newly synthesized compounds was also examined.
The reaction of 5(4H)-pyrazolone with phosphorus ylides afforded new triphenylphosphanylidene alk... more The reaction of 5(4H)-pyrazolone with phosphorus ylides afforded new triphenylphosphanylidene alkanone derivatives. Moreover, its benzylidene derivative reacted with Wittig–Horner reagents to give the corresponding dialkoxyphosphoryl, alkyl phosphonate, and heterocyclic products. Treatment of pyrazole-4-carbaldehyde with Wittig–Horner reagents and
trialkyl phosphites gave the respective alkyl phosphonate adducts. Mechanisms accounting forthe formation of the new products are discussed. The biological activity of some of the newly synthesized compounds was also examined
The reaction of 1,2-bis(diphenylphosphino)ethane with substituted o-benzoquinones afforded new bi... more The reaction of 1,2-bis(diphenylphosphino)ethane with substituted o-benzoquinones afforded new bis(6-hydroxycyclohexa-2,4-dienone) derivatives. Treatment of the same reagent with o-naphthoquinone, phenanthrenequinone, and acenaphthenequinone gave the respective bis(diphenylphosphoryl)ethylidenes or diacenaphthylenone derivatives. On the other hand, p-quinones react with 1,2-bis(diphenylphosphino)methane to yield the corresponding 4-hydroxycyclohexa-2,5-dien-1-ones. Possible reaction mechanisms are considered and the structural assignments are based on compatible analytical and spectroscopic data.
4-Benzylidene-2-phenyl-5(4H)-oxazolones react with Wittig-Horner reagents in the presence of alco... more 4-Benzylidene-2-phenyl-5(4H)-oxazolones react with Wittig-Horner reagents in the presence of
alcoholic sodium alkoxide to give novel dioxopyrrolidinephosphonates, diethyl [3-(benzoylamino)-
1-cyano-2-oxo-4-phenylbut-3-en-1-yl]phosphonate and phosphonoalkenoate derivatives. Both the
phosphonate adducts and the ester products were also isolated from the reaction of oxazolones with
triethyl phosphonoacetate using alcoholic sodium ethoxide and/or sodium hydride as a base. Possi-
ble reaction mechanisms are considered, and the structural assignments are based on analytical and
spectroscopic results. The biological evaluation of the new compounds is reported.
The reaction of 2-phenyl-5-(4H)-oxazolone 1 and its 4-benzylidene derivative 2 with oxovinylidene... more The reaction of 2-phenyl-5-(4H)-oxazolone 1 and its 4-benzylidene derivative 2 with oxovinylidenetriphenylphosphorane 3 afforded 2-phenylfuro [3,2-d] [1,3]oxazol-5-(6H)-one 6 and 2,7-diphenyl-5H-pyrano[3,2-d][1,3]oxazol-5-one 7
along with triphenylphosphine. Alternatively, when 2-phenyl-5-(4H)-oxazolone 1 reacts with phosphorus ylides 4a–f the corresponding new phosphorane, the cyclic and/or the olefinic adducts were obtained. Moreover, oxazolone reacts with N-
(triphenylphosphoranylidene)aniline 5 to give the new imino product 14 together with triphenylphosphine oxide. Possible reaction mechanisms are considered and the structural assignments are based on analytical and spectroscopic results. Bio-logical evaluations of the new products are also studied.
Drafts by Dr.Ewies Fawzy
Synthesis and utility of naphthalene-benzofuran chalcone in different types of reactions for synt... more Synthesis and utility of naphthalene-benzofuran chalcone in different types of reactions for syntheses of various heterocyclic compounds such as pyrazole, isooxazole, thiazole, pyrimidine, pyran, pyridine rings were done. Also, formation of azide derivatives from pyridine acetohydrazide that used in synthesis of 2,4-dioxothiazolidine and 2,4-dioxo-1,2-dihydroquinazolin derivatives were run and reacted with different types of phenol and amine such as phenol, 4-aminophenol, p-chloroaniline and 4-aminopyridine respectively. The structures of the newly synthesized compounds were confirmed based on different spectroscopic and elemental analyses (IR, 1H, 13C NMR and MS). Selected new compounds were evaluated their activity as antiviral. In addition, The antitumor activities of certain selected new compounds were screened, in vitro, against a panel of human solid tumor cell lines. These compounds showed high to moderate activity.
The reactions of 5-azido-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde (azidopyrazole) with severa... more The reactions of 5-azido-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde (azidopyrazole) with several classes of organophosphorus reagents: phosphonium ylides, Wittig-Horner reagents, dialkylphosphonates, trialkylphosphites, tris(dialkylamino)phosphines, triph-enylstibine, triphenylarsine, and Lawesson's reagent are reported. Structural reasoning for the new products was based on compatible analytical and spectral data. The cytotoxic activity of most of the new products was evaluated against human breast carcinoma cell line (MCF7) and human hepatocellular carcinoma cell line(HepG2). Certain tested compounds showed promising results.
Research Journal of Pharmaceutical, Biological and Chemical Sciences
The reaction of diazoisatin with five derivatives of Wittig-Horner reagents; trialkylphosphonoace... more The reaction of diazoisatin with five derivatives of Wittig-Horner reagents; trialkylphosphonoacetates, diethyl(pyrrolidinomethyl)phosphonate, diethyl (1,3-dioxoisoindolin-2-yl) methylphosphonate, (diethylphospho) acetonitrile and diethyl 4-methoxybenzylphosphonate has been reported. Some of the prepared products were screened for their antimicrobial activity.
Reactions of 3-amino-4-aminoximidofurazan (AAOF) with Wittig-Horner reagents, trial-kylphosphites... more Reactions of 3-amino-4-aminoximidofurazan (AAOF) with Wittig-Horner reagents, trial-kylphosphites, trisdialkylaminophosphines as well as the thiating Lawesson and Japanese reagents were studied. Elemental analysis and spectroscopic measurements were in good accord with the structures postulated for the new products. The antitumor activities of certain selected new compounds were screened, in vitro, against a panel of five (liver; HepG2; breast; MCF-7; lung; A549; colon; HCT116; and prostate PC3) human solid tu-mor cell lines.
3-Methyl-2-benzothiazolinone hydrazone condensed with some selected aldehydes to give the corresp... more 3-Methyl-2-benzothiazolinone hydrazone condensed with some selected aldehydes to give the corresponding Schiff bases. Cyclizing the obtained Schiff base derivatives with thioglycolic acid afforded the respective thiazolylideneaminothiazolidenones. Condensation of 3-methyl-2-benzothiazolinone hydrazone with ethyl cyanoacetate yielded a mixture of the bishydrazine and the cyanoacetohydrazide derivatives. Meanwhile, its condensation with ethyl acetoacetate produced a mixture of the monoketone and the β-diketone derivatives. Besides, the reaction of the starting hydrazone with malononitrile afforded a mixture of the cyanomethylylidene and cyanomethyl hydrazone derivatives beside the bishydrazine derivative. Elementary and spectroscopic measurements were in good accord with the structures postulated for the new compounds. The antitumor activities of certain selected new compounds were screened, in vitro, against a panel of four (liver, HepG2; breast, MCF-7; lung, A549; and colon; HCT116) human solid tumor cell lines. The cells that showed better activity were HepG2 and MCF-7. Structure-activity relationship (SAR) was also discussed.
5,6-Diphenyl-3-thioxo-2,3-dihydropyridazine-4-carbonitrile (1) reacted with Wittig-Horner reagent... more 5,6-Diphenyl-3-thioxo-2,3-dihydropyridazine-4-carbonitrile (1) reacted with
Wittig-Horner reagents 2a-g in presence of sodium alkoxide to afford new pyridazine
derivatives with antitumor activity.
The reaction of 1,1-bis(diphenylphosphino)methane with substituted o-quinones afforded the novel ... more The reaction of 1,1-bis(diphenylphosphino)methane with substituted o-quinones afforded the novel 6-[bis(diphenylphosphoryl)methyl]-, and 6-[bis(diphenyl phosphoryl)methylidene derivatives. Moreover, 1,1-bis(diphenylphosphino)methane reacts with 3,4,5,6-tetrabromo-o-benzoquinone to give only the new 6-[bis(diphenylphosphoryl)methyl] derivative. Mechanisms accounting for the formation of the new products are discussed. The antimicrobial activity of some of the newly synthesized compounds was also examined
The reactions are reported of 4-(furan-3-ylcarbonyl)-1,5-diphenylpyrrolidine-2,3-dione with six c... more The reactions are reported of 4-(furan-3-ylcarbonyl)-1,5-diphenylpyrrolidine-2,3-dione with six classes of organophosphorus
reagents: carboalkoxymethylene triphenylphosphoranes, triphenyl (phenylimino)-λ5
-phosphane, trialkylphosphonoacetates,
trialkylphosphites, tris (dialkylamino)phosphines, and Lawesson’s reagent. Several of the products showed antitumour activity.
The reaction of diazoisatin with five derivatives of Wittig-Horner reagents; trialkylphosphonoace... more The reaction of diazoisatin with five derivatives of Wittig-Horner reagents; trialkylphosphonoacetates,
diethyl(pyrrolidinomethyl)phosphonate, diethyl (1,3-dioxoisoindolin-2-yl) methylphosphonate,
(diethylphospho) acetonitrile and diethyl 4-methoxybenzylphosphonate has been reported. Some of the
prepared products were screened for their antimicrobial activity.
3-(4-Nitrobenzylidene)-5-phenylfuran-2(3H)-one 2 was prepared and converted into a variet... more 3-(4-Nitrobenzylidene)-5-phenylfuran-2(3H)-one 2 was prepared and converted into a variety of heterocyclic systems of
synthetic and biological importance via reaction with nitrogen nucleophiles. Benzylamine reacted with the furanone 2; the
product was found to depend on the reaction conditions. Thus, at room temperature the open-chain N-benzylamide 3 was
obtained, whereas under refluxing conditions the 3-(4-Nitrobenzylidene)-5-phenyl-1-benzyl-2(3H)-pyrrolone 4 was obtained.
Hydrazine hydrate affected ring opening of the furanone to give the corresponding acid hydrazide 5. The latter was used as
key starting materials for the synthesis of aminotriazole 17 and 1,3,4-oxadiazole derivatives 15a-c. The structural elucidation
of products is reported and also some of the products were screened for their antimicrobial activity.
The present review represents a board description for the methods used in the synthesis of chromo... more The present review represents a board description for the methods used in the synthesis of chromones
and some of its derivatives. The rigid bicyclic chromone fragment has been classified as a privileged
structure in drug discovery, due to its use in a wide variety of pharmacologically active compounds;
few examples as therapeutic agents chromones are used as scaffolds for the development of bioactive
compounds, the application in medicinal chemistry, such as preparation of fluorescence probes, due to
photochemical properties of chromones have been also mentioned. This review is limited to the work
done during the last ten years.
Phase-transfer Catalysis (PTC) can increase yields, reduce cycle times, eliminate hazardous or ex... more Phase-transfer Catalysis (PTC) can increase yields, reduce cycle times, eliminate hazardous or expensive reagents and solvents, and provide numerous other benefits to organic chemical manufacturers, so that much effort has been directed toward the coupling of phase-transfer catalysis with asymmetric synthesis. There are hundreds of industrial applications of PTC for a variety of processes of organic synthesis and major advantages of PTC in industrial applications; which easily recognized in the given examples. Also, many synthetic approaches of PTC are discussed in this review.
Organoarsenic compounds have been known for over 200 years and in that time have given insight i... more Organoarsenic compounds have been known for over 200 years and in that time have given insight into important theoretical topics in chemistry from valency to aromaticity. They have also proved to have beneficial pharmacological effects. Organoarsenic compounds are produced industrially with uses as insecticides, herbicides, and fungicides. In general these applications are declining in step with growing concerns about their impact on the environment and human health. The parent compound is arsine. Despite their toxicity, organoarsenic biomolecules are well known.
The reaction of 5(4H)-oxazolones with tetraethyl methanediylbis(phosphonate) afforded new 1,1-bis... more The reaction of 5(4H)-oxazolones with tetraethyl methanediylbis(phosphonate) afforded new
1,1-bisphosphonate and 1,1-bisphosphonic acid derivatives. Moreover, 5(4H)-oxazolones reacted
with Wittig reagents to give the corresponding heterocyclic products. Treatment of 5(4H)-oxazolones
with trisdialkylaminophosphanes gave the corresponding N-(1-dialkylcarbamoyl)-2-phenylvinylbenzamides.
Mechanisms accounting for the formation of the new products are discussed. The
biological activity of the newly synthesized compounds was also examined.
The reaction of 5(4H)-pyrazolone with phosphorus ylides afforded new triphenylphosphanylidene alk... more The reaction of 5(4H)-pyrazolone with phosphorus ylides afforded new triphenylphosphanylidene alkanone derivatives. Moreover, its benzylidene derivative reacted with Wittig–Horner reagents to give the corresponding dialkoxyphosphoryl, alkyl phosphonate, and heterocyclic products. Treatment of pyrazole-4-carbaldehyde with Wittig–Horner reagents and
trialkyl phosphites gave the respective alkyl phosphonate adducts. Mechanisms accounting forthe formation of the new products are discussed. The biological activity of some of the newly synthesized compounds was also examined
The reaction of 1,2-bis(diphenylphosphino)ethane with substituted o-benzoquinones afforded new bi... more The reaction of 1,2-bis(diphenylphosphino)ethane with substituted o-benzoquinones afforded new bis(6-hydroxycyclohexa-2,4-dienone) derivatives. Treatment of the same reagent with o-naphthoquinone, phenanthrenequinone, and acenaphthenequinone gave the respective bis(diphenylphosphoryl)ethylidenes or diacenaphthylenone derivatives. On the other hand, p-quinones react with 1,2-bis(diphenylphosphino)methane to yield the corresponding 4-hydroxycyclohexa-2,5-dien-1-ones. Possible reaction mechanisms are considered and the structural assignments are based on compatible analytical and spectroscopic data.
4-Benzylidene-2-phenyl-5(4H)-oxazolones react with Wittig-Horner reagents in the presence of alco... more 4-Benzylidene-2-phenyl-5(4H)-oxazolones react with Wittig-Horner reagents in the presence of
alcoholic sodium alkoxide to give novel dioxopyrrolidinephosphonates, diethyl [3-(benzoylamino)-
1-cyano-2-oxo-4-phenylbut-3-en-1-yl]phosphonate and phosphonoalkenoate derivatives. Both the
phosphonate adducts and the ester products were also isolated from the reaction of oxazolones with
triethyl phosphonoacetate using alcoholic sodium ethoxide and/or sodium hydride as a base. Possi-
ble reaction mechanisms are considered, and the structural assignments are based on analytical and
spectroscopic results. The biological evaluation of the new compounds is reported.
The reaction of 2-phenyl-5-(4H)-oxazolone 1 and its 4-benzylidene derivative 2 with oxovinylidene... more The reaction of 2-phenyl-5-(4H)-oxazolone 1 and its 4-benzylidene derivative 2 with oxovinylidenetriphenylphosphorane 3 afforded 2-phenylfuro [3,2-d] [1,3]oxazol-5-(6H)-one 6 and 2,7-diphenyl-5H-pyrano[3,2-d][1,3]oxazol-5-one 7
along with triphenylphosphine. Alternatively, when 2-phenyl-5-(4H)-oxazolone 1 reacts with phosphorus ylides 4a–f the corresponding new phosphorane, the cyclic and/or the olefinic adducts were obtained. Moreover, oxazolone reacts with N-
(triphenylphosphoranylidene)aniline 5 to give the new imino product 14 together with triphenylphosphine oxide. Possible reaction mechanisms are considered and the structural assignments are based on analytical and spectroscopic results. Bio-logical evaluations of the new products are also studied.
Synthesis and utility of naphthalene-benzofuran chalcone in different types of reactions for synt... more Synthesis and utility of naphthalene-benzofuran chalcone in different types of reactions for syntheses of various heterocyclic compounds such as pyrazole, isooxazole, thiazole, pyrimidine, pyran, pyridine rings were done. Also, formation of azide derivatives from pyridine acetohydrazide that used in synthesis of 2,4-dioxothiazolidine and 2,4-dioxo-1,2-dihydroquinazolin derivatives were run and reacted with different types of phenol and amine such as phenol, 4-aminophenol, p-chloroaniline and 4-aminopyridine respectively. The structures of the newly synthesized compounds were confirmed based on different spectroscopic and elemental analyses (IR, 1H, 13C NMR and MS). Selected new compounds were evaluated their activity as antiviral. In addition, The antitumor activities of certain selected new compounds were screened, in vitro, against a panel of human solid tumor cell lines. These compounds showed high to moderate activity.