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Papers by Anna Nolan

Research paper thumbnail of Obstructive Airways Disease With Air Trapping Among Firefighters Exposed to World Trade Center Dust

Research paper thumbnail of Severe alcohol withdrawal in the ICU, treatments and complications

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Caspase 6 Cleaves the Macrophage Inhibitor IRAK-M in Contact Dependent Innate Immune Activation

D31. NEW INSIGHTS INTO INFLAMMATION AND ACUTE LUNG INJURY, 2009

Research paper thumbnail of Role of CD 40 ligand in early sepsis

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of The CD80/86-CD28 interaction is significant to mortality in murine polymicrobial sepsis

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Correlation of PPD status of immunocompetent tuberculosis patients and bronchoalveolar lavage (BAL) cell differential

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Blockade of CD80/86 improves survival in a murine model of polymicrobial sepsis

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Role of combined costimulatory molecule inhibition in sepsis

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Macrophage expressed co-stimulatory molecules CD80/86 in murine polymicrobial sepsis

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Treatment with -1 antitrypsin confers protection from mortality in murine polymicrobial sepsis

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Computed Tomography Derived Vascular Injury Marker Correlates With Forced Expiratory Volume In One Second (FEV1) Loss In World Trade Center Exposed Firefighters

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Role of interferons in an in vivo model of inhalational anthrax

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Role of macrophage costimulatory molecules in human sepsis

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Biomarkers of World Trade Center Particulate Matter Exposure: Physiology of Distal Airway and Blood Biomarkers that Predict FEV1 Decline

Seminars in Respiratory and Critical Care Medicine, 2015

Biomarkers can be important predictors of disease severity and progression. The intense exposure ... more Biomarkers can be important predictors of disease severity and progression. The intense exposure to particulates and other toxins from the destruction of the World Trade Center (WTC) overwhelmed the lung's normal protective barriers. The Fire Department of New York (FDNY) cohort not only had baseline pre-exposure lung function measures but also had serum samples banked soon after their WTC exposure. This well-phenotyped group of highly exposed first responders is an ideal cohort for biomarker discovery and eventual validation. Disease progression was heterogeneous in this group in that some individuals subsequently developed abnormal lung function while others recovered. Airflow obstruction predominated in WTC-exposed patients who were symptomatic. Multiple independent disease pathways may cause this abnormal FEV1 after irritant exposure. WTC exposure activates one or more of these pathways causing abnormal FEV1 in an individual. Our hypothesis was that serum biomarkers expressed within 6 months after WTC exposure reflect active disease pathways and predict subsequent development or protection from abnormal FEV1 below the lower limit of normal known as WTC-Lung Injury (WTC-LI). We utilized a nested case-cohort control design of previously healthy never smokers who sought subspecialty pulmonary evaluation to explore predictive biomarkers of WTC-LI. We have identified biomarkers of inflammation, metabolic derangement, protease/antiprotease balance, and vascular injury expressed in serum within 6 months of WTC exposure that were predictive of their FEV1 up to 7 years after their WTC exposure. Predicting future risk of airway injury after particulate exposures can focus monitoring and early treatment on a subset of patients in greatest need of these services.

Research paper thumbnail of The Duration of an Exposure Response Gradient between Incident Obstructive Airways Disease and Work at the World Trade Center Site: 2001-2011

PLoS currents, 2015

Adverse respiratory effects of World Trade Center (WTC) exposure have been widely documented, but... more Adverse respiratory effects of World Trade Center (WTC) exposure have been widely documented, but the length of time that exposure remains associated with disease is uncertain. We estimate the incidence of new cases of physician-diagnosed obstructive airway disease (OAD) as a function of time since 9/11/2001 in WTC-exposed firefighters. Exposure was categorized by first WTC arrival time: high (9/11/2001 AM); moderate (9/11/2001 PM or 9/12/2001); or low (9/13-24/2001). We modeled relative rates (RR) and 95% confidence intervals (CI) of OAD incidence by exposure over the first 10 years post-9/11/2001, estimating the time(s) of change in the RR with change point models. We further examined the relationship between self-reported lower respiratory symptoms and physician diagnoses. Change points were observed at 15 and 84 months post-9/11/2001, with relative incidence rates for the high versus low exposure group of 4.02 (95% CI 2.62-6.16) prior to 15 months, 1.90 (95% CI 1.49-2.44) from m...

Research paper thumbnail of World Trade Center Collapse Produced Airway Injury and Air Trapping

D40. UNDERSTANDING INHALATIONAL DISASTERS, 2009

Research paper thumbnail of Costimulatory Molecules in the Inflammatory Response to PM 2.5 Exposure

B45. ANIMAL AND CELL MODELS FOR THE CARDIOVASCULAR EFFECTS OF AIR POLLUTION, 2009

Research paper thumbnail of Low Serum IgA And IgG4 Levels Predict Accelerated Decline In Lung Function Of WTC Dust Exposed Firefighters

C52. OCCUPATIONAL LUNG DISEASE, 2011

Research paper thumbnail of Similar Exposure To World Trade Center (WTC) Dust Produced Variable Lung Function Decline: Defining Most And Least Effected Subgroups In The FDNY Cohort

A29. NOVEL INSIGHTS INTO LUNG MECHANICS IN HEALTH AND DISEASE, 2010

Research paper thumbnail of Enlarged pulmonary artery is predicted by vascular injury biomarkers and is associated with WTC-Lung Injury in exposed fire fighters: a case-control study

BMJ open, 2014

We hypothesise that there is an association between an elevated pulmonary artery/aorta (PA/A) and... more We hypothesise that there is an association between an elevated pulmonary artery/aorta (PA/A) and World Trade Center-Lung Injury (WTC-LI). We assessed if serum vascular disease biomarkers were predictive of an elevated PA/A. Retrospective case-cohort analysis of thoracic CT scans of WTC-exposed firefighters who were symptomatic between 9/12/2001 and 3/10/2008. Quantification of vascular-associated biomarkers from serum collected within 200 days of exposure. Urban tertiary care centre and occupational healthcare centre. Male never-smoking firefighters with accurate pre-9/11 forced expiratory volume in 1 s (FEV1)≥75%, serum sampled ≤200 days of exposure was the baseline cohort (n=801). A subcohort (n=97) with available CT scans and serum biomarkers was identified. WTC-LI was defined as FEV1≤77% at the subspecialty pulmonary evaluation (n=34) and compared with controls (n=63) to determine the associated PA/A ratio. The subcohort was restratified based on PA/A≥0.92 (n=38) and PA/A<0....

Research paper thumbnail of Obstructive Airways Disease With Air Trapping Among Firefighters Exposed to World Trade Center Dust

Research paper thumbnail of Severe alcohol withdrawal in the ICU, treatments and complications

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Caspase 6 Cleaves the Macrophage Inhibitor IRAK-M in Contact Dependent Innate Immune Activation

D31. NEW INSIGHTS INTO INFLAMMATION AND ACUTE LUNG INJURY, 2009

Research paper thumbnail of Role of CD 40 ligand in early sepsis

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of The CD80/86-CD28 interaction is significant to mortality in murine polymicrobial sepsis

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Correlation of PPD status of immunocompetent tuberculosis patients and bronchoalveolar lavage (BAL) cell differential

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Blockade of CD80/86 improves survival in a murine model of polymicrobial sepsis

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Role of combined costimulatory molecule inhibition in sepsis

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Macrophage expressed co-stimulatory molecules CD80/86 in murine polymicrobial sepsis

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Treatment with -1 antitrypsin confers protection from mortality in murine polymicrobial sepsis

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Computed Tomography Derived Vascular Injury Marker Correlates With Forced Expiratory Volume In One Second (FEV1) Loss In World Trade Center Exposed Firefighters

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Role of interferons in an in vivo model of inhalational anthrax

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Role of macrophage costimulatory molecules in human sepsis

American Journal of Respiratory and Critical Care Medicine

Research paper thumbnail of Biomarkers of World Trade Center Particulate Matter Exposure: Physiology of Distal Airway and Blood Biomarkers that Predict FEV1 Decline

Seminars in Respiratory and Critical Care Medicine, 2015

Biomarkers can be important predictors of disease severity and progression. The intense exposure ... more Biomarkers can be important predictors of disease severity and progression. The intense exposure to particulates and other toxins from the destruction of the World Trade Center (WTC) overwhelmed the lung&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s normal protective barriers. The Fire Department of New York (FDNY) cohort not only had baseline pre-exposure lung function measures but also had serum samples banked soon after their WTC exposure. This well-phenotyped group of highly exposed first responders is an ideal cohort for biomarker discovery and eventual validation. Disease progression was heterogeneous in this group in that some individuals subsequently developed abnormal lung function while others recovered. Airflow obstruction predominated in WTC-exposed patients who were symptomatic. Multiple independent disease pathways may cause this abnormal FEV1 after irritant exposure. WTC exposure activates one or more of these pathways causing abnormal FEV1 in an individual. Our hypothesis was that serum biomarkers expressed within 6 months after WTC exposure reflect active disease pathways and predict subsequent development or protection from abnormal FEV1 below the lower limit of normal known as WTC-Lung Injury (WTC-LI). We utilized a nested case-cohort control design of previously healthy never smokers who sought subspecialty pulmonary evaluation to explore predictive biomarkers of WTC-LI. We have identified biomarkers of inflammation, metabolic derangement, protease/antiprotease balance, and vascular injury expressed in serum within 6 months of WTC exposure that were predictive of their FEV1 up to 7 years after their WTC exposure. Predicting future risk of airway injury after particulate exposures can focus monitoring and early treatment on a subset of patients in greatest need of these services.

Research paper thumbnail of The Duration of an Exposure Response Gradient between Incident Obstructive Airways Disease and Work at the World Trade Center Site: 2001-2011

PLoS currents, 2015

Adverse respiratory effects of World Trade Center (WTC) exposure have been widely documented, but... more Adverse respiratory effects of World Trade Center (WTC) exposure have been widely documented, but the length of time that exposure remains associated with disease is uncertain. We estimate the incidence of new cases of physician-diagnosed obstructive airway disease (OAD) as a function of time since 9/11/2001 in WTC-exposed firefighters. Exposure was categorized by first WTC arrival time: high (9/11/2001 AM); moderate (9/11/2001 PM or 9/12/2001); or low (9/13-24/2001). We modeled relative rates (RR) and 95% confidence intervals (CI) of OAD incidence by exposure over the first 10 years post-9/11/2001, estimating the time(s) of change in the RR with change point models. We further examined the relationship between self-reported lower respiratory symptoms and physician diagnoses. Change points were observed at 15 and 84 months post-9/11/2001, with relative incidence rates for the high versus low exposure group of 4.02 (95% CI 2.62-6.16) prior to 15 months, 1.90 (95% CI 1.49-2.44) from m...

Research paper thumbnail of World Trade Center Collapse Produced Airway Injury and Air Trapping

D40. UNDERSTANDING INHALATIONAL DISASTERS, 2009

Research paper thumbnail of Costimulatory Molecules in the Inflammatory Response to PM 2.5 Exposure

B45. ANIMAL AND CELL MODELS FOR THE CARDIOVASCULAR EFFECTS OF AIR POLLUTION, 2009

Research paper thumbnail of Low Serum IgA And IgG4 Levels Predict Accelerated Decline In Lung Function Of WTC Dust Exposed Firefighters

C52. OCCUPATIONAL LUNG DISEASE, 2011

Research paper thumbnail of Similar Exposure To World Trade Center (WTC) Dust Produced Variable Lung Function Decline: Defining Most And Least Effected Subgroups In The FDNY Cohort

A29. NOVEL INSIGHTS INTO LUNG MECHANICS IN HEALTH AND DISEASE, 2010

Research paper thumbnail of Enlarged pulmonary artery is predicted by vascular injury biomarkers and is associated with WTC-Lung Injury in exposed fire fighters: a case-control study

BMJ open, 2014

We hypothesise that there is an association between an elevated pulmonary artery/aorta (PA/A) and... more We hypothesise that there is an association between an elevated pulmonary artery/aorta (PA/A) and World Trade Center-Lung Injury (WTC-LI). We assessed if serum vascular disease biomarkers were predictive of an elevated PA/A. Retrospective case-cohort analysis of thoracic CT scans of WTC-exposed firefighters who were symptomatic between 9/12/2001 and 3/10/2008. Quantification of vascular-associated biomarkers from serum collected within 200 days of exposure. Urban tertiary care centre and occupational healthcare centre. Male never-smoking firefighters with accurate pre-9/11 forced expiratory volume in 1 s (FEV1)≥75%, serum sampled ≤200 days of exposure was the baseline cohort (n=801). A subcohort (n=97) with available CT scans and serum biomarkers was identified. WTC-LI was defined as FEV1≤77% at the subspecialty pulmonary evaluation (n=34) and compared with controls (n=63) to determine the associated PA/A ratio. The subcohort was restratified based on PA/A≥0.92 (n=38) and PA/A<0....

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