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Research paper thumbnail of Terapias de apoyo a pacientes con Enfermedad de

Research paper thumbnail of PROYECTO DE REINSTALACION DE TERAPIAS DE APOYO AL

Proyecto de reinstalacion de terapias de apoyo al adulto mayor el cual esta expuesto a las princi... more Proyecto de reinstalacion de terapias de apoyo al adulto mayor el cual esta expuesto a las principales afecciones neuro degenerativas hablamos de enfermedad de alzhaimer y enfermedad de parkinson. ¿qué similitud existe entre una y la otra? las dos son neuro degenerativas.

Research paper thumbnail of Frente del Libro

Research paper thumbnail of EN TODAS LAS TIERRAS SALE EL SOL

Research paper thumbnail of Aviso de Libro y Terapias de apoyo a Pacientes de Alzahamer

Por este conducto me permito enviarte 2 asuntos muy importantes: 1. El dia de hoy regalaremos a l... more Por este conducto me permito enviarte 2 asuntos muy importantes: 1. El dia de hoy regalaremos a las 10 primeros pacientes de Parkinson que se presenten Un libro HISTORIA DE ÉXITO VIVIR 30 AÑOS CON PARKINSON a las 11.30 am En Av. Guadalupe No 1638-2 tels 40 00 97 93 o 31 22 34 44 2. A Partir del mes de Noviembre ASOCIACION PARKINSON DARA TERAPIAS DE APOYO A Pacientes de ALZHAIMER.

Research paper thumbnail of Desde naciiento

Research paper thumbnail of CURRICULUM DE

Research paper thumbnail of 2reunion de rehabilitadores

Research paper thumbnail of 2 1a reunio de profesionales 24 y 25 de Agosto

Research paper thumbnail of 1a Anual de PROFESIONALES EN LA REHABILITACION NEUROLOGICAEN PACIENTES DE EP

Research paper thumbnail of Actin filaments are involved in the maintenance of Golgi cisternae morphology and intra-Golgi pH

Cell Motility and The Cytoskeleton, 2006

Research paper thumbnail of Part 4: Conflict of interest management before, during, and after the 2010 International Consensus Conference on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations

Research paper thumbnail of ELS SECTORS CULTURALS COM ESTRATÈGIA DE DESENVOLUPAMENT TERRITORIAL A LES COMARQUES CENTRALS VALENCIANES

Research paper thumbnail of Part 3: Evidence evaluation process

Research paper thumbnail of A tridimensional view of the organization of actin filaments in the central nervous system by use of fluorescent photooxidation

Cellular and subcellular organization and distribution of actin filaments have been studied with ... more Cellular and subcellular organization and distribution of actin filaments have been studied with various techniques. The use of fluorescence photo-oxidation combined with phalloidin conjugates with eosin has allowed the examination of the precise cellular and subcellular location of F-actin. Correlative fluorescence light microscopy and transmission electron microscopy studies of F-actin distribution are facilitated with this method for morphological and physiological studies. Because phalloidin-eosin is smaller than other markers, this method allows the analysis of the three-dimensional location of F-actin with high-resolution light microscopy, three-d serial sections reconstructions, and electron tomography. The combination of selective staining and three-dimensional reconstructions provide a valuable tool for revealing aspects of the synaptic morphology that are not available when conventional electron microscopy is used. By applying this selective staining technique and three-dimensional imaging, we uncovered the structural organization of actin in the postsynaptic densities in physiological and pathological conditions. BIOCELL 2008, 32(1): 1-8

Research paper thumbnail of Supplement II: Abstracts of the international symposium on Skin Carcinogenesis in man and in experimental models. Heidelberg, 29–31 October 1991 (pp S61–S88

Journal of Cancer Research and Clinical Oncology, 1991

We have proposed that cellular senescence is controlled by normal genes that are activated or who... more We have proposed that cellular senescence is controlled by normal genes that are activated or whose functions become manifest at the end of the life span of a cell. Defects in these genes allow cells to escape senescence and become immortal. Senescence genes have ...

Research paper thumbnail of ChemInform Abstract: A Schottky Barrier Junction Based on Nanometer-Scale Interpenetrating GaP/Gold Networks

Cheminform, 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Research paper thumbnail of Production of cattle lacking prion protein

Nature Biotechnology, 2006

Prion diseases are caused by propagation of misfolded forms of the normal cellular prion protein ... more Prion diseases are caused by propagation of misfolded forms of the normal cellular prion protein PrP C , such as PrP BSE in bovine spongiform encephalopathy (BSE) in cattle and PrP CJD in Creutzfeldt-Jakob disease (CJD) in humans 1 . Disruption of PrP C expression in mice, a species that does not naturally contract prion diseases, results in no apparent developmental abnormalities 2-5 . However, the impact of ablating PrP C function in natural host species of prion diseases is unknown. Here we report the generation and characterization of PrP C -deficient cattle produced by a sequential gene-targeting system 6 . At over 20 months of age, the cattle are clinically, physiologically, histopathologically, immunologically and reproductively normal. Brain tissue homogenates are resistant to prion propagation in vitro as assessed by protein misfolding cyclic amplification 7 . PrP C -deficient cattle may be a useful model for prion research and could provide industrial bovine products free of prion proteins.

Research paper thumbnail of Regulation of Neurogenesis by Interkinetic Nuclear Migration through an Apical-Basal Notch Gradient

Cell, 2008

The different cell types in the central nervous system develop from a common pool of progenitor c... more The different cell types in the central nervous system develop from a common pool of progenitor cells. The nuclei of progenitors move between the apical and basal surfaces of the neuroepithelium in phase with their cell cycle, a process termed interkinetic nuclear migration (INM). In the retina of zebrafish mikre oko (mok) mutants, in which the motor protein Dynactin-1 is disrupted, interkinetic nuclei migrate more rapidly and deeply to the basal side and more slowly to the apical side. We found that Notch signaling is predominantly activated on the apical side in both mutants and wild-type. Mutant progenitors are, thus, less exposed to Notch and exit the cell cycle prematurely. This leads to an overproduction of early-born retinal ganglion cells (RGCs) at the expense of later-born interneurons and glia. Our data indicate that the function of INM is to balance the exposure of progenitor nuclei to neurogenic versus proliferative signals.

Research paper thumbnail of PROYECTO DE REINSTALACION DE TERAPIAS DE APOYO AL

Proyecto de reinstalacion de terapias de apoyo al adulto mayor el cual esta expuesto a las princi... more Proyecto de reinstalacion de terapias de apoyo al adulto mayor el cual esta expuesto a las principales afecciones neuro degenerativas hablamos de enfermedad de alzhaimer y enfermedad de parkinson. ¿qué similitud existe entre una y la otra? las dos son neuro degenerativas.

Research paper thumbnail of Terapias de apoyo a pacientes con Enfermedad de

Research paper thumbnail of PROYECTO DE REINSTALACION DE TERAPIAS DE APOYO AL

Proyecto de reinstalacion de terapias de apoyo al adulto mayor el cual esta expuesto a las princi... more Proyecto de reinstalacion de terapias de apoyo al adulto mayor el cual esta expuesto a las principales afecciones neuro degenerativas hablamos de enfermedad de alzhaimer y enfermedad de parkinson. ¿qué similitud existe entre una y la otra? las dos son neuro degenerativas.

Research paper thumbnail of Frente del Libro

Research paper thumbnail of EN TODAS LAS TIERRAS SALE EL SOL

Research paper thumbnail of Aviso de Libro y Terapias de apoyo a Pacientes de Alzahamer

Por este conducto me permito enviarte 2 asuntos muy importantes: 1. El dia de hoy regalaremos a l... more Por este conducto me permito enviarte 2 asuntos muy importantes: 1. El dia de hoy regalaremos a las 10 primeros pacientes de Parkinson que se presenten Un libro HISTORIA DE ÉXITO VIVIR 30 AÑOS CON PARKINSON a las 11.30 am En Av. Guadalupe No 1638-2 tels 40 00 97 93 o 31 22 34 44 2. A Partir del mes de Noviembre ASOCIACION PARKINSON DARA TERAPIAS DE APOYO A Pacientes de ALZHAIMER.

Research paper thumbnail of Desde naciiento

Research paper thumbnail of CURRICULUM DE

Research paper thumbnail of 2reunion de rehabilitadores

Research paper thumbnail of 2 1a reunio de profesionales 24 y 25 de Agosto

Research paper thumbnail of 1a Anual de PROFESIONALES EN LA REHABILITACION NEUROLOGICAEN PACIENTES DE EP

Research paper thumbnail of Actin filaments are involved in the maintenance of Golgi cisternae morphology and intra-Golgi pH

Cell Motility and The Cytoskeleton, 2006

Research paper thumbnail of Part 4: Conflict of interest management before, during, and after the 2010 International Consensus Conference on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations

Research paper thumbnail of ELS SECTORS CULTURALS COM ESTRATÈGIA DE DESENVOLUPAMENT TERRITORIAL A LES COMARQUES CENTRALS VALENCIANES

Research paper thumbnail of Part 3: Evidence evaluation process

Research paper thumbnail of A tridimensional view of the organization of actin filaments in the central nervous system by use of fluorescent photooxidation

Cellular and subcellular organization and distribution of actin filaments have been studied with ... more Cellular and subcellular organization and distribution of actin filaments have been studied with various techniques. The use of fluorescence photo-oxidation combined with phalloidin conjugates with eosin has allowed the examination of the precise cellular and subcellular location of F-actin. Correlative fluorescence light microscopy and transmission electron microscopy studies of F-actin distribution are facilitated with this method for morphological and physiological studies. Because phalloidin-eosin is smaller than other markers, this method allows the analysis of the three-dimensional location of F-actin with high-resolution light microscopy, three-d serial sections reconstructions, and electron tomography. The combination of selective staining and three-dimensional reconstructions provide a valuable tool for revealing aspects of the synaptic morphology that are not available when conventional electron microscopy is used. By applying this selective staining technique and three-dimensional imaging, we uncovered the structural organization of actin in the postsynaptic densities in physiological and pathological conditions. BIOCELL 2008, 32(1): 1-8

Research paper thumbnail of Supplement II: Abstracts of the international symposium on Skin Carcinogenesis in man and in experimental models. Heidelberg, 29–31 October 1991 (pp S61–S88

Journal of Cancer Research and Clinical Oncology, 1991

We have proposed that cellular senescence is controlled by normal genes that are activated or who... more We have proposed that cellular senescence is controlled by normal genes that are activated or whose functions become manifest at the end of the life span of a cell. Defects in these genes allow cells to escape senescence and become immortal. Senescence genes have ...

Research paper thumbnail of ChemInform Abstract: A Schottky Barrier Junction Based on Nanometer-Scale Interpenetrating GaP/Gold Networks

Cheminform, 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Research paper thumbnail of Production of cattle lacking prion protein

Nature Biotechnology, 2006

Prion diseases are caused by propagation of misfolded forms of the normal cellular prion protein ... more Prion diseases are caused by propagation of misfolded forms of the normal cellular prion protein PrP C , such as PrP BSE in bovine spongiform encephalopathy (BSE) in cattle and PrP CJD in Creutzfeldt-Jakob disease (CJD) in humans 1 . Disruption of PrP C expression in mice, a species that does not naturally contract prion diseases, results in no apparent developmental abnormalities 2-5 . However, the impact of ablating PrP C function in natural host species of prion diseases is unknown. Here we report the generation and characterization of PrP C -deficient cattle produced by a sequential gene-targeting system 6 . At over 20 months of age, the cattle are clinically, physiologically, histopathologically, immunologically and reproductively normal. Brain tissue homogenates are resistant to prion propagation in vitro as assessed by protein misfolding cyclic amplification 7 . PrP C -deficient cattle may be a useful model for prion research and could provide industrial bovine products free of prion proteins.

Research paper thumbnail of Regulation of Neurogenesis by Interkinetic Nuclear Migration through an Apical-Basal Notch Gradient

Cell, 2008

The different cell types in the central nervous system develop from a common pool of progenitor c... more The different cell types in the central nervous system develop from a common pool of progenitor cells. The nuclei of progenitors move between the apical and basal surfaces of the neuroepithelium in phase with their cell cycle, a process termed interkinetic nuclear migration (INM). In the retina of zebrafish mikre oko (mok) mutants, in which the motor protein Dynactin-1 is disrupted, interkinetic nuclei migrate more rapidly and deeply to the basal side and more slowly to the apical side. We found that Notch signaling is predominantly activated on the apical side in both mutants and wild-type. Mutant progenitors are, thus, less exposed to Notch and exit the cell cycle prematurely. This leads to an overproduction of early-born retinal ganglion cells (RGCs) at the expense of later-born interneurons and glia. Our data indicate that the function of INM is to balance the exposure of progenitor nuclei to neurogenic versus proliferative signals.

Research paper thumbnail of PROYECTO DE REINSTALACION DE TERAPIAS DE APOYO AL

Proyecto de reinstalacion de terapias de apoyo al adulto mayor el cual esta expuesto a las princi... more Proyecto de reinstalacion de terapias de apoyo al adulto mayor el cual esta expuesto a las principales afecciones neuro degenerativas hablamos de enfermedad de alzhaimer y enfermedad de parkinson. ¿qué similitud existe entre una y la otra? las dos son neuro degenerativas.