Online Mendelian Inheritance in Man (OMIM) (original) (raw)
% 600883
TYPE 1 DIABETES MELLITUS 8; T1D8
Alternative titles; symbols
DIABETES MELLITUS, INSULIN-DEPENDENT, 8; IDDM8
INSULIN-DEPENDENT DIABETES MELLITUS 8
HGNC Approved Gene Symbol: IDDM8
DO: 0110747;
Cytogenetic location: 6q25-q27 Genomic coordinates (GRCh38) : 6:148,500,001-170,805,979
Gene-Phenotype Relationships
| Location | Phenotype | Phenotype MIM number | Inheritance | Phenotype mapping key |
|---|---|---|---|---|
| 6q25-q27 | {Diabetes mellitus, insulin-dependent, 8} | 600883 | 2 |
TEXT
Mapping
Luo et al. (1995) performed affected-sib-pair analyses in 104 Caucasian families to map genes predisposed to type 1 diabetes mellitus. They observed linkage for D6S446 (maximum lod = 2.8) and for D6S264 (maximum lod = 2.0) on 6q25-q27. Together with a previously reported data set, linkage could be firmly established (maximum lod score = 3.4 for D6S264), and the disease locus was designated IDDM8.
REFERENCES
- Luo, D.-F., Bui, M. M., Muir, A., Maclaren, N. K., Thomson, G., She, J.-X.Affected sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27. Am. J. Hum. Genet. 57: 911-919, 1995. [PubMed: 7573053]
Creation Date:
Victor A. McKusick : 10/19/1995
Edit History:
carol : 09/04/2020
joanna : 03/18/2004
terry : 9/24/1997
mark : 8/19/1997
mimadm : 11/3/1995
mark : 10/19/1995