Online Mendelian Inheritance in Man (OMIM) (original) (raw)

  1. Abdelmohsen, K., Pullmann, R., Jr., Lal, A., Kim, H. H., Galban, S., Yang, X., Blethrow, J. D., Walker, M., Shubert, J., Gillespie, D. A., Furneaux, H., Gorospe, M.Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Molec. Cell 25: 543-557, 2007. [PubMed: 17317627] [Full Text: https://doi.org/10.1016/j.molcel.2007.01.011\]
  2. Anderson, R. M., Latorre-Esteves, M., Neves, A. R., Lavu, S., Medvedik, O., Taylor, C., Howitz, K. T., Santos, H., Sinclair, D. A.Yeast life-span extension by calorie restriction is independent of NAD fluctuation. Science 302: 2124-2126, 2003. [PubMed: 14605207] [Full Text: https://doi.org/10.1126/science.1088697\]
  3. Araki, T., Sasaki, Y., Milbrandt, J.Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 305: 1010-1013, 2004. [PubMed: 15310905] [Full Text: https://doi.org/10.1126/science.1098014\]
  4. Biason-Lauber, A., Boni-Schnetzler, M., Hubbard, B. P., Bouzakri, K., Brunner, A., Cavelti-Weder, C., Keller, C., Meyer-Boni, M., Meier, D. T., Brorsson, C., Timper, K., Leibowitz, G., and 25 others.Identification of a SIRT1 mutation in a family with type 1 diabetes. Cell Metab. 17: 448-455, 2013. [PubMed: 23473037] [Full Text: https://doi.org/10.1016/j.cmet.2013.02.001\]
  5. Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., Hu, L. S., Cheng, H.-L., Jedrychowski, M. P., Gygi, S. P., Sinclair, D. A., Alt, F. W., Greenberg, M. E.Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303: 2011-2015, 2004. [PubMed: 14976264] [Full Text: https://doi.org/10.1126/science.1094637\]
  6. Canto, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., Auwerx, J.AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458: 1056-1060, 2009. [PubMed: 19262508] [Full Text: https://doi.org/10.1038/nature07813\]
  7. Chen, D., Steele, A. D., Lindquist, S., Guarente, L.Increase in activity during calorie restriction requires Sirt1. Science 310: 1641 only, 2005. [PubMed: 16339438] [Full Text: https://doi.org/10.1126/science.1118357\]
  8. Chen, D., Steele, A., Lindquist, S., Guarante, L.Response to Pani et al. (Letter) Science 311: 1553-1554, 2006.
  9. Chen, J., Zhou, Y., Mueller-Steiner, S., Chen, L.-F., Kwon, H., Yi, S., Mucke, L., Gan, L.SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J. Biol. Chem. 280: 40364-40374, 2005. [PubMed: 16183991] [Full Text: https://doi.org/10.1074/jbc.M509329200\]
  10. Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Howitz, K. T., Gorospe, M., de Cabo, R., Sinclair, D. A.Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305: 390-392, 2004. [PubMed: 15205477] [Full Text: https://doi.org/10.1126/science.1099196\]
  11. Dang, W., Steffen, K. K., Perry, R., Dorsey, J. A., Johnson, F. B., Shilatifard, A., Kaeberlein, M., Kennedy, B. K., Berger, S. L.Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature 459: 802-807, 2009. [PubMed: 19516333] [Full Text: https://doi.org/10.1038/nature08085\]
  12. Das, C., Lucia, M. S., Hansen, K. C., Tyler, J. K.CBP/p300-mediated acetylation of histone H3 on lysine56. Nature 459: 113-117, 2009. Note: Erratum: Nature 460: 1164 only, 2009. [PubMed: 19270680] [Full Text: https://doi.org/10.1038/nature07861\]
  13. Donmez, G., Wang, D., Cohen, D. E., Guarente, L.SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 142: 320-332, 2010. Note: Erratum: Cell 142: 494-495, 2010; Retraction: Cell 158: 959 only, 2014. [PubMed: 20655472] [Full Text: https://doi.org/10.1016/j.cell.2010.06.020\]
  14. Frye, R. A.Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem. Biophys. Res. Commun. 260: 273-279, 1999. [PubMed: 10381378] [Full Text: https://doi.org/10.1006/bbrc.1999.0897\]
  15. Gao, J., Wang, W.-Y., Mao, Y.-W., Graff, J., Guan, J.-S., Pan, L., Mak, G., Kim, D., Su, S. C., Tsai, L.-H.A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature 466: 1105-1109, 2010. [PubMed: 20622856] [Full Text: https://doi.org/10.1038/nature09271\]
  16. Guarani, V., Deflorian, G., Franco, C. A., Kruger, M., Phng, L.-K., Bentley, K., Toussaint, L., Dequiedt, F., Mostoslavsky, R., Schmidt, M. H. H., Zimmermann, B., Brandes, R. P., Mione, M., Westphal, C. H., Braun, T., Zeiher, A. M., Gerhardt, H., Dimmeler, S., Potente, M.Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase. Nature 473: 234-238, 2011. [PubMed: 21499261] [Full Text: https://doi.org/10.1038/nature09917\]
  17. Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., Scherer, B., Sinclair, D. A.Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425: 191-196, 2003. [PubMed: 12939617] [Full Text: https://doi.org/10.1038/nature01960\]
  18. Hubbard, B. P., Gomes, A. P., Dai, H., Li, J., Case, A. W., Considine, T., Riera, T. V., Lee, J. E., S. Y. E, Lamming, D. W., Pentelute, B. L., Schuman, E. R., and 18 others.Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science 339: 1216-1219, 2013. [PubMed: 23471411] [Full Text: https://doi.org/10.1126/science.1231097\]
  19. Imai, S., Armstrong, C. M., Kaeberlein, M., Guarente, L.Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403: 795-800, 2000. [PubMed: 10693811] [Full Text: https://doi.org/10.1038/35001622\]
  20. Jeong, H., Cohen, D. E., Cui, L., Supinski, A., Savas, J. N., Mazzulli, J. R., Yates, J. R., III, Bordone, L., Guarente, L., Krainc, D.Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nature Med. 18: 159-165, 2012. [PubMed: 22179316] [Full Text: https://doi.org/10.1038/nm.2559\]
  21. Jiang, M., Wang, J., Fu, J., Du, L., Jeong, H., West, T., Xiang, L., Peng, Q., Hou, Z., Cai, H., Seredenina, T., Arbez, N., and 18 others.Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nature Med. 18: 153-158, 2012. [PubMed: 22179319] [Full Text: https://doi.org/10.1038/nm.2558\]
  22. Kaeberlein, M., Steffen, K. K., Hu, D., Dang, N., Kerr, E. O., Tsuchiya, M., Fields, S., Kennedy, B. K.Comment on 'HST2 mediates SIR2-independent life-span extension by calorie restriction.' (Abstract) Science 312: 1312 only, 2006.
  23. Kim, E.-J., Kho, J.-H., Kang, M.-R., Um, S.-J.Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. Molec. Cell 28: 277-290, 2007. Note: Erratum: Molec. Cell 28: 513 only, 2007. [PubMed: 17964266] [Full Text: https://doi.org/10.1016/j.molcel.2007.08.030\]
  24. Kim, J.-E., Chen, J., Lou, Z.DBC1 is a negative regulator of SIRT1. Nature 451: 583-586, 2008. [PubMed: 18235501] [Full Text: https://doi.org/10.1038/nature06500\]
  25. Kimura, A., Umehara, T., Horikoshi, M.Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencing. Nature Genet. 32: 370-377, 2002. [PubMed: 12410229] [Full Text: https://doi.org/10.1038/ng993\]
  26. Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., Geny, B., Laakso, M., Puigserver, P., Auwerx, J.Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1-alpha. Cell 127: 1109-1122, 2006. [PubMed: 17112576] [Full Text: https://doi.org/10.1016/j.cell.2006.11.013\]
  27. Lamming, D. W., Latorre-Esteves, M., Medvedik, O., Wong, S. N., Tsang, F. A., Wang, C., Lin, S.-J., Sinclair, D. A.HST2 mediates SIR2-independent life-span extension by calorie restriction. Science 309: 1861-1864, 2005. [PubMed: 16051752] [Full Text: https://doi.org/10.1126/science.1113611\]
  28. Lamming, D. W., Latorre-Esteves, M., Medvedik, O., Wong, S. N., Tsang, F. A., Wang, C., Lin, S.-J., Sinclair, D. A.Response to comment on 'HST2 mediates SIR2-independent life-span extension by calorie restriction.' Science 312: 1312 only, 2006.
  29. Langley, E., Pearson, M., Faretta, M., Bauer, U.-M., Frye, R. A., Minucci, S., Pelicci, P. G., Kouzarides, T.Human SIR2 deacetylases p53 and antagonizes PML/p53-induced cellular senescence. EMBO J. 21: 2383-2396, 2002. [PubMed: 12006491] [Full Text: https://doi.org/10.1093/emboj/21.10.2383\]
  30. Lee, H. R., Shin, H. K., Park, S. Y., Kim, H. Y., Lee, W. S., Rhim, B. Y., Hong, K. W., Kim, C. D.Cilostazol suppresses beta-amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1-coupled retinoic acid receptor-beta. J. Neurosci. Res. 92: 1581-1590, 2014. [PubMed: 24903973] [Full Text: https://doi.org/10.1002/jnr.23421\]
  31. Libert, S., Pointer, K., Bell, E. L., Das, A., Cohen, D. E., Asara, J. M., Kapur, K., Bergmann, S., Preisig, M., Otowa, T., Kendler, K. S., Chen, X., Hettema, J. M., van den Oord, E. J., Rubio, J. P., Guarente, L.SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive. Cell 147: 1459-1472, 2011. [PubMed: 22169038] [Full Text: https://doi.org/10.1016/j.cell.2011.10.054\]
  32. Liu, Y., Dentin, R., Chen, D., Hedrick, S., Ravnskjaer, K., Schenk, S., Milne, J., Meyers, D. J., Cole, P., Yates, J., III, Olefsky, J., Guarente, L., Montminy, M.A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 456: 269-273, 2008. [PubMed: 18849969] [Full Text: https://doi.org/10.1038/nature07349\]
  33. Luo, J., Nikolaev, A. Y., Imai, S., Chen, D., Su, F., Shiloh, A., Guarente, L., Gu, W.Negative control of p53 by Sir2-alpha promotes cell survival under stress. Cell 107: 137-148, 2001. [PubMed: 11672522] [Full Text: https://doi.org/10.1016/s0092-8674(01)00524-4\]
  34. Mattagajasingh, I., Kim, C.-S., Naqvi, A., Yamamori, T., Hoffman, T. A., Jung, S.-B., DeRicco, J., Kasuno, K., Irani, K.SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc. Nat. Acad. Sci. 104: 14855-14860, 2007. [PubMed: 17785417] [Full Text: https://doi.org/10.1073/pnas.0704329104\]
  35. McBurney, M. W., Yang, X., Jardine, K., Hixon, M., Boekelheide, K., Webb, J. R., Lansdorp, P. M., Lemieux, M.The mammalian SIR2-alpha protein has a role in embryogenesis and gametogenesis. Molec. Cell. Biol. 23: 38-54, 2003. [PubMed: 12482959] [Full Text: https://doi.org/10.1128/MCB.23.1.38-54.2003\]
  36. Menghini, R., Casagrande, V., Cardellini, M., Martelli, E., Terrinoni, A., Amati, F., Vasa-Nicotera, M., Ippoliti, A., Novelli, G., Melino, G., Lauro, R., Federici, M.MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation 120: 1524-1532, 2009. [PubMed: 19786632] [Full Text: https://doi.org/10.1161/CIRCULATIONAHA.109.864629\]
  37. Milne, J. C., Lambert, P. D., Schenk, S., Carney, D. P., Smith, J. J., Gagne, D. J., Jin, L., Boss, O., Perni, R. B., Vu, C. B., Bemis, J. E., Xie, R., and 16 others.Small molecular activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450: 712-716, 2007. [PubMed: 18046409] [Full Text: https://doi.org/10.1038/nature06261\]
  38. Motta, M. C., Divecha, N., Lemieux, M., Kamel, C., Chen, D., Gu, W., Bultsma, Y., McBurney, M., Guarente, L.Mammalian SIRT1 represses forkhead transcription factors. Cell 116: 551-563, 2004. [PubMed: 14980222] [Full Text: https://doi.org/10.1016/s0092-8674(04)00126-6\]
  39. Murayama, A., Ohmori, K., Fujimura, A., Minami, H., Yasuzawa-Tanaka, K., Kuroda, T., Oie, S., Daitoku, H., Okuwaki, M., Nagata, K., Fukamizu, A., Kimura, K., Shimizu, T., Yanagisawa, J.Epigenetic control of rDNA loci in response to intracellular energy status. Cell 133: 627-639, 2008. [PubMed: 18485871] [Full Text: https://doi.org/10.1016/j.cell.2008.03.030\]
  40. Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M., Sassone-Corsi, P.Circadian control of the NAD+ salvage pathway by CLOCK:SIRT1. Science 324: 654-657, 2009. [PubMed: 19286518] [Full Text: https://doi.org/10.1126/science.1170803\]
  41. Naqvi, A., Hoffman, T. A., DeRicco, J., Kumar, A., Kim, C.-S., Jung, S.-B., Yamamori, T., Kim, Y.-R., Mehdi, F., Kumar, S., Rankinen, T., Ravussin, E., Irani, K.A single-nucleotide variation in a p53-binding site affects nutrient-sensitive human SIRT1 expression. Hum. Molec. Genet. 19: 4123-4133, 2010. [PubMed: 20693263] [Full Text: https://doi.org/10.1093/hmg/ddq331\]
  42. Nemoto, S., Fergusson, M. M., Finkel, T.Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science 306: 2105-2108, 2004. [PubMed: 15604409] [Full Text: https://doi.org/10.1126/science.1101731\]
  43. Ou, X., Chae, H.-D., Wang, R.-H., Shelley, W. C., Cooper, S., Taylor, T., Kim, Y.-J., Deng, C.-X., Yoder, M. C., Broxmeyer, H. E.SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse. Blood 117: 440-450, 2011. [PubMed: 20966168] [Full Text: https://doi.org/10.1182/blood-2010-03-273011\]
  44. Pani, G., Fusco, S., Galeotti, T.Smaller, hungrier mice. (Letter) Science 311: 1553 only, 2006. [PubMed: 16543441] [Full Text: https://doi.org/10.1126/science.311.5767.1553\]
  45. Picard, F., Kurtev, M., Chung, N,, Topark-Ngarm, A., Senawong, T., Machado de Oliveira, R., Leid, M., McBurney, M. W., Guarente, L.Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429: 771-775, 2004. Note: Erratum: Nature 430: 921 only, 2004. [PubMed: 15175761] [Full Text: https://doi.org/10.1038/nature02583\]
  46. Potente, M., Ghaeni, L., Baldessari, D., Mostoslavsky, R., Rossig, L., Dequiedt, F., Haendeler, J., Mione, M., Dejana, E., Alt, F. W., Zeiher, A. M., Dimmeler, S.SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev. 21: 2644-2658, 2007. [PubMed: 17938244] [Full Text: https://doi.org/10.1101/gad.435107\]
  47. Qiang, L., Wang, H., Farmer, S. R.Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L-alpha. Molec. Cell. Biol. 27: 4698-4707, 2007. [PubMed: 17452443] [Full Text: https://doi.org/10.1128/MCB.02279-06\]
  48. Qin, W., Yang, T., Ho, L., Zhao, Z., Wang, J., Chen, L., Zhao, W., Thiyagarajan, M., MacGrogan, D., Rodgers, J. T., Puigserver, P., Sadoshima, J., Deng, H., Pedrini, S., Gandy, S., Sauve, A. A., Pasinetti, G. M.Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J. Biol. Chem. 281: 21745-21754, 2006. [PubMed: 16751189] [Full Text: https://doi.org/10.1074/jbc.M602909200\]
  49. Ramsey, K. M., Yoshino, J., Brace, C. S., Abrassart, D., Kobayashi, Y., Marcheva, B., Hong, H.-K., Chong, J. L., Buhr, E. D., Lee, C., Takahashi, J. S., Imai, S., Bass, J.Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science 324: 651-655, 2009. [PubMed: 19299583] [Full Text: https://doi.org/10.1126/science.1171641\]
  50. Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., Puigserver, P.Nutrient control of glucose homeostasis through a complex of PGC-1-alpha and SIRT1. Nature 434: 113-118, 2005. [PubMed: 15744310] [Full Text: https://doi.org/10.1038/nature03354\]
  51. Shore, D., Squire, M., Nasmyth, K. A.Characterization of two genes required for the position-effect control of yeast mating-type genes. EMBO J. 3: 2817-2823, 1984. [PubMed: 6098447] [Full Text: https://doi.org/10.1002/j.1460-2075.1984.tb02214.x\]
  52. Singh, S. K., Williams, C. A., Klarmann, K., Burkett, S. S., Keller, J. R., Oberdoerffer, P.Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance. J. Exp. Med. 210: 987-1001, 2013. [PubMed: 23630229] [Full Text: https://doi.org/10.1084/jem.20121608\]
  53. Suka, N., Luo, K., Grunstein, M.Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine16 and spreading of heterochromatin. Nature Genet. 32: 378-383, 2002. [PubMed: 12379856] [Full Text: https://doi.org/10.1038/ng1017\]
  54. Tanny, J. C., Dowd, G. J., Huang, J., Hilz, H., Moazed, D.An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing. Cell 99: 735-745, 1999. [PubMed: 10619427] [Full Text: https://doi.org/10.1016/s0092-8674(00)81671-2\]
  55. Theendakara, V., Patent, A., Peters Libeu, C. A., Philpot, B., Flores, S., Descamps, O., Poksay, K. S., Zhang, Q., Cailing, G., Hart, M., John, V., Rao, R. V., Bredesen, D. E.Neuroprotective sirtuin ratio reversed by ApoE4. Proc. Nat. Acad. Sci. 110: 18303-18308, 2013. [PubMed: 24145446] [Full Text: https://doi.org/10.1073/pnas.1314145110\]
  56. Vaquero, A., Scher, M., Erdjument-Bromage, H., Tempst, P., Serrano, L., Reinberg, D.SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature 450: 440-444, 2007. [PubMed: 18004385] [Full Text: https://doi.org/10.1038/nature06268\]
  57. Vaquero, A., Scher, M., Lee, D., Erdjument-Bromage, H., Tempst, P., Reinberg, D.Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Molec. Cell 16: 93-105, 2004. [PubMed: 15469825] [Full Text: https://doi.org/10.1016/j.molcel.2004.08.031\]
  58. Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S.-I., Frye, R. A., Pandita, T. K., Guarente, L., Weinberg, R. A.hSIR2-SIRT1 functions as an NAD-dependent p53 deacetylase. Cell 107: 149-159, 2001. [PubMed: 11672523] [Full Text: https://doi.org/10.1016/s0092-8674(01)00527-x\]
  59. Wang, R.-H., Zheng, Y., Kim, H.-S., Xu, X., Cao, L., Luhasen, T., Lee, M.-H., Xiao, C., Vassilopoulos, A., Chen, W., Gardner, K., Man, Y.-G., Hung, M.-C., Finkel, T., Deng, C.-X.Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Molec. Cell 32: 11-20, 2008. [PubMed: 18851829] [Full Text: https://doi.org/10.1016/j.molcel.2008.09.011\]
  60. Westerheide, S. D., Anckar, J., Stevens, S. M., Jr., Sistonen, L., Morimoto, R. I.Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science 323: 1063-1066, 2009. Note: Erratum: Science 342: 931 only, 2013. [PubMed: 19229036] [Full Text: https://doi.org/10.1126/science.1165946\]
  61. Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., Sinclair, D.Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430: 686-689, 2004. Note: Erratum: Nature 431: 107 only, 2004. [PubMed: 15254550] [Full Text: https://doi.org/10.1038/nature02789\]
  62. Yamakuchi, M., Ferlito, M., Lowenstein, C. J.miR-34a repression of SIRT1 regulates apoptosis. Proc. Nat. Acad. Sci. 105: 13421-13426, 2008. [PubMed: 18755897] [Full Text: https://doi.org/10.1073/pnas.0801613105\]
  63. Yang, Y., Fu, W., Chen, J., Olashaw, N., Zhang, X., Nicosia, S. V., Bhalla, K., Bai, W.SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nature Cell Biol. 9: 1253-1262, 2007. Note: Erratum: Nature Cell Biol. 9: 1442 only, 2007. [PubMed: 17934453] [Full Text: https://doi.org/10.1038/ncb1645\]
  64. Yin, H., Hu, M., Zhang, R., Shen, Z., Flatow, L., You, M.MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1. J. Biol. Chem. 287: 9817-9826, 2012. [PubMed: 22308024] [Full Text: https://doi.org/10.1074/jbc.M111.333534\]
  65. Yuan, Z., Zhang, X., Sengupta, N., Lane, W. S., Seto, E.SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Molec. Cell 27: 149-162, 2007. [PubMed: 17612497] [Full Text: https://doi.org/10.1016/j.molcel.2007.05.029\]
  66. Zhao, W., Kruse, J.-P., Tang, Y., Jung, S. Y., Qin, J., Gu, W.Negative regulation of the deacetylase SIRT1 by DBC1. Nature 451: 587-590, 2008. [PubMed: 18235502] [Full Text: https://doi.org/10.1038/nature06515\]