A theoretically based index of consciousness independent of sensory processing and behavior (original) (raw)

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A theoretically based index of consciousness independent of sensory processing and behavior

; Gosseries, Olivia; Rosanova, Mario et al.

2013 • In Science Translational Medicine, 5

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Keywords :

adult; anesthesia; brain cortex; brain function; brain injury; Anesthetics; consciousness; coma

Abstract :

[en] One challenging aspect of the clinical assessment of brain-injured, unresponsive patients is the lack of an objective measure of consciousness that is independent of the subject's ability to interact with the external environment. Theoretical considerations suggest that consciousness depends on the brain's ability to support complex activity patterns that are, at once, distributed among interacting cortical areas (integrated) and differentiated in space and time (information-rich). We introduce and test a theory-driven index of the level of consciousness called the perturbational complexity index (PCI). PCI is calculated by (i) perturbing the cortex with transcranial magnetic stimulation (TMS) to engage distributed interactions in the brain (integration) and (ii) compressing the spatiotemporal pattern of these electrocortical responses to measure their algorithmic complexity (information). We test PCI on a large data set of TMS-evoked potentials recorded in healthy subjects during wakefulness, dreaming, nonrapid eye movement sleep, and different levels of sedation induced by anesthetic agents (midazolam, xenon, and propofol), as well as in patients who had emerged from coma (vegetative state, minimally conscious state, and locked-in syndrome). PCI reliably discriminated the level of consciousness in single individuals during wakefulness, sleep, and anesthesia, as well as in patients who had emerged from coma and recovered a minimal level of consciousness. PCI can potentially be used for objective determination of the level of consciousness at the bedside

Research Center/Unit :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Author, co-author :

Casali, AG ✱

Gosseries, Olivia ✱; Université de Liège - ULiège > Centre de recherches du cyclotron

Rosanova, Mario

Sarasso, Simone

Casali, KR

Casarotto, Silvia

Bruno, Marie-Aurélie ; Université de Liège - ULiège > Centre de recherches du cyclotron

Laureys, Steven ; Université de Liège - ULiège > Centre de recherches du cyclotron

Tononi, Giulio

Massimini, Marcello

✱ These authors have contributed equally to this work.

Title :

A theoretically based index of consciousness independent of sensory processing and behavior

Publication date :

14 August 2013

Journal title :

Science Translational Medicine

Publisher :

American Association for the Advancement of Science, United States

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 24 August 2014

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Scopus citations®
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