Tellervo Tervonen | University of Oulu (original) (raw)

Papers by Tellervo Tervonen

Journal of Clinical Periodontology, 1991

The short-term response (3-4 months) to non-surgical periodontal treatment, i.e., oral hygiene in... more The short-term response (3-4 months) to non-surgical periodontal treatment, i.e., oral hygiene instruction, scaling and root planing, was determined in 34 diabetic and 45 control subjects. Measurements of probing pocket depth and gingival bleeding (%) were used for evaluation. No significant difference could be observed in the response to non-surgical periodontal treatment between the diabetics and controls.

Journal of Oral Rehabilitation, Sep 1, 1988

Prosthetic treatment needs were studied in a sample of 1600 adults distributed equally into cohor... more Prosthetic treatment needs were studied in a sample of 1600 adults distributed equally into cohorts aged 25,35,50 and 65 years. A total of 1275 subjects (80%) were clinically examined with respect to the condition and age of existing prosthetic constructions, subjective needs for replacing missing teeth and the frequency of oral mujcosal lesions associated with the wearing of dentures. Approximately half of the removable dentures (56%) were objectively non-acceptable and one-third (36%) subjectively so. One in four of those subjects with missing anterior teeth and premolars, or with 0-2 remaining mandibular molars and one in five of those with 0-2 remaining maxillary molars expressed a need to have one or more of the missing teeth replaced. The replacement needs were slightly greater for missing anterior teeth and premolars than for molars. Subjective needs for replacing missing teeth were greatest at the age of 50 years. The condition of removable dentures according to objective assessment was poorest among those aged 65 years. A high frequency of mucosal lesions associated with old and non-acceptable removable dentures was observed.

Journal of Clinical Periodontology, Jul 1, 1997

Variation in the periodontal health status and the response to oral hygiene education, scaling an... more Variation in the periodontal health status and the response to oral hygiene education, scaling and root planing were studied in 36 subjects with type-1 diabetes meilitus (DM) and in 10 non-diabetic control subjects. The age range of the subjects was 24-36 years. The diabetic group was divided into 3 subgroups based on the levels of glycosylated hemoglobin (HbAlc) over a 3 year period and the presence of diabetic complications as follows: (DI) subjects with good metabolic control and no complications (n=13). (D2) subjects with varying metabolic control with/without retinopathy («= 15) and (D3) subjects with severe diabetes, i.e.. with poor long-term control and/or multiple complications («= 8). Clinical measurements (plaque, subgingival calculus, probing pocket depth, bleeding after probing and clinicai attachment level) were performed at the baseline and 4 weeks and 6 and 12 months after periodontal therapy. The betweengroup comparisons were made using the Student (-test and ANOVA. Based on the plaque scores, the oral hygiene status was similar in all groups during the whole study. No statistically-significant differences in the periodontai health status could be found between the diabetic group as a whole and the non-diabetic controls at any examination. The level of periodontal health of the diabetics with good control and no complications (DI) and those with moderate control with, without retinopathy (D2) was on the same level with that seen in the non-diabetic controls. Our findings of the significantly higher extent of al 5>2 mm at the baseline and the fast recurrence of pd s=4 mm during the longitudinal study in diabetic subjects with poor metabolic control and/or multiple complications (D3) indicate increased periodontal breakdown as a complication of DM in these subjects. To be able to assess the periodontai prognosis and the need for periodontal therapy on an individual basis.the clinical practitioner should be well aware of the diabetic status of his,'her patients.

Journal of Periodontology, May 1, 1993

Diabetics are generally considered at higher risk for periodontitis than non‐diabetics. Among dia... more Diabetics are generally considered at higher risk for periodontitis than non‐diabetics. Among diabetics, those with poorer metabolic control have often been found to have more periodontitis. This study investigated the relationship between two crevicular fluid en2ymes, β‐glucuronidase (βG) and lactic dehydrogenase (LDH), and metabolic control in 93 adults with type 1 or 2 diabetes. Metabolic control was evaluated by glycosylated hemoglobin (HbA1c) levels. The most visibly inflamed site was sampled for crevicular fluid enzymes and plaque for microbial assessment. Plaque, calculus, and probing depth were also recorded, β‐glucuronidase was found at significantly higher levels in patients with poorer diabetic control while LDH levels were not related to control. Using multiple regression analysis, good metabolic control was the only predicting variable for β‐glucuronidase when considered with microbes, probing depth, plaque, calculus, age, duration, and type of diabetes. If β‐glucuronidase is a predictor of periodontal disease activity, diabetics with poor metabolic control are at higher risk for periodontitis. J Periodontol 1993; 64:358–362.

Journal of Periodontology, May 1, 1994

Journal of the American Dental Association, Dec 1, 1993

Journal of Clinical Periodontology, Jul 1, 1993

The purpose of this study was to evaluate the association between long‐term control of diabetes m... more The purpose of this study was to evaluate the association between long‐term control of diabetes mellitus (DM) and periodontitis, A total of 75 diabetics (Type I or II) aged 20–70 years with long‐term records of their diabetic control were selected for the study. The following periodontal variables were recorded in a randomized half‐mouth examination: plaque, calculus (+/−), probing depth (pd) and attachment loss (al). The mean of glycosylated hemoglobin measurements (IIbAlc) over the past 2–5 years was used to indicate the long‐term control of DM. The study participants were divided into well‐, moderately‐ and poorly‐controlled diabetics. An increase in the prevalence, severity and extent of periodontitis with poorer control of diabetes was observed. The extent of calculus also increased with poorer control. In a multiple regression analysis, calculus and long‐term control of diabetes were significant variables when pd≥4 mm was used as the dependent variable. Age was a significant predictor for al > 3 mm but not for pd ≥4 mm. Sex, duration and type of DM were not significant variables in the regression models. Less than 2% of sites with no calculus demonstrated pd≥4mm. When calculus was present, the frequency of pd ≥4 mm increased from 6% in the well‐controlled diabetics to 16% in the poorly‐controlled ones. We conclude that periodontitis in diabetics is associated with long‐term metabolic control and presence of calculus. Therefore, regular maintenance care, including patient motivation and instruction as well as professional calculus removal, is important for diabetic patients.

PubMed, Sep 1, 1987

In earlier years, studies on the epidemiology of periodontal disease were often reported in the f... more In earlier years, studies on the epidemiology of periodontal disease were often reported in the form of mean scores for the population studied. Use of the WHO recommended Community Periodontal Index of Treatment Needs (CPITN) has given important additional information, particularly about the distribution of indicators of current periodontal disease within various age groups of the population. In the analysis of survey data, the use of CPITN cross-tabulations has been found particularly promising for the assessment of both preventive and therapeutic needs. For example, in Finnish schoolchildren the proportion of subjects with two or more sextants scoring Code 2 for calculus increased from 0 per cent at age 7 to 5 per cent at age 12 and 9 per cent at age 17 years. In the same population, 0 per cent at 7, 1 per cent at 12, and 4 per cent at 17 years of age had one or more pockets measuring more than 3 mm. In another population, comprising dentate adults from rural Finland, the prevalence of Code 4 for 6 mm or deeper pockets increased from 1 per cent at age 25 to 6 per cent at age 35, 18 per cent at age 50, and 27 per cent at 65 years of age. An important additional observation was that a total of 58 per cent of those who had one or more Code 4's, had their advanced periodontal disease confined to only one sextant. The latter finding may prove useful when deciding between partial and full mouth examinations in future epidemiological studies.

Community Dentistry and Oral Epidemiology, Jun 1, 1986

Periodontal treatment needs of 895 dentate subjects aged 25, 35, 50 and 65 yr were studied accord... more Periodontal treatment needs of 895 dentate subjects aged 25, 35, 50 and 65 yr were studied according to the Community Periodontal Index of Treatment Needs (CPITN). The relative influence of calculus and overhanging margins of restorations on the need for professional debridement of shallow (≤3 mm) pockets was calculated. The mean number of sextants per person scoring CPITN Code 2 decreased from 2.6 in the 25‐yr group to 1.1 in the 65‐yr group. Overhangs of fillings alone were detected in 0.8 sextants of the 25‐yr‐olds and in 0.1 sextants of the 65‐yr‐olds. The mean number of sextants containing calculus with or without overhangs decreased from 1.8 in the 25‐yr group to 1.0 in the 65‐yr group. The relative influence of calculus was higher in the aged than in the young population. The recording of overhangs is important for accurate assessment of periodontal treatment needs in populations with a high caries experience.

Special Care in Dentistry, May 1, 2001

ABSTRACTThe numbers of dentate elderly are growing rapidly in all industrialized countries, and e... more ABSTRACTThe numbers of dentate elderly are growing rapidly in all industrialized countries, and epidemiological information about their oral health is urgently needed. Our study is part of the population‐based Helsinki Ageing Study (HAS), and this paper describes the periodontal health status as well as the need for periodontal treatment among the dentate elderly born in 1904, 1909, and 1914 and living in January, 1989, in Helsinki, Finland (n = 175). The dental examinations were carried out during 1990 and 1991 at the Institute of Dentistry, University of Helsinki, Finland. The subjects' periodontal health was recorded by the CPITN (Community Periodontal Index of Treatment Needs) method. The mean number of remaining teeth was 15.1 among men and 14.0 among women, with the mean number of remaining sextants 3.7 and 3.5, respectively. Healthy periodontal tissues (CPI = 0) were found in 7% of the subjects. Bleeding on probing (CPI = 1) was recorded in 6%, and calculus and/or overhanging margins of restorations (CPI = 2) in 41% of the subjects, as the worst finding. Altogether, 46% of the subjects had deep periodontal pockets, 35% with at least one 4‐ to 5‐mm pocket (CPI = 3), and 11% with at least one ≥ 6‐mm pocket (CPI = 4). Overall, 93% of the subjects required oral hygiene instruction, 87% scaling and root planing, and 11% complex periodontal treatment. The periodontal treatment need was significantly higher in men than in women; however, no significant differences were observed among the three age cohorts. The need for complex periodontal treatment was unexpectedly low, probably explained by the fact that there were many missing teeth, especially molars, perhaps lost due to poor periodontal health.

Journal of Clinical Periodontology, Oct 9, 2011

High-density lipoprotein (HDL) cholesterol is known for its anti-inflammatory and antioxidant act... more High-density lipoprotein (HDL) cholesterol is known for its anti-inflammatory and antioxidant activities in protection against cardiovascular diseases. We investigated whether a protective association also exists between serum HDL and periodontal inflammation in type 1 diabetic subjects (T1DM). Plaque and periodontal inflammation (bleeding and PD ≥ 4 mm) were examined in 80 subjects with T1DM. The serum levels of glycosylated haemoglobin (HbA1c, %) and HDL (mmol/l) were determined. Adjusted associations between inflammation and serum HDL were analysed using linear regression analysis. To study the linearity of the association, the subjects were categorized into HDL tertiles (I-III). A statistically significant negative association was observed between serum HDL level and the extent of bleeding and PD ≥ 4 mm. Subjects in HDL tertiles II and III (high HDL) presented significantly fewer inflamed sites when compared with the subjects in tertile I (low HDL), whereas no significant difference in the number of inflamed sites was observed between tertiles II and III. Based on the finding of a negative association between serum HDL and periodontal inflammation, HDL may be considered a marker of susceptibility to periodontal inflammation. A longitudinal study is needed to verify possible causal relationship between serum HDL and inflammation.

Research Square (Research Square), Mar 30, 2021

Background: A genome-wide association study is an analytical approach that investigates whether g... more Background: A genome-wide association study is an analytical approach that investigates whether genetic variants across the whole genome contribute to disease progression. The aim of this study was to investigate genome-wide associations of periodontal condition measured as deepened periodontal pockets (≥ 4 mm) in Finnish adults. Methods: This study was based on the data of the national Health 2000 Survey (BRIF8901) in Finland and the Northern Finland Birth Cohort 1966 Study totalling 3,245 individuals. The genotype data were analyzed using the SNPTEST v.2.4.1. The number of teeth with deepened periodontal pockets (≥ 4 mm deep) was employed as a continuous response variable in additive regression analyses performed separately for the two studies and the results were combined in a meta-analysis applying a fixed effects model. Results: Genome-wide significant associations with the number of teeth with ≥ 4 mm deep pockets were not found at the p-level of < 5 × 10 −8 , while in total 17 loci reached the p-level of 5 × 10 −6. Of the top hits, SNP rs4444613 in chromosome 20 showed the strongest association (p = 1.35 × 10 −7). Conclusion: No statistically significant genome-wide associations with deepened periodontal pockets were found in this study.

PubMed, May 15, 2018

Orofacial granulomatosis (OFG) is a chronic inflammatory disorder characterized by lip swelling a... more Orofacial granulomatosis (OFG) is a chronic inflammatory disorder characterized by lip swelling and gingival alterations. OFG occurs either as a separate clinical entity or associated with a systemic disorder such as Crohn's disease (CD). The purpose of this paper is to report the case of a 13-year old boy who presented with marked granulomatous gingival inflammation and stomach discomfort. Periodontal therapy resulted in only slight reduction in gingival inflammation and enlargement. The diagnosis of OFG, which was evidently associated with inflammation in the bowel, was based on the gingival status and biopsy, self-reported symptoms, and laboratory markers of iron metabolism and fecal calprotectin level. The gingival and bowel inflammation was controlled with, strict adherence to a cinnamon- and benzoate-free diet combined with periodontal prophylaxis. At this point at the age of 17 years, the patient has avoided the use of immune modulatory treatments.

Journal of Clinical Periodontology

AimTo investigate whether long‐term obesity, long‐term central obesity and weight gain are associ... more AimTo investigate whether long‐term obesity, long‐term central obesity and weight gain are associated with alveolar bone loss.Materials and MethodsA sub‐population (n = 1318) of the Northern Finland Birth Cohort 1966 was categorized based on body mass index (BMI: normal weight, overweight and obesity) and waist circumference (WC: no central obesity, central obesity) at ages 31 and 46. These categories were combined to define whether the participants stayed in the same categories or passed on to a higher category (weight gain). Alveolar bone level (BL) data were collected at age 46.ResultsThe associations of long‐term obesity and weight gain with BL ≥ 5 mm were stronger in smokers than in the total population and in never smokers. Males who passed on to higher BMI and WC categories showed a higher likelihood for BL ≥ 5 mm (range in relative risks [RRs] 1.3–2.2) than males who stayed in the same categories (range in RRs 0.7–1.1). The associations with BL ≥ 5 mm were weak or non‐existe...

Den norske tannlegeforenings Tidende

Caries Research, 1988

Past caries experience as expressed by means of the DIMFT index was studied in 1982–1983 in an ad... more Past caries experience as expressed by means of the DIMFT index was studied in 1982–1983 in an adult, high-caries Finnish population. The random sample for the survey comprised 1,600 adults, 400 in each age group of 25, 35, 50 and 65 years. A total of 1,275 subjects (80&amp;percnt;) were clinically examined, and of these 941 had one or more remaining

Journal of Oral and Maxillofacial Research, Sep 9, 2016

Objectives: To study the efficacy of supportive peri-implant therapies in preventing clinical and... more Objectives: To study the efficacy of supportive peri-implant therapies in preventing clinical and radiological signs of periimplantitis and implant loss. Material and Methods: Longitudinal human studies, published between January 1, 2006, and February 1, 2016, were included based on an electronic search using MEDLINE and EMBASE databases and complemented by a manual search. Articles were included only if 1) they comprised a group of patients involved in/adhering to regular supportive peri-implant therapies (SPTs) and a control group without such therapies or with poor adherence to them, 2) the protocol of the SPTs was clearly described and 3) the outcome was indicated by means of clinical/radiological changes or implant loss. Results: After initially identifying a total of 710 titles and abstracts, 12 full text articles were selected for eligibility assessment. Seven studies, three prospective and four retrospective, fulfilled the inclusion criteria for this review. The frequency of recall visits varied between the studies from a minimum of one visit every three months to an individually tailored regimen. In all the studies a lack of SPTs or poor adherence to them resulted in significantly higher frequencies of sites with mucosal bleeding, deepened peri-implant pockets or alveolar bone loss. In line with the above, a lack of/poor adherence to SPTs was associated with higher implant loss. Conclusions: To prevent peri-implantitis, an individually tailored supportive programme based on patient motivation and reinstruction in oral hygiene measures combined with professional implant cleaning seem to be crucial.