Biljana Stangeland | Oslo University Hospital Rikshospitalet (original) (raw)

Biljana Stangeland

Address: Oslo, Oslo, Norway

less

Uploads

Papers by Biljana Stangeland

Research paper thumbnail of How to evaluate the success of the COVID-19 measures implemented by the Norwegian government by analyzing changes in doubling time

medRxiv (Cold Spring Harbor Laboratory), Mar 30, 2020

Research paper thumbnail of Supplementary Table 2 behnan et al., 2016 Oncogene

Research paper thumbnail of Additional file 11: Figure S10. of Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells

NAT12/NAA30 knockdown resulted in reduction of CD133+ cells as shown by flow cytometry.

Research paper thumbnail of Additional file 7:Â Supplementary File 3. of Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells

Functional annotation based on the microarray analysis of NAT12/NAA30 knockdown cultures. (XLSX 2... more Functional annotation based on the microarray analysis of NAT12/NAA30 knockdown cultures. (XLSX 201 kb)

Research paper thumbnail of Additional file 4: Supplemetary File 2. of Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells

Additional qPCR statistics for Fig. 1, Fig. 3 and Fig. 5. (PDF 254 kb)

Research paper thumbnail of Additional file 2: Figure S2. of Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells

K-means clustering of the expression data for the selected NAT genes.

Research paper thumbnail of Additional file 3: Supplementary File 1. of Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells

Oligonucleotides and microarray probes. (PDF 115 kb)

Research paper thumbnail of Additional file 8: Figure S5-S7. of Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells

Figure S5. NAT12/NAA30 knockdown resulted in dysregulation of ribosome assembly as shown by micro... more Figure S5. NAT12/NAA30 knockdown resulted in dysregulation of ribosome assembly as shown by microarray analysis. Using the DAVID functional annotation tool we analyzed the KEGG pathway "Ribosome" where 13 genes (p=5.6E-06) were differentially regulated in KD1 and KD2. See also Supplementary File 3. Dysregulated genes are marked with red asterisks. Figure S6. NAT12/NAA30 knockdown resulted in dysregulation of the p53 pathway as shown by microarray analysis. Using the DAVID functional annotation tool we analyzed the KEGG pathway "p53" where 8 genes (p=3.1E-03) were differentially regulated in KD1 and KD2. See also Supplementary File 3. Dysregulated genes are marked with red asterisks. Figure S7. NAT12/NAA30 knockdown resulted in dysregulation of sphingolipid metabolism as shown by microarray analysis. Using the DAVID functional annotation tool we analyzed the KEGG pathway "Sphingolipid metabolism" where 6 genes (p=4.8E-03) were differentially regulated in...

Research paper thumbnail of Additional file 12:Â Supplementary File 4. of Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells

List of antibodies used for western blot. (DOCX 53 kb)

Research paper thumbnail of RESEARCH Open Access Targeting PBK/TOPK decreases growth and

survival of glioma initiating cells in vitro and attenuates tumor growth in vivo

Research paper thumbnail of Supplementary Table 7 Behnan et al., 2016 Oncogene

Research paper thumbnail of Drastic Measures, The Scandinavian Way. How Effective Has the Shutdown Been?

Archives of Clinical and Medical Case Reports, 2021

Research paper thumbnail of Differential propagation of stroma and cancer stem cells dictates tumorigenesis and multipotency

Oncogene, Jan 27, 2016

Glioblastoma Multiforme (GBM) is characterized by high cancer cell heterogeneity and the presence... more Glioblastoma Multiforme (GBM) is characterized by high cancer cell heterogeneity and the presence of a complex tumor microenvironment. Those factors are a key obstacle for the treatment of this tumor type. To model the disease in mice, the current strategy is to grow GBM cells in serum-free non-adherent condition, which maintains their tumor-initiating potential. However, the so-generated tumors are histologically different from the one of origin. In this work, we performed high-throughput marker expression analysis and investigated the tumorigenicity of GBM cells enriched under different culture conditions. We identified a marker panel that distinguished tumorigenic sphere cultures from non-tumorigenic serum cultures (high CD56, SOX2, SOX9, and low CD105, CD248, αSMA). Contrary to previous work, we found that 'mixed cell cultures' grown in serum conditions are tumorigenic and express cancer stem cell (CSC) markers. As well, 1% serum plus bFGF and TGF-α preserved the tumorig...

Research paper thumbnail of PBK/TOPK as a Potential Therapeutic Target in Glioblastoma and Other Malignancies

Research paper thumbnail of Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo

Research paper thumbnail of Expansion of Multipotent Stem Cells from the Adult Human Brain

Research paper thumbnail of Comparison of glioma stem cells to neural stem cells from the adult human brain identifies dysregulated Wnt- signaling and a fingerprint associated with clinical outcome

Experimental Cell Research, 2013

Research paper thumbnail of The Role of N-Terminal Acetyltransferase NAA30 in Glioblastoma- Initiating Cells

Research paper thumbnail of Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells

Research paper thumbnail of Supplementary Table 6 Behnan et al., 2016 Oncogene

Research paper thumbnail of How to evaluate the success of the COVID-19 measures implemented by the Norwegian government by analyzing changes in doubling time

medRxiv (Cold Spring Harbor Laboratory), Mar 30, 2020

Research paper thumbnail of Supplementary Table 2 behnan et al., 2016 Oncogene

Research paper thumbnail of Additional file 11: Figure S10. of Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells

NAT12/NAA30 knockdown resulted in reduction of CD133+ cells as shown by flow cytometry.

Research paper thumbnail of Additional file 7:Â Supplementary File 3. of Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells

Functional annotation based on the microarray analysis of NAT12/NAA30 knockdown cultures. (XLSX 2... more Functional annotation based on the microarray analysis of NAT12/NAA30 knockdown cultures. (XLSX 201 kb)

Research paper thumbnail of Additional file 4: Supplemetary File 2. of Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells

Additional qPCR statistics for Fig. 1, Fig. 3 and Fig. 5. (PDF 254 kb)

Research paper thumbnail of Additional file 2: Figure S2. of Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells

K-means clustering of the expression data for the selected NAT genes.

Research paper thumbnail of Additional file 3: Supplementary File 1. of Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells

Oligonucleotides and microarray probes. (PDF 115 kb)

Research paper thumbnail of Additional file 8: Figure S5-S7. of Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells

Figure S5. NAT12/NAA30 knockdown resulted in dysregulation of ribosome assembly as shown by micro... more Figure S5. NAT12/NAA30 knockdown resulted in dysregulation of ribosome assembly as shown by microarray analysis. Using the DAVID functional annotation tool we analyzed the KEGG pathway "Ribosome" where 13 genes (p=5.6E-06) were differentially regulated in KD1 and KD2. See also Supplementary File 3. Dysregulated genes are marked with red asterisks. Figure S6. NAT12/NAA30 knockdown resulted in dysregulation of the p53 pathway as shown by microarray analysis. Using the DAVID functional annotation tool we analyzed the KEGG pathway "p53" where 8 genes (p=3.1E-03) were differentially regulated in KD1 and KD2. See also Supplementary File 3. Dysregulated genes are marked with red asterisks. Figure S7. NAT12/NAA30 knockdown resulted in dysregulation of sphingolipid metabolism as shown by microarray analysis. Using the DAVID functional annotation tool we analyzed the KEGG pathway "Sphingolipid metabolism" where 6 genes (p=4.8E-03) were differentially regulated in...

Research paper thumbnail of Additional file 12:Â Supplementary File 4. of Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells

List of antibodies used for western blot. (DOCX 53 kb)

Research paper thumbnail of RESEARCH Open Access Targeting PBK/TOPK decreases growth and

survival of glioma initiating cells in vitro and attenuates tumor growth in vivo

Research paper thumbnail of Supplementary Table 7 Behnan et al., 2016 Oncogene

Research paper thumbnail of Drastic Measures, The Scandinavian Way. How Effective Has the Shutdown Been?

Archives of Clinical and Medical Case Reports, 2021

Research paper thumbnail of Differential propagation of stroma and cancer stem cells dictates tumorigenesis and multipotency

Oncogene, Jan 27, 2016

Glioblastoma Multiforme (GBM) is characterized by high cancer cell heterogeneity and the presence... more Glioblastoma Multiforme (GBM) is characterized by high cancer cell heterogeneity and the presence of a complex tumor microenvironment. Those factors are a key obstacle for the treatment of this tumor type. To model the disease in mice, the current strategy is to grow GBM cells in serum-free non-adherent condition, which maintains their tumor-initiating potential. However, the so-generated tumors are histologically different from the one of origin. In this work, we performed high-throughput marker expression analysis and investigated the tumorigenicity of GBM cells enriched under different culture conditions. We identified a marker panel that distinguished tumorigenic sphere cultures from non-tumorigenic serum cultures (high CD56, SOX2, SOX9, and low CD105, CD248, αSMA). Contrary to previous work, we found that 'mixed cell cultures' grown in serum conditions are tumorigenic and express cancer stem cell (CSC) markers. As well, 1% serum plus bFGF and TGF-α preserved the tumorig...

Research paper thumbnail of PBK/TOPK as a Potential Therapeutic Target in Glioblastoma and Other Malignancies

Research paper thumbnail of Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo

Research paper thumbnail of Expansion of Multipotent Stem Cells from the Adult Human Brain

Research paper thumbnail of Comparison of glioma stem cells to neural stem cells from the adult human brain identifies dysregulated Wnt- signaling and a fingerprint associated with clinical outcome

Experimental Cell Research, 2013

Research paper thumbnail of The Role of N-Terminal Acetyltransferase NAA30 in Glioblastoma- Initiating Cells

Research paper thumbnail of Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells

Research paper thumbnail of Supplementary Table 6 Behnan et al., 2016 Oncogene

Log In