Ferda Bir | Pamukkale University (original) (raw)

Papers by Ferda Bir

European Radiology, Sep 6, 2007

Imaging findings were reported in an unusual case of endobronchial lipomatous hamartoma obstructi... more Imaging findings were reported in an unusual case of endobronchial lipomatous hamartoma obstructing the left mainstem bronchus. Computed tomography readily demonstrated the presence of fat density within the lesion narrowing the differential diagnosis to endobronchial lipoma or lipomatous hamartoma.

The Journal of Thoracic and Cardiovascular Surgery, Jun 1, 2007

Firat Tip Dergisi, 2009

Objective: Surgical manuplations during harvesting saphenous vein graft (SVG) and application of ... more Objective: Surgical manuplations during harvesting saphenous vein graft (SVG) and application of organ bath for CABG causes intimal injury. A prospective study was performed with the postulation that in-situ harvesting technique would protect the graft from ischemic ...

Interventional Neuroradiology, Mar 1, 2006

We report the imaging findings and endovascular treatment in an unusual case of petrous internal ... more We report the imaging findings and endovascular treatment in an unusual case of petrous internal carotid artery pseudoaneurysm due to primary tuberculous otitis. The aneurysm was recognized and ruptured during a surgical intervention for otitis. Successful endovascular treatment of the aneurysm was performed by occlusion of the parent vessel using detachable balloon and coils.

Toraks dergisi, Sep 1, 2011

Lenfanjioleimyomatozis (LAM) çoğunlukla genç kadınları etkileyen, genellikle solunum yetmezliği v... more Lenfanjioleimyomatozis (LAM) çoğunlukla genç kadınları etkileyen, genellikle solunum yetmezliği ve ölüme ilerleyebilen bir tablodur. 33 yaşında postpartum periyodda kadın hasta ilerleyici nefes darlığı ve yüksek CA-125 seviyeleri ile başvurdu. Hastada bilateral şilopnömotoraks, şilöz asit mevcut idi ve açık akciğer biyopsisi ile LAM tanısı aldı. Hastanın takibi oldukça karmaşıktı ve şilöz asit ve plevral efüzyonlar tedaviye çok dirençliydi. Betadin plörodezisi şilotoraksların tedavisinde oldukça başarılı oldu. Literatürde yüksek CA-125 seviyeleri ile başvuran LAM vakası sunulmamıştır. Takipte CA-125 seviyelerinin yararlı bir parametre olabileceğini düşünmekteyiz.

Circulation journal, 2008

ntracardiac myxomas are the most common benign tumors of the heart in adults. Approximately 75-80... more ntracardiac myxomas are the most common benign tumors of the heart in adults. Approximately 75-80% of myxomas originate from the left atrial septum; 10-20% are localized in the right atrium; and the rest of 6-8% are bi-atrial, or in the right or left ventricle. 1 Isolated left ventricular (LV) myxoma is extremely rare, accounting for 2.5-4% of all cases. 2 The most common treatment strategy is surgical extirpation under cardiopulmonary bypass, with an excellent prognosis. We present an extremely rare case of 2 LV myxomas originating from the mitral anterior and posterior leaflets into the LV cavity and obstructing the outflow tract (LVOT), and discuss the current literature.

Journal of Surgical Research, Jun 1, 2007

Background. Abdominal aortic surgery can cause ischemic/reperfusion (I/R) injury in not only the ... more Background. Abdominal aortic surgery can cause ischemic/reperfusion (I/R) injury in not only the lower extremities, but also in the remote organs and tissues such as lungs, kidneys, heart, and liver during abdominal aortic surgery. It can result in mortality and morbidity because of the remote organ injury in early postoperative period. In this study, we investigate the effects of iloprost and vitamin C on the kidney remote organ damage after I/R following abdominal aortic surgery. Material and methods. Thirty-four adult male Wistar rats were used and divided into five groups. I/R was studied infrarenally in the abdominal aorta following a median laparotomy. The left kidney was excised immediately following the laparotomy in group I (n ‫؍‬ 6, normal group). Group II (n ‫؍‬ 6) was the sham group. Group III (n ‫؍‬ 6, control group) was subjected to 3 h of ischemia followed by an hour of reperfusion. Group IV (n ‫؍‬ 8) was given iloprost 20 ng/kg/min during I/R period before aortic-clamping. Group V (n ‫؍‬ 8) was given vitamin C 100 mg/kg during I/R period before aortic-clamping. Arterial blood samples were obtained to determine the levels of blood pH, pO 2 (mmHg), pCO2 (mmHg), HCO 3 (mmol/L), and plasma malondialdehyde (MDA, nmol/mL) at the end of reperfusion period in all groups. The left kidneys were used for remote measurements of tissue MDA (nmol/g.w.t) and scored by histopathological examination for acute inflammation. Results. While the arterial blood pO 2 and HCO 3 levels significantly increased, the plasma and renal parenchymal MDA levels significantly decreased in both group IV and group V when compared to group III (P < 0.05). Histopathological and acute inflammation scores statistically decreased in both group IV and V compared with group III (P < 0.05). Although MDA levels, histopathologic and acute inflammation scores in group V were lower than group IV, the differences were not statistically significant (P > 0.05). Conclusion. Both iloprost and vitamin C decreased remote organ damage on the kidney after I/R of lower extremities in the rat model. However, vitamin C is more effective than iloprost in preventing postoperative renal dysfunction.

Fırat Tıp Dergisi, Jun 1, 2009

Koroner bypass cerrahisi (CABG) sırasında safen ven grefti hazırlanırken gerek cerrahi manüplasyo... more Koroner bypass cerrahisi (CABG) sırasında safen ven grefti hazırlanırken gerek cerrahi manüplasyonlara bağlı, gerekse organ banyosunda iskemik ortamda bekletilmeye bağlı intimal hasar oluşmaktadır. İn-situ teknik ile damar endotelinin iskemiden korunacağı ve intimal hasarın azalacağı öngörüsü ile prospektif bir çalışma planlandı. Gereç ve Yöntemler: CABG yapılacak ardışık 40 hastadan hazırlanan safen ven grefti çalışmaya alındı. Yirmişer hastadan oluşan iki grup oluşturuldu. Grup-1'de geleneksel "açık cilt kesiği tekniğiyle" safen ven grefti hazırlandı ve papaverinli organ banyosunda 45 dk. bekletildi. Grup-2'de in-situ teknikle safen ven grefti hazırlandı ve etrafına papaverinli spanç sarılarak 45 dk. bekletildi. Histopatolojik değerlendirme için, greftlerin distal uç kısmından 1 cm'lik safen parçası alındı. Doku örnekleri hemotoksilin-eosin ile boyanarak ışık mikroskopisinde incelendi ve histopatolojik olarak skorlandı. İstatistiksel değerlendirmede ki-kare testi kullanıldı. Bulgular: Her iki grupta da safen ven örneklerinden elde edilen patolojik hasar median skorları 2 bulundu ve istatistiksel fark saptanmadı (p = 0.987). Her iki grupta da hafif-orta derecede intimal desquamasyon saptandı. Sonuç: İn-situ teknikle safen ven grefti hazırlama geleneksel açık cilt kesiği tekniğiyle hazırlamaya intimal hasar bakımından üstün değildir.

Toraks Dergisi, 2008

... Göksel Kıter 1 , Gökhan Yuncu 2 , Ferda Bir 3 , Nevzat Karabulut 4 , Sibel Özkurt 1 , Fatma E... more ... Göksel Kıter 1 , Gökhan Yuncu 2 , Ferda Bir 3 , Nevzat Karabulut 4 , Sibel Özkurt 1 , Fatma Evyapan 1. ... dansite (Şekil 3), toraks bilgisayarlı tomografisinde sol alt lob posterobazal segmentte 3x3x5 cm boyutlarında kitle görünümünde lezyon ve çevresinde buzlu cam dansitesi ile ...

Turkish Journal of Internal Medicine

Low back pain is one of the most common symptoms, having a broad range of etiologies in different... more Low back pain is one of the most common symptoms, having a broad range of etiologies in differential diagnosis, such as inflammatory and degenerative disorders, malignancy and infections. Herein we present an interesting patient who initially presented with sacroiliitis and was ultimately diagnosed with stage IV lung cancer. She was initially misdiagnosed as axial spondyloarthritis. We aim to emphasize red flags in the differential diagnosis of sacroiliitis. Hypercalcemia and progressive, unbearable low back pain were supportive factors for underlying malignancy in our case.

Annals of Medical Research, 2021

Aim: The excision repair cross-complementation group 1 (ERCC-1) protein is a potential prognostic... more Aim: The excision repair cross-complementation group 1 (ERCC-1) protein is a potential prognostic biomarker of the efficacy of platinum-based chemotherapy in non–small-cell lung cancer (NSCLC). The purpose of this study was to evaluate the clinicopathology and prognostic significance of ERCC-1 expression, ERCC-1 (19q13) amplification in NSCLC patients; and the relationship between platinum-based chemotherapy. Materials and Methods: We used the ERCC-1 antibody to measure the level of expression of ERCC-1 protein by immunohistochemical analysis from 351 patients and ERCC-1 gene copy number was evaluated by fluorescence in situ hybridization (FISH) in tumors from 81 patients. Results: ERCC-1 expression in tumor cells was positive in 312 patients (88.9%). The ERCC-1 amplification in tumor cells was positive in 58 patients (71.6%) out of 81. The ERCC-1 amplification was also more frequent in early-stage tumors than late-stage tumors (p = 0.025). In the patients with positive ERCC-1 expre...

Iranian Journal of Radiation Research, 2014

Background: Vitamin D, especially its most ac ve metabolite 1,25‐dihydroxyvitamin D3(Vit D) is es... more Background: Vitamin D, especially its most ac ve metabolite 1,25‐dihydroxyvitamin D3(Vit D) is essen al in regula ng a wide variety of biologic processes, such as regula ng mesangial cell ac va on. The objec ve of this study was to assess the histopathological changes of effec veness of Vit D as a protec ve agent against radia on induced lung injury. Materials and Methods: Eighteen Wistar rats were divided into three groups: control group (group 1:4 rats), irradia on alone group (group 2:7 rats) and irradia on+vit D (group 3:7 rats). Rats in group 2 and 3 were exposed to 20 Gy radia ons to the right lung in a Co radiotherapy machine under general anesthesia. Addi onally, rats in group 3 received Vit D at a single dose of 0.2 mcg injected IM 2 hours before exposure to irradia on. Rats were sacrificed and lungs were dissected fi y days a er post‐irradia on. Myofibroblasts and vitamin D3 receptors (VDR) in extracted lungs were stained by immunohistochemistry using alpha‐smooth muscle a...

iranian journal of nuclear medicine, 2020

Introduction 18F-FDG PET/CT provides very effective results in detecting metastases of breast can... more Introduction 18F-FDG PET/CT provides very effective results in detecting metastases of breast cancer. In our study, we investigated the relationship between maximum standard uptake value (SUVmax) and prognostic pathologic factors in breast cancer cases with isolated bone metastasis and whether there was any difference in terms of prognostic pathologic factors between the group with and without bone metastasis. Methods Between 2013 and 2016, isolated bone metastases (55 female; 56±12 years; 32-87), and non-metastatic (46 female; 55±13 years; 30-81) patients who were referred to department of nuclear medicine and underwent 18F-FDG PET/CT for staging were included in the study. PET/CT images of patients and pathologic prognostic factors were evaluated retrospectively. SUVmax value of the most intense activity from metastatic bone lesions was calculated. Results In the metastatic group, there was no statistically significant relationship between measured SUVmax value of bone metastasis ...

Hellenic journal of nuclear medicine, 2020

Positron emission tomography /CT images showed a moderately increased 18F-FDG uptake in the mass ... more Positron emission tomography /CT images showed a moderately increased 18F-FDG uptake in the mass of left lung lower lobe superior segment (SUVmax: 2.71). No pathological 18F-FDG involvement was detected in another region of the whole body scan. The patient underwent tru-cut biopsy. Since histopathological diagnosis could not be made, thoracotomy was performed. Schwannomas are the second most common benign peripheral nerve sheath originated tumor. Due to its development from Schwann cells, it can be seen in all organs or tissues during intracranial, extracranial, or spinal nerve courses where these cells are found. Schwannomas are extremely rare in the lung, regardless of the patients age. Ohtsuka et al. (2005) stated that in the review of 62 patients with intrapulmonary or bronchial schwannoma (5-83 years; 28 male, 34 female patients), this neoplasm constitutes approximately 0.2% of all pulmonary neoplasms. Although it is usually sporadic and single lesion, it can also be seen with ...

Journal of Oncological Sciences, 2020

Lung cancer continues to be the leading cause of cancer-related deaths. 1 Only 15% of all patient... more Lung cancer continues to be the leading cause of cancer-related deaths. 1 Only 15% of all patients with lung cancer have more than five years of survival after diagnosis. 2 Cytotoxic chemotherapy is the standard first-line therapy for patients with squamous cell lung cancer. More recent efforts have been made to identify novel biomarkers for the prediction of prognosis and response to chemotherapy. Intrinsic and extrinsic apoptotic pathways use caspase steps. In the intrinsic pathway, Bax and Bak are activated by various apoptotic stimuli through DNA damage or cellular signals. The activated Bax and Bak initiate mitochondria-dependent apoptotic pathway by inducingpore formation in the mitochondrial membrane, leading to the release of cytochrome c and other factors that form an apoptosome complex.Apoptosome activates caspase-9. Activated caspase-9cleaves procaspase-3 to generate the active caspase-3 that leads to DNA fragmentation. The extrinsic pathway is activated when a death ligand, such as FasL or tumor

Contrast Media & Molecular Imaging, 2020

This study was designed to evaluate the accuracy of detecting pulmonary embolism (PE) using the T... more This study was designed to evaluate the accuracy of detecting pulmonary embolism (PE) using the Technegas SPECT/CT combined with 68Ga PET/CT in a rabbit model. One hour after artificial PE (n = 6) and sham (n = 6) models were created, Technegas SPECT/CT ventilation and 68Ga-MAA PET/CT perfusion scan (V/Q scan) were performed. Ventilation imaging was performed first on all cases. Technegas SPECT/CT and 68Ga-MAA PET/CT images were evaluated by a nuclear medicine physician who recorded the presence, number, and location of PE on a per-lobe basis. The sensitivity, specificity, and accuracy of Technegas SPECT/CT and 68Ga-MAA PET/CT for detecting PE were calculated using a histopathological evaluation as a reference standard. A total of 60 lung lobes were evaluated in 12 rabbits, and PE was detected in 20 lobes in V/Q scans and histopathological analysis. The overall sensitivity, specificity, and accuracy were 100%, 100%, and 100%, respectively, for both the Technegas SPECT/CT and 68Ga-MA...

Northern Clinics of Istanbul, 2020

T he salivary glands consist of three major glands as parotid, submandibular and sublingual gland... more T he salivary glands consist of three major glands as parotid, submandibular and sublingual glands and hundreds of minor glands, which are diffusely located in the beginning part of the respiratory system. Tumors of the salivary glands are rarely encountered. However, they appear with different histopathological characters. Different biological behaviors can be observed even in neoplasms defined by the same name. In the latest classification made by the World Health Organization (WHO) in 2017, salivary gland tumors were classified into more than 30 benign and malignant histologic subtypes [1]. This wide histopathological spectrum and significant differences in prognosis between them distinguish salivary gland tumors from other organ neoplasms. Salivary gland tumors account for approximately 3-4% of all head and neck tumors [2]. Their inci-ABSTRACT OBJECTIVE: To determine the demographic characteristics of benign and malignant salivary gland tumors in our department in the last 15 years. METHODS: In this study, the files of the patients who underwent salivary gland surgery between 2004 and 2019 in our department were analyzed retrospectively. A total of 366 patients whose diagnoses of salivary gland tumor histopathologically confirmed were included in this study. The demographic data of the patients and tumor localizations were recorded, and their relationships with histopathological results were examined. RESULTS: Of the 366 tumors, 292 (80%) of them was originated from the parotid gland, 52 (14%) from the submandibular gland, and 22 (6%) from the minor salivary gland. The male: female ratio was found as 1.2:1, and the mean age of the patients was 50.37 years. A total of 259 (70.8%) tumors were benign, and 107 (29.2%) were malignant. The most frequent benign tumor was pleomorphic adenoma, with 121 cases (46.7%). While pleomorphic adenomas constituted the majority of the benign tumors of the submandibular gland and minor salivary glands, Warthin tumor was detected more than pleomorphic adenoma in the parotid gland. The most common malignant tumor was mucoepidermoid carcinoma, with 26 cases (24.3%). CONCLUSION: The distribution of the salivary gland tumors detected in our department was found to be substantially similar to other worldwide series. Unlike the literature, we concluded that salivary gland tumors were seen slightly more in males, minor salivary gland tumors were relatively rare and Warthin tumors were more frequently detected in our region.