Valery M Dembitsky | Institute Far East Branch Russian Academy of Sciences of Marine Biology (original) (raw)
Address: Institute of Drug Discovery,
less
Uploads
Papers by Valery M Dembitsky
Synthesis, May 5, 2011
ABSTRACT A novel method was developed for the selective oxidation of α-monosubstituted malononitr... more ABSTRACT A novel method was developed for the selective oxidation of α-monosubstituted malononitrile and cyanoacetic ester derivatives at the α-position based on transition-metal-catalyzed reaction (Cu, Fe, Mn, Co) with tert-butyl hydroperoxide giving unsymmetrical peroxides in 63-94% yields. The method is facile, does not require large excesses of reagents, and is amenable to gram-scale synthesis.
Synthesis, May 5, 2011
ABSTRACT A novel method was developed for the selective oxidation of α-monosubstituted malononitr... more ABSTRACT A novel method was developed for the selective oxidation of α-monosubstituted malononitrile and cyanoacetic ester derivatives at the α-position based on transition-metal-catalyzed reaction (Cu, Fe, Mn, Co) with tert-butyl hydroperoxide giving unsymmetrical peroxides in 63-94% yields. The method is facile, does not require large excesses of reagents, and is amenable to gram-scale synthesis.
BOOK, 2023
The assumption that sea water is the cradle of the origin of primitive living organisms is beyond... more The assumption that sea water is the cradle of the origin of primitive living organisms is beyond doubt. No one
knows how this happened, but there are many assumptions, although the evidence base for all these assumptions
raises many questions. This book is an attempt to elucidate the origin of the protomembrane and its transformation
into a bilayer lipid membrane in an inanimate substance. Presumably, protomembranes consisting of fatty acids
and other amphiphiles were a simple type of membrane, but with the advent of polyols and, accordingly, complex
lipids, a new type of protomembranes appears. Perhaps this new type of protomembrane, consisting of complex
lipids, was the beginning of the emergence of the future biological membrane and all life on Earth. Coacervates
from the Oparin – Haldane hypothesis were used as a model to explain the formation of protomembranes. The
chemical model shows which polyols could spontaneously form in the primary broth, and the mathematical model
shows that ethylene glycol (40%), glycerol (33%), butane-1,2,3,4-tetraols (17%) account for 90% of all polyols
produced. This indicates the possible predominance of diol lipids in the primary primitive protomembranes. During
chemical evolution and with changes in temperature, pH, and environmental conditions, diol lipids were replaced
by glycerolipids, which have more suitable physicochemical characteristics for the formation of biological
membranes of all living organisms. The book presents polyols as part of complex lipids that are found in modern
biological membranes.