Harold Kyriazi | University of Pittsburgh (original) (raw)
Papers by Harold Kyriazi
Pittsburgh Post-Gazette, 2024
Pittsburgh Post-Gazette, 2024
Physics and cosmology have been in a deep rut for over 100 years, with mysteries multiplying and ... more Physics and cosmology have been in a deep rut for over 100 years, with mysteries multiplying and no solutions in sight. In order to salvage their paradigmatic Big Bang theory along with their main theory of gravitation--Einstein's theory of General Relativity--cosmologists have had to postulate that 95% of the (gravitating) matter and energy of the Universe is invisible to us as "dark matter" and "dark energy." Witness also the current belief in 29 "fundamental" fields all overlapping but somehow not interfering with each other, "expanding space," wave/particle duality of both light and matter, "quantum indeterminacy," and "spooky action at a distance."
These mysteries and puzzling ideas exist because physicists lack an understanding of the fundamental nature of the vacuum, matter, and ,consequently, gravity and its mechanism. A summary of a new, purely mechanical, atomistic paradigm is provided that actually explains rather than just merely describes.
Murmurs, 1990
Guest column in the University of Pittsburgh's medical school newsletter, containing my views aga... more Guest column in the University of Pittsburgh's medical school newsletter, containing my views against capital punishment and for the notions of compensating victims and work-as-rehabilitation for convicted criminals.
Pittsburgh Tribune-Review, 2000
Column in the Opinion and Commentary section of the Sunday, April 9th edition of the Pittsburgh T... more Column in the Opinion and Commentary section of the Sunday, April 9th edition of the Pittsburgh Tribune-Review. It presents my view of all victimless crimes, and how laws against such behavior force police either to violate peoples' natural rights to engage in behavior that does not directly harm others, or else not enforce such laws, damaging respect for law in general and providing tremendous incentives for corruption of law enforcement and our judicial system.
Pittsburgh Tribune-Review, 2020
There are many factors underlying “systemic racism” in the United States. One rarely mentioned bu... more There are many factors underlying “systemic racism” in the United States. One rarely mentioned but surprisingly vital root cause, however, is our system of land tenure. ... [This was published on July 9, 2020, during the George Floyd-inspired marches and associated riots. A link to the original newspaper column, which contains working links, is provided at the top of the docx file.]
Journal of Neurophysiology, 1996
Carbon fiber multibarrel glass microelectrodes were used to record extracellular single-unit acti... more Carbon fiber multibarrel glass microelectrodes were used to record extracellular single-unit activity during microiontophoretic application of gamma-aminobutyric acid (GABA) or bicuculline methiodide (BMI) onto layer IV barrel neurons in the somatosensory cortex of fentanyl-sedated rats. Excitatory and inhibitory aspects of the neurons' receptive fields were quantified with the use of controlled whisker stimuli. The principally activating whisker and one of its immediately adjacent neighbors were deflected alone or in paired combinations involving a condition-test paradigm. 2. Units were distinguished electrophysiologically on the basis of the time course of their action potential waveforms. Data were obtained from 26 regular-spike units (RSUs; presumed spiny stellate cells) and 7 fast-spike units (FSUs; presumed GABAergic neurons). An average of 15.0 nA of GABA produced a one-third to one-half reduction in RSU responses evoked by the maximally effective stimulus. An average of 8.7 nA of BMI was needed to counteract this reduction. This amount of BMI, in the absence of exogenous GABA, was found to increase average RSU and FSU responses by 98 and 53%, respectively, relative to predrug levels. 3. For RSUs, the BMI-induced twofold increase in responses evoked by moving the principal whisker at the neuron's best deflection angle was accompanied by an almost threefold increase in responses evoked by similarly moving an adjacent whisker. Disproportionately large percentage increases were also seen for responses to nonpreferred directions of principal and adjacent whisker movement. BMI thus effectively increased receptive field size and decreased angular tuning. Similarly, responses to stimulus offsets, which are normally smaller than ON responses, were increased proportionally more. 4. Predrug responses of FSUs were more vigorous than those of RSUs. However, FSUs showed a similar inverse relationship between percentage increase with BMI and initial response magnitude, although the proportional increases were less pronounced. 5. GABA, like BMI, had the greatest proportional effects on those responses that were initially smallest. It produced results opposite those of BMI, effectively decreasing receptive field size and sharpening angular tuning. 6. A previously described computational model of a barrel was tested for its ability to reproduce quantitatively the effects of BMI and GABA. The application of BMI was simulated by decreasing the strength of the inhibitory inputs onto the particular cell under study in the model network. GABA microiontophoresis was simulated by adding a constant hyperpolarizing voltage. The model RSUs and FSUs displayed proportional changes in response magnitude that were quantitatively similar to those of their biological counterparts. 7. Surround inhibition was greatly attenuated by BMI application, both for the real and simulated barrel neurons. Disinhibition was less pronounced for the former, perhaps because, unlike the simulated neurons, they also possess GABAB receptors, which are unaffected by BMI. 8. We conclude that the inhibitory receptive field properties of barrel neurons can be explained by intrabarrel inhibition and that the expansion of receptive field size and loss of angular tuning with BMI is due to an enhanced effectiveness of convergent, multi-whisker thalamocortical input. Examination of the model neurons' behavior suggests that the altered activity in response to GABA or BMI application, respectively, can be explained by the nonlinear effects of shifting somal membrane potential away from or toward the neuron's firing threshold.
Archives of Biochemistry and Biophysics, 1986
These studies addressed the question of the in vivo distribution of rat brain hexokinase (HK), an... more These studies addressed the question of the in vivo distribution of rat brain hexokinase (HK), and whether physiologically relevant changes in the glycolytic rate are accompanied by changes in the distribution of HK. Homogenates of fresh tissue showed only 11-15% of the overt (assayable without added detergent) HK to be soluble (found in high-speed centrifugation supernatant fractions) when homogenization was begun within 15-20 s of sacrifice. Freeze-blown rat brain tissue also was used, coupled with a new technique wherein it was homogenized as it thawed in a buffered sucrose solution containing 1 mM EDTA. In tissue sampled 15 min (anesthetized) or 60 min (waking) after ip Nembutal injection (40 mg/kg), 23% of the overt HK and 79% of the total lactate dehydrogenase were soluble. The average phosphocreatine content of these and similar homogenates had decreased only 23% from in vivo levels, while ATP had decreased by 65%, due to the combined effects of a high level of endogenous ATPase, chelation of Mg2+ by EDTA, and the greater stability of Mg-ATP2- relative to Mg-ADP1-. These data indicated that the tissue experienced, at most, the equivalent of 6 s of complete ischemia prior to the completion of homogenization. Synaptosomes derived from rat and chicken cerebra were incubated at 37 degrees C in a physiological salt solution containing 10 mM glucose. Addition of veratridine has been shown to stimulate glycolysis and oxidative phosphorylation two- to threefold (H. T. Kyriazi and R. E. Basford (1986) J. Neurochem., in press), but did not alter the HK distribution, as 21% was found in the supernatant fractions of both control and veratridine-stimulated synaptosomes treated with digitonin. These results indicate that in brain tissue, large net movements of HK on and off the outer mitochondrial membrane do not occur, and thus play no role in the regulation of glycolysis.
American Journal of Economics and Sociology, 2004
Conclusion: Murray Rothbard was no land economist. He carefully sniffed the Georgist literature, ... more Conclusion: Murray Rothbard was no land economist. He carefully sniffed the Georgist literature, detected a faint aroma of socialism, felt the presence of The State, with whose stench he was already thoroughly familiar, and without bothering to root out the minor socialist aspect of traditional Georgism or to consider Chodorov’s suggested decentralized implementation, threw the baby out with the bathwater. His views on the land question were intellectually consistent, but entirely flawed, and reminiscent of the complexly interwoven, delusional alternate realities dreamed up by clever paranoid-schizophrenics. He had an answer to everything, and all of his answers were wrong. His “alternate reality” was based on a failure to understand a) the positive spatial externalities attaching to land use, b) that the contributions of these to the value of individual parcels of land could be separately assessed, c) the vicious cycle nature of purely private land ownership, and d) that any system that permits all land to be privately appropriated in a fashion that excludes some, is, to the excluded, inherently coercive, depriving them of basic rights. Rothbard wrote that great thinkers, “however great they may have been, ... can slip into error and inconsistency, and even write gibberish on occasion.” As we have seen, he himself was not immune, but this should not lead us to disparage his immense contribution to the reawakening of the spirit of liberty in the latter half of the twentieth century, much as Henry George provided in the final twenty years of the previous one, and beyond.
Brain Research, 1996
Extracellular single-unit recordings were made in somatosensory cortical barrels of fentanyl-seda... more Extracellular single-unit recordings were made in somatosensory cortical barrels of fentanyl-sedated rats. Whiskers were deflected singly or in paired combinations. Iontophoretically-applied (-)-baclofen disproportionately reduced weak responses, and phaclofen disproportionately increased them, resulting in more tightly focused or more broadly focused receptive fields, respectively. Both drugs had only minor effects on surround inhibition. In light of previous findings, we conclude that GABA-A and GABA-B mechanisms both act to enhance spatial contrast, but that the former plays a much greater role in enhancing temporal resolution.
Journal of Neurochemistry, 1986
Synaptosomes prepared and incubated in a variety of ways from rat cerebra exhibited intractable, ... more Synaptosomes prepared and incubated in a variety of ways from rat cerebra exhibited intractable, unphysiologically low adenylate energy charge values (~0.37-0.60), low total adenine nucleotide contents (~8-10 nmol/mg protein), and much higher adenylate kinase apparent Keq values (~3-8) as compared to intact brain tissue (values of ~0.90, 25 nmol/mg, and 0.74; respectively). Synaptosomes prepared from mouse, dog, and chicken cerebra had values essentially identical to those from rat. When incubated under oxygen in a physiological salt solution containing glucose, synaptosomes metabolized more glucose to lactic acid than to CO2, and the addition of 100 microM veratridine caused a two- to threefold stimulation of O2 uptake, lactate accumulation, and CO2 output. It is known that synaptosome fractions contain a substantial number (at least 30-45% by volume) of cytoplasm-containing particles devoid of mitochondria (henceforth termed "cytosolic particles"), and that approximately 80% of brain hexokinase is bound to the outer mitochondrial membrane. For the cytosolic particles, lacking oxidative phosphorylation, to maintain their "in vivo" ATP turnover would require about a 19-fold increase in the glycolytic rate, which is not possible due to limiting amounts of hexokinase, and thus these particles are postulated to be responsible for the high level of aerobic lactate accumulation and the intractable low energy charge values found in synaptosome fractions. The mitochondria-containing particles are postulated to have a normal energy charge, a submaximal glycolytic rate, and minimal lactate production, on the basis of the capacity of veratridine to stimulate synaptosomal O2 uptake and CO2 and lactate output. Calculations based on this "two populations of particles" hypothesis indicate that for synaptosome fractions in general, (1) the cytosolic particles contain approximately 35-64% of the total adenine nucleotides and maintain an energy charge of approximately 0.12; (2) the cytosolic particles and mitochondria-containing particles have adenylate kinase apparent Keq values of approximately 0.21-1.66 and 0.74, respectively, revealing that the higher apparent Keq values of the synaptosome fractions probably are not real departures from equilibrium: and (3) approximately 31-45% of synaptosome fraction protein is contained in debris, which, when taken into account, yields total adenine nucleotide contents in the cytosolic particles and mitochondria-containing particles of approximately 15-24 and approximately 11-19 nmol/mg of particle protein, respectively.
The Pragmatist, 1997
A professional biochemist (me) debunks Behe's "irreducible biochemical complexity" argument again... more A professional biochemist (me) debunks Behe's "irreducible biochemical complexity" argument against evolution.
The Pragmatist, 1997
Part of a Forum discussion about the basis of human rights, i.e., individual freedom, with me arg... more Part of a Forum discussion about the basis of human rights, i.e., individual freedom, with me arguing for rights arising naturally and necessarily from our evolved desire to survive and prosper maximally, and another libertarian/anarchist arguing that only a minority of people really value their individual liberty, with the latter having no basis other than personal preference (i.e., that there's no moral or practical basis for human rights).
The Pragmatist, 1996
Half of a debate Forum in The Pragmatist, with me arguing, from a minarchist (minimalist governme... more Half of a debate Forum in The Pragmatist, with me arguing, from a minarchist (minimalist government) perspective, for public safety, restitution (to both victims and taxpayers) via rehabilitative gainful employment (with entrepreneurs hiring convicts to work in prison), vs. an anarcho-capitalist view of criminal justice, based upon the principle of restitution and a free market in policing.
Analytical Biochemistry, 1985
The enzymatic inosine 5'-monophosphate assay described by Grassl [in Methods of Enzymatic Analysi... more The enzymatic inosine 5'-monophosphate assay described by Grassl [in Methods of Enzymatic Analysis (H. U. Bergman, ed.) pp. 2168-2171, Academic Press, New York (1974)] is highly nonspecific, as ITP, ATP, ADP, AMP and adenosine react stoichiometrically. The reactivity with the adenine derivatives is due to the tri- and diphosphatase activity of alkaline phosphatase (AP), coupled with adenosine deaminase (and possibly AMP deaminase) contamination of commercially available preparations of AP, purine-nucleoside phosphorylase, and/or xanthine oxidase. The inclusion of coformycin (0.05ug/ml), a potent inhibitor of these deaminases, completely inhibited the cross-reactivity. ITP, however, still reacted stoichiometrically due to the tri- and diphosphatase activity of AP. Meyer and Terjung [Amer. J. Physiol. 237 C111-C118 (1979)] introduced a modification of Grassl's procedure, substituting 5'-nucleotidase for AP. It has been found that this disallows reactivity with ATP, ADP and ITP, but that AMP and adenosine still react completely. Coformycin prevents this cross-reactivity. It is therefore recommended that the assay be carried out with 5-nucleotidase (instead of AP) and coformycin, in order to achieve a more specific assay, and one more suitable for use with whole tissue extracts.
Journal of Neurophysiology, 1999
Layer IV of rodent primary somatosensory cortex is characterized by an array of whisker-related g... more Layer IV of rodent primary somatosensory cortex is characterized by an array of whisker-related groups of neurons, known as “barrels.” Neurons within each barrel respond best to a particular whisker on the contralateral face, and, on deflection of adjacent whiskers, display relatively weak excitation followed by strong inhibition. A prominent hypothesis for the processing of vibrissal information within layer IV is that the multi-whisker receptive fields of barrel neurons reflect interconnections among neighboring barrels. An alternative view is that the receptive field properties of barrel neurons are derived from operations performed on multi-whisker, thalamic inputs by local circuitry within each barrel, independently of neighboring barrels. Here we report that adjacent whisker-evoked excitation and inhibition within a barrel are unaffected by ablation of the corresponding adjacent barrel. In supra-granular neurons, on the other hand, excitatory responses to the ablated barrel’s associated whisker are substantially reduced. We conclude that the layer IV barrels function as an array of independent parallel processors, each of which individually transforms thalamic afferent input for subsequent processing by horizontally interconnected circuits in other layers.
This is an early (2013) version of my development of "Gyron Aether Theory.," at which time I had ... more This is an early (2013) version of my development of "Gyron Aether Theory.," at which time I had not yet grasped the underlying basis of electric charge and magnetism. It belongs in the "unpublished" section here (viXra.org is not a peer-reviewed website). I subsequently broke the theory down into 5 parts, and developed each part much more fully, posting those manuscripts in the "drafts" section here on Academia.
Issues in Medical Ethics, 2001
SUMMARY Given the above considerations, were I a transplant surgeon in India, I would have five ... more SUMMARY
Given the above considerations, were I a transplant surgeon in India, I would have five relevant ethical concerns:
1. Economic justice: support the establishment of genuine economic justice.
2. Cadaveric vs. living donors: support a transition from a system emphasizing living donors to one relying mostly on cadaver organs from those who have suffered brain death.
3. Fair compensation: try to ensure that donors are paid as much as possible (since the current market contains some degree of exploitation, due to the entrenched economic injustice). In practice, this would entail dealing only with organ brokers who treat donors fairly.
4. Do no harm: over and above the usual concerns expressed in the Hippocratic Oath, take all reasonable steps to ensure that patients have adequate follow-up care and legal options for redress of grievances.
5. Legalize organ selling: because the above-mentioned legal options are unlikely to be feasible under a black market system (lawbreakers rarely wish to attract legal attention to their own “criminal” behavior), one must seek to remove the laws banning organ selling. Their existence, in an atmosphere in which black market activity nevertheless thrives, not only places those involved outside the protection of the law, but engenders disrespect for law and law enforcement in general, to the detriment of society. More importantly from an immediate standpoint, removing the ban will free the operations from the clutches of organized crime, and make transplants less expensive for recipients, less exploitative of poor donors, and less dangerous for all involved.
The Journal of Neuroscience, 1993
Layer IV of rodent somatosensory cortex contains identifiable networks of neurons, called "b... more Layer IV of rodent somatosensory cortex contains identifiable networks of neurons, called "barrels," that are related one-to-one to individual whiskers on the face. A previous study (Simons and Carvell, 1989) described differences between the response properties of thalamic and cortical vibrissa neurons and proposed that these transformations can be explained by several features of barrel anatomy and physiology: nonlinear neuronal properties, strongly responsive inhibitory and less responsive excitatory neurons, convergent thalamic inputs to cells of both types, and interconnections among barrel neurons. In the present study these features were incorporated into a computational model in order to test their explanatory power quantitatively. The relative numbers of excitatory and inhibitory cells and the relative numbers of synapses of thalamic and intrabarrel origin were chosen to be consistent with available light and electron microscopic data. Known functional differences between excitatory and inhibitory barrel neurons were simulated through differences in spike activation functions, refractory periods, postsynaptic potential decay rates, and synaptic strengths. The model network was activated by spike trains recorded previously from thalamic neurons in response to three different whisker deflection protocols, and output, which consisted of spikes generated by the simulated neurons, was compared to data from our previous neurophysiological experiments. For each type of whisker stimulus, the same set of parameter values yielded accurate simulations of the cortical response. Realistic output was obtained under conditions where each barrel cell integrated excitatory and inhibitory synaptic inputs from a number of thalamic and other barrel neurons and where the ratios between network excitation, network inhibition, and thalamic excitation were approximately constant. Several quantities are defined that may be generally useful in characterizing neuronal networks. One important implication of the results is that thalamic relay neurons not only provide essential drive to the cortex but could, by changing their tonic activities, also directly regulate the tonic inhibition present in the cortex and thereby modulate cortical receptive field properties.
Journal of neurophysiology, 1994
1. Previous studies have demonstrated marked differences in the relative sizes of ON and OFF resp... more 1. Previous studies have demonstrated marked differences in the relative sizes of ON and OFF responses of neurons in the whisker/barrel system. In particular, OFF responses are unexpectedly large in thalamic neurons. Extracellular unit recordings were used to examine whether varying the time between stimulus onset and offset differently affects OFF responses of neurons in the trigeminal ganglion, ventrobasal thalamus, and somatosensory cortical layer IV. Controlled whisker stimuli were used to deflect individual vibrissal hairs in different directions. We hypothesized that, in part because of the gradual waning of central inhibition evoked by stimulus onset, OFF responses of thalamic and cortical neurons but not trigeminal ganglion cells would increase in size with longer duration stimuli, with relative changes being greatest in the cortex. 2. OFF response magnitudes for thalamic and cortical neuronal populations increased as the stimulus duration was increased from 200 to 1,400 ms. Increases were greater at nonoptimal deflection angles. Similarly, individual cells having smaller OFF responses for the short-duration stimulus tended to display proportionately greater increases when the stimulus was lengthened. OFF responses of trigeminal ganglion cells were largely unaffected by stimulus duration. 3. Barrel neurons were subclassified as regular-spike units (RSUs) or fast-spike units (FSUs) on the basis of the time course of their action potentials. ON and OFF responses were smaller in the former and, when the stimulus was lengthened, percentage increases in their OFF responses were greater than those in FSUs. Results illustrate nonlinear transformations of the thalamic input signal by RSUs, which are presumed to be excitatory barrel neurons, and extend previous findings of response similarities between thalamocortical units (TCUs) and FSUs, the latter of which are thought to be inhibitory. 4. The time course of OFF response suppression in cortical neurons suggests that stimulus onset evokes central inhibition having two components, a potent one lasting several tens of milliseconds and a weaker one lasting many hundreds of milliseconds. Background activity levels in cortex and thalamus were diminished for > or = 1,800 ms after whisker movement. 5. For TCUs, 200-ms stimuli were less likely than 1,400-ms stimuli to elicit an OFF response, but when responses occurred they consisted of a greater number of spikes timed closer together. By contrast, the 200-ms stimulus OFF responses of the RSUs and FSUs displayed longer interspike intervals than did their 1400-ms responses, with no change in the number of spikes per response.
Pittsburgh Post-Gazette, 2024
Pittsburgh Post-Gazette, 2024
Physics and cosmology have been in a deep rut for over 100 years, with mysteries multiplying and ... more Physics and cosmology have been in a deep rut for over 100 years, with mysteries multiplying and no solutions in sight. In order to salvage their paradigmatic Big Bang theory along with their main theory of gravitation--Einstein's theory of General Relativity--cosmologists have had to postulate that 95% of the (gravitating) matter and energy of the Universe is invisible to us as "dark matter" and "dark energy." Witness also the current belief in 29 "fundamental" fields all overlapping but somehow not interfering with each other, "expanding space," wave/particle duality of both light and matter, "quantum indeterminacy," and "spooky action at a distance."
These mysteries and puzzling ideas exist because physicists lack an understanding of the fundamental nature of the vacuum, matter, and ,consequently, gravity and its mechanism. A summary of a new, purely mechanical, atomistic paradigm is provided that actually explains rather than just merely describes.
Murmurs, 1990
Guest column in the University of Pittsburgh's medical school newsletter, containing my views aga... more Guest column in the University of Pittsburgh's medical school newsletter, containing my views against capital punishment and for the notions of compensating victims and work-as-rehabilitation for convicted criminals.
Pittsburgh Tribune-Review, 2000
Column in the Opinion and Commentary section of the Sunday, April 9th edition of the Pittsburgh T... more Column in the Opinion and Commentary section of the Sunday, April 9th edition of the Pittsburgh Tribune-Review. It presents my view of all victimless crimes, and how laws against such behavior force police either to violate peoples' natural rights to engage in behavior that does not directly harm others, or else not enforce such laws, damaging respect for law in general and providing tremendous incentives for corruption of law enforcement and our judicial system.
Pittsburgh Tribune-Review, 2020
There are many factors underlying “systemic racism” in the United States. One rarely mentioned bu... more There are many factors underlying “systemic racism” in the United States. One rarely mentioned but surprisingly vital root cause, however, is our system of land tenure. ... [This was published on July 9, 2020, during the George Floyd-inspired marches and associated riots. A link to the original newspaper column, which contains working links, is provided at the top of the docx file.]
Journal of Neurophysiology, 1996
Carbon fiber multibarrel glass microelectrodes were used to record extracellular single-unit acti... more Carbon fiber multibarrel glass microelectrodes were used to record extracellular single-unit activity during microiontophoretic application of gamma-aminobutyric acid (GABA) or bicuculline methiodide (BMI) onto layer IV barrel neurons in the somatosensory cortex of fentanyl-sedated rats. Excitatory and inhibitory aspects of the neurons' receptive fields were quantified with the use of controlled whisker stimuli. The principally activating whisker and one of its immediately adjacent neighbors were deflected alone or in paired combinations involving a condition-test paradigm. 2. Units were distinguished electrophysiologically on the basis of the time course of their action potential waveforms. Data were obtained from 26 regular-spike units (RSUs; presumed spiny stellate cells) and 7 fast-spike units (FSUs; presumed GABAergic neurons). An average of 15.0 nA of GABA produced a one-third to one-half reduction in RSU responses evoked by the maximally effective stimulus. An average of 8.7 nA of BMI was needed to counteract this reduction. This amount of BMI, in the absence of exogenous GABA, was found to increase average RSU and FSU responses by 98 and 53%, respectively, relative to predrug levels. 3. For RSUs, the BMI-induced twofold increase in responses evoked by moving the principal whisker at the neuron's best deflection angle was accompanied by an almost threefold increase in responses evoked by similarly moving an adjacent whisker. Disproportionately large percentage increases were also seen for responses to nonpreferred directions of principal and adjacent whisker movement. BMI thus effectively increased receptive field size and decreased angular tuning. Similarly, responses to stimulus offsets, which are normally smaller than ON responses, were increased proportionally more. 4. Predrug responses of FSUs were more vigorous than those of RSUs. However, FSUs showed a similar inverse relationship between percentage increase with BMI and initial response magnitude, although the proportional increases were less pronounced. 5. GABA, like BMI, had the greatest proportional effects on those responses that were initially smallest. It produced results opposite those of BMI, effectively decreasing receptive field size and sharpening angular tuning. 6. A previously described computational model of a barrel was tested for its ability to reproduce quantitatively the effects of BMI and GABA. The application of BMI was simulated by decreasing the strength of the inhibitory inputs onto the particular cell under study in the model network. GABA microiontophoresis was simulated by adding a constant hyperpolarizing voltage. The model RSUs and FSUs displayed proportional changes in response magnitude that were quantitatively similar to those of their biological counterparts. 7. Surround inhibition was greatly attenuated by BMI application, both for the real and simulated barrel neurons. Disinhibition was less pronounced for the former, perhaps because, unlike the simulated neurons, they also possess GABAB receptors, which are unaffected by BMI. 8. We conclude that the inhibitory receptive field properties of barrel neurons can be explained by intrabarrel inhibition and that the expansion of receptive field size and loss of angular tuning with BMI is due to an enhanced effectiveness of convergent, multi-whisker thalamocortical input. Examination of the model neurons' behavior suggests that the altered activity in response to GABA or BMI application, respectively, can be explained by the nonlinear effects of shifting somal membrane potential away from or toward the neuron's firing threshold.
Archives of Biochemistry and Biophysics, 1986
These studies addressed the question of the in vivo distribution of rat brain hexokinase (HK), an... more These studies addressed the question of the in vivo distribution of rat brain hexokinase (HK), and whether physiologically relevant changes in the glycolytic rate are accompanied by changes in the distribution of HK. Homogenates of fresh tissue showed only 11-15% of the overt (assayable without added detergent) HK to be soluble (found in high-speed centrifugation supernatant fractions) when homogenization was begun within 15-20 s of sacrifice. Freeze-blown rat brain tissue also was used, coupled with a new technique wherein it was homogenized as it thawed in a buffered sucrose solution containing 1 mM EDTA. In tissue sampled 15 min (anesthetized) or 60 min (waking) after ip Nembutal injection (40 mg/kg), 23% of the overt HK and 79% of the total lactate dehydrogenase were soluble. The average phosphocreatine content of these and similar homogenates had decreased only 23% from in vivo levels, while ATP had decreased by 65%, due to the combined effects of a high level of endogenous ATPase, chelation of Mg2+ by EDTA, and the greater stability of Mg-ATP2- relative to Mg-ADP1-. These data indicated that the tissue experienced, at most, the equivalent of 6 s of complete ischemia prior to the completion of homogenization. Synaptosomes derived from rat and chicken cerebra were incubated at 37 degrees C in a physiological salt solution containing 10 mM glucose. Addition of veratridine has been shown to stimulate glycolysis and oxidative phosphorylation two- to threefold (H. T. Kyriazi and R. E. Basford (1986) J. Neurochem., in press), but did not alter the HK distribution, as 21% was found in the supernatant fractions of both control and veratridine-stimulated synaptosomes treated with digitonin. These results indicate that in brain tissue, large net movements of HK on and off the outer mitochondrial membrane do not occur, and thus play no role in the regulation of glycolysis.
American Journal of Economics and Sociology, 2004
Conclusion: Murray Rothbard was no land economist. He carefully sniffed the Georgist literature, ... more Conclusion: Murray Rothbard was no land economist. He carefully sniffed the Georgist literature, detected a faint aroma of socialism, felt the presence of The State, with whose stench he was already thoroughly familiar, and without bothering to root out the minor socialist aspect of traditional Georgism or to consider Chodorov’s suggested decentralized implementation, threw the baby out with the bathwater. His views on the land question were intellectually consistent, but entirely flawed, and reminiscent of the complexly interwoven, delusional alternate realities dreamed up by clever paranoid-schizophrenics. He had an answer to everything, and all of his answers were wrong. His “alternate reality” was based on a failure to understand a) the positive spatial externalities attaching to land use, b) that the contributions of these to the value of individual parcels of land could be separately assessed, c) the vicious cycle nature of purely private land ownership, and d) that any system that permits all land to be privately appropriated in a fashion that excludes some, is, to the excluded, inherently coercive, depriving them of basic rights. Rothbard wrote that great thinkers, “however great they may have been, ... can slip into error and inconsistency, and even write gibberish on occasion.” As we have seen, he himself was not immune, but this should not lead us to disparage his immense contribution to the reawakening of the spirit of liberty in the latter half of the twentieth century, much as Henry George provided in the final twenty years of the previous one, and beyond.
Brain Research, 1996
Extracellular single-unit recordings were made in somatosensory cortical barrels of fentanyl-seda... more Extracellular single-unit recordings were made in somatosensory cortical barrels of fentanyl-sedated rats. Whiskers were deflected singly or in paired combinations. Iontophoretically-applied (-)-baclofen disproportionately reduced weak responses, and phaclofen disproportionately increased them, resulting in more tightly focused or more broadly focused receptive fields, respectively. Both drugs had only minor effects on surround inhibition. In light of previous findings, we conclude that GABA-A and GABA-B mechanisms both act to enhance spatial contrast, but that the former plays a much greater role in enhancing temporal resolution.
Journal of Neurochemistry, 1986
Synaptosomes prepared and incubated in a variety of ways from rat cerebra exhibited intractable, ... more Synaptosomes prepared and incubated in a variety of ways from rat cerebra exhibited intractable, unphysiologically low adenylate energy charge values (~0.37-0.60), low total adenine nucleotide contents (~8-10 nmol/mg protein), and much higher adenylate kinase apparent Keq values (~3-8) as compared to intact brain tissue (values of ~0.90, 25 nmol/mg, and 0.74; respectively). Synaptosomes prepared from mouse, dog, and chicken cerebra had values essentially identical to those from rat. When incubated under oxygen in a physiological salt solution containing glucose, synaptosomes metabolized more glucose to lactic acid than to CO2, and the addition of 100 microM veratridine caused a two- to threefold stimulation of O2 uptake, lactate accumulation, and CO2 output. It is known that synaptosome fractions contain a substantial number (at least 30-45% by volume) of cytoplasm-containing particles devoid of mitochondria (henceforth termed "cytosolic particles"), and that approximately 80% of brain hexokinase is bound to the outer mitochondrial membrane. For the cytosolic particles, lacking oxidative phosphorylation, to maintain their "in vivo" ATP turnover would require about a 19-fold increase in the glycolytic rate, which is not possible due to limiting amounts of hexokinase, and thus these particles are postulated to be responsible for the high level of aerobic lactate accumulation and the intractable low energy charge values found in synaptosome fractions. The mitochondria-containing particles are postulated to have a normal energy charge, a submaximal glycolytic rate, and minimal lactate production, on the basis of the capacity of veratridine to stimulate synaptosomal O2 uptake and CO2 and lactate output. Calculations based on this "two populations of particles" hypothesis indicate that for synaptosome fractions in general, (1) the cytosolic particles contain approximately 35-64% of the total adenine nucleotides and maintain an energy charge of approximately 0.12; (2) the cytosolic particles and mitochondria-containing particles have adenylate kinase apparent Keq values of approximately 0.21-1.66 and 0.74, respectively, revealing that the higher apparent Keq values of the synaptosome fractions probably are not real departures from equilibrium: and (3) approximately 31-45% of synaptosome fraction protein is contained in debris, which, when taken into account, yields total adenine nucleotide contents in the cytosolic particles and mitochondria-containing particles of approximately 15-24 and approximately 11-19 nmol/mg of particle protein, respectively.
The Pragmatist, 1997
A professional biochemist (me) debunks Behe's "irreducible biochemical complexity" argument again... more A professional biochemist (me) debunks Behe's "irreducible biochemical complexity" argument against evolution.
The Pragmatist, 1997
Part of a Forum discussion about the basis of human rights, i.e., individual freedom, with me arg... more Part of a Forum discussion about the basis of human rights, i.e., individual freedom, with me arguing for rights arising naturally and necessarily from our evolved desire to survive and prosper maximally, and another libertarian/anarchist arguing that only a minority of people really value their individual liberty, with the latter having no basis other than personal preference (i.e., that there's no moral or practical basis for human rights).
The Pragmatist, 1996
Half of a debate Forum in The Pragmatist, with me arguing, from a minarchist (minimalist governme... more Half of a debate Forum in The Pragmatist, with me arguing, from a minarchist (minimalist government) perspective, for public safety, restitution (to both victims and taxpayers) via rehabilitative gainful employment (with entrepreneurs hiring convicts to work in prison), vs. an anarcho-capitalist view of criminal justice, based upon the principle of restitution and a free market in policing.
Analytical Biochemistry, 1985
The enzymatic inosine 5'-monophosphate assay described by Grassl [in Methods of Enzymatic Analysi... more The enzymatic inosine 5'-monophosphate assay described by Grassl [in Methods of Enzymatic Analysis (H. U. Bergman, ed.) pp. 2168-2171, Academic Press, New York (1974)] is highly nonspecific, as ITP, ATP, ADP, AMP and adenosine react stoichiometrically. The reactivity with the adenine derivatives is due to the tri- and diphosphatase activity of alkaline phosphatase (AP), coupled with adenosine deaminase (and possibly AMP deaminase) contamination of commercially available preparations of AP, purine-nucleoside phosphorylase, and/or xanthine oxidase. The inclusion of coformycin (0.05ug/ml), a potent inhibitor of these deaminases, completely inhibited the cross-reactivity. ITP, however, still reacted stoichiometrically due to the tri- and diphosphatase activity of AP. Meyer and Terjung [Amer. J. Physiol. 237 C111-C118 (1979)] introduced a modification of Grassl's procedure, substituting 5'-nucleotidase for AP. It has been found that this disallows reactivity with ATP, ADP and ITP, but that AMP and adenosine still react completely. Coformycin prevents this cross-reactivity. It is therefore recommended that the assay be carried out with 5-nucleotidase (instead of AP) and coformycin, in order to achieve a more specific assay, and one more suitable for use with whole tissue extracts.
Journal of Neurophysiology, 1999
Layer IV of rodent primary somatosensory cortex is characterized by an array of whisker-related g... more Layer IV of rodent primary somatosensory cortex is characterized by an array of whisker-related groups of neurons, known as “barrels.” Neurons within each barrel respond best to a particular whisker on the contralateral face, and, on deflection of adjacent whiskers, display relatively weak excitation followed by strong inhibition. A prominent hypothesis for the processing of vibrissal information within layer IV is that the multi-whisker receptive fields of barrel neurons reflect interconnections among neighboring barrels. An alternative view is that the receptive field properties of barrel neurons are derived from operations performed on multi-whisker, thalamic inputs by local circuitry within each barrel, independently of neighboring barrels. Here we report that adjacent whisker-evoked excitation and inhibition within a barrel are unaffected by ablation of the corresponding adjacent barrel. In supra-granular neurons, on the other hand, excitatory responses to the ablated barrel’s associated whisker are substantially reduced. We conclude that the layer IV barrels function as an array of independent parallel processors, each of which individually transforms thalamic afferent input for subsequent processing by horizontally interconnected circuits in other layers.
This is an early (2013) version of my development of "Gyron Aether Theory.," at which time I had ... more This is an early (2013) version of my development of "Gyron Aether Theory.," at which time I had not yet grasped the underlying basis of electric charge and magnetism. It belongs in the "unpublished" section here (viXra.org is not a peer-reviewed website). I subsequently broke the theory down into 5 parts, and developed each part much more fully, posting those manuscripts in the "drafts" section here on Academia.
Issues in Medical Ethics, 2001
SUMMARY Given the above considerations, were I a transplant surgeon in India, I would have five ... more SUMMARY
Given the above considerations, were I a transplant surgeon in India, I would have five relevant ethical concerns:
1. Economic justice: support the establishment of genuine economic justice.
2. Cadaveric vs. living donors: support a transition from a system emphasizing living donors to one relying mostly on cadaver organs from those who have suffered brain death.
3. Fair compensation: try to ensure that donors are paid as much as possible (since the current market contains some degree of exploitation, due to the entrenched economic injustice). In practice, this would entail dealing only with organ brokers who treat donors fairly.
4. Do no harm: over and above the usual concerns expressed in the Hippocratic Oath, take all reasonable steps to ensure that patients have adequate follow-up care and legal options for redress of grievances.
5. Legalize organ selling: because the above-mentioned legal options are unlikely to be feasible under a black market system (lawbreakers rarely wish to attract legal attention to their own “criminal” behavior), one must seek to remove the laws banning organ selling. Their existence, in an atmosphere in which black market activity nevertheless thrives, not only places those involved outside the protection of the law, but engenders disrespect for law and law enforcement in general, to the detriment of society. More importantly from an immediate standpoint, removing the ban will free the operations from the clutches of organized crime, and make transplants less expensive for recipients, less exploitative of poor donors, and less dangerous for all involved.
The Journal of Neuroscience, 1993
Layer IV of rodent somatosensory cortex contains identifiable networks of neurons, called "b... more Layer IV of rodent somatosensory cortex contains identifiable networks of neurons, called "barrels," that are related one-to-one to individual whiskers on the face. A previous study (Simons and Carvell, 1989) described differences between the response properties of thalamic and cortical vibrissa neurons and proposed that these transformations can be explained by several features of barrel anatomy and physiology: nonlinear neuronal properties, strongly responsive inhibitory and less responsive excitatory neurons, convergent thalamic inputs to cells of both types, and interconnections among barrel neurons. In the present study these features were incorporated into a computational model in order to test their explanatory power quantitatively. The relative numbers of excitatory and inhibitory cells and the relative numbers of synapses of thalamic and intrabarrel origin were chosen to be consistent with available light and electron microscopic data. Known functional differences between excitatory and inhibitory barrel neurons were simulated through differences in spike activation functions, refractory periods, postsynaptic potential decay rates, and synaptic strengths. The model network was activated by spike trains recorded previously from thalamic neurons in response to three different whisker deflection protocols, and output, which consisted of spikes generated by the simulated neurons, was compared to data from our previous neurophysiological experiments. For each type of whisker stimulus, the same set of parameter values yielded accurate simulations of the cortical response. Realistic output was obtained under conditions where each barrel cell integrated excitatory and inhibitory synaptic inputs from a number of thalamic and other barrel neurons and where the ratios between network excitation, network inhibition, and thalamic excitation were approximately constant. Several quantities are defined that may be generally useful in characterizing neuronal networks. One important implication of the results is that thalamic relay neurons not only provide essential drive to the cortex but could, by changing their tonic activities, also directly regulate the tonic inhibition present in the cortex and thereby modulate cortical receptive field properties.
Journal of neurophysiology, 1994
1. Previous studies have demonstrated marked differences in the relative sizes of ON and OFF resp... more 1. Previous studies have demonstrated marked differences in the relative sizes of ON and OFF responses of neurons in the whisker/barrel system. In particular, OFF responses are unexpectedly large in thalamic neurons. Extracellular unit recordings were used to examine whether varying the time between stimulus onset and offset differently affects OFF responses of neurons in the trigeminal ganglion, ventrobasal thalamus, and somatosensory cortical layer IV. Controlled whisker stimuli were used to deflect individual vibrissal hairs in different directions. We hypothesized that, in part because of the gradual waning of central inhibition evoked by stimulus onset, OFF responses of thalamic and cortical neurons but not trigeminal ganglion cells would increase in size with longer duration stimuli, with relative changes being greatest in the cortex. 2. OFF response magnitudes for thalamic and cortical neuronal populations increased as the stimulus duration was increased from 200 to 1,400 ms. Increases were greater at nonoptimal deflection angles. Similarly, individual cells having smaller OFF responses for the short-duration stimulus tended to display proportionately greater increases when the stimulus was lengthened. OFF responses of trigeminal ganglion cells were largely unaffected by stimulus duration. 3. Barrel neurons were subclassified as regular-spike units (RSUs) or fast-spike units (FSUs) on the basis of the time course of their action potentials. ON and OFF responses were smaller in the former and, when the stimulus was lengthened, percentage increases in their OFF responses were greater than those in FSUs. Results illustrate nonlinear transformations of the thalamic input signal by RSUs, which are presumed to be excitatory barrel neurons, and extend previous findings of response similarities between thalamocortical units (TCUs) and FSUs, the latter of which are thought to be inhibitory. 4. The time course of OFF response suppression in cortical neurons suggests that stimulus onset evokes central inhibition having two components, a potent one lasting several tens of milliseconds and a weaker one lasting many hundreds of milliseconds. Background activity levels in cortex and thalamus were diminished for > or = 1,800 ms after whisker movement. 5. For TCUs, 200-ms stimuli were less likely than 1,400-ms stimuli to elicit an OFF response, but when responses occurred they consisted of a greater number of spikes timed closer together. By contrast, the 200-ms stimulus OFF responses of the RSUs and FSUs displayed longer interspike intervals than did their 1400-ms responses, with no change in the number of spikes per response.
According to gyron aether theory (GAT), the strong vortices constituting matter are in constant ... more According to gyron aether theory (GAT), the strong vortices constituting matter are in constant competition for ideal spin rate gyrons with the weaker vortices constituting the vacuum. Matter vortices have crossed a dynamic and structural threshold, engaging a positive feedback loop that maintains their distinction from vacuum vortices. It seems likely that matter vortices have continued, slowly, to strengthen at the expense of vacuum ones since the present cycle of the Universe began, billions of years ago. In addition, it is possible that a small part of the weakening of the matrix of vacuum vortices is due to an increase in the amount of black hole matter—which conceivably could sequester more “vortex engine gyron” spinners than ordinary matter—and/or de novo matter synthesis in the void spaces between galactic filaments and walls. However produced, the gradual weakening of the matrix, along with the much greater strengthening of the vortices of ordinary matter, has resulted in the redshift/distance relationship observed with other galaxies, which has mistakenly either been reasonably interpreted as a Doppler shift or unreasonably as the “spatial expansion” of Big Bang theory. Similar to Fritz Zwicky’s 1929 “tired light” hypothesis, the GAT interpretation includes a “tiring vacuum” component, although “strengthening matter” is judged to be the larger factor. The GAT version of “dark matter,” including a possible mechanism underlying Milgrom’s modified Newtonian dynamics hypothesis, is presented. An acceleration of the rate of matrix weakening and concomitant matter strengthening (and possibly matter creation) can account for the evidence for “dark energy.” The progressive and accelerating strengthening of matter and weakening of the matrix, along with alterations of the matrix’s self-sustaining gravitational gyron (GG) flux, will lead eventually to a Big Dissolution of all vortices, followed by a “Down Time” of undetermined duration, during which the GG flux will rapidly diminish and almost certainly disappear completely, whereupon passive diffusion of gyrons will predominate before vortices once again form everywhere in another Big Crystallization. The Universe, according to GAT, is already infinite in extent, not “expanding,” and galaxies are not, on average, receding from one another. Gravity transitioning to repulsive at large distances keeps most galaxies apart. The possibility of an infinite Universe cycling more or less together, triggered (and synchronized) by widespread hotspots of both dissolution and crystallization, is discussed, along with possible mechanisms to explain the secondary, atomic-level matter/antimatter imbalance (charge neutral atoms having been hypothesized to consist of equal numbers of electrons and positrons, i.e., equal parts matter and antimatter), the theory’s main strengths and weaknesses, questions yet to answer, current paradigm major mysteries solved, and ways forward for the theory.
Gyrons are the needle-like, fundamental, Planck-length size particles proposed to underlie existe... more Gyrons are the needle-like, fundamental, Planck-length size particles proposed to underlie existence. Gravitational gyrons (GGs), the quanta of gravity, are lengthwise and greatly superluminally travelling gyrons ejected from the toroidal vortices constituting both matter and the vacuum. Gravity, according to gyron aether theory, results from the difference in outward GG pressure produced by matter’s vortices vs. those of the vacuum. The GGs ejected by vacuum vortices are less well-aligned, present a larger cross-section as they travel, and thus tend to collide closer to their ejecting vortices than those of matter, generating greater outward pressure at sub-galactic supercluster distances than matter vortices, the latter of which thus, at these relatively close distances, represent regions of negative GG pressure. Thus, we are not “attracted” to the earth, but simply pushed downward by the vacuum above us. Because the GGs ejected by matter vortices tend to travel farther than those of their vacuum counterparts, gravity transitions to repulsive beyond galactic cluster distance, offering a reasonable explanation for the Universe’s large-scale grouping of galaxies into filaments and sheets separated by large void spaces. The strength of the gravitational “constant” can increase with distance prior to going negative, and that variation can help provide a reasonable substitute for “dark matter,” along with a weaker makeup of both vacuum and matter vortices in less matter-dense regions of space. Neutron stars and black holes are expected to display aether drag, and rapidly orbiting binary systems of them generate strong, periodic compression/rarefaction waves in the plane of their mutual orbit, which have been detected as gravitational waves. Supermassive black holes may display the surprising property of both attracting and being repulsed by nearby matter if they have significant levels of “self-shielding.” If a strong magnetic field can precisely and rapidly orient the protons (and hence GG streams) of liquid H2, it could constitute a directional transmitter capable of virtually instantaneous signaling across the galaxy.
Part II of this series showed the vacuum plausibly to be a diffuse gas of myriad, inert, Planck l... more Part II of this series showed the vacuum plausibly to be a diffuse gas of myriad, inert, Planck length, fast-moving, needle-like fundamental particles termed gyrons that naturally and periodically evolves over cosmic time scales into a Universe-wide, light- and neutrino-carrying medium that consists of a densely packed matrix of jointly self-sustaining toroidal vortices, each vortex containing ~10^55 gyrons. Electrons and positrons are postulated to be oppositely-twisting, stronger versions of vacuum vortices. The mathematical identity between Lorentz’s theory of a fixed ether and Einstein’s theory of special relativity tells us that both are equally valid, suggesting that the vacuum matrix is largely fixed. The vortices of matter and the vacuum must differ in some significant way so as to allow the former to move through the matrix of the latter. A 2-electron, 3-positron (1+3+1) axially symmetric structure for the proton, and proton+electron structure for the neutron, are postulated, that seem capable of accounting for the quantized, and equal and opposite, aspects of charge, the much greater mass of nucleons vs. their constituent leptons, the existence and nature of quarks and gluons, as well as the proton’s great stability vis a vis free neutrons. The nucleons’ non-close-packed structure may cause “melting” of adjacent matrix and, in conjunction with collisions with the longitudinally oriented and vastly superluminal “gravitational gyrons” (GGs; ejected by vortices), result in net zero resistance passage (i.e., “inertial movement”). The much greater mass of the “bound” electrons and positrons constituting nucleons is postulated to be due ultimately to their having a much greater increment of gyrons incorporated into their structure than their free versions (for a total of ~2-3*10^55 gyrons). The supposed cosmological “matter/anti-matter imbalance” disappears with these proposed nucleon substructures, leaving only the question of whether a second order imbalance exists such that atomic matter everywhere consists solely of nuclei of protons and neutrons surrounded by electron clouds, rather than being an approximately equal mix, on a multi-galaxy scale, with nuclei of antiprotons and antineutrons surrounded by positron clouds. Even this possible secondary imbalance may be largely illusory, as many nuclei here on earth likely contain some antiprotons and antineutrons, based on the existence of positron emission from some radioactive nuclei. Groupings of these composite nucleons yield atomic nuclei that are stable because: 1) protons are essentially non-repulsive at these close separations, 2) the vortices’ reactive tangential surface forces (the precursor and source of “charge”) help to maintain the component vortices’ positions and mutual orientations, and 3) “micro-shadow gravity” exists in the form of collisions of their dense cores with the omnidirectional flux of GGs, pushing the component vortices together. Together, these factors constitute the attractive aspect of the strong nuclear force. These “nuclei of nuclei” combinations can yield triangular- and planar-symmetric, and hence presumably highly stable, structures for He-4 and Li-7, concomitantly explaining the great instability of nuclei of 5 and 8 nucleons. Vortex tangential surface forces suggest plausible mechanical explanations for electromagnetic phenomena, as dreamt of by 19th century physicists. The unusual combination of linear and rotational forces operating between adjacent vortices, along with long-range orientation-stabilizing mutual effects of widely separated co-linear vortices in the matrix, offer the hope of providing mechanical explanations for the wave/particle duality of light and various other quantum mechanical phenomena.
A purely mechanical, gaseous atomistic aether is presented, which. in the absence of action-at-a-... more A purely mechanical, gaseous atomistic aether is presented, which. in the absence of action-at-a-distance forces, violates the 2nd law of thermodynamics by maintaining---and plausibly having created from a less ordered state---a universal, tightly packed matrix of toroidal vortices that constitutes the vacuum, a.k.a. the luminiferous aether. Matter consists of collections of left-and right-twisting, stronger versions of the vacuum vortices. The postulated fundamental corpuscles, termed "gyrons," have a unique, extremely skinny barbell-like shape and are Planck length in length. Some gyrons, termed "spinners," have a high degree of orientation-stabilizing axial spin which, in conjunction with a co-orienting tendency upon collision, along with all gyrons' essentially line-like shape and greater shape-dependent z-axis "viscosity" when side-by-side, is conjectured to result in a self-grouping tendency of like-oriented spinners, leading them to form cylindrically-shaped flocks. Such flocks are most stable as rings and when adjacent to cross-oriented flocks, and are conjectured to evolve ultimately---and periodically over cosmic time scales---into the vacuum matrix. The vortices collectively generate a gravitational aether consisting of an omnidirectional flux of greatly superluminal streams of lengthwise-oriented gyrons ejected from vortex funnels, that, in turn, is responsible not only for gravity, but for helping the vortices to maintain one another. Kinetic rationales for these dynamic features are provided.
Four common misconceptions that inhibit consideration of subquantum level atomism are discussed. ... more Four common misconceptions that inhibit consideration of subquantum level atomism are discussed. Given our evolution in our macroscopic world of objects moving about freely and interacting in a largely mechanical cause-and-effect fashion, it follows that if a viable form of philosophic atomism were to be developed, devoid of mysterious "action-at-a-distance" forces, it would provide the ideal "Theory of Everything," being intuitively comprehensible. In contrast to atomism, all of the more ontologically primitive theoretical entities in current mainstream physics are unvisualizable and ontologically indistinguishable from a non-volitional, "zombie" type of spiritualism. Given that almost every other reason mankind has had for believing in spirits has found better explanation in terms of invisible-to-the-naked-eye material entities, it seems reasonable that the "law-abiding spirits" of contemporary physics and cosmology may similarly find their explanation in atomistic entities that are too small to be detected directly by experiment. A theory based on such inert, sub-quantum level fundamental entities will be presented in subsequent articles in this series.
Libertarian Party at Sea on Land, 2000
I’m a libertarian. I believe that the ideas embodied by the libertarian movement in general, and ... more I’m a libertarian. I believe that the ideas embodied by the libertarian movement in general, and the Libertarian Party in particular, represent humanity’s only hope for a future worth living. But I also think the Libertarian Party and the majority of today’s libertarians (along with almost everyone else) are wrong about a seemingly insignificant, but fundamental aspect of political philosophy — our system of ownership of land and other natural resources — and have strayed far from our classical liberal roots. I believe that a recognition of this aberration, and a return to our roots, will open up a common ground, of economic freedom and justice, on which freedom lovers of all persuasions — left, right, and libertarian — may join together in an unbeatable coalition. The future is ours for the taking, if only we’ll all do a bit more studying! This essay is written toward that end.