Zelia Ferreira Worman | University of Pittsburgh (original) (raw)

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Papers by Zelia Ferreira Worman

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Orthologue nonhuman primate sequences were used to infer the ancestral state at each sit... more Orthologue nonhuman primate sequences were used to infer the ancestral state at each site. SNPs typed in HapMap phaseII are shown on a white background; SNPs not typed by HapMap are shown on a grey background. Numbers indicate the chromosome position of each polymorphic site, based on a NC000018 reference sequence. Non-synonymous and synonymous sites are labeled. SNPs with a significant iHS statistic are marked by an asterisk.</p

*Haplotype E90-T181-P303.•Blood Group Antigen genes significantly ass... more *Haplotype E90-T181-P303.•Blood Group Antigen genes significantly associated with pathogen richness <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0032518#pone.0032518-Fumagalli1" target="_blank">[33]</a>. ABO: ABO blood group; AQP3: Aquaporin 3; CD44: CD44 antigen; CD55: CD55 antigen; CIGALT1: Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1; ERMAP: Erythroblast membrane-associated protein; FUT2: Fucosyltransferase 2; GCNT2: glucosaminyl (N-acetyl) transferase 2, I-branching enzyme; GYPC: Glycophorin C; SLC4A1: Solute carrier family 4, anion exchanger, member 1; SLC14A1: Solute carrier family 14, member 1.</p

Upper diagram shows the relative position of the SERPINB genes in the... more Upper diagram shows the relative position of the SERPINB genes in the cluster and lower diagram shows SERPINB11 gene organization (exons are represented by grey boxes). Large white arrows indicate the extent of segments surveyed in the resequencing study of the YRI population.</p

aModel assuming a single ω value for all lineages in the phylogeny;bM... more aModel assuming a single ω value for all lineages in the phylogeny;bModel assuming diferent ω values for each lineage in the phylogeny – value obtained for the human lineage;cModel assuming a different ω value in foreground branch (in this case human lineage);dSites Classes: 0 – sites under constrains; 1 – neutral sites; 2a – constrained sites under positive selection in the foreground branch; 2b – neutral sites under positive selection in the foreground branch. NS – non-significant; NA – not applicable.</p

aN – number of chromosomes.bL – total number of sites surveyed.</p... more aN – number of chromosomes.bL – total number of sites surveyed.cS – number of segregating sites.dπ – Nucleotide diversity per base pair (×104).eθW – Population mutation rate parameter: Watterson's estimator of θ (4Neμ) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0032518#pone.0032518-Watterson1" target="_blank">[94]</a> per base pair (×104).fD – Tajima's D statistic <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0032518#pone.0032518-Tajima1" target="_blank">[21]</a>.gρ – Population recombination rate parameter: Hudson's estimator of ρ (4Ner) per base pair (×104), based on a conversion-to-crossover ratio of 2 and a mean conversi...

Column headers are as follows: Male=Male genotype; SVS1:SVS5=abundance of each protein band/sum o... more Column headers are as follows: Male=Male genotype; SVS1:SVS5=abundance of each protein band/sum of the abundances of the four protein bands; Total=Absolute value of abundance of 4protein band

Column headers are as follows:Male= Male genotype; Male No= Individual male's ID; Date of Bir... more Column headers are as follows:Male= Male genotype; Male No= Individual male's ID; Date of Birth= Male's date of birth; Body Weight (g)= Body weight at dissection; Seminal Vesicle Weight (g)=Absolute weight of the left seminal vesicle; Right Testis Weight (g)= Absolute weight of the right testis; Left Testis Weight (g)= Absolute weight of the left testi

Column headers as follows: Female=Female genotype; Male= Male genotype; Male No= Individual male&... more Column headers as follows: Female=Female genotype; Male= Male genotype; Male No= Individual male's ID; Time After Split (hrs)= Time (hrs) between mating and dissection; Plug (Y/N)= Indicating if the plug was still present at time of dissection; Mating (Y/N)= Indicates if a plug was present after experimental cross; Weight of Plug (g)= The absolute mass of the plug (NA indicates non successful mating); Weight of Female (g): Weight of female at dissection; Female DOB: Female's date of birth; Dissection Date= Date female was euthanize

Across a diversity of animals, male seminal fluid coagulates upon ejaculation to form a hardened ... more Across a diversity of animals, male seminal fluid coagulates upon ejaculation to form a hardened structure known as a copulatory plug. Previous studies suggest that copulatory plugs evolved as a mechanism for males to impede remating by females, but detailed investigations into the time course over which plugs survive in the female’s reproductive tract are lacking. Here, we cross males from eight inbred strains to females from two inbred strains of house mice (Mus musculus domesticus). Plug survival was significantly affected by male genotype. Against intuition, plug survival time was negatively correlated with plug size: long-lasting plugs were small and relatively more susceptible to proteolysis. Plug size was associated with divergence in major protein composition of seminal vesicle fluid, suggesting that changes in gene expression may play an important role in plug dynamics. In contrast, we found no correlation to genetic variation in the protein-coding regions of five genes thought to be important in copulatory plug formation (Tgm4, Svs1, Svs2, Svs4 and Svs5). Our study demonstrates a complex relationship between copulatory plug characteristics and survival. We discuss several models to explain unexpected variation in plug phenotypes

eLife, Jan 16, 2017

The underground environment imposes unique demands on life that have led subterranean species to ... more The underground environment imposes unique demands on life that have led subterranean species to evolve specialized traits, many of which evolved convergently. We studied convergence in evolutionary rate in subterranean mammals in order to associate phenotypic evolution with specific genetic regions. We identified a strong excess of vision- and skin-related genes that changed at accelerated rates in the subterranean environment due to relaxed constraint and adaptive evolution. We also demonstrate that ocular-specific transcriptional enhancers were convergently accelerated, whereas enhancers active outside the eye were not. Furthermore, several uncharacterized genes and regulatory sequences demonstrated convergence and thus constitute novel candidate sequences for congenital ocular disorders. The strong evidence of convergence in these species indicates that evolution in this environment is recurrent and predictable and can be used to gain insights into phenotype-genotype relationships.

Empirical distributions of Tajima's D and  built using the 316 genes surveyed by SeattleSNPs (ht... more Empirical distributions of Tajima's D and  built using the 316 genes surveyed by SeattleSNPs (http://pga.gs.washington.edu/. Genes within the upper extreme of the distribution are marked in grey. Gene classes with values close to survey genes are indicated by WFDC gene name. A and B: CEU samples-SeattleSNPs panels 1 to 3. C and D: YRI sample-SeattleSNPs panel 2. E and

Letters in Drug Design & Discovery, 2006

The aging of the Portuguese population is a reality. It is imperative that society has the capaci... more The aging of the Portuguese population is a reality. It is imperative that society has the capacity to face the specific necessities of those who are in this phase of their lives. Therefore, this change in the demographics requires investment in scientific knowledge in order to know the consequences at levels such as: the economic, social cultural, biological and physical, mainly related to health. The main purpose of this study has been to evaluate the perceptions of elderly people concerning their health conditions. There were nine institutions involved, which are referred to as nursing homes, and a sample of 75 people between 66 and 100 yearsold, from both genders, cooperated. Data has been collected through socialdemographic, Mini Mental State and also through the questionnaire of the selfevaluation of health and physical well-being (from Fonseca and Paúl, 1999). The obtained data was worked within a perspective of descriptive/ inference statistic. From this analysis, it was determined that the great majority of the sample describes their perception of health as "acceptable" or "weak", in general; the socialdemographic information and the institution to where each person belongs do not show a connection with their perception of their health condition; however, there seems to be a significant relation between an institutionalized elderly person´s perception of their health condition and their spouse's health, mainly when related to physical issues. In as far as life styles are concerned, do not show a connection between elderly people's perception of health and smoking habits and alcohol habits. The obtained data does not always match expectations; nevertheless they make sense when being complemented by the theory.

eLife, Jan 16, 2017

Letters in Drug Design & Discovery, 2006