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Papers by Mark Rosenfeld

Research paper thumbnail of Compounds for use in weight loss and appetite suppression in humans

Research paper thumbnail of Novel compounds for use in weight loss and appetite suppression in humans

Research paper thumbnail of Compounds for use as antidepressants, aphrodisiacs and adjunctive therapies in humans

Research paper thumbnail of Methods for augmenting immune defenses contemplating the administration of phenolic and indoleamine-like compounds for use in animals ans humans

Research paper thumbnail of Novel compounds for use as antidepressants, aphrodisiacs and adjunctive therapies in humans

Research paper thumbnail of Peptides from the E2 proteins of human papillomaviruses 16 and 18 for detecting and/or diagnosing cervical and other human papillomavirus associated cancers

Research paper thumbnail of Peptides from the E7 protein of human papilloma viruses 16 and 18 for detecting and/or diagnosing cervical and other human papilloma virus associated cancers

Research paper thumbnail of Methods for Inducing Anti-Anxiety and Calming Effects in Animals and Humans

Research paper thumbnail of Peptides from the E2, E6, and E7 proteins of human papilloma viruses 16 and 18 for detecting and/or diagnosing cervical and other human papillomavirus associated cancers

Research paper thumbnail of Cannabinoids for neuropathic pain

Current pain and headache reports, 2014

Treatment options for neuropathic pain have limited efficacy and use is fraught with dose-limitin... more Treatment options for neuropathic pain have limited efficacy and use is fraught with dose-limiting adverse effects. The endocannabinoid system has been elucidated over the last several years, demonstrating a significant interface with pain homeostasis. Exogenous cannabinoids have been demonstrated to be effective in a range of experimental neuropathic pain models, and there is mounting evidence for therapeutic use in human neuropathic pain conditions. This article reviews the history, pharmacologic development, clinical trials results, and the future potential of nonsmoked, orally bioavailable, nonpsychoactive cannabinoids in the management of neuropathic pain.

Research paper thumbnail of Biochemical Genetics of the Colorado River Gila Complex (Pisces: Cyprinidae)

The Southwestern Naturalist, 1989

Page 1. THE SOUTHWESTERN NATURALIST 34(2):232-244 JUNE 1989 BIOCHEMICAL GENETICS OF THE COLORADO ... more Page 1. THE SOUTHWESTERN NATURALIST 34(2):232-244 JUNE 1989 BIOCHEMICAL GENETICS OF THE COLORADO RIVER GILA COMPLEX (PISCES: CYPRINIDAE) MARK J. ROSENFELD AND JEFFERY A. WILKINSON ...

Research paper thumbnail of The Endocannabinoid System, Cannabinoids, and Pain

Rambam Maimonides Medical Journal, 2013

The endocannabinoid system is involved in a host of homeostatic and physiologic functions, includ... more The endocannabinoid system is involved in a host of homeostatic and physiologic functions, including modulation of pain and inflammation. The specific roles of currently identified endocannabinoids that act as ligands at endogenous cannabinoid receptors within the central nervous system (primarily but not exclusively CB1 receptors) and in the periphery (primarily but not exclusively CB2 receptors) are only partially elucidated, but they do exert an influence on nociception. Exogenous plant-based cannabinoids (phytocannabinoids) and chemically related compounds, like the terpenes, commonly found in many foods, have been found to exert significant analgesic effects in various chronic pain conditions. Currently, the use of Δ9-tetrahydrocannabinol is limited by its psychoactive effects and predominant delivery route (smoking), as well as regulatory or legal constraints. However, other phytocannabinoids in combination, especially cannabidiol and β-caryophyllene, delivered by the oral route appear to be promising candidates for the treatment of chronic pain due to their high safety and low adverse effects profiles. This review will provide the reader with the foundational basic and clinical science linking the endocannabinoid system and the phytocannabinoids with their potentially therapeutic role in the management of chronic pain.

Research paper thumbnail of Persistence of the SV40 early region without expression in permissive simian cells

Virus Research, 1994

SV40 containing recombinant vectors were introduced into permissive simian, non-permissive rodent... more SV40 containing recombinant vectors were introduced into permissive simian, non-permissive rodent and semi-permissive human cell lines, and assayed for transformation. All mouse and human cell clones expressed T-antigen (T-Ag) and were morphologically transformed when they contained only the wt TAg gene (ESV40) or the entire wt viral

Research paper thumbnail of Compounds for use in weight loss and appetite suppression in humans

Research paper thumbnail of Novel compounds for use in weight loss and appetite suppression in humans

Research paper thumbnail of Compounds for use as antidepressants, aphrodisiacs and adjunctive therapies in humans

Research paper thumbnail of Methods for augmenting immune defenses contemplating the administration of phenolic and indoleamine-like compounds for use in animals ans humans

Research paper thumbnail of Novel compounds for use as antidepressants, aphrodisiacs and adjunctive therapies in humans

Research paper thumbnail of Peptides from the E2 proteins of human papillomaviruses 16 and 18 for detecting and/or diagnosing cervical and other human papillomavirus associated cancers

Research paper thumbnail of Peptides from the E7 protein of human papilloma viruses 16 and 18 for detecting and/or diagnosing cervical and other human papilloma virus associated cancers

Research paper thumbnail of Methods for Inducing Anti-Anxiety and Calming Effects in Animals and Humans

Research paper thumbnail of Peptides from the E2, E6, and E7 proteins of human papilloma viruses 16 and 18 for detecting and/or diagnosing cervical and other human papillomavirus associated cancers

Research paper thumbnail of Cannabinoids for neuropathic pain

Current pain and headache reports, 2014

Treatment options for neuropathic pain have limited efficacy and use is fraught with dose-limitin... more Treatment options for neuropathic pain have limited efficacy and use is fraught with dose-limiting adverse effects. The endocannabinoid system has been elucidated over the last several years, demonstrating a significant interface with pain homeostasis. Exogenous cannabinoids have been demonstrated to be effective in a range of experimental neuropathic pain models, and there is mounting evidence for therapeutic use in human neuropathic pain conditions. This article reviews the history, pharmacologic development, clinical trials results, and the future potential of nonsmoked, orally bioavailable, nonpsychoactive cannabinoids in the management of neuropathic pain.

Research paper thumbnail of Biochemical Genetics of the Colorado River Gila Complex (Pisces: Cyprinidae)

The Southwestern Naturalist, 1989

Page 1. THE SOUTHWESTERN NATURALIST 34(2):232-244 JUNE 1989 BIOCHEMICAL GENETICS OF THE COLORADO ... more Page 1. THE SOUTHWESTERN NATURALIST 34(2):232-244 JUNE 1989 BIOCHEMICAL GENETICS OF THE COLORADO RIVER GILA COMPLEX (PISCES: CYPRINIDAE) MARK J. ROSENFELD AND JEFFERY A. WILKINSON ...

Research paper thumbnail of The Endocannabinoid System, Cannabinoids, and Pain

Rambam Maimonides Medical Journal, 2013

The endocannabinoid system is involved in a host of homeostatic and physiologic functions, includ... more The endocannabinoid system is involved in a host of homeostatic and physiologic functions, including modulation of pain and inflammation. The specific roles of currently identified endocannabinoids that act as ligands at endogenous cannabinoid receptors within the central nervous system (primarily but not exclusively CB1 receptors) and in the periphery (primarily but not exclusively CB2 receptors) are only partially elucidated, but they do exert an influence on nociception. Exogenous plant-based cannabinoids (phytocannabinoids) and chemically related compounds, like the terpenes, commonly found in many foods, have been found to exert significant analgesic effects in various chronic pain conditions. Currently, the use of Δ9-tetrahydrocannabinol is limited by its psychoactive effects and predominant delivery route (smoking), as well as regulatory or legal constraints. However, other phytocannabinoids in combination, especially cannabidiol and β-caryophyllene, delivered by the oral route appear to be promising candidates for the treatment of chronic pain due to their high safety and low adverse effects profiles. This review will provide the reader with the foundational basic and clinical science linking the endocannabinoid system and the phytocannabinoids with their potentially therapeutic role in the management of chronic pain.

Research paper thumbnail of Persistence of the SV40 early region without expression in permissive simian cells

Virus Research, 1994

SV40 containing recombinant vectors were introduced into permissive simian, non-permissive rodent... more SV40 containing recombinant vectors were introduced into permissive simian, non-permissive rodent and semi-permissive human cell lines, and assayed for transformation. All mouse and human cell clones expressed T-antigen (T-Ag) and were morphologically transformed when they contained only the wt TAg gene (ESV40) or the entire wt viral

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