The genes coding for human pro alpha 1(IV) collagen and pro alpha 2(IV) collagen are both located at the end of the long arm of chromosome 13 (original) (raw)

. 1988 Feb;42(2):309–314.

Abstract

We have isolated and characterized a cDNA clone containing DNA sequences coding for the noncollagenous carboxy-terminal domain of human pro alpha 2(IV) collagen. Using this cDNA clone in both Southern blot analysis of DNA isolated from human-mouse somatic-cell hybrids and in situ hybridization of normal human metaphase chromosomes, we have demonstrated that the gene coding for human pro alpha 2(IV) collagen is located at 13q33----34, in the same position on chromosome 13 as the pro alpha 1(IV) collagen gene.

309

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boedtker H., Finer M., Aho S. The structure of the chicken alpha 2 collagen gene. Ann N Y Acad Sci. 1985;460:85–116. doi: 10.1111/j.1749-6632.1985.tb51159.x. [DOI] [PubMed] [Google Scholar]
  2. Boyd C. D., Weliky K., Toth-Fejel S., Deak S. B., Christiano A. M., Mackenzie J. W., Sandell L. J., Tryggvason K., Magenis E. The single copy gene coding for human alpha 1 (IV) procollagen is located at the terminal end of the long arm of chromosome 13. Hum Genet. 1986 Oct;74(2):121–125. doi: 10.1007/BF00282074. [DOI] [PubMed] [Google Scholar]
  3. Emanuel B. S., Cannizzaro L. A., Seyer J. M., Myers J. C. Human alpha 1(III) and alpha 2(V) procollagen genes are located on the long arm of chromosome 2. Proc Natl Acad Sci U S A. 1985 May;82(10):3385–3389. doi: 10.1073/pnas.82.10.3385. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Emanuel B. S., Sellinger B. T., Gudas L. J., Myers J. C. Localization of the human procollagen alpha 1(IV) gene to chromosome 13q34 by in situ hybridization. Am J Hum Genet. 1986 Jan;38(1):38–44. [PMC free article] [PubMed] [Google Scholar]
  5. Feinberg A. P., Vogelstein B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem. 1983 Jul 1;132(1):6–13. doi: 10.1016/0003-2697(83)90418-9. [DOI] [PubMed] [Google Scholar]
  6. Huerre-Jeanpierre C., Henry I., Bernard M., Gallano P., Weil D., Grzeschik K. H., Ramirez F., Junien C. The pro alpha 2(V) collagen gene (COL5A2) maps to 2q14----2q32, syntenic to the pro alpha 1 (III) collagen locus (COL3A1). Hum Genet. 1986 May;73(1):64–67. doi: 10.1007/BF00292666. [DOI] [PubMed] [Google Scholar]
  7. Huerre-Jeanpierre C., Mattei M. G., Weil D., Grzeschik K. H., Chu M. L., Sangiorgi F. O., Sobel M. E., Ramirez F., Junien C. Further evidence for the dispersion of the human fibrillar collagen genes. Am J Hum Genet. 1986 Jan;38(1):26–37. [PMC free article] [PubMed] [Google Scholar]
  8. Huerre C., Junien C., Weil D., Chu M. L., Morabito M., Van Cong N., Myers J. C., Foubert C., Gross M. S., Prockop D. J. Human type I procollagen genes are located on different chromosomes. Proc Natl Acad Sci U S A. 1982 Nov;79(21):6627–6630. doi: 10.1073/pnas.79.21.6627. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kurkinen M., Condon M. R., Blumberg B., Barlow D. P., Quinones S., Saus J., Pihlajaniemi T. Extensive homology between the carboxyl-terminal peptides of mouse alpha 1(IV) and alpha 2(IV) collagen. J Biol Chem. 1987 Jun 25;262(18):8496–8499. [PubMed] [Google Scholar]
  10. Maxam A. M., Gilbert W. A new method for sequencing DNA. Proc Natl Acad Sci U S A. 1977 Feb;74(2):560–564. doi: 10.1073/pnas.74.2.560. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Messing J. New M13 vectors for cloning. Methods Enzymol. 1983;101:20–78. doi: 10.1016/0076-6879(83)01005-8. [DOI] [PubMed] [Google Scholar]
  12. Mohandas T., Heinzmann C., Sparkes R. S., Wasmuth J., Edwards P., Lusis A. J. Assignment of human 3-hydroxy-3-methylglutaryl coenzyme A reductase gene to q13----q23 region of chromosome 5. Somat Cell Mol Genet. 1986 Jan;12(1):89–94. doi: 10.1007/BF01560731. [DOI] [PubMed] [Google Scholar]
  13. Pihlajaniemi T., Tryggvason K., Myers J. C., Kurkinen M., Lebo R., Cheung M. C., Prockop D. J., Boyd C. D. cDNA clones coding for the pro-alpha1(IV) chain of human type IV procollagen reveal an unusual homology of amino acid sequences in two halves of the carboxyl-terminal domain. J Biol Chem. 1985 Jun 25;260(12):7681–7687. [PubMed] [Google Scholar]
  14. Prockop D. J., Kivirikko K. I. Heritable diseases of collagen. N Engl J Med. 1984 Aug 9;311(6):376–386. doi: 10.1056/NEJM198408093110606. [DOI] [PubMed] [Google Scholar]
  15. Sanger F., Nicklen S., Coulson A. R. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463–5467. doi: 10.1073/pnas.74.12.5463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Solomon E., Hiorns L. R., Spurr N., Kurkinen M., Barlow D., Hogan B. L., Dalgleish R. Chromosomal assignments of the genes coding for human types II, III, and IV collagen: a dispersed gene family. Proc Natl Acad Sci U S A. 1985 May;82(10):3330–3334. doi: 10.1073/pnas.82.10.3330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Solomon E., Hiorns L., Dalgleish R., Tolstoshev P., Crystal R., Sykes B. Regional localization of the human alpha 2(I) collagen gene on chromosome 7 by molecular hybridization. Cytogenet Cell Genet. 1983;35(1):64–66. doi: 10.1159/000131838. [DOI] [PubMed] [Google Scholar]
  18. Strom C. M., Eddy R. L., Shows T. B. Localization of human type II procollagen gene (COL2A1) to chromosome 12. Somat Cell Mol Genet. 1984 Nov;10(6):651–655. doi: 10.1007/BF01535232. [DOI] [PubMed] [Google Scholar]
  19. Vandenplas S., Wiid I., Grobler-Rabie A., Brebner K., Ricketts M., Wållis G., Bester A., Boyd C., Måthew C. Blot hybridisation analysis of genomic DNA. J Med Genet. 1984 Jun;21(3):164–172. doi: 10.1136/jmg.21.3.164. [DOI] [PMC free article] [PubMed] [Google Scholar]