Prevalence of age related maculopathy in a representative Japanese population: the Hisayama study (original) (raw)

Abstract

_AIM_—To determine the prevalence of age related maculopathy (ARM) in a representative older Japanese population. _METHODS_—1486 residents of Hisayama town, Fukuoka, Japan, aged 50 years or older were examined and the presence of ARM was determined by grading from fundus examination by indirect ophthalmoscope, slit lamp, and colour fundus photographs. _RESULTS_—The prevalence rate of drusen, which occurred with comparable frequency in men and women, was 9.6%. The frequency of drusen increased with age (p <0.01). Hyperpigmentation and/or hypopigmentation of the retina was present in 3.2%, geographic atrophy in 0.2%, and neovascular age related macular degeneration in 0.67%. The frequency of neovascular age related macular degeneration was significantly higher in the men (1.2% v 0.34%, p <0.01). _CONCLUSIONS_—Early and late stage ARM is less common among Japanese people than among white people in Western countries, while late stage ARM is more common among Japanese than among black people.

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Figure 1 .

Figure 1  

The frequency of the drusen size by age in the Hisayama study. There were no significant differences in the frequency of these larger drusen in terms of sex or age.

Selected References

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  1. Bird A. C., Bressler N. M., Bressler S. B., Chisholm I. H., Coscas G., Davis M. D., de Jong P. T., Klaver C. C., Klein B. E., Klein R. An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group. Surv Ophthalmol. 1995 Mar-Apr;39(5):367–374. doi: 10.1016/s0039-6257(05)80092-x. [DOI] [PubMed] [Google Scholar]
  2. Bressler N. M., Bressler S. B., West S. K., Fine S. L., Taylor H. R. The grading and prevalence of macular degeneration in Chesapeake Bay watermen. Arch Ophthalmol. 1989 Jun;107(6):847–852. doi: 10.1001/archopht.1989.01070010869032. [DOI] [PubMed] [Google Scholar]
  3. Friedman D. S., Katz J., Bressler N. M., Rahmani B., Tielsch J. M. Racial differences in the prevalence of age-related macular degeneration: the Baltimore Eye Survey. Ophthalmology. 1999 Jun;106(6):1049–1055. doi: 10.1016/S0161-6420(99)90267-1. [DOI] [PubMed] [Google Scholar]
  4. Iwamoto H., Kiyohara Y., Fujishima M., Kato I., Nakayama K., Sueishi K., Tsuneyoshi M. Prevalence of intracranial saccular aneurysms in a Japanese community based on a consecutive autopsy series during a 30-year observation period. The Hisayama study. Stroke. 1999 Jul;30(7):1390–1395. doi: 10.1161/01.str.30.7.1390. [DOI] [PubMed] [Google Scholar]
  5. Klein R., Davis M. D., Magli Y. L., Segal P., Klein B. E., Hubbard L. The Wisconsin age-related maculopathy grading system. Ophthalmology. 1991 Jul;98(7):1128–1134. doi: 10.1016/s0161-6420(91)32186-9. [DOI] [PubMed] [Google Scholar]
  6. Klein R., Klein B. E., Jensen S. C., Mares-Perlman J. A., Cruickshanks K. J., Palta M. Age-related maculopathy in a multiracial United States population: the National Health and Nutrition Examination Survey III. Ophthalmology. 1999 Jun;106(6):1056–1065. doi: 10.1016/S0161-6420(99)90255-5. [DOI] [PubMed] [Google Scholar]
  7. Klein R., Klein B. E., Linton K. L. Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology. 1992 Jun;99(6):933–943. doi: 10.1016/s0161-6420(92)31871-8. [DOI] [PubMed] [Google Scholar]
  8. Klein R., Meuer S. M., Moss S. E., Klein B. E. Detection of drusen and early signs of age-related maculopathy using a nonmydriatic camera and a standard fundus camera. Ophthalmology. 1992 Nov;99(11):1686–1692. doi: 10.1016/s0161-6420(92)31745-2. [DOI] [PubMed] [Google Scholar]
  9. Klein R., Rowland M. L., Harris M. I. Racial/ethnic differences in age-related maculopathy. Third National Health and Nutrition Examination Survey. Ophthalmology. 1995 Mar;102(3):371–381. doi: 10.1016/s0161-6420(95)31012-3. [DOI] [PubMed] [Google Scholar]
  10. Leibowitz H. M., Krueger D. E., Maunder L. R., Milton R. C., Kini M. M., Kahn H. A., Nickerson R. J., Pool J., Colton T. L., Ganley J. P. The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975. Surv Ophthalmol. 1980 May-Jun;24(Suppl):335–610. [PubMed] [Google Scholar]
  11. Mitchell P., Smith W., Attebo K., Wang J. J. Prevalence of age-related maculopathy in Australia. The Blue Mountains Eye Study. Ophthalmology. 1995 Oct;102(10):1450–1460. doi: 10.1016/s0161-6420(95)30846-9. [DOI] [PubMed] [Google Scholar]
  12. Ohmura T., Ueda K., Kiyohara Y., Kato I., Iwamoto H., Nakayama K., Nomiyama K., Ohmori S., Yoshitake T., Shinkawu A. Prevalence of type 2 (non-insulin-dependent) diabetes mellitus and impaired glucose tolerance in the Japanese general population: the Hisayama Study. Diabetologia. 1993 Nov;36(11):1198–1203. doi: 10.1007/BF00401066. [DOI] [PubMed] [Google Scholar]
  13. Schachat A. P., Hyman L., Leske M. C., Connell A. M., Wu S. Y. Features of age-related macular degeneration in a black population. The Barbados Eye Study Group. Arch Ophthalmol. 1995 Jun;113(6):728–735. doi: 10.1001/archopht.1995.01100060054032. [DOI] [PubMed] [Google Scholar]
  14. Smith W., Mitchell P., Leeder S. R. Smoking and age-related maculopathy. The Blue Mountains Eye Study. Arch Ophthalmol. 1996 Dec;114(12):1518–1523. doi: 10.1001/archopht.1996.01100140716016. [DOI] [PubMed] [Google Scholar]
  15. Tamakoshi A., Yuzawa M., Matsui M., Uyama M., Fujiwara N. K., Ohno Y. Smoking and neovascular form of age related macular degeneration in late middle aged males: findings from a case-control study in Japan. Research Committee on Chorioretinal Degenerations. Br J Ophthalmol. 1997 Oct;81(10):901–904. doi: 10.1136/bjo.81.10.901. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Vingerling J. R., Dielemans I., Hofman A., Grobbee D. E., Hijmering M., Kramer C. F., de Jong P. T. The prevalence of age-related maculopathy in the Rotterdam Study. Ophthalmology. 1995 Feb;102(2):205–210. doi: 10.1016/s0161-6420(95)31034-2. [DOI] [PubMed] [Google Scholar]
  17. Vingerling J. R., Hofman A., Grobbee D. E., de Jong P. T. Age-related macular degeneration and smoking. The Rotterdam Study. Arch Ophthalmol. 1996 Oct;114(10):1193–1196. doi: 10.1001/archopht.1996.01100140393005. [DOI] [PubMed] [Google Scholar]
  18. Wu L. H. Study of aging macular degeneration in China. Jpn J Ophthalmol. 1987;31(3):349–367. [PubMed] [Google Scholar]
  19. Yuzawa M., Tamakoshi A., Kawamura T., Ohno Y., Uyama M., Honda T. Report on the nationwide epidemiological survey of exudative age-related macular degeneration in Japan. Int Ophthalmol. 1997;21(1):1–3. doi: 10.1023/a:1005845521424. [DOI] [PubMed] [Google Scholar]