Molecules controlling lymphocyte migration to the gut (original) (raw)

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Figure 1 .

Figure 1  

Multistep model of lymphocyte homing into the gut. The five separate steps in lymphocyte trafficking from the blood into gut are shown. The molecules mediating different stages of binding of naive lymphocytes to Peyer's patch (PP) high endothelial venules (HEV) and adhesion of activated immunoblasts to Peyer's patch HEV or flat walled venules in lamina propria are shown. In the three first steps only molecules which have been shown to function in vivo under flow conditions in the gut are included. MAdCAM, mucosal addressin cell adhesion molecule; ICAM, intercellular adhesion molecule; LFA, lymphocyte function associated antigen; MAdCAMcho, MAdCAM with special carbohydrate structures.

Figure 2 .

Figure 2  

Structure of the mucosal adhesion antigens. The mosaic nature of L-selectin, mucosal addressin cell adhesion molecule (MAdCAM) 1 and special carbohydrate containing forms of MAdCAM-1 (MAdCAM-1 CHO) is shown together with the prototypic structure of integrins and intercellular adhesion molecules (ICAM). Lectin, C-type (calcium dependent) lectin domain; EGF-like, epidermal growth factor-like domain; and CR, complement regulatory protein-like motif in selectins. Metal binding = divalent cation binding repeats in α subunits of integrins; I-domain = inserted domain in αL subunit of lymphocyte function associated antigen (LFA) 1 and I-domain-like, a putative inserted domain-like area in β subunits of integrins.

Selected References

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