Flavone acetic acid--an interesting novel therapeutic agent or just another disappointment? (original) (raw)

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beutler B., Milsark I. W., Cerami A. C. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science. 1985 Aug 30;229(4716):869–871. doi: 10.1126/science.3895437. [DOI] [PubMed] [Google Scholar]
  2. Bibby M. C., Double J. A., Loadman P. M., Duke C. V. Reduction of tumor blood flow by flavone acetic acid: a possible component of therapy. J Natl Cancer Inst. 1989 Feb 1;81(3):216–220. doi: 10.1093/jnci/81.3.216. [DOI] [PubMed] [Google Scholar]
  3. Bibby M. C., Double J. A., Phillips R. M., Loadman P. M. Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid). Br J Cancer. 1987 Feb;55(2):159–163. doi: 10.1038/bjc.1987.32. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bibby M. C., Phillips R. M., Double J. A. Influence of site on the chemosensitivity of transplantable murine colon tumours to flavone acetic acid (LM975, NSC 347512). Cancer Chemother Pharmacol. 1989;24(2):87–94. doi: 10.1007/BF00263126. [DOI] [PubMed] [Google Scholar]
  5. Capolongo L. S., Balconi G., Ubezio P., Giavazzi R., Taraboletti G., Regonesi A., Yoder O. C., D'Incalci M. Antiproliferative properties of flavone acetic acid (NSC 347512) (LM 975), a new anticancer agent. Eur J Cancer Clin Oncol. 1987 Oct;23(10):1529–1535. doi: 10.1016/0277-5379(87)90096-4. [DOI] [PubMed] [Google Scholar]
  6. Chabot G. G., Bissery M. C., Gouyette A. Flavone acetic acid (LM-975; NSC-347512) activation to cytotoxic species in vivo and in vitro. Cancer Chemother Pharmacol. 1989;24(5):273–276. doi: 10.1007/BF00304757. [DOI] [PubMed] [Google Scholar]
  7. Ching L. M., Baguley B. C. Effect of flavone acetic acid (NSC 347,512) on splenic cytotoxic effector cells and their role in tumour necrosis. Eur J Cancer Clin Oncol. 1989 May;25(5):821–828. doi: 10.1016/0277-5379(89)90127-2. [DOI] [PubMed] [Google Scholar]
  8. Ching L. M., Baguley B. C. Enhancement of in vitro cytotoxicity of mouse peritoneal exudate cells by flavone acetic acid (NSC 347512). Eur J Cancer Clin Oncol. 1988 Sep;24(9):1521–1525. doi: 10.1016/0277-5379(88)90345-8. [DOI] [PubMed] [Google Scholar]
  9. Ching L. M., Baguley B. C. Induction of natural killer cell activity by the antitumour compound flavone acetic acid (NSC 347 512). Eur J Cancer Clin Oncol. 1987 Jul;23(7):1047–1050. doi: 10.1016/0277-5379(87)90357-9. [DOI] [PubMed] [Google Scholar]
  10. Corbett T. H., Bissery M. C., Wozniak A., Plowman J., Polin L., Tapazoglou E., Dieckman J., Valeriote F. Activity of flavone acetic acid (NSC-347512) against solid tumors of mice. Invest New Drugs. 1986;4(3):207–220. doi: 10.1007/BF00179586. [DOI] [PubMed] [Google Scholar]
  11. Cummings J., Double J. A., Bibby M. C., Farmer P., Evans S., Kerr D. J., Kaye S. B., Smyth J. F. Characterization of the major metabolites of flavone acetic acid and comparison of their disposition in humans and mice. Cancer Res. 1989 Jul 1;49(13):3587–3593. [PubMed] [Google Scholar]
  12. Double J. A., Bibby M. C., Loadman P. M. Pharmacokinetics and anti-tumour activity of LM985 in mice bearing transplantable adenocarcinomas of the colon. Br J Cancer. 1986 Oct;54(4):595–600. doi: 10.1038/bjc.1986.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Evelhoch J. L., Bissery M. C., Chabot G. G., Simpson N. E., McCoy C. L., Heilbrun L. K., Corbett T. H. Flavone acetic acid (NSC 347512)-induced modulation of murine tumor physiology monitored by in vivo nuclear magnetic resonance spectroscopy. Cancer Res. 1988 Sep 1;48(17):4749–4755. [PubMed] [Google Scholar]
  14. Finlay G. J., Smith G. P., Fray L. M., Baguley B. C. Effect of flavone acetic acid on Lewis lung carcinoma: evidence for an indirect effect. J Natl Cancer Inst. 1988 Apr 20;80(4):241–245. doi: 10.1093/jnci/80.4.241. [DOI] [PubMed] [Google Scholar]
  15. Giavazzi R., Garofalo A., Damia G., Garattini S., D'Incalci M. Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts. Br J Cancer. 1988 Mar;57(3):277–280. doi: 10.1038/bjc.1988.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Hill S., Williams K. B., Denekamp J. Vascular collapse after flavone acetic acid: a possible mechanism of its anti-tumour action. Eur J Cancer Clin Oncol. 1989 Oct;25(10):1419–1424. doi: 10.1016/0277-5379(89)90099-0. [DOI] [PubMed] [Google Scholar]
  17. Hornung R. L., Young H. A., Urba W. J., Wiltrout R. H. Immunomodulation of natural killer cell activity by flavone acetic acid: occurrence via induction of interferon alpha/beta. J Natl Cancer Inst. 1988 Oct 5;80(15):1226–1231. doi: 10.1093/jnci/80.15.1226. [DOI] [PubMed] [Google Scholar]
  18. Kerr D. J., Kaye S. B., Cassidy J., Bradley C., Rankin E. M., Adams L., Setanoians A., Young T., Forrest G., Soukop M. Phase I and pharmacokinetic study of flavone acetic acid. Cancer Res. 1987 Dec 15;47(24 Pt 1):6776–6781. [PubMed] [Google Scholar]
  19. Mace K. F., Hornung R. L., Wiltrout R. H., Young H. A. Correlation between in vivo induction of cytokine gene expression by flavone acetic acid and strict dose dependency and therapeutic efficacy against murine renal cancer. Cancer Res. 1990 Mar 15;50(6):1742–1747. [PubMed] [Google Scholar]
  20. Mahadevan V., Malik S. T., Meager A., Fiers W., Lewis G. P., Hart I. R. Role of tumor necrosis factor in flavone acetic acid-induced tumor vasculature shutdown. Cancer Res. 1990 Sep 1;50(17):5537–5542. [PubMed] [Google Scholar]
  21. Parr I., Wheeler E., Alexander P. Similarities of the anti-tumour actions of endotoxin, lipid A and double-stranded RNA. Br J Cancer. 1973 May;27(5):370–389. doi: 10.1038/bjc.1973.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Plowman J., Narayanan V. L., Dykes D., Szarvasi E., Briet P., Yoder O. C., Paull K. D. Flavone acetic acid: a novel agent with preclinical antitumor activity against colon adenocarcinoma 38 in mice. Cancer Treat Rep. 1986 May;70(5):631–635. [PubMed] [Google Scholar]
  23. Schroyens W. A., Dodion P. F., Sanders C., Loos M., Dethier N. E., Delforge A. R., Stryckmans P. A., Kenis Y. In vitro chemosensitivity testing of flavone acetic acid (LM975; NSC 347512) and its diethylaminoethyl ester derivative (LM985; NSC 293015). Eur J Cancer Clin Oncol. 1987 Aug;23(8):1135–1139. doi: 10.1016/0277-5379(87)90146-5. [DOI] [PubMed] [Google Scholar]
  24. Semenzato G. Tumour necrosis factor: a cytokine with multiple biological activities. Br J Cancer. 1990 Mar;61(3):354–361. doi: 10.1038/bjc.1990.78. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Smith G. P., Calveley S. B., Smith M. J., Baguley B. C. Flavone acetic acid (NSC 347512) induces haemorrhagic necrosis of mouse colon 26 and 38 tumours. Eur J Cancer Clin Oncol. 1987 Aug;23(8):1209–1211. doi: 10.1016/0277-5379(87)90157-x. [DOI] [PubMed] [Google Scholar]
  26. Urba W. J., Longo D. L., Lombardo F. A., Weiss R. B. Enhancement of natural killer activity in human peripheral blood by flavone acetic acid. J Natl Cancer Inst. 1988 Jun 1;80(7):521–525. doi: 10.1093/jnci/80.7.521. [DOI] [PubMed] [Google Scholar]
  27. Wiltrout R. H., Boyd M. R., Back T. C., Salup R. R., Arthur J. A., Hornung R. L. Flavone-8-acetic acid augments systemic natural killer cell activity and synergizes with IL-2 for treatment of murine renal cancer. J Immunol. 1988 May 1;140(9):3261–3265. [PubMed] [Google Scholar]
  28. Wiltrout R. H., Hornung R. L. Natural products as antitumor agents: direct versus indirect mechanisms of activity of flavonoids. J Natl Cancer Inst. 1988 Apr 20;80(4):220–222. doi: 10.1093/jnci/80.4.220. [DOI] [PubMed] [Google Scholar]
  29. Zaharko D. S., Grieshaber C. K., Plowman J., Cradock J. C. Therapeutic and pharmacokinetic relationships of flavone acetic acid: an agent with activity against solid tumors. Cancer Treat Rep. 1986 Dec;70(12):1415–1421. [PubMed] [Google Scholar]
  30. Zwi L. J., Baguley B. C., Gavin J. B., Wilson W. R. Blood flow failure as a major determinant in the antitumor action of flavone acetic acid. J Natl Cancer Inst. 1989 Jul 5;81(13):1005–1013. doi: 10.1093/jnci/81.13.1005. [DOI] [PubMed] [Google Scholar]