N-Acetylglucosamine Assimilation in Escherichia coli and Its Relation to Catabolite Repression (original) (raw)

Abstract

The ability of _N_-acetylglucosamine to enhance catabolite repression by glucose was studied by using cultures grown on a combination of these substrates. Under these conditions, it was shown that two-thirds of the _N_-acetylglucosamine utilized was routed into dissimilatory pathways, whereas the remaining one-third was channeled into biosynthesis. It was established that over 50% of the _N_-acetylglucosamine assimilated was incorporated directly into amino sugar polymers. It was also shown that this exogenous supply of _N_-acetylglucosamine was in fact used preferentially over glucose as the precursor for amino sugar polymer biosynthesis. These findings provided support for the prediction that catabolite repression in Escherichia coli may be interrelated with certain reactions involved in amino sugar biosynthesis.

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Selected References

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