A Genetic Method for Determining the Order of Events in a Biological Pathway (original) (raw)

Abstract

We describe the application of a simple genetic test that indicates the order of events in a morphogenic or biochemical pathway. The test uses temperature-sensitive (ts) and cold-sensitive (cs) mutants, and it orders the times at which the ts and cs defects are expressed.

Keywords: cold-sensitive mutants, temperature-sensitive mutants, phage P22, morphogenesis, temporal sequence

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Selected References

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